Chitosan In Biomedical Applications

Book Description :

"Chitosan Based Biomaterials: Fundamentals, Volume 1, " provides the latest information on chitosan, a natural polymer derived from the marine material chitin. Chitosan displays unique properties, most notably biocompatibility and biodegradability. It can also be easily tuned to modify its structure or properties, making chitosan an excellent candidate as a biomaterial. Consequently, chitosan is being developed for many biomedical functions, ranging from tissue engineering and implant coatings to drug and gene delivery. This book looks at the fundamentals of chitosan-based biomaterials. Contains specific focus on the techniques and technologies needed to develop chitosan for biomedical applicationsPresents a comprehensive treatment of the fundamentalsProvides contributions from leading researchers with extensive experience in chitosan

Book Description :

This volume presents the recent developments on the biomedical applications of chitosan and its derivatives. Chitosan exhibits unique properties such as non-toxicity, biodegradability and biocompatibility. Since its chemical structure and properties can be easily modified, it can be an ideal candidate as a biomaterial. Consequently, chitosan and its derivatives are being developed in different forms such as nanoparticles, micelles, nanofibers, hydrogels, films and 3D porous materials for various biomedical applications, ranging from drug and gene delivery to tissue engineering and regenerative medicine. The chapters of this volume focus on the potential use of chitosan and its derivatives as a hemostatic agent, tissue sealants, tissue engineering scaffolds, delivery carriers for bioactive molecules in bone tissue engineering and wound dressings. Some chapter’s deal with recent advancements of chitosan-based biomaterials as a drug, gene and transdermal drug delivery carrier. In addition, the volume focusses on the prospects of chitosan-based systems for the treatment of cancer, eye and other infectious diseases. The volume will be of interest to material scientists, chemists and biotechnologists by providing a better understanding of the physicochemical and biological characteristics of chitosan and its derivatives to develop more appropriate and innovative chitosan-based materials modified for unlimited practical applications in biomedical fields.

Book Description :

Thanks to their unique properties, chitosan and chitosan-based materials have numerous applications in the field of biomedicine, especially in drug delivery. This book examines biomedical applications of functional chitosan, exploring the various functions and applications in the development of chitosan-based biomaterials. It also describes the chemical structure of chitosan and discusses the relationship between their structure and functions, providing a theoretical basis for the design of biomaterials. Lastly, it reviews chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and gene delivery.

Book Description :

Chitosan in Biomedical Applications provides a thorough insight into the complete chitosan chemistry, collection, chemical modifications, characterization and applications of chitosan in biomedical applications and healthcare fields. Chitosan, a biopolymer of natural origin, has been explored for its variety of applications in biomedical research, medical diagnostic aids and material science. It is the second most abundant natural biopolymer after cellulose, and considered as an excellent excipient because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of chitosan in biomedical applications. The book explores key topics, such as molecular weight, degree of deacetylation, and molecular geometry, along with an emphasis on recent advances in the field written by academic, industry, and clinical researchers. Chitosan in Biomedical Applications will be of interest to those in biomedical fields including the biomaterials and tissue engineering community investigating and developing biomaterials for biomedical applications, particularly graduate students, young faculty and others exploring chitosan-based materials. Provides methodology for the design, development and selection of chitosan in biomedical applications for particular therapeutic applications Includes illustrations demonstrating the mechanism of biological interaction of chitosan Discusses the regulatory aspects and demonstrates the clinical efficacy of chitosan

Book Description :

This book delves deeply in to the preparation, characterization and multiple applications of chitin and chitosan. The 17 chapters written by leading experts is an excellent reference source and state-of-the-art review for researchers and scientists using chitosan or biopolymers in their respective areas. This book is divided into following sections: • Production and derivatives of chitosan • Chitosan in the textile and food industries • Chitosan in biomedical applications • Chitosan in agriculture and water treatment The book is practical as readers will be able to see descriptions of chitosan production methods as well as techniques that can be used to estimate and modify their physical and chemical properties. It provides a full description not only of the traditional and recent developments in the applications of chitosan in the fields of biotechnology, environmental studies, food, medicine, water treatments, drug delivery, but it includes all of the therapeutically usages as well.

Book Description :

Chitosan is a rather abundant material with exquisite properties, which may be processed into a variety of materials including hydrogels, fibres, membranes, etc. The production of chitosan-based nanogels, also known as macromolecular miceles, has been successfully achieved using different techniques, which will be reviewed. This book covers the properties and applications of chitosan nanogels in the biomedical field, namely as a drug delivery vehicle for biopharmaceuticals. The main achievements and recent developments will be addressed in this book.

Book Description :

Chitosan is one of the most studied polysaccharides nowadays. Because of its biocompatibility, biodegradability and abundance in nature, it has had a wide number of applications. In this chapter, an overview of chitosan including its physicochemical properties and characterization methods is presented. Subsequently, the main chitosan chemical modifications via the hydroxyl and amino groups are discussed. These chemical modifications improve chitosan physical properties and expand its range of applications especially in the biomedical field which will also be studied.

Book Description :

The modified formulations were tested for their in vitro gene delivery properties and it was found that these ligands improved gene transfection efficiencies significantly. Chitosan nanoparticles were optimized further for enzyme immobilization purposes using sodium sulfate and glutaraldehyde as physical and chemical cross-linking agents, respectively. These particles and chitosan films were used for immobilizing trypsin utilizing several techniques. Enzyme immobilization via avidin-biotin interaction resulted in high immobilization efficiency and high enzymatic activity in different reaction conditions. Additionally, the immobilized trypsin systems were stable and amenable to be regenerated for multiple uses. Finally, glutaraldehyde cross-linked chitosan films were modified with PEG and RGD for their cell repellant and cell adhesion properties, respectively, using avidin-biotin interaction. This method was again effective in engineering chitosan surfaces for modulating cell adhesion and proliferation. In conclusion, using avidin-biotin technique to modify biotinylated chitosan surfaces is a facile method to attach a wide variety of ligands in mild reaction conditions, while preserving the functionality of these ligands.

Book Description :

The second edition of Chitin underscores the important factors for standardizing chitin processing and characterization. It captures the essential interplay between chitin's assets and limitations as a biomaterial, placing the past promises of chitin in perspective, addressing its present realities and offering insight into what is required to realize chitin's destiny (including its derivative, chitosan) as a biomaterial of the twenty-first century. This book is an ideal guide for both industrialists and researchers with a vested interest in commercializing chitin. An update on the research since 2001 as it pertains to the biomaterials and biomedical applications of chitin and chitosan An expanded discussion on positioning chitin and chitosan for biomedical applications Presents regulatory aspects of chitin and chitosan

Book Description :

Download Chitosan based Nanofibers for Biomedical Applications book written by Ashleigh Cooper, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Book Description :

Chitosan Based Biomaterials: Tissue Engineering and Therapeutics, Volume 2, provides the latest information on chitosan, a natural polymer derived from the marine material chitin. Chitosan displays unique properties, most notably biocompatibility and biodegradability. It can also be easily tuned to modify its structure or properties, making chitosan an excellent candidate as a biomaterial. Consequently, chitosan is being developed for many biomedical functions, ranging from tissue engineering and implant coatings to drug and gene delivery. This book provides readers with a full coverage of the applications of chitosan-based biomaterials. Presents specific focus on tissue engineering and therapeutics Provides comprehensive treatment of all biomaterial applications of chitosan Contains contributions by leading researchers with extensive experience in the material

Book Description :

A natural long-chain polymer, chitin is the main component of the cell walls of fungi, the exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and the beaks and internal shells of cephalopods. However, marine crustacean shells are the primary sources of the chitin derivative chitosan. Chitin and chitosan are useful for various biological and biomedical applications, although they have been limited by poor solubility in the past. Current research focuses on increasing their solubility and bioactivity through molecular modifications. The resulting derivatives are receiving much attention for interesting properties, such as biocompatibility, biodegradability, and nontoxicity, that make them suitable for use in the biomedical field. Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments presents current research trends in the synthesis of chitin and chitosan derivatives, their biological activities, and their biomedical applications. Part I discusses basic information about the synthesis and characterization of a variety of derivatives, including the preparation of chitin nanofibers. Part II covers chitin and chitosan modifications as the basis for biological applications. It describes antioxidant, anti-inflammatory, anticancer, antiviral, anticoagulant, and antimicrobial activities. Part III addresses chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and wound dressing. A must-have reference for novices and experts in biotechnology, natural products, materials science, nutraceuticals, and biomedical engineering, this book presents a wide range of biological and biomedical applications of chitin and chitosan derivatives for drug discovery and development.

Book Description :

Chitosan Based Biomaterials: Fundamentals, Volume 1, provides the latest information on chitosan, a natural polymer derived from the marine material chitin. Chitosan displays unique properties, most notably biocompatibility and biodegradability. It can also be easily tuned to modify its structure or properties, making chitosan an excellent candidate as a biomaterial. Consequently, chitosan is being developed for many biomedical functions, ranging from tissue engineering and implant coatings to drug and gene delivery. This book looks at the fundamentals of chitosan-based biomaterials. Contains specific focus on the techniques and technologies needed to develop chitosan for biomedical applications Presents a comprehensive treatment of the fundamentals Provides contributions from leading researchers with extensive experience in chitosan

Book Description :

Chitin, poly (ß-(1?4)-N-acetyl-d-glucosamine), is a natural polysaccharide of major importance, first identified in 1884. It is the second most abundant natural polymer after cellulose and exists largely in the marine crustacean. Chitin occurs in nature as ordered crystalline microfibrils forming structural components in the exoskeleton of arthropods or in the cell walls of fungi and yeast. The most important derivative of chitin is chitosan, which is obtained by partial N-deacetylation of chitin in the solid state under alkaline conditions (concentrated NaOH) or by enzymatic hydrolysis in the presence of a chitin deacetylase. Because of the semicrystalline morphology of chitin, chitosans obtained by an alkaline reaction have a heterogeneous distribution of acetyl groups along the chains. Studies on chitin and chitosan have been intensified since 1990 because these polysaccharides show excellent biological properties such as biodegradation in the human body, and immunological, antibacterial, and wound-healing activity. In recent studies, especially, chitosan has been found to be a good candidate as a support material for gene delivery, cell culture, and tissue engineering. Therefore, chitin and chitosan are receiving greater attention as novel functional materials. Despite their interesting biological properties, utilization has been scarcely developed. This review book is a comprehensive introduction to the bioscience and biomedical applications of chitin and chitosan. This review book covers the synthesis and biological properties of chitin and chitosan derivatives and their applications in drug delivery, medical and biological fields. This review book also covers almost all the important findings in these fields and explored these results clearly. The main importance of this review book is to know the chemical and biological properties of chitin and chitosan. These broad ranges of topics that are systematically discussed in this review book will be helpful to carry out more innovative researches in chitin and chitosan in the near future. This review book contains seven chapters included with the various topics of current research interest. Chapter 1 is focusing various methods of preparation of water soluble derivatives of chitin and chitosan. Moreover, the potential applications of these derivatives in the various fields such as drug delivery, food, cosmetics, tissue engineering and environmental is also discussed. In Chapter 2 are reviews the various methods of synthesis, properties of the chemically modified chitosans and their applications of the chemically modified chitosans derivatives for controlled drug and non-viral gene delivery. The knowledge of chitosan scaffold preparation and their characterization and biological activities, which are reported in recent literatures, are discussed in Chapter 3. The Chapter 4, the developments of chitin and chitosan interfaces for the applications in biosensors, microarray, cell arrays, micro fluidic devices and bioimaging are focused. The recent research and development of chitin/chitosan based biomaterials for potential application in orthopedic or bone and cartilage tissue engineering is reviewed in the Chapter 5. The chapter 6 is focusing on the various types of chitosan derivatives and their use in various tissue engineering applications namely, skin, bone, cartilage, liver, nerve and blood vessel. In chapter 7 is focusing about the production and properties of chitin and chitosan obtained from crustacean and fungal sources and their applications in medical and biological sectors are discussed. This review book explains that the advantage of chitin and chitosan over the other polysaccharides. As described in this review, the chemical structure of chitin and chitosan allows specific modifications at their reactive sites, without changing the bulk properties. Specific groups can be introduced into their reactive sites to design polymers for selected applications. Since the biological properties of chitin and chitosan are valuable for medical applications, the developments in these filed can be considered as valuable extensions of the use of chitin and its derivatives. I expect that this review book will be helpful to the people, who are interesting in chitin and chitosan research. I warmly thank the authors for their efforts in producing such informed and enlightening exposition on these topics in chitin and chitosan. Finally, I acknowledge the staff of Research Signpost (India) for their patience and assistance.

Book Description :

Download Physically Crosslinked Chitosan Based Hydrogels for Biomedical Applications book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Book Description :

The book is an excellent reference for scientists, researchers and students working in the field of areas of biopolymeric biomaterials, biomedical engineering, therapeutics, tissue engineering and regenerative medicine. The book is divided into two parts: Part I will focus on the tissue engineering and Part II focuses on therapeutics, functionalization and computer-aided techniques. The book consists of 13 chapters contributed by 20 international contributors who are leading experts in the field of biopolymers and its applications. It will focus on the advancements of chitin and chitosan in regenerative medicine. Regenerative medicine in tissue engineering is the process of replacing or regenerating human cells, tissues, or organs to restore or establish normal function. It is an incredibly progressive field of medicine that may, in the near future, help with the shortage of life-saving organs available through donation for transplantation vis-a-vis regenerative medicine focuses on therapeutics, functionalization and computer-aided techniques. It also covers physical and chemical aspects of chitin and chitosan, structural modifications for biomedical applications, chitosan based scaffolds and biomodelling in tissue engineering, nanomedicines and therapeutic applications. With the broad range of applications, the world is waiting for biopolymers to serve as the basis for regenerative medicine and biomedical applications.

Book Description :

Chitosan is a favorable natural polymer for biomedical application for its biocompatible, biodegradable, non-toxic, and hydrophilic properties. It has a chemical structure analogous to glycosaminoglycans, a component of extracellular matrix, indicating its potential bioactivity. However, chitosan's low mechanical strength precludes pristine chitosan scaffolds from tissue engineering. To achieve higher mechanical strength, different reinforcing agents are incorporated into the scaffold system; however, improved mechanical properties are obtained at the cost of compromised structure, porosity, and biological properties of the scaffold. Therefore, pristine chitosan is often preferred over its composites in biomedical applications due to its superior biological properties. This dissertation research presents several novel approaches such as controlling chitosan concentration in scaffold, applying the right temperature gradient, and developing a modular-collector electrospinning system to fabricate chitosan scaffolds with higher mechanical properties and appropriate morphology, pore size, and porosity for different tissue engineering uses, including bone and muscle. In the first approach, we controlled chitosan concentration in acidic solution to increase the crystallinity of chitosan scaffolds and thus fabricate stiffer scaffolds. Scaffolds of increased chitosan concentration, i.e., with greater mechanical strength, showed efficient bone tissue engineering with improved adhesion, proliferation, and osteogenic activity of MG-63 osteoblast cells. In the second approach, we applied appropriate temperature gradients to control pore size and porosity of the scaffold by regulating the rate of ice crystal formation in chitosan solution. Thus, we produced uniaxial tubular porous chitosan scaffolds with pore size and mechanical properties comparable to those of native skeletal muscle tissues. These scaffolds demonstrated the ability to align muscle cells, guide and promote cell fusion, and produce thick myotubes. In the third approach, we developed a novel portable electrospinning system with a modular-collector to control scaffold shape. This approach produced chitosan-based aligned nanofibrous cylindrical, tubular, and membrane scaffolds for different tissue engineering. In a model application, muscle cells cultured on chitosan-based cylindrical and tubular scaffolds showed their effectiveness in producing highly aligned and densely populated myotubes required for muscle tissue engineering. In the fourth approach, we developed a novel hybrid substrate in which a stripe-pattern chitosan substrate, several microns in thickness, is overlaid on a chitosan-based aligned nanofibrous membrane parallel to mimic native micro/nano environment. The results from muscle cell culture showed a higher level of expression of later-stage differentiation genes such as myogenin and myosin heavy chain on the hybrid substrate compared to that found on only nanofibrous membrane or stripe-pattern chitosan substrate. Finally, we stacked cell-cultured substrates to produce 3D tissue-engineered scaffold constructs. These findings prove chitosan's effectiveness as a material that can be used to design and develop scaffolds of required native forms with controlled structure, size, porosity, and mechanical properties for different tissue engineering needs.

Book Description :

In recent years there have been tremendous advances in the fields of chemistry, physics and biology which have a direct impact on advances in biomaterials science. These advances have contributed significantly to the improvement of modern health care and continue to influence the practice of medicine. A biomaterial is any material, natural or man-made, that comprises whole or part of a living structure or biomedical device which performs, augments, or replaces a natural function. Among the biomaterials, chitin and chitosan have received much attention due to their non-toxicity, biodegradability, biocompatibility and multifunctional properties with applications in biomedical and pharmaceutical sciences. The main driving force behind the development of new applications for chitin and its derivative chitosan lies with the fact that these polysaccharides represent a renewable source of natural biodegradable polymers. Since chitin is the second most abundant natural polymer, academic as well as industrial scientists are faced with a great challenge to find new and practical applications for this material. This book provides an examination of the state of the art, and discusses current research as well as new biomedical applications of chitin and chitosan. Applications of chitin and chitosan will be of interest to industrial personnel involved in bioprocessing as well as bioengineering students, specialists in the biomedical and biopharmaceutical industry, biochemists, food engineers, environmentalists, and microbiologists and biologists who specialize in chitosan technology. The subject matter of the book is divided into nine chapters. Chapter 1 deals with the preparation and physico-chemical properties of amphiphilic derivatives of chitin and chitosan. The potential applications of these derivatives in the fields of controlled drug and gene delivery are discussed in details. Chapter 2 deals with the inhibitory activity of chitosan against bacteria and fungi potentially encountered in foodstuffs and the modes of action as suggested in the literature. Recent approaches, such as enzymatic depolymerization and chemical modifications, developed to improve the bioactivity of chitosan are reported. In addition, the applications of chitosan based products as biopackaging materials in food preservation are explored. In chapter 3, the recent developments and applications of stimuli-responsive materials based on chitosan are discussed. Moreover, different approaches used to prepare chitosan interpenetrating networks are analyzed and the potential of the resultant system for biomedical applications are critically reviewed. Different methods of chitosan deposition onto substrates for tissue engineering, wound dressing, separation membranes, biocompatible and antibacterial coatings, stent coatings, and sensors applications are reported in chapter 4. Chapter 5 of this book deals with the mechanisms involved in the in vitro calcification of chitosan while chapter 6 discusses the role of chitosan and its derivatives as potent adjuvant/delivery systems for mucosal immunization both in human and veterinary medicine. The current research and developments on chitin and chitosan nanoscaffolds for tissue engineering applications and future demands on bio-products are discussed in chapter 7. Chapter 8 reviews the different techniques of chitosan microsphere preparation for the drug delivery applications. In addition, the advantages of using chitosan microsphere as drug carrier are also explored. Recently, considerable works have been directed to develop an ideal scaffold based on polymer/ceramic composite materials. In this context, chitosan/calcium phosphate composite materials would have an importance in bone tissue engineering. The preparation methods, properties and applications of composite scaffolds and cements based on calcium phosphate and chitosan are reported in chapter 9. We hope this book can serve as a comprehensive introduction to researchers in biomaterials science and engineering in general, and can also be used as a graduate level text in related areas. We thank the authors for their excellent contributions to this book and our publishers for their encouragement which motivated us to produce this book. We believe this will make a lasting contribution to the field of biomaterials science.

Book Description :

Keywords: nanofibers, chitosan, electrospinning, surgical adhesion.

Book Description :

Download Development of Chitosan based Membranes for Biomedical Applications book written by Mayra Gabriela Brito Charles, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.