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Chiral Analysis

Chiral Analysis Book
Author : P.L. Polavarapu
Publisher : Elsevier
Release : 2018-05-30
ISBN : 0444640282
Language : En, Es, Fr & De

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Book Description :

Chiral Analysis: Advances in Spectroscopy, Chromatography and Emerging Methods, Second Edition covers an important area of analytical chemistry of relevance to a wide variety of scientific professionals, including chemistry graduate students, analytical chemists, organic chemists, professionals in the pharmaceutical industry, and others with an interest in chirality and chiral analysis. This thoroughly revised second edition covers several new, important areas of chiral analysis that have emerged since the first edition. Three of the new methods provide higher sensitivity than can be realized with the current methods and are expected to become mainstream applications: cavity based methods offer vastly higher sensitivity than conventional polarimetric methods, microwave chiral detection provides unsurpassed sensitivity for identifying diastereomers, and the rotating electric field method offers a competing new approach for the separation of enantiomers. Another topic, chirality in extraterrestrial life, has not been discussed in any other book and is important for understanding the origin of life. Offers the only book to cover both spectroscopic and separation methods in a single volume Provides an up-to-date and detailed review of the various techniques available, including new techniques that have emerged since the first edition Includes contributions from a range of leading experts in the field, now edited by award-winning chirality researcher Prasad Polavarapu

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Chiral Separation Methods for Pharmaceutical and Biotechnological Products Book
Author : Satinder Ahuja
Publisher : John Wiley & Sons
Release : 2011-03-31
ISBN : 9781118097755
Language : En, Es, Fr & De

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Book Description :

Discusses chiral separations and offers guidance for selectingthe optimum method for desired results Chiral separations represent the most intriguing and, by somemeasures, most difficultseparations of chemical compounds. Thisbook provides researchers and students an under-standing of chiralseparations and offers a convenient route to selecting the bestseparation method, saving considerable time and cost in productdevelopment. Considering chiral separations in the biotechnological andpharmaceutical industries, as well as for food applications, Dr.Ahuja provides insights into a broad range of topics. Opening witha broad overview of chiral separations, regulatory considerationsin drug product development, and basic issues in methoddevelopment, the book: Covers a variety of modern methods such as gas chromatography,high performance liquid chromatography, supercritical fluidchromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity ofsmall and large molecules Provides detailed information on useful chiral stationary phases(CSPs) for HPLC Includes handy information on selection of an appropriate CSP,including mechanistic studies Offers strategies for fast method development with HPLC, SFC,and CE Discusses preparatory methods utilized in the pharmaceuticalindustry With in-depth discussions of the current state of the field aswell as suggestions to assist future developments, ChiralSeparation Methods for Pharmaceutical and BiotechnologicalProducts is an essential text for laboratory investigators,managers, and regulators who are involved in chiral separations inthe pharmaceutical industry, as well as students preparing forcareers in these fields.

Capillary Electrophoresis in Chiral Analysis

Capillary Electrophoresis in Chiral Analysis Book
Author : Bezhan Chankvetadze
Publisher : John Wiley & Sons
Release : 1997-12-29
ISBN : 9780471974154
Language : En, Es, Fr & De

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Book Description :

Capillary Electrophoresis in Chiral Analysis Bezhan Chankvetadze Tbilisi State University, Republic of Georgia The application of capillary electrophoresis (CE) to the field of chiral analysis has exploded recently. The advantages of capillary electrophoresis - extremely high peak efficiency, excellent compatibility with biological samples, short analysis time, simplicity, versatility and low cost - are perfect for the accurate measurement of optical purity, increasingly important in the regulation-ruled pharmaceutical industry. Although there have been a number of books on capillary electrophoresis and chiral analysis separately, as yet there has been no dedicated monograph on the application of capillary electrophoresis to chiral analysis. This book bridges the gap. Capillary Electrophoresis in Chiral Analysis charts the evolution of chiral capillary electrophoresis and describes new types of chiral selectors and mechanistic aspects of chiral recognition. While on the one hand, it is an excellent introduction to newcomers, on the other, it is of practical use to experienced researchers in the field wishing to solve a particular separation problem. It includes an alphabetical list of chiral compounds resolved using CE with appropriate references, which any one working in the field will find invaluable.

Chiral Pollutants

Chiral Pollutants Book
Author : Imran Ali,Hassan Y. Aboul-Enein
Publisher : John Wiley & Sons
Release : 2005-07-15
ISBN : 0470867817
Language : En, Es, Fr & De

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Book Description :

Today, among the various chiral discrimination methods, chromatography and capillary electrophoresis techniques have become powerful tools in environmental analysis. Therefore, there is a need to describe the art of the determination of the chiral pollutants in the environmental matrices. This book provides the complete information on the types of the chiral pollutants, their toxicities and methods of determination by chromatography and capillary electrophoresis.

