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Chitosan In Drug Delivery

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Chitosan and Its Derivatives as Promising Drug Delivery Carriers

Chitosan and Its Derivatives as Promising Drug Delivery Carriers Book
Author : M. Prabaharan
Publisher : Momentum Press
Release : 2012-10-19
ISBN : 1606504134
Language : En, Es, Fr & De

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Book Description :

Chitosan, a natural based polymer obtained by alkaline deacetylation of chitin, is non-toxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for the development of conventional and novel drug delivery systems. Recently, there has been a growing interest in the chemical modification of chitosan in order to improve its solubility and widen its applications. Chemical modification of chitosan is useful for the association of bioactive molecules to the polymer and controlling the drug release profile. Chemical modification will introduce desired properties and enlarge the field of the potential applications of chitosan with the choice of various types of side chains. In this monograph, recent studies on the various types of chitosan microspheres are discussed from the viewpoint of drug delivery applications. Moreover, different types of chitosan derivatives developed as controlled drug delivery carriers and their preparation methods are discussed in detail. The modifications discussed here include amphiphilic chitosan derivatives, N-(aminoalkyl) chitosan, carboxymethyl chitosan, thiolated chitosans, phosphorylated chitosan, etc. Special emphasis has been given to the development of chitosan-based polyelectrolyte complexes, graft copolymerized chitosan and chitosan-based stimuli-responsive hydrogels as drug delivery carriers. The reviewed studies lead to the conclusion that chitosan derivatives are promising materials for the controlled delivery of various types of therapeutic agents.

Functional Chitosan

Functional Chitosan Book
Author : Sougata Jana,Subrata Jana
Publisher : Springer Nature
Release : 2020-03-05
ISBN : 9811502633
Language : En, Es, Fr & De

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Book Description :

Thanks to their unique properties, chitosan and chitosan-based materials have numerous applications in the field of biomedicine, especially in drug delivery. This book examines biomedical applications of functional chitosan, exploring the various functions and applications in the development of chitosan-based biomaterials. It also describes the chemical structure of chitosan and discusses the relationship between their structure and functions, providing a theoretical basis for the design of biomaterials. Lastly, it reviews chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and gene delivery.

Study of Chitosan based Nanocarrier for Drug Delivery

Study of Chitosan based Nanocarrier for Drug Delivery Book
Author : Yiu Ming Ng
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Study of Chitosan based Nanocarrier for Drug Delivery book written by Yiu Ming Ng, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Synthesis and Characterization of Cyclodextrin Based Chitosan Nanoparticles for Drug Delivery of Esential Oil

Synthesis and Characterization of Cyclodextrin Based Chitosan Nanoparticles for Drug Delivery of Esential Oil Book
Author : Kabo I. Matshetshe
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Synthesis and Characterization of Cyclodextrin Based Chitosan Nanoparticles for Drug Delivery of Esential Oil book written by Kabo I. Matshetshe, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chitosan Based Materials and its Applications

Chitosan Based Materials and its Applications Book
Author : Guilherme Luiz Dotto, Sergio Paulo Campana-Filho and Luiz Antonio de Almeida Pinto
Publisher : Bentham Science Publishers
Release : 2017-06-07
ISBN : 1681084856
Language : En, Es, Fr & De

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Book Description :

This volume presents 10 reviews contributed by eminent researchers around the world on chitosan based materials. The introductory chapters present information on general characteristics of chitosan and various types of materials which are based on it such as nanofibers, nanoparticles, nanocapsules and other chemically modified chitosans. This is followed by an explanation of chitosan characterization and extraction techniques. Concluding chapters describe the applications of chitosan products in water treatment, drug delivery, edible films and pervaporation membranes. Readers will therefore gain an understanding about chitosan and materials derived from this polymer and their practical applications. The volume serves as a simple reference for chemical engineering students and professionals interested in the basic and applied chemistry of chitosan and chitosan-derived products.

A Novel Drug Delivery System

A Novel Drug Delivery System Book
Author : Marla Reid
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download A Novel Drug Delivery System book written by Marla Reid, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chitin and Chitosan Derivatives

Chitin and Chitosan Derivatives Book
Author : Se-Kwon Kim
Publisher : CRC Press
Release : 2013-12-04
ISBN : 1466566329
Language : En, Es, Fr & De

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Book Description :

