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Cellular Response To Biomaterials

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Cellular Response to Biomaterials

Cellular Response to Biomaterials Book
Author : Lucy Di Silvio
Publisher : Elsevier
Release : 2008-12-22
ISBN : 184569547X
Language : En, Es, Fr & De

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Book Description :

The response of cells to biomaterials is critical in medical devices. Traditionally inert biomaterials were used to minimise the reaction in cells in contact with the material. However, it has been realised that specific cell responses may be beneficial in such areas as encouraging adhesion, healing or cell multiplication. Cellular response to biomaterials discusses the response of cells to a wide range of biomaterials targeted at specific medical applications. Part one discusses cell responses to a variety of polymers and ceramics with chapters on such topics as degradable polymers and biocompatibility. Part two covers cell responses and regenerative medicine with coverage of themes such as vascular grafts, nerve repair and Bioglass®. Part three examines the effect of surfaces and proteins on cell response. Specific chapters review nano-engineered surfaces, the influence of plasma proteins on bone cell adhesion and surface modification of titanium implants. With its distinguished editor and team of international contributors, Cellular response to biomaterials is an essential read for those researching or studying medical devices in industry and academia. Examines the response of cells to a wide range of biomaterials targeted at specific medical applications Discusses cell responses and regenerative medicine with specific chapters on vascular grafts and nerve repair Assesses the effect of surfaces and proteins on cell response including the influence of plasma proteins on cell adhesion and surface modification of titanium implants

Host Response to Biomaterials

Host Response to Biomaterials Book
Author : Stephen F Badylak
Publisher : Academic Press
Release : 2015-05-08
ISBN : 0128005009
Language : En, Es, Fr & De

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Book Description :

Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine. Explains the various categories of biomaterials and their significance for clinical applications Contains a range of extensive coverage, including, but not limited to, orthopedic, surgery, dental, general surgery, neurosurgery, lower urinary tract, and regenerative medicine Includes regulations regarding combination devices

Biomaterials and Immune Response

Biomaterials and Immune Response Book
Author : Nihal Engin Vrana
Publisher : CRC Press
Release : 2018-07-20
ISBN : 1351377566
Language : En, Es, Fr & De

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Book Description :

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Monitoring Cellular Response to Biomaterials

Monitoring Cellular Response to Biomaterials Book
Author : Ryan S. Czarny
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Monitoring Cellular Response to Biomaterials book written by Ryan S. Czarny, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Immunomodulatory Biomaterials

Immunomodulatory Biomaterials Book
Author : Stephen F. Badylak,Jennifer Elisseeff
Publisher : Woodhead Publishing
Release : 2021-07-15
ISBN : 9780128214404
Language : En, Es, Fr & De

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Book Description :

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert” immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

The Immune Response to Implanted Materials and Devices

The Immune Response to Implanted Materials and Devices Book
Author : Bruna Corradetti
Publisher : Springer
Release : 2016-11-30
ISBN : 3319454331
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

Microstructure Cellular Response and Selected Properties of Titanium Based Biomaterials Applied in Regenerative Medicine of Bone Tissue and Joints

Microstructure  Cellular Response and Selected Properties of Titanium Based Biomaterials Applied in Regenerative Medicine of Bone Tissue and Joints Book
Author : Joanna Karbowniczek
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Microstructure Cellular Response and Selected Properties of Titanium Based Biomaterials Applied in Regenerative Medicine of Bone Tissue and Joints book written by Joanna Karbowniczek, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Handbook of Biomaterials Biocompatibility

Handbook of Biomaterials Biocompatibility Book
Author : Masoud Mozafari
Publisher : Woodhead Publishing
Release : 2020-06-17
ISBN : 0081029683
Language : En, Es, Fr & De

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Book Description :

Handbook of Biomaterials Biocompatibility is a systematic reference on host response to different biomaterials, taking into account their physical, mechanical and chemical properties. The book reviews recent progress in the design and study of biomaterials biocompatibility, along with current understanding on how to control immune system response. Sections provide the fundamental theories and challenges of biomaterials biocompatibility, the role of different biomaterials physicochemical surface properties on cell responses, cell responses to different physicochemical properties of polymers, ceramics, metals, carbons and nanomaterials, and biomaterials in different tissues, such as the cardiac, nervous system, cartilage and bone. This resource will be suitable for those working in the fields of materials science, regenerative engineering, medicine, medical devices and nanotechnology. Reviews the fundamental theories and challenges of biomaterials biocompatibility, including an overview of the standards and regulations Provides an overview on the cellular and molecular mechanisms involved in host responses to biomaterials Systematically looks at cellular response and tissue response to a wide range of biomaterials, including polymers, metals, ceramics, alloys and nanomaterials

Control of Cellular Response by Laser Interference ablated Biomaterials

Control of Cellular Response by Laser Interference ablated Biomaterials Book
Author : Ping Li
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Control of Cellular Response by Laser Interference ablated Biomaterials book written by Ping Li, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Characterization of Biomaterials