Chiral Analysis

Chiral Analysis Book
Author : Kenneth W. Busch,Marianna A. Busch
Publisher : Elsevier
Release : 2011-10-13
ISBN : 9780080469287
Language : En, Es, Fr & De

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Book Description :

Chiral Analysis covers an important area of analytical chemistry of relevance to a wide variety of scientific professionals. The target audience is scientific professionals with an undergraduate background in chemistry or a related discipline, specifically organic chemists, researchers in drug discovery, pharmaceutical researchers involved with process analysis or combinatorial libraries, and graduate students in chemistry. Chapters have been written with the nonspecialist in mind so as to be self-contained. * Broad coverage - spectroscopic and separation methods covered in a single volume * Up-to-date and detailed review of the various techniques available and/or under development in this field * Contributions from leading experts in the field

Chiral Environmental Pollutants

Chiral Environmental Pollutants Book
Author : R. Kallenborn,H. Hühnerfuss
Publisher : Springer Science & Business Media
Release : 2013-04-17
ISBN : 3662062437
Language : En, Es, Fr & De

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Book Description :

This monograph contains a survey on the role of chirality in ecotoxicological processes. The focus is on environmental trace analysis. Areas such as toxicology, ecotoxicology, synthetic chemistry, biology, and physics are also covered in detail in order to explain the different properties of enantiomers in environmental samples. This monograph delivers a comprehensive survey for environmental trace analysts, analytical chemists, ecotoxicologists, food scientists and experienced lab workers.

Analysis of Chiral Organic Molecules

Analysis of Chiral Organic Molecules Book
Author : Peter Schreier,Alexander Bernreuther,Manfred Huffer
Publisher : Walter de Gruyter
Release : 1995-01-01
ISBN : 3110867850
Language : En, Es, Fr & De

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Book Description :

Download Analysis of Chiral Organic Molecules book written by Peter Schreier,Alexander Bernreuther,Manfred Huffer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Thin Layer Chromatography in Chiral Separations and Analysis

Thin Layer Chromatography in Chiral Separations and Analysis Book
Author : Teresa Kowalska,Joseph Sherma
Publisher : CRC Press
Release : 2007-06-22
ISBN : 1000654311
Language : En, Es, Fr & De

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Book Description :

Thin layer chromatography (TLC) is well suited for performing enantioseparations for research as well as larger-scale applications. A fast, inexpensive, and versatile separation technique, there are many practical considerations that contribute to its effectiveness. Thin Layer Chromatography in Chiral Separations and Analysis is the first bo

Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis

Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis Book
Author : Peter Mikuš
Publisher : BoD – Books on Demand
Release : 2012-08-29
ISBN : 9535106570
Language : En, Es, Fr & De

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Book Description :

The scientific monograph by the author Peter Mikus entitled "Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis" provides a comprehensive view on the advanced capillary electrophoresis techniques aimed to current chiral bioanalysis. The advances in the chiral electrophoresis analytical approaches are divided and theoretically described in three sections involving (i) advanced chiral separations for the optimization of chiral resolution (separation mechanisms; electrophoresis techniques in capillary and microchip format; electrophoretic modes such as ITP, CZE/EKC, CEC; chiral additives / pseudophases / phases), (ii) advanced sample preparation for the on-line preconcentration, sample clean-up and analyte derivatization (implementation of electrophoretic effects such as stacking; non-electrophoretic effects such as SPE, chromatography, dialysis; combinations of these effects; multidimensional CE systems; instrumental schemes), (iii) advanced combinations of detection and electrophoresis for the optimization in qualitative and quantitative evaluation (the most important universal as well as selective detection approaches such as absorption and fluorescence spectrophotometry, electrochemical detection, mass spectrometry vs. (i) and/or (ii)). Real analytical potential (benefits and limitations) of these advanced analytical approaches is emphasized by selected performance parameters of the methods and illustrated by many current practical applications including chiral analyses of drugs, their (bio)degradation products and biomarkers in pharmaceutical and biological matrices. The author wishes the readers many inspirations in the creation of new innovative approaches in the field of advanced chiral electrophoresis techniques with the aim to overcome capabilities of the current analytical techniques.