A natural long-chain polymer, chitin is the main component of the cell walls of fungi, the exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and the beaks and internal shells of cephalopods. However, marine crustacean shells are the primary sources of the chitin derivative chitosan. Chitin and chitosan are useful for various biological and biomedical applications, although they have been limited by poor solubility in the past. Current research focuses on increasing their solubility and bioactivity through molecular modifications. The resulting derivatives are receiving much attention for interesting properties, such as biocompatibility, biodegradability, and nontoxicity, that make them suitable for use in the biomedical field. Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments presents current research trends in the synthesis of chitin and chitosan derivatives, their biological activities, and their biomedical applications. Part I discusses basic information about the synthesis and characterization of a variety of derivatives, including the preparation of chitin nanofibers. Part II covers chitin and chitosan modifications as the basis for biological applications. It describes antioxidant, anti-inflammatory, anticancer, antiviral, anticoagulant, and antimicrobial activities. Part III addresses chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and wound dressing. A must-have reference for novices and experts in biotechnology, natural products, materials science, nutraceuticals, and biomedical engineering, this book presents a wide range of biological and biomedical applications of chitin and chitosan derivatives for drug discovery and development.

Chitosan

Chitosan Book
Author : Shakeel Ahmed,Saiqa Ikram
Publisher : John Wiley & Sons
Release : 2017-08-04
ISBN : 1119364817
Language : En, Es, Fr & De

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Book Description :

This book delves deeply in to the preparation, characterization and multiple applications of chitin and chitosan. The 17 chapters written by leading experts is an excellent reference source and state-of-the-art review for researchers and scientists using chitosan or biopolymers in their respective areas. This book is divided into following sections: • Production and derivatives of chitosan • Chitosan in the textile and food industries • Chitosan in biomedical applications • Chitosan in agriculture and water treatment The book is practical as readers will be able to see descriptions of chitosan production methods as well as techniques that can be used to estimate and modify their physical and chemical properties. It provides a full description not only of the traditional and recent developments in the applications of chitosan in the fields of biotechnology, environmental studies, food, medicine, water treatments, drug delivery, but it includes all of the therapeutically usages as well.

Chitosan for Biomaterials I

Chitosan for Biomaterials I Book
Author : R. Jayakumar,M. Prabaharan,Riccardo A. A. Muzzarelli
Publisher : Springer Science & Business Media
Release : 2011-09-15
ISBN : 3642231136
Language : En, Es, Fr & De

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Book Description :

Polymeric Nanoparticles of Chitosan Derivatives as DNA and siRNA Carriers, by Y. K. Kim, H. L. Jiang, Y. J. Choi, I. K. Park, M. H. Cho and C. S. Cho.- Chitosan and Its Derivatives for Drug Delivery Perspective, by T. A. Sonia and C. P. Sharma.- Chitosan-based Nanoparticles in Cancer Therapy, by V.-K. Lakshmanan, K. S. Snima, J. D. Bumgardner, S. V. Nair, and R. Jayakumar.- Chitosan and Thiolated Chitosan, by F. Sarti and A. Bernkop-Schnürch.- Chitosan-Based Particulate Systems for Non-Invasive Vaccine Delivery, by S. Şenel.- Multifunctional Chitosan Nanoparticles for Tumor Imaging and Therapy, by J. Y. Yhee, Heebeom Koo, Dong Eun Lee, Kuiwon Choi, Ick Chan Kwon and Kwangmeyung Kim.- Chitosan-Coated Iron Oxide Nanoparticles for Molecular Imaging and Drug Delivery, by H. Arami, Z. Stephen, O. Veiseh and M. Zhang.- Chitosan: Its Applications in Drug-Eluting Devices, by Mei -Chin Chen, Fwu -Long Mi, Zi -Xian Liao and Hsing -Wen Sung.-

Chitosan Based Systems for Biopharmaceuticals

Chitosan Based Systems for Biopharmaceuticals Book
Author : Bruno Sarmento,Jose das Neves
Publisher : John Wiley & Sons
Release : 2012-02-16
ISBN : 1119964075
Language : En, Es, Fr & De

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Book Description :

