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Cellular Senescence and Inflammation in Aging and Age related Disease

Cellular Senescence and Inflammation in Aging and Age related Disease Book
Author : Rijksuniversiteit Groningen
Publisher : Unknown
Release : 2015
ISBN : 9789036777575
Language : En, Es, Fr & De

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Book Description :

Download Cellular Senescence and Inflammation in Aging and Age related Disease book written by Rijksuniversiteit Groningen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cellular Senescence in Disease

Cellular Senescence in Disease Book
Author : Manuel Serrano,Daniel Munos
Publisher : Academic Press
Release : 2021-09-15
ISBN : 9780128225141
Language : En, Es, Fr & De

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Book Description :

Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others). The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions. Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases. All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells. Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities Provides a thorough introduction to Cellular Senescence Covers all major pathologies for which cellular senescence has shown evidence of involvement Focuses on possible therapeutic pathways Edited and authored by worldwide experts

Senolytics in Disease Ageing and Longevity

Senolytics in Disease  Ageing and Longevity Book
Author : Daniel Muñoz-Espin,Marco Demaria
Publisher : Springer
Release : 2021-05-12
ISBN : 9783030449056
Language : En, Es, Fr & De

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Book Description :

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.

Aging and Age Related Disorders

Aging and Age Related Disorders Book
Author : Stephen Bondy,Kenneth Maiese
Publisher : Springer Science & Business Media
Release : 2010-09-02
ISBN : 9781607616023
Language : En, Es, Fr & De

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Book Description :

Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.

Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease

Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease Book
Author : Sofía Ferreira-González
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease book written by Sofía Ferreira-González, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cellular Ageing and Replicative Senescence

Cellular Ageing and Replicative Senescence Book
Author : Suresh I.S. Rattan,Leonard Hayflick
Publisher : Springer
Release : 2016-05-09
ISBN : 3319262394
Language : En, Es, Fr & De

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Book Description :

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases

Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases Book
Author : Ryusaku Matsumoto
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A number of observations suggest a close connection between telomere length and mortality and age-related disease, suggesting that telomere length is a useful marker of individual biological aging and the shortening of telomere length is causally related with the pathogenesis in age-related diseases. To date, the significance of telomere length in metabolic and endocrine diseases has also been clarified. It has been reported that obesity, type 2 diabetes mellitus (T2DM), NAFLD, and hypertension were associated with shortened telomere length. In endocrine diseases, polycystic ovary syndrome (PCOS), Cushing's syndrome, and acromegaly were associated with shortened telomere length. In these conditions, an increased oxidative stress associated with the metabolic and hormonal abnormalities appears to play a pivotal role in the shortened telomere length. Recently, a large population-based study demonstrated that shortened telomeres at baseline were associated with an increased risk of metabolic diseases, suggesting that the shortened telomere itself plays a causal role for the onset or development of the metabolic diseases. In this chapter, the pathophysiological role of shortened telomere length in metabolic and endocrine diseases and the significance of cellular senescence are discussed.

Tumor Dormancy Quiescence and Senescence Volume 2

Tumor Dormancy  Quiescence  and Senescence  Volume 2 Book
Author : M.A. Hayat
Publisher : Springer Science & Business Media
Release : 2013-11-29
ISBN : 9400777264
Language : En, Es, Fr & De

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Book Description :

In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor. Taking a broad and varied perspective, this volume was written by 70 contributors representing 11 countries.

Autophagy and Senescence in Cancer Therapy

Autophagy and Senescence in Cancer Therapy Book
Author : Anonim
Publisher : Academic Press
Release : 2021-04-26
ISBN : 0128241594
Language : En, Es, Fr & De

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Book Description :

Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more. Addresses the relationship between autophagy and senescence in cancer therapy Covers autophagy and senescence in tumor dormancy Explores autophagy and senescence in disease recurrence

Aging and Age Related Disorders

Aging and Age Related Disorders Book
Author : Stephen Bondy,Kenneth Maiese
Publisher : Humana Press
Release : 2010-09-08
ISBN : 9781607616016
Language : En, Es, Fr & De

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Book Description :

Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.