Chiral Chromatography

Chiral Chromatography Book
Author : Thomas E. Beesley,Raymond P. W. Scott
Publisher : John Wiley & Sons
Release : 1999-01-26
ISBN : 9780471974277
Language : En, Es, Fr & De

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Book Description :

Chiral Chromatography Thomas E. Beesley Advanced Separation Technologies Inc., Whippany, New Jersey, USA Raymond P. W. Scott Chemistry Department, Georgetown University, Washington DC, USA and Chemistry Department, Birkbeck College, University of London, UK Analytical techniques based on separation processes, such as chromatography and electrophoresis, are finding a growing range of applications in chemical, pharmaceutical and clinical laboratories. The Wiley Separation Science Series provides the analyst in these laboratories with well-focused books covering individual techniques, so that they can be applied more efficiently and effectively to contemporary analytical problems. The different enantiomers of a drug can exhibit widely different physiological activity in degree and nature. As a result, the separation and identification of enantiomers is now a very important analytical problem and chiral chromatography is the natural technique to apply to the resolution of such mixtures. Chiral Chromatography provides the reader with a basic understanding of the nature of chromatographic separations and relates the principles specifically to the separation of enantiomers. The following information is included: * chiral separations involving both gas and liquid chromatography * descriptions of the apparatus used for both techniques * detailed discussion on the retention mechanism that results in chiral selectivity * the structure and synthesis of a wide range of chirally active stationary phases used in both gas and liquid chromatography * preparative applications for large scale purification of enantiomers * applications of capillary electrophoresis and capillary electrochromatography. In addition to the above, a large number of examples of the separation of both commercially and physiologically interesting chiral mixtures are given, as is a detailed discussion on the mechanism of selectivity of each example. Thomas Beesley was founder and is the CEO for a leading manufacturer of chiral stationary phases and has published papers on TLC, HPLC and chiral separations involving cyclodextrins. He has also coauthored papers with Daniel W. Armstrong, an expert on modern cyclodextrin columns. Raymond Scott has worked in the field of separation science for over 40 years and has contributed extensively to the development of both gas and liquid chromatography publishing over 160 papers on the subjects.

A Practical Guide to Chiral Analysis

A Practical Guide to Chiral Analysis Book
Author : Louis (Pete) A. Silks, III
Publisher : Wiley
Release : 2015-08-24
ISBN : 9780470455500
Language : En, Es, Fr & De

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Book Description :

Written by an acclaimed expert in the field, A Practical Guide to Chiral Analysis provides an entry-level, user-friendly introduction to the subject. Highlighting common methods of chiral analysis used by the practitioner as well as recent advances, the text is destined to become the go-to source for analytical chemists, pharmaceutical scientists, and lab technicians when a chiral analytical process needs to be understood or performed. The author includes an entire chapter on the strategies of choosing the correct method chiral analysis method.

Chiral Recognition in Separation Methods

Chiral Recognition in Separation Methods Book
Author : Alain Berthod
Publisher : Springer Science & Business Media
Release : 2010-06-16
ISBN : 3642124453
Language : En, Es, Fr & De

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Book Description :

What drives a scientist to edit a book on a speci c scienti c subject such as chiral mechanisms in separation methods? Until December 2005, the journal Analytical Chemistry of the American Chemical Society (Washington, DC) had an A-page section that was dedicated to simple and clear presentations of the most recent te- niques or the state of the art in a particular eld or topic. The “A-page” section was prepared for a broad audience of chemists including industrial professionals, s- dents as well as academics looking for information outside their eld of expertise. 1 Daniel W. Armstrong, one of the editors of this journal and a twenty-year+ long friend, invited me to present my view on chiral recognition mechanisms in a simple and clear way in an “A-page” article. In 2006, the “A-page” section was maintained as the rst articles at the beginning of each rst bi-monthly issue but the pagination was no longer page distinguished from the regular research articles published by the journal. During the time between the invitation and the submission, the A-page section was integrated into the rest of the journal and the article appeared as (2006) Anal Chem (78):2093–2099.

