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Cellular Senescence In Disease

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Cellular Senescence in Disease

Cellular Senescence in Disease Book
Author : Manuel Serrano,Daniel Munos
Publisher : Academic Press
Release : 2021-09-01
ISBN : 0128225157
Language : En, Es, Fr & De

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Book Description :

Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others). The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions. Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases. All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells. Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities Provides a thorough introduction to Cellular Senescence Covers all major pathologies for which cellular senescence has shown evidence of involvement Focuses on possible therapeutic pathways Edited and authored by worldwide experts

Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease

Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease Book
Author : Sofía Ferreira-González
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease book written by Sofía Ferreira-González, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Journal of the National Cancer Institute

Journal of the National Cancer Institute Book
Author : Anonim
Publisher : Unknown
Release : 1997-10
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of the National Cancer Institute book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research Book
Author : Anonim
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomedical Index to PHS supported Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Research Grants Index

Research Grants Index Book
Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher : Unknown
Release : 1975
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Research Grants Index book written by National Institutes of Health (U.S.). Division of Research Grants, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Research Awards Index

Research Awards Index Book
Author : Anonim
Publisher : Unknown
Release : 2021-05-14
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Research Awards Index book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Telomerase Aging and Disease

Telomerase  Aging and Disease Book
Author : M.P. Mattson
Publisher : Elsevier Science Limited
Release : 2001-10-26
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume of Advances in Cell Aging and Gerontology critically reviews the rapidly advancing area of telomerase research with a focus at the molecular and cellular levels. The clearly established function of telomerase is to maintain chromosome ends during successive rounds of cell division by adding a six base DNA repeat on to the telomeric ends of chromosomes. As presented in the chapters of this volume, the mechanisms that regulate telomerase expression and activity are complex. Moreover, emerging data suggest additional roles for telomerase in the regulation of cell differentiation and survival. It is expected that this quite comprehensive volume will provide a valuable resource for graduate students and postdocs in the telomerase field and for established investigators in other fields who are beginning to study telomerase in their particular research program. With an increasing number of proteins being brought into the fold of telomerase research (e.g., DNA damage and repair response proteins, heat-shock proteins, and proteins in various signal transduction cascades) many new scientists are beginning to study this enzyme from novel vantage points.

A Means to an End

A Means to an End Book
Author : William R. Clark
Publisher : Oxford University Press on Demand
Release : 2002
ISBN : 0195153758
Language : En, Es, Fr & De

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Book Description :

Draws on recent discoveries in the fields of cell biology and molecular genetics to explore the biology of aging and examine the possibilities and implications of extended life spans

Cellular Aging and Cell Death

Cellular Aging and Cell Death Book
Author : Nikki J. Holbrook,George R. Martin,Richard A. Lockshin
Publisher : John Wiley & Sons
Release : 1995-12-20
ISBN : 9780471121237
Language : En, Es, Fr & De

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Book Description :

Cellular AGING AND CELL DEATH Edited by Nikki J. Holbrook, George R. Martin, and Richard A.Lockshin Cellular Aging and Cell Death provides a thorough understanding ofthe mechanisms responsible for cellular aging, covering the recentresearch on programmed cell death and senescence, and describingtheir role in the control of cell proliferation and the agingprocess. This one-of-a-kind book is the first to combine the twohottest research areas of cell biology into one comprehensivetext. Leading experts contribute to give readers an authoritativeoverview of the distinct fields of cellular aging and programmedcell death, as well as to demonstrate how both fields are criticalto understanding the aging process. They address the large andgrowing interest in apoptosis, especially with regard to themolecular signals that induce and regulate programmed cell death,and the role of apoptosis in a variety of age-associated diseasesand disabilities. Throughout the book, a strong emphasis is placedon the interrelationship of the molecular, cellular, andphysiological aspects of senescence. Individual chapters discuss such topics as the role and regulationof apoptosis in development, the potential impact of cell death onsuch postmitotic tissues as nerve and muscle, and suggest thatprogrammed cell death plays an important role in both pathologicaland nonpathological aspects of aging, including neurodegenerativediseases. One important chapter focuses on the most recent research involvingthe study of telomeres, whose reduction in length with age and celldivision may underlie cellular senescence. The subject of neuronalcell death is also put into the perspective of aging. Cellular Aging and Cell Death bridges the rapidly growing fields ofcellular aging and programmed cell death. This thorough, yetconcise book will be of particular interest to graduate studentsand researchers within the fields of cell and developmentalbiology, neurobiology, immunology, and physiology. Physicians andmedical students involved in the fields of gerontology andpathology will also find this an informative reference.