Chitosan is a linear polysaccharide commercially produced by the deacetylation of chitin. It is non-toxic, biodegradable, biocompatible, and acts as a bioadhesive with otherwise unstable biomolecules - making it a valuable component in the formulation of biopharmaceutical drugs. Chitosan-Based Systems for Biopharmaceuticals provides an extensive overview of the application of chitosan and its derivatives in the development and optimisation of biopharmaceuticals. The book is divided in four different parts. Part I discusses general aspects of chitosan and its derivatives, with particular emphasis on issues related to the development of biopharmaceutical chitosan-based systems. Part II deals with the use of chitosan and derivatives in the formulation and delivery of biopharmaceuticals, and focuses on the synergistic effects between chitosan and this particular subset of pharmaceuticals. Part III discusses specific applications of chitosan and its derivatives for biopharmaceutical use. Finally, Part IV presents diverse viewpoints on different issues such as regulatory, manufacturing and toxicological requirements of chitosan and its derivatives related to the development of biopharmaceutical products, as well as their patent status, and clinical application and potential. Topics covered include: chemical and technological advances in chitins and chitosans useful for the formulation of biopharmaceuticals physical properties of chitosan and derivatives in sol and gel states absorption promotion properties of chitosan and derivatives biocompatibility and biodegradation of chitosan and derivatives biological and pharmacological activity of chitosan and derivatives biological, chemical and physical compatibility of chitosan and biopharmaceuticals approaches for functional modification or crosslinking of chitosan use of chitosan and derivatives in conventional biopharmaceutical dosage forms manufacture techniques of chitosan-based microparticles and nanoparticles for biopharmaceuticals chitosan and derivatives for biopharmaceutical use: mucoadhesive properties chitosan-based systems for mucosal delivery of biopharmaceuticals chitosan-based delivery systems for mucosal vaccination chitosan-based nanoparticulates for oral delivery of biopharmaceuticals chitosan-based systems for ocular delivery of biopharmaceuticals chemical modification of chitosan for delivery of DNA and siRNA target-specific chitosan-based nanoparticle systems for nucleic acid delivery functional PEGylated chitosan systems for biopharmaceuticals stimuli-sensitive chitosan-based systems for biopharmaceuticals chitosan copolymers for biopharmaceuticals application of chitosan for anti-cancer biopharmaceutical delivery chitosan-based biopharmaceuticals scaffolds in tissue engineering and regenerative medicine wound healing properties of chitosan and its use in wound dressing biopharmaceuticals toxicological properties of chitosan and derivatives for biopharmaceutical applications regulatory status of chitosan and derivatives patentability and intellectual property issues quality control and good manufacturing practice preclinical and clinical use of chitosan and derivatives for biopharmaceuticals Chitosan-Based Systems for Biopharmaceuticals is an important compendium of fundamental concepts, practical tools and applications of chitosan-based biopharmaceuticals for researchers in academia and industry working in drug formulation and delivery, biopharmaceuticals, medicinal chemistry, pharmacy, bioengineering and new materials development.

Smart Universal Chitosan Nanoformulations

Smart Universal Chitosan Nanoformulations Book
Author : Sami Al-Harbi,Hammed Al-Saidi,Abdelaziz Sayed El-Ahl
Publisher : LAP Lambert Academic Publishing
Release : 2013
ISBN : 9783659418211
Language : En, Es, Fr & De

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Book Description :

This book provides an overview in recent progress in the field of chitosan based smart nanoformulations and describes the basic concepts of passive and active cancer targeting chitosan based drug delivery vehicles including organ-specific drug delivery systems. Also, the construction and applications of multifunctional chitosan nanoparticulates used in cancer diagnosis, imaging and therapy have been described. The book also introduced an insight into various, mono, dual and multi-responsive smart chitosan nanoparticles that respond to their environment and their application in controlled gene and drug release nanoformulations.

Chitosan for Biomaterials IV

Chitosan for Biomaterials IV Book
Author : R. Jayakumar,M. Prabaharan
Publisher : Springer Nature
Release : 2021-09-30
ISBN : 3030830217
Language : En, Es, Fr & De

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Book Description :

This volume presents the recent developments on the biomedical applications of chitosan and its derivatives. Chitosan exhibits unique properties such as non-toxicity, biodegradability and biocompatibility. Since its chemical structure and properties can be easily modified, it can be an ideal candidate as a biomaterial. Consequently, chitosan and its derivatives are being developed in different forms such as nanoparticles, micelles, nanofibers, hydrogels, films and 3D porous materials for various biomedical applications, ranging from drug and gene delivery to tissue engineering and regenerative medicine. The chapters of this volume focus on the potential use of chitosan and its derivatives as a hemostatic agent, tissue sealants, tissue engineering scaffolds, delivery carriers for bioactive molecules in bone tissue engineering and wound dressings. Some chapter’s deal with recent advancements of chitosan-based biomaterials as a drug, gene and transdermal drug delivery carrier. In addition, the volume focusses on the prospects of chitosan-based systems for the treatment of cancer, eye and other infectious diseases. The volume will be of interest to material scientists, chemists and biotechnologists by providing a better understanding of the physicochemical and biological characteristics of chitosan and its derivatives to develop more appropriate and innovative chitosan-based materials modified for unlimited practical applications in biomedical fields.

Current Status of Chitosan on Dermal Transdermal Drug Delivery Systems

Current Status of Chitosan on Dermal Transdermal Drug Delivery Systems Book
Author : Ipek Ozcan
Publisher : Nova Science Pub Incorporated
Release : 2010
ISBN : 9781617612985
Language : En, Es, Fr & De

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Book Description :

In case of targeting the drug to the desired part of the skin, vehicles play an important role beside the characteristics of the drug. Many natural and synthetic vehicles have been used for various topical dermal/transdermal preparations. However, chitosan has been standing out with its many advantages based mainly on its biological and physicochemical properties. Chitosan is a unique hydrophilic biopolymer obtained by partial deacetylation of chitin, which is one of the most abundant polysaccharides. It is a natural product widely found in crustacean shells, fungal cell walls, insect exoskeletons, and mollusks. Chitosan is a linear glycosaminoglycan made up of N-acetyl-D-glucosamine units. This book focuses on the use of chitosan for dermal/transdermal drug delivery systems following a general overview of chitosan.

Chitosan Strategies to Increase and Modulate Drug Release Rate

Chitosan  Strategies to Increase and Modulate Drug Release Rate Book
Author : David Lucio
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Chitin is the second most abundant polysaccharide present in nature; however, chitin has more applications when transformed into chitosan (CS). It is biocompatible, biodegradable, mucoadhesive, soluble in acidic-solutions, nontoxic and nonallergenic. The main drawback of chitosan in pharmaceutical procedures is its low solubility in physiological medium. Chitosan shows physicochemical characteristics that allow it to interact with a wide variety of molecules. This is of particular interest when increasing the solubility of poor water-soluble drugs. For this purpose, chitosan can be used in oral, nasal and ocular routes. In order to modulate drug release rate and achieve a proper drug delivery in physiological medium, some parameters can be modified when solid dispersions or nanoparticles (NPs) based on chitosan are being designed. In case of nanoparticles, chitosan can be used as the main component or as a modifying agent. In order to optimize drug loading and drug delivery, response surface methodology (RSM) is an interesting tool usually underestimated in the pharmaceutical field, which allows us to optimize the parameters involved in the process simultaneously and not by different steps, which usually lead to mistakes.

Chitosan Derivatives in Drug Delivery

Chitosan Derivatives in Drug Delivery Book
Author : Maria Thanou
Publisher : Unknown
Release : 2000
ISBN : 9789603170532
Language : En, Es, Fr & De

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Book Description :

Download Chitosan Derivatives in Drug Delivery book written by Maria Thanou, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Plasticized Chitosan based Xerogel Nanocomposite for Controlled Drug Delivery

Plasticized Chitosan based Xerogel Nanocomposite for Controlled Drug Delivery Book
Author : Feiran Li
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Plasticized Chitosan based Xerogel Nanocomposite for Controlled Drug Delivery book written by Feiran Li, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chitosan Membrane Permeated Transdermal Drug Delivery of Ondansetron

Chitosan Membrane Permeated Transdermal Drug Delivery of Ondansetron Book
Author : Amit Kumar Singh
Publisher : LAP Lambert Academic Publishing
Release : 2013
ISBN : 9783659381881
Language : En, Es, Fr & De

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Book Description :

Conventional dosage forms often lead to wide swings in serum drug concentrations. Most of the drug content is released soon after administration, causing drug level in the body to rise rapidly, attain maximum concentration and then decline sharply. This sharp fluctuations often cause unacceptable side effects at the peaks, followed by inadequate therapy at the troughs. In the transdermal drug delivery system, drug is released at a constant rate and provides plasma concentration that remains constant over an extended period of time. In the present work, chitosan film has been used as rate controlling membrane for the transdermal drug delivery of an antiemetic drug, Ondansetron HCl. This book throws light on the preparation and evaluation of chitosan membrane as well as provides a new method for the preparation of chitosan gel.This book also, provides the way of fabrication and evaluation of transdermal patches utilising chitosan films which shows promising potential for use in the transdermal delivery of Ondansetron HCl.

Chitosan Microspheres for Controlled Drug Delivery

Chitosan Microspheres for Controlled Drug Delivery Book
Author : Ping He
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Chitosan Microspheres for Controlled Drug Delivery book written by Ping He, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Hydrophobic Chitosan Derivatives in Controlled Release Drug Delivery Systems

Hydrophobic Chitosan Derivatives in Controlled Release Drug Delivery Systems Book
Author : Farooq Aristo Tayab
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Hydrophobic Chitosan Derivatives in Controlled Release Drug Delivery Systems book written by Farooq Aristo Tayab, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.