Differentiation of Chiral Compounds Using NMR Spectroscopy

Differentiation of Chiral Compounds Using NMR Spectroscopy Book
Author : Thomas J. Wenzel
Publisher : John Wiley & Sons
Release : 2018-06-01
ISBN : 1119324777
Language : En, Es, Fr & De

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Book Description :

An updated guide to the most current information available for determining how to use NMR spectroscopy to differentiate chiral compounds Differentiation of Chiral Compounds Using NMR Spectroscopy offers a thoroughly revised second edition to the essential volume that puts the focus on the chiral systems that are commercially available and have been widely vetted for use in NMR spectroscopy. The text covers a broad range of reagents that make it possible to determine the enantiomeric purity and assign the absolute configuration of many classes of compounds. Comprehensive in scope, the text describes the chiral NMR differentiating agents as derivatizing agents, solvating agents, metal-based reagents and liquid crystals and gels, and explains the range and types of compounds for which they can be used for analysis. New to this edition are the most recent findings in the field as well as the development of advanced NMR measurement techniques that allow for the simplification of complex spectra resulting in more readily identified enantiodifferentiation. This important resource: Includes the most recent coverage of a large range of compounds that can be analyzed using chiral NMR reagents Explores the use of chiral NMR reagents and explains their relationship to the stereochemistry of the analyzed molecules Offers the essential information needed to help decide which method is the best NMR method to apply to a class or molecules Contains experimental strategies for using the reagents that are likely to improve the quality of the results Differentiation of Chiral Compounds Using NMR Spectroscopy is a comprehensive guide designed for investigators planning to use NMR spectroscopy to determine enantiomeric purity or assign the absolute configuration of a compound.

Chiral Separation Techniques

Chiral Separation Techniques Book
Author : Ganapathy Subramanian
Publisher : John Wiley & Sons
Release : 2008-01-08
ISBN : 352761172X
Language : En, Es, Fr & De

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Book Description :

Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.

Chirality in Drug Research

Chirality in Drug Research Book
Author : Eric Francotte,Wolfgang Lindner
Publisher : John Wiley & Sons
Release : 2007-09-24
ISBN : 3527608710
Language : En, Es, Fr & De

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Book Description :

Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.

Chiral Organic Pollutants

Chiral Organic Pollutants Book
Author : Edmond Sanganyado,Basil K. Munjanja,Leo M.L. Nollet
Publisher : CRC Press
Release : 2020-12-30
ISBN : 1000298965
Language : En, Es, Fr & De

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Book Description :

Chiral Organic Pollutants introduces readers to the growing challenges of chirality in synthetic chemicals. In this volume, contributors brilliantly summarize the characteristics of chiral pollutants to provide tools and techniques for effectively assessing their environmental and human health risks. Chapters cover recent research on the physicochemical properties, sources, exposure pathways, environmental fate, toxicity, and enantioselective analysis of chiral organic pollutants. Chiral Organic Pollutants also provides comprehensive discussions on the current trends in the synthesis and legislation of chiral chemicals. Key Features: Includes sampling and analytical methods for the enantioselective analysis of a wide array of chiral organic pollutants in food and the environment Summarizes recent research on the sources, fate, transport, and toxicity of chiral organic pollutants in the environment Critically examines the sources and pathways of chiral organic pollutants such as pesticides, pharmaceuticals, and flame retardants in food Includes a comprehensive discussion on current trends in the enantioselective synthesis and chiral switching of pesticides and pharmaceuticals Provides analysis of current national and international regulations of chiral synthetic chemicals The use of chiral synthetic chemicals such as pesticides, pharmaceuticals, personal care products, and halogenated flame retardants has significantly grown in the past 60 years. Hence, understanding the human and environmental health effects of chiral organic pollutants is crucial in the industry, academia, and policymaking. Chiral Organic Pollutants is an excellent textbook and reference for students, scientists, engineers, and policymakers interested in food quality, environmental pollution, chemical analysis, organic synthesis, and toxicology. Also available in the Food Analysis and Properties Series: Analysis of Nanoplastics and Microplastics in Food, edited by Leo. M.L. Nollet and Khwaja Salahuddin Siddiqi (ISBN: 9781138600188) Proteomics for Food Authentication, edited by Leo M.L. Nollet, and Semih Ötleş (ISBN: 9780367205058) Mass Spectrometry Imaging in Food Analysis, edited by Leo M.L. Nollet (ISBN: 9781138370692) For a complete list of books in this series, please visit our website at: www.crcpress.com/Food-Analysis--Properties/book-series/CRCFOODANPRO

Chiral Separations by Capillary Electrophoresis

Chiral Separations by Capillary Electrophoresis Book
Author : Ann Van Eeckhaut,Yvette Michotte
Publisher : CRC Press
Release : 2009-11-11
ISBN : 9781420069341
Language : En, Es, Fr & De

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Book Description :

Covers the Fundamentals of Chiral Separation, Available Chiral Selectors, and Numerous Applications of Chiral Separation by Capillary Electrophoresis Since the 1980s, modern analytical tools have enabled capillary electrophoresis to become a standard part of the chemist’s toolkit. With contributions from international experts, Chiral Separations by Capillary Electrophoresis provides a general overview of the principles of chiral separation by capillary electrophoresis and the different chiral selectors available. The book discusses the most important as well as several new chiral selectors used in capillary electrophoresis. It reviews recent pharmaceutical and biomedical applications and explores novel techniques, such as capillary electrophoresis coupled to mass spectrometry and microchip technology. The book also examines the quantitative aspects of capillary electrophoresis, the possibilities of capillary electrochromatography, and the various chiral columns available. Capillary electrophoresis has proven to be an effective tool for chiral separation. This book explains how this technique can be used in the separation of molecules, offering insight into both existing and emerging applications.

