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Cellular And Molecular Pathobiology Of Cardiovascular Disease

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Cellular and Molecular Pathobiology of Cardiovascular Disease

Cellular and Molecular Pathobiology of Cardiovascular Disease Book
Author : Monte Willis,Jonathon W. Homeister,James R. Stone
Publisher : Academic Press
Release : 2013-12-23
ISBN : 0124055257
Language : En, Es, Fr & De

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Book Description :

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Cellular and Molecular Pathobiology of Cardiovascular Disease

Cellular and Molecular Pathobiology of Cardiovascular Disease Book
Author : Monte S. Willis,Jonathon W. Homeister,James R. Stone
Publisher : Unknown
Release : 2014-01-23
ISBN : 9780124052062
Language : En, Es, Fr & De

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Book Description :

Focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine.

Endocrinology of the Heart in Health and Disease

Endocrinology of the Heart in Health and Disease Book
Author : Jonathan C. Schisler,Charles H Lang,Monte Willis
Publisher : Academic Press
Release : 2016-10-19
ISBN : 0128031123
Language : En, Es, Fr & De

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Book Description :

Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented. The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds. The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology. Develops the concept of the heart as both an endocrine organ and an endocrine target, exploring the endocrine function of the heart in both health and disease Explains how the levels of several cardiac hormones are changed in various cardiac pathologies and how some hormones can be used therapeutically Offers a single resource on cardio-endocrine disease which collates and curates the wide range of advances being made in the areas of molecular biology, biochemistry, physiology, and pathology

Cellular and Molecular Biology of Atherosclerosis

Cellular and Molecular Biology of Atherosclerosis Book
Author : Antonio M. Jr. Gotto
Publisher : Springer
Release : 2011-11-23
ISBN : 9781447119111
Language : En, Es, Fr & De

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Book Description :

Atherosclerotic cardiovascular disease remains the major cause of death and disability in Western society. The field of atherosclerosis research has grown tremendously over the last forty years, shedding a great deal of light on the contributing factors and natural history of the disorder and enabling strategies for its treatment and prevention. Some of the greatest strides in this field in recent years have derived from advances in molecular biology techniques. These strides were chosen for emphasis in the most recent Princess Lilian symposium, whose proceedings this volume represents. Historically, the Princess Lilian meetings have been small ones aimed at bringing together investigators from diverse specialties to discuss a particular subject. The most recent meeting was no exception and included clinicians, clinical investigators, and research ers in basic science. The symposium began with an extensive review of coronary morphopathological findings in patients who died of coronary heart disease. Any rational hypothesis of atherogenesis must take into account clinical findings, and any attempt to bridge the gap between experimental laboratory findings and studies in man is highly desirable. Three chapters focus on endothelial injury: one on the nitric oxide pathway in physiology and pathology, a second on the activation of endothelial cells, and a third on the monocyte and endothelial injury. Still another chapter examines growth factors, in particular the fibroblast growth factor in atherogenesis.

Cardiovascular Disease

Cardiovascular Disease Book
Author : Linda L. Gallo
Publisher : Springer
Release : 2012-10-21
ISBN : 9781461358053
Language : En, Es, Fr & De

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Book Description :

The Fourteenth Washington International Spring Symposium, held in Washington, D.C., in June 1994, brought together over 400 leading scientists from 21 countries to review and update research on cardiovascular disease. This group satisfied the symposium goals of formulating a more comprehensive and integrated picture of the events contributing to atherosclerosis and of exploring modified gene expression as an to understanding the causes of atherosclerosis and providing clues to the approach prevention and treatment. This volume contains most of the papers presented at the eight plenary sessions together with selected contributions from the special sessions. The multidisciplinary nature of the chapters and their authors should stimulate the interests of biochemists, cell and molecular biologists, pathologists, pharmacologists, epidemiologists, nutritionists, and clinicians. The volume is divided into eight sections which reflect the focus of the plenary sessions. Part I focuses on the pathophysiology of atherosclerotic plaques and predicts that the nature of the fibrous cap of atheroma determines plaque disruption and clinical events. Papers in Part II deal with atherogenic lipoproteins. The introductory paper reviews the current view of the role of plasma lipoproteins in atherosclerosis. With respect to the newer members on the list,: [oxidized LDL, Lp(a)] evidence is provided that suggests the involvement of one major gene in the development of oxidized LDL lipids. the expression of inflammatory genes, and the development of aortic fatty streaks.