Implications of Oxidative Stress on Premature Cellular Senescence and Development of Alzheimer s Disease

Implications of Oxidative Stress on Premature Cellular Senescence and Development of Alzheimer s Disease Book
Author : Danijela Domazet-Damjanov
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Implications of Oxidative Stress on Premature Cellular Senescence and Development of Alzheimer s Disease book written by Danijela Domazet-Damjanov, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Human Aging

Human Aging Book
Author : Calogero Caruso,Giuseppina Candore
Publisher : Academic Press
Release : 2021-05-21
ISBN : 0128227370
Language : En, Es, Fr & De

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Book Description :

Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging Offers the ability to access cross-sectional knowledge more easily Written by expert researchers in biogerontology who are actively involved in various fields within aging research

Metabolic Interventions Delay Cellular Senescence

Metabolic Interventions Delay Cellular Senescence Book
Author : Timothy Nacarelli
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Cellular homeostasis is progressively diminished in multiple tissues during aging. Proliferation-arrested senescent cells accumulate within tissues and contribute towards reduced maintenance and repair and increased inflammation, a universal hallmark of age-related pathologies. Indeed, senescent cells are found at sites of age-related pathologies and thought to be a major contributor to aging and susceptibility to disease. In addition to the inability to divide and pro-inflammatory function, senescent cells exhibit distinct mitochondrial and metabolic changes. Studies have raised the possibility that senescent cells are metabolically reprogrammed and require these changes for the induction and maintenance of the senescent state. Highlighting a reciprocal relationship between mitochondrial dysfunction and cellular senescence, we show that mitochondrial stress can induce cellular senescence by signaling through the mTORC1 pathway. Rapamycin treatment and methionine restriction are two of the most effective and consistent regimens that extend the lifespan of rodents and have been shown to delay cellular senescence, extending the replicative lifespan of cells in vitro. Each intervention provides resistance to mitochondrial stress and alterations that induce and accompany cellular senescence. We show that rapamycin treatment and methionine restriction have complementary effects when simultaneously administered and extend replicative lifespan further than either regimen alone. Combinatorial rapamycin treatment and methionine restriction altered status of nutrient sensing pathways including inhibition of mTORC1 signaling and activation of GCN2 signaling, resulting in enhanced autophagy and mitochondrial biogenesis with enrichment in particular mitochondrial regulatory proteins including UCP2. These alterations were associated with enhanced mitochondrial function and metabolic flexibility that may aid in the bioenergetic demand for cellular maintenance and proliferation, resulting in improved cellular longevity. Through improving mitochondrial homeostasis, combinatorial rapamycin treatment and methionine restriction metabolically intervene with cellular aging and senescence, and have potential in slowing the aging process in vivo.

Characterization and Treatment of Cellular Senescence in Human Lung Fibroblasts

Characterization and Treatment of Cellular Senescence in Human Lung Fibroblasts Book
Author : Priscilla Tang
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Cellular senescence is a state in which cells are arrested in the G1 phase of the cell cycle, but remain metabolically active. Senescent cell can secrete cytokines, chemokines, and proteases that contribute to development of age-related conditions such as osteoarthritis and Alzheimer's disease. Drugs able to selectively kill senescent cells termed senolytics , reduce multiple age-related symptoms in mouse models. To develop as assay to screen for senolytics likely to function in humans, senescence was induced in human lung IMR-90 cells by the drug Etoposide. IMR-90 senescence was identified through proliferation inhibition, SA-ß-Galactosidase staining, y-H2Ax immunoflorescence, and ELISAs (Enzyme Linked Immunosorbent Assays). Compounds identified as senolytics in mouse studies, rapamycin, IKK Inhibitor VII, 17DMAG, and Ganetespib, functioned similarly in IMR-90 cells by reducing the amount of senescent cells in vitro. Senolytics have the potential to treat age-related diseases on the cellular level and even delay the onset of the diseases themselves.

Cellular Senescence and Their Role in Liver Metabolism in Health and Disease Overview and Future Directions

Cellular Senescence and Their Role in Liver Metabolism in Health and Disease  Overview and Future Directions Book
Author : Matthew Schade
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Chronic liver disease has globally risen mainly due to a prevalent hepatitis C virus (HCV) infection rate and an epidemic of obesity. It is estimated by the year 2030, 2.2 billion people around the world will be overweight and 1.1 billion people will be obese. Diabetes and obesity are the main risk factors for the development of the metabolic syndrome and in the liver of non-alcoholic fatty liver disease (NAFLD) which could progress to non-alcoholic fatty steatohepatitis (NASH) related cirrhosis and liver malignancy. At present there is not effective therapy for NASH besides loss of weight and exercise. Furthermore, optimal management of HCC with curative intent includes resection or liver transplantation. Nevertheless, these therapies are limited because the degree of liver dysfunction or the medical conditions at the time of diagnosis and the scarcity of available liver grafts. The role of cellular lipid management and metabolism in human health and disease is taking a center stage. The present overview articulates the current pathophysiology of fatty liver disease under the aging processes, potential biological markers of liver disease diagnosis and progression and future therapies.

Senescence and Senescence Related Disorders

Senescence and Senescence Related Disorders Book
Author : Wang Zhiwei,Hiroyuki Inuzuka
Publisher : BoD – Books on Demand
Release : 2013-02-20
ISBN : 9535109979
Language : En, Es, Fr & De

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Book Description :

Senescence is a biological process that causes a progressive deterioration of structure and function of all organs chronologically. Recent studies have revealed the detailed molecular mechanisms of senescence using cell culture system and experimental organisms. It is thought that senescence is a potential cause for the development of various age-related disorders such as cancer, cardiovascular and neurodegenerative disorders. This book discusses in detail senescence and its related diseases by distinguished researchers and practicing clinicians. The cumulative knowledge from the studies could lead to developing new approaches for anti-senescence interventions.

Telomeres and Telomerase in Aging Disease and Cancer

Telomeres and Telomerase in Aging  Disease  and Cancer Book
Author : K. Lenhard Rudolph
Publisher : Springer Science & Business Media
Release : 2007-11-07
ISBN : 354073709X
Language : En, Es, Fr & De

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Book Description :

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Cellular Aging and Cell Death

Cellular Aging and Cell Death Book
Author : Nikki J. Holbrook,George R. Martin,Richard A. Lockshin
Publisher : John Wiley & Sons
Release : 1995-12-20
ISBN : 9780471121237
Language : En, Es, Fr & De

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Book Description :

Cellular AGING AND CELL DEATH Edited by Nikki J. Holbrook, George R. Martin, and Richard A.Lockshin Cellular Aging and Cell Death provides a thorough understanding ofthe mechanisms responsible for cellular aging, covering the recentresearch on programmed cell death and senescence, and describingtheir role in the control of cell proliferation and the agingprocess. This one-of-a-kind book is the first to combine the twohottest research areas of cell biology into one comprehensivetext. Leading experts contribute to give readers an authoritativeoverview of the distinct fields of cellular aging and programmedcell death, as well as to demonstrate how both fields are criticalto understanding the aging process. They address the large andgrowing interest in apoptosis, especially with regard to themolecular signals that induce and regulate programmed cell death,and the role of apoptosis in a variety of age-associated diseasesand disabilities. Throughout the book, a strong emphasis is placedon the interrelationship of the molecular, cellular, andphysiological aspects of senescence. Individual chapters discuss such topics as the role and regulationof apoptosis in development, the potential impact of cell death onsuch postmitotic tissues as nerve and muscle, and suggest thatprogrammed cell death plays an important role in both pathologicaland nonpathological aspects of aging, including neurodegenerativediseases. One important chapter focuses on the most recent research involvingthe study of telomeres, whose reduction in length with age and celldivision may underlie cellular senescence. The subject of neuronalcell death is also put into the perspective of aging. Cellular Aging and Cell Death bridges the rapidly growing fields ofcellular aging and programmed cell death. This thorough, yetconcise book will be of particular interest to graduate studentsand researchers within the fields of cell and developmentalbiology, neurobiology, immunology, and physiology. Physicians andmedical students involved in the fields of gerontology andpathology will also find this an informative reference.

Advances in Geroscience

Advances in Geroscience Book
Author : Felipe Sierra,Ronald Kohanski
Publisher : Springer
Release : 2015-11-10
ISBN : 3319232460
Language : En, Es, Fr & De

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Book Description :

This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.