Chiral Separations

Chiral Separations Book
Author : Gerald Gübitz,Martin G. Schmid
Publisher : Springer Science & Business Media
Release : 2004
ISBN : 1592596487
Language : En, Es, Fr & De

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Book Description :

Prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale. Described in step-by-step detail to ensure successful experimental results, the procedures are presented as either general methods or as specific applications to substance classes and special compounds, with emphasis on high performance liquid chromatography and capillary electrophoresis techniques, but also including thin layer chromotographic, gas chromatographic, supercritical fluid chromatographic as well as recent electrochromotographic techniques.

Studies on New Approaches of Chiral Discrimination for Chiral Analysis by Regression Modeling of Spectral Data

Studies on New Approaches of Chiral Discrimination for Chiral Analysis by Regression Modeling of Spectral Data Book
Author : Selorm Kwame Modzabi
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Two new approaches of chiral discrimination for enantiomeric composition analysis using isotropic spectroscopic techniques and multivariate regression modeling were investigated. This is in view of the urgent need for rapid and improved strategies for chiral analysis due to the rising preference and demand for chiral drugs. In the first approach, (S)-(+)-1,2-propanediol or the racemic mixture of 2-butanol was reacted with the enantiomers of amino acids or chiral pharmaceutical compounds to form covalent derivatives (diastereomers). To circumvent usually long and cumbersome separation processes required by some chiral analysis techniques, the isotropic UV or fluorescence spectra of solutions of the reaction matrix containing the derivatized enantiomers were subjected to partial least squares regression (PLSR) modeling. PLSR was used as a means of extracting latent or structured information from the spectral data, which might contain interference and/or redundant information from the reaction matrix. Evaluation of the above approach using a test set of samples gave results with root-mean-square errors (RMSEs) of 0.0012-0.042. In the second approach, PLS-1 regression analysis were performed on the UV spectral data of samples containing different compositions of enantiomeric pairs, which were non-covalently discriminated in situ using a multi-functional chiral selected, (S)-( - )-1-phenylethylamine. Enantiomeric compositions of test samples of three amino acids and a carbohydrate determined using the second approach gave RMSEs of 0.006-0.025. In view of the need for micro-scale techniques in analyses such as this, a capillary tube, with a total volume of 95 [micro]L, was custom-designed in the cause of this research for the measurement of fluorescence emission spectra of micro volumes of samples. The custom-designed capillary tube, which has an internal diameter of 1 mm and requires not more than 25 [micro]L of sample solution for spectral measurement, was found to result in higher fluorescence emission intensities than measured using a commercial 10-mm pathlength fluorometer cell. Results of quantitative studies performed using the custom-designed capillary micro cell for spectral measurement were significantly identical to the results of studies conducted using the commercial cell.

Chiral Analysis of Beta blockers

Chiral Analysis of Beta blockers Book
Author : Iacob Bogdan-Cezar
Publisher : LAP Lambert Academic Publishing
Release : 2015-03-16
ISBN : 9783659642692
Language : En, Es, Fr & De

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Book Description :

In this book, new methods for the chiral analysis of -blockers are presented, divided into three sections: capillary electrochromatography (CEC), chiral electrochemical sensors and multivariate data analysis. Several types of molecular imprinted polymers (MIPs) were developed as monolithic chiral stationary phases for the separation of -blockers by CEC and the factors that influence the degree of imprinting were discussed. In the second part of the book, the development and the characterization of MIP-based electrochemical sensors for the chiral analysis of -blockers are presented. The developed electrode is the first reported chiral electrochemical sensor able to demonstrate absolute selectivity towards several -blocker representatives, offering good prospects in the simple, sensitive and fast assessment of their enantiomeric ratio and total concentration. In the last section, Partial Least Squares Projection to Latent Structures (PLS) regression modeling is applied to UV spectral absorption data from guest-host inclusion complexes between CDs and guest molecules to perform the determination of the enantiomeric composition of -antagonists."