Heart Failure

Heart Failure Book
Author : Arnold M. Katz,Marvin A. Konstam
Publisher : Lippincott Williams & Wilkins
Release : 2012-11-07
ISBN : 146980185X
Language : En, Es, Fr & De

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Book Description :

This Second Edition of Dr. Katz's highly acclaimed text has been thoroughly revised to incorporate the latest advances in the study and treatment of heart failure. The book explains the pathophysiology, molecular mechanisms, clinical manifestations, and therapy of heart failure in an integrated, reader-friendly manner that is accessible to both clinicians and basic scientists. More than 100 illustrations, most created for this book by the authors, complement the text. This edition has been completely reorganized. Chapters describe the hemodynamic basis for the clinical manifestations of heart failure; the neurohumoral responses in heart failure and key signaling pathways that mediate functional responses; the proliferative responses in failing hearts; the cellular and molecular abnormalities in the failing heart; the rationale for various therapeutic approaches; and the management of specific groups of patients. The chapters on therapy have been written by a noted clinician, Marvin A. Konstam.

Molecular Pathology

Molecular Pathology Book
Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Release : 2017-11-09
ISBN : 0128027878
Language : En, Es, Fr & De

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Book Description :

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase

Modulation of Oxidative Stress in Heart Disease

Modulation of Oxidative Stress in Heart Disease Book
Author : Sajal Chakraborti,Naranjan S. Dhalla,Madhu Dikshit,Nirmal K. Ganguly
Publisher : Springer Nature
Release : 2019-11-10
ISBN : 9811389462
Language : En, Es, Fr & De

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Book Description :

This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.

Cardiovascular Pathology

Cardiovascular Pathology Book
Author : Jagdish Butany,L. Maximilian Buja
Publisher : Academic Press
Release : 2015-10-01
ISBN : 9780124202191
Language : En, Es, Fr & De

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Book Description :

Cardiovascular Pathology, Fourth Edition, provides users with a comprehensive overview that encompasses its examination, cardiac structure, both normal and physiologically altered, and a multitude of abnormalities. This updated edition offers current views on interventions, both medical and surgical, and the pathology related to them. Congenital heart disease and its pathobiology are covered in some depth, as are vasculitis and neoplasias. Each section has been revised to reflect new discoveries in clinical and molecular pathology, with new chapters updated and written with a practical approach, especially with regards to the discussion of pathophysiology. New chapters reflect recent technological advances with cardiac devices, transplants, genetics, and immunology. Each chapter is highly illustrated and covers contemporary aspects of the disease processes, including a section on the role of molecular diagnostics and cytogenetics as specifically related to cardiovascular pathology. Customers buy the Print + Electronic product together! Serves as a contemporary, all-inclusive guide to cardiovascular pathology for clinicians and researchers, as well as clinical residents and fellows of pathology, cardiology, cardiac surgery, and internal medicine Offers new organization of each chapter to enable uniformity for learning and reference: Definition, Epidemiology, Clinical Presentation, Pathogenesis/Genetics, Light and Electron Microscopy/Immunohistochemistry, Differential Diagnosis, Treatment and Potential Complications Features six new chapters and expanded coverage of the normal heart and blood vessels, cardiovascular devices, congenital heart disease, tropical and infectious cardiac disease, and forensic pathology of the cardiovascular system Contains 400+ full color illustrations and an online image collection facilitate research, study, and lecture slide creation

Essential Concepts in Molecular Pathology

Essential Concepts in Molecular Pathology Book
Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Release : 2019-11-23
ISBN : 0128132582
Language : En, Es, Fr & De

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Book Description :

Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today’s advances in pathology and medicine. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology

Fetal and Neonatal Physiology for the Advanced Practice Nurse

Fetal and Neonatal Physiology for the Advanced Practice Nurse Book
Author : Amy Jnah, DNP, NNP-BC,Andrea Nicole Trembath, MD, MPH, FAAP
Publisher : Springer Publishing Company
Release : 2019-01-08
ISBN : 0826157459
Language : En, Es, Fr & De

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Book Description :

Written for neonatal and pediatric nurse practitioner students, Fetal and Neonatal Physiology for the Advanced Practice Nurse explores the developmental physiology of premature and term infants and presents common diseases that affect this specialized population. This unique text offers an innovative and engaging approach to learning normal and abnormal physiology to prepare students for their roles as resourceful and informed problem-solvers, caregivers, and health promoters. Part One introduces core concepts including fetal origins of disease, genetic inheritance patterns, and placental physiology. Part Two investigates each major human body system. Finally, Part Three offers an exploration into the transition to extrauterine life and common challenges for perinatal and neonatal clinicians. With a multitude of student learning resources and tools, Fetal and Neonatal Physiology for the Advanced Practice Nurse promotes contemplative thinking, understanding, and retention. Every chapter includes learning objectives for guidance, advice from the authors, and a mind map to visualize difficult concepts. Written by junior and senior nurses and physicians, this text embodies the interprofessional approach associated with optimal outcomes. Chapter podcasