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Chemical Sciences In Early Drug Discovery

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Chemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery Book
Author : Pierfausto Seneci
Publisher : Elsevier
Release : 2018-06-05
ISBN : 008099928X
Language : En, Es, Fr & De

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Book Description :

Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways in which medicinal chemistry is widening its reach to meet modern demands, and how modern technologies and approaches are facilitating this growth into new fields. Supported by examples throughout, the book is a practical resource for organic-medicinal chemists, biological chemists and pharmacologists involved in drug discovery. Reviews the key application of chemistry in drug discovery for both medicinal and non-medicinal chemists, clarifying and explaining the role of medicinal chemistry in supporting the modern drug discovery pipeline Shows how a wider medicinal chemistry view is essential for anyone in an integrated drug discovery project looking to reduce costs and save time Provides the critical success factors needed to successfully identify hits from both biological and chemical perspectives

Mass Spectrometry in Medicinal Chemistry

Mass Spectrometry in Medicinal Chemistry Book
Author : Klaus Wanner,Georg H?fner
Publisher : John Wiley & Sons
Release : 2007-04-09
ISBN : 3527314563
Language : En, Es, Fr & De

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Book Description :

This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.

Early Drug Development 2 Volume Set

Early Drug Development  2 Volume Set Book
Author : Fabrizio Giordanetto
Publisher : John Wiley & Sons
Release : 2018-12-10
ISBN : 3527341498
Language : En, Es, Fr & De

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Book Description :

This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources. Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.

Burger s Medicinal Chemistry Drug Discovery and Development 8 Volume Set

Burger s Medicinal Chemistry  Drug Discovery and Development  8 Volume Set Book
Author : Anonim
Publisher : John Wiley & Sons
Release : 2021-04-20
ISBN : 111953030X
Language : En, Es, Fr & De

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Book Description :

This flagship reference for medicinal chemists and pharmaceutical professionals has been thoroughly updated and expanded to incorporate the concepts of drug hunting along with its existing coverage of the entire process of drug discovery and development. Features thematic volumes or sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, antiinfectives, and CNS disorders Updates existing chapters and adds 35 new ones, incorporating the concepts of drug hunting Includes topics like: opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures

Chemogenomics in Drug Discovery

Chemogenomics in Drug Discovery Book
Author : Hugo Kubinyi,Gerhard Müller
Publisher : John Wiley & Sons
Release : 2006-03-06
ISBN : 3527604022
Language : En, Es, Fr & De

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Book Description :

Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.

Small Molecule Drug Discovery

Small Molecule Drug Discovery Book
Author : Andrea Trabocchi,Elena Lenci
Publisher : Elsevier
Release : 2019-11-23
ISBN : 0128183500
Language : En, Es, Fr & De

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Book Description :

Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology. Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules

Pharmaceutical Process Development

Pharmaceutical Process Development Book
Author : A. John Blacker,Mike T. Williams
Publisher : Royal Society of Chemistry
Release : 2011
ISBN : 1849731462
Language : En, Es, Fr & De

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Book Description :

This book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry by informing them about the breadth of the work carried out in chemical research and development departments. It is also of great value to academics wishing to advise students on the merits of careers in chemical development over discovery.

High Throughput Analysis for Early Drug Discovery

High Throughput Analysis for Early Drug Discovery Book
Author : James Kyranos
Publisher : Elsevier
Release : 2004-09-18
ISBN : 9780080472928
Language : En, Es, Fr & De

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Book Description :

High Throughput Analysis for Early Drug Discovery offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description of the synthesis approach and its advantages. The description of various combinatorial and high-throughput parallel synthesis techniques provide a relevant point of entry for synthetic chemists who need to set up appropriate characterisation methods for his/her organisation. This is an invaluable resource for all organic and analytical chemists in the pharmaceutical, agrochemical, and biotechnology fields who are either involved in, or beginning to investigate combinatorial techniques to increase overall efficiency and productivity. First reference to focus on the analytical side of synthesis

Enterprise of the Chemical Sciences

Enterprise of the Chemical Sciences Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Enterprise of the Chemical Sciences book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Platform Technologies in Drug Discovery and Validation

Platform Technologies in Drug Discovery and Validation Book
Author : Anonim
Publisher : Academic Press
Release : 2017-11-21
ISBN : 0128130709
Language : En, Es, Fr & De

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Book Description :

Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides. Unique for its treatment of platform technologies for medicinal chemistry and target validation Provides a single, rich volume that summaries a broad spectrum of expertise relevant to the field Presents state-of-the-art summaries of platform technologies

Luminaries of the Chemical Sciences

Luminaries of the Chemical Sciences Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Luminaries of the Chemical Sciences book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Medicinal Chemistry and Drug Discovery Drug discovery and drug development

Medicinal Chemistry and Drug Discovery  Drug discovery and drug development Book
Author : Alfred Burger
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Medicinal Chemistry and Drug Discovery Drug discovery and drug development book written by Alfred Burger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Oral Formulation Roadmap from Early Drug Discovery to Development

Oral Formulation Roadmap from Early Drug Discovery to Development Book
Author : Elizabeth Kwong
Publisher : John Wiley & Sons
Release : 2017-02-06
ISBN : 1118907337
Language : En, Es, Fr & De

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Book Description :

Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development. • Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry • Focuses on pre (or non-) clinical and early stage development, the phases where most compounds are used in drug research • Features case studies to illustrate practical challenges and solutions in formulation selection • Covers regulatory filing, drug metabolism and physical and chemical properties, toxicology formulation, biopharmaceutics classification system (BCS), screening approaches, early stage clinical formulation development, and outsourcing

Generic Pharmaceuticals

Generic Pharmaceuticals Book
Author : United States. Congress. Senate. Committee on Commerce, Science, and Transportation
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Generic Pharmaceuticals book written by United States. Congress. Senate. Committee on Commerce, Science, and Transportation, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Health and Medicine

Health and Medicine Book
Author : National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Committee on Challenges for the Chemical Sciences in the 21st Century,Organizing Committee for the Workshop on Health and Medicine
Publisher : National Academies Press
Release : 2004-03-02
ISBN : 0309087201
Language : En, Es, Fr & De

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Book Description :

The report assesses the current state of chemistry and chemical engineering within the context of drug discovery, disease diagnosis, and disease prevention. Also addressed are chemical and chemical engineering challenges in pharmaceutical synthesis, delivery, and manufacture.

Pharmaceutical Journal

Pharmaceutical Journal  Book
Author : Anonim
Publisher : Unknown
Release : 1893
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Reducing the Time from Basic Research to Innovation in the Chemical Sciences

Reducing the Time from Basic Research to Innovation in the Chemical Sciences Book
Author : National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Chemical Sciences Roundtable
Publisher : National Academies Press
Release : 2003-05-18
ISBN : 0309087341
Language : En, Es, Fr & De

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Book Description :

Innovation, the process by which fundamental research becomes a commercial product, is increasingly important in the chemical sciences and is changing the nature of research and development efforts in the United States. The workshop was held in response to requests to speed the R&D process and to rapidly evolve the patterns of interaction among industry, academe, and national laboratories. The report contains the authors' written version of the workshop presentations along with audience reaction.

40 Years of Research

40 Years of Research Book
Author : N. R. Rajagopal
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Contributed articles on science and technology.

The pharmaceutical journal and transactions

  The pharmaceutical journal and transactions Book
Author : Anonim
Publisher : Unknown
Release : 1878
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Magnetic Resonance

Magnetic Resonance Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Magnetic Resonance book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.