Robbins and Cotran Pathologic Basis of Disease

Robbins and Cotran Pathologic Basis of Disease Book
Author : Vinay Kumar
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Accompanying CD-ROM contains ... "over 100 clinical case studies and approximately 1,500 images ..."--Page 4 of cover.

Crossroads in Aging

Crossroads in Aging Book
Author : Manfred Bergener,M. Ermini,Hannes Stähelin
Publisher : Unknown
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Crossroads in Aging book written by Manfred Bergener,M. Ermini,Hannes Stähelin, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Ageing Vulnerability

Ageing Vulnerability Book
Author : Gregory R. Bock,Tom Kirkwood,Jamie A. Goode,Novartis Foundation
Publisher : Wiley-Blackwell
Release : 2001-03-30
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

With the ever-increasing rise in life expectancy, there is an urgent need to improve our understanding of the relationship between ageing and the pathogenesis of age-related diseases in order to identify more effective means of prevention, amelioration and management of such diseases. In addition, there is a need to reduce the social and economic impact of the ageing population. Age-related morbidity and mortality vary dramatically among individuals; this book focusses on individual differences in susceptibility to age-related disorders. It contains contributions from leading experts in the field on topics such as: age-related pathology in the brain, age-related processes in stem cells, and age-related effects on the immune system and in bone, muscle and cardiovascular tissue. For all those with an interest in the biology of ageing, this is compulsory reading.

Robbins Pathologic Basis of Disease

Robbins Pathologic Basis of Disease Book
Author : Ramzi S. Cotran,Vinay Kumar,Tucker Collins,Abul K. Abbas,Stanley Leonard Robbins
Publisher : W B Saunders Company
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Presenting the latest edition of this popular, comprehensive and practical text of pathology. Written with great clarity for easy readability, this reference offers detailed discussions of genetic disorders, cellular injury and death, neoplasia, the skeletal system and soft tissue tumors, and much more. Completely revised and updated, this edition is even more user-friendly with the use of text boxes for key topics in each chapter and a new full-color design. Features 1200 excellent 4-color illustrations!

The Band 3 Proteins

The Band 3 Proteins Book
Author : Ernst Bamberg,Hermann Passow
Publisher : Elsevier Science Limited
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A collection of papers on the molecular biology of the band 3 proteins and their various functions: as anion transporters, binding proteins for membrane skeleton, haemoglobin and glycolytic enzymes and as a recognition signal for the removal of senescent cells by the immuno-system of the body.

Encyclopedia of Gerontology A K

Encyclopedia of Gerontology  A K Book
Author : James E. Birren,James Emmett Birren
Publisher : Unknown
Release : 1996
ISBN : 9780122268618
Language : En, Es, Fr & De

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Book Description :

A comprehensive source that offers a multidisciplinary overview of all aspects of aging.

The Journals of Gerontology

The Journals of Gerontology Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Journals of Gerontology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Endocrinology

Endocrinology Book
Author : Leslie J. DeGroot
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Revised throughout, the 5th Edition presents a complete and up-to-date review and analysis of all aspects of endocrinology, diabetes, and bone metabolism. Readers will also find state-of-the-art information on genetics, proteinomics, and hormone signaling, and coverage of the field{19}s hottest topics in nearly 20 new chapters. Joined by an international team of leading experts (many new to this edition) Drs. Jameson and DeGroot provide guidance that integrates the basic science of endocrinology with clinical medicine and the practical management of endocrine disorders with a clinical focus emphasizes diagnosis and therapy. It organizes information into basic and clinical sections that makes reference quick and easy, and provides tables designed to summarize and organize information, presenting over 1,400 illustrations that clarify complex concepts.

Genes Aging and Immortality

Genes  Aging  and Immortality Book
Author : Charlotte Spencer
Publisher : Benjamin-Cummings Publishing Company
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This booklet answers questions about the mysteries of aging and the search for immortality. It describes some of the current progress in the scientific study of aging and explores social and ethical questions surrounding the real possibility of human lifespan extension.

Aging and Age Related Disorders

Aging and Age Related Disorders Book
Author : Stephen Bondy,Kenneth Maiese
Publisher : Springer Science & Business Media
Release : 2010-09-02
ISBN : 9781607616023
Language : En, Es, Fr & De

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Book Description :

Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.