Characterization of Biomaterials Book
Author : Y.M. Thasneem,Chandra P. Sharma
Publisher : Elsevier Inc. Chapters
Release : 2013-03-12
ISBN : 0128070994
Language : En, Es, Fr & De

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Book Description :

The development of biomaterials as a powerful regulator of the cellular microenvironment for application in drug discovery/delivery, tissue engineering, and implant biology, requires a better understanding of cell-surface interactions at macro, micro, and nanometre levels. Cell–substrate interactions are multifaceted, involving the integration of various physical and biochemical signals. The interactions among these micro-environmental factors cannot be facilely elucidated and quantified by conventional experimentations, and this necessitates multifactorial strategies. A major task in the biomaterials field would be to develop advanced tools that can offer greater insight into characterizing the cellular behavior and interactions on the material interface. Obtaining this information is crucial in taking biomaterial science to new realms for biomedical applications. The contribution of molecular techniques to elucidate the cell–biomaterial interactions is indispensable on the time-course and level of expression of particular genes that determine cellular phenotype. The amalgamation of multiple disciplines has already produced many interesting techniques and approaches for the cell–biomaterial characterization, of which we have tried to provide a comprehensive and integrated description. The main focus of this book chapter is to explore the toolbox contents available in elucidating the cell–biomaterial interactions. We brief about the topographical, mechanical and biochemical changes faced by a cell upon the rendezvous of any surface in particular with the cell–biomaterial interface. The material characteristics playing cards in directing cellular behavior are straightened out. We also discuss the current knowledge of how a cell can interact with a substrate at the nanoscale and the effect of size, morphology, organization and separation of nanofeatures on cell response.

Biomaterials in Regenerative Medicine and the Immune System

Biomaterials in Regenerative Medicine and the Immune System Book
Author : Laura Santambrogio
Publisher : Springer
Release : 2015-09-04
ISBN : 3319180452
Language : En, Es, Fr & De

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Book Description :

The generation of tridimensional tissues, assembled from scaffolding materials populated with biologically functional cells, is the great challenge and hope of tissue bioengineering and regenerative medicine. The generation of biomaterials capable of harnessing the immune system has been particularly successful. This book provides a comprehensive view of how immune cells can be manipulated to suppresses inflammation, deliver vaccines, fight cancer cells, promote tissue regeneration or inhibit blood clotting and bacterial infections by functionally engineered biomaterials. However, long-lived polymers, such as those employed in orthopedic surgery or vascular stents, can often induce an immune reaction to their basic components. As a result, this book is also an important step towards coming to understand how to manipulate biomaterials to optimize their beneficial effects and downplay detrimental immune responses.

An Introduction to Tissue Biomaterial Interactions

An Introduction to Tissue Biomaterial Interactions Book
Author : Kay C. Dee,David A. Puleo,Rena Bizios
Publisher : John Wiley & Sons
Release : 2003-04-14
ISBN : 0471461121
Language : En, Es, Fr & De

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Book Description :

An Introduction to Tissue-Biomaterial Interactions acquaintsan undergraduate audience with the fundamental biological processesthat influence these sophisticated, cutting-edge procedures.Chapters one through three provide more detail about themolecular-level events that happen at the tissue-implant interface,while chapters four through ten explore selected material,biological, and physiological consequences of these events. Theimportance of the body’s wound-healing response is emphasizedthroughout. Specific topics covered include:Structure andproperties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples oftissue-biomaterial interactions The text also provides extensive coverage of the three pertinentinterfaces between the body and the biomaterial, between the bodyand the living cells, and between the cells and the biomaterialthat are critical in the development of tissue-engineered productsthat incorporate living cells within a biomaterial matrix. Idealfor a one-semester, biomedical engineering course, An Introductionto Tissue-Biomaterial Interactions provides a solid framework forunderstanding today’s and tomorrow’s implantablebiomedical devices.

Biomaterials

Biomaterials Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomaterials book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Using Biomaterials to Elicit an Immune Response and Trigger Tissue Regeneration

Using Biomaterials to Elicit an Immune Response and Trigger Tissue Regeneration Book
Author : Abigail Corrin Parks
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Soft tissue loss can be the result of many clinical issues. An engineered injectable material to stimulate soft tissue regeneration would be an improvement for many clinical applications within tissue augmentation including dermal augmentation, periurethral bulking, and gingival augmentation. Implanted biomaterials are usually held to a standard of biocompatibility meaning that the overall goal for a biomaterial is to have it as inert as possible and to act stealthily when it comes in contact with the body. This is to avoid a chronic foreign body response and ultimately rejection of the biomaterial. The goal of this project was to utilize a mild, transient immune response within the soft tissue of the body to accelerate regeneration of the extracellular matrix proteins and therefore tissue augmentation. An injectable biomaterial was utilized to increase the volume of the soft tissue, then it was combined with a bioactive coating that elicited an immune response. The injectable material was fabricated out of macroporous poly [epsilon]-caprolactone (PCL) microparticles and coated in the bioactive polymer, poly lactic co-glycolic acid (PLGA). The host-material interaction of the bioactive PLGA with biological cells was characterized in vitro by inflammatory cytokine production using a multiplex system. It was found that the co-culture of human fibroblasts and monocytes produced elevated levels of IL-[beta], IL-6, GM-CSF, and TNF-[alpha]; in response to the PLGA biomaterial. Subsequently, the cell infiltration, inflammatory response, blood vessel infiltration, and collagen deposition were analyzed to determine tissue regeneration and healing in vivo. The murine model showed more thorough tissue integration and healing with added porosity and bioactive PLGA coating through blood vessel infiltration and extracellular matrix deposition. The accelerated healing response seen with the bioactive coating is shown to be important to prevent migration of the particles within tissue. Additionally the PLGA coating did enhance the immune response early on in the in vivo studies corroborating with the in vitro findings. The overall goal of this research was to engineer an injectable material that can be used to induce an acute immune response which will lead to the accelerated production of extracellular matrix proteins to augment tissue and eventually create a soft tissue network with the ultimate clinical application being dermal augmentation, periurethral bulking, or gingival augmentation.

Biomimicked Biomaterials

Biomimicked Biomaterials Book
Author : Heung Jae Chun,Rui L. Reis,Antonella Motta,Gilson Khang
Publisher : Springer Nature
Release : 2020-06-29
ISBN : 9811532621
Language : En, Es, Fr & De

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Book Description :

This book is the second of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. In this volume, which is devoted to biomimetic biomaterials, the opening section discusses bone regeneration by means of duck’s feet-derived collagen scaffold and the use of decellularized extracellular matrices. The role of various novel biomimetic hydrogels in regenerative medicine is then considered in detail. The third section focuses on the control of stem cell fate by biomimetic biomaterials, covering exosome-integrated biomaterials for bone regeneration, cellular responses to materials for biomedical engineering, and the regulation of stem cell functions by micropatterned structures. Finally, the use of nano-intelligent biocomposites in regenerative medicine is addressed, with discussion of, for example, recent advances in biphasic calcium phosphate bioceramics and blood-contacting polymeric biomaterials. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.

Tissue Engineering

Tissue Engineering Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Tissue Engineering book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Tissue Reactions to Biomaterials

Tissue Reactions to Biomaterials Book
Author : Agneta Rosengren
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Tissue Reactions to Biomaterials book written by Agneta Rosengren, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

T cell Interactions in the Foreign Body Response to Biomaterials

T cell Interactions in the Foreign Body Response to Biomaterials Book
Author : Analiz Rodriguez
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download T cell Interactions in the Foreign Body Response to Biomaterials book written by Analiz Rodriguez, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Advances in Chemical Engineering

Advances in Chemical Engineering Book
Author : Nicholas Peppas,Michael J Sefton,Michael V. Sefton
Publisher : Academic Press
Release : 2004-07-15
ISBN : 9780120085293
Language : En, Es, Fr & De

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Book Description :

This latest volume in the Advances in Chemical Engineering series, is a contemporary analysis of the preparation, structure and properties of biomaterials with emphasis on the molecular design and material/polymer interactions. The book addresses cell-biomaterials adhesion, biomaterials and gene therapy, protein adsorption, platelet and white cell activation processes, molecular design and surface modification of novel biomaterials. Original reviews Leading chemical engineers as authors Update on biomaterials use Novel subject on use of biomaterials in drug delivery and gene therapy Mathematical modeling

Bio Implant Interface

Bio Implant Interface Book
Author : J E Ellingsen,S P Lyngstadaas
Publisher : CRC Press
Release : 2019-08-30
ISBN : 9780367395230
Language : En, Es, Fr & De

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Book Description :

Achieving good clinical outcomes with implanted biomaterials depends upon achieving optimal function, both mechanical and biological, which in turn depends upon integrating advances realized in biological science, material science, and tissue engineering. As these advances push back the frontiers of biomaterial medicine, the control and patterning of bio-implant interface reactions will have a tremendous impact on future design and prospects of implant treatments. Bio-Implant Interface: Improving Biomaterials and Tissue Reactions brings together a remarkable panel of scientists to present the state-of-the-art in our understanding of interactions at the interface between biomaterials and living tissue. Much of the focus is on the importance of the implant surface's topography and chemistry to its interaction with the biological environment. Biomineralization along with the biological content of the interface and its role in directing cellular response along desired pathways also receive particular attention. The pursuit of new and better designs for improved biocompatibility and patient response to implants continues to challenge clinicians and scientists alike. This book offers a unique opportunity to bring yourself up-to-date on recent advances in the field and new strategies for controlling the bio-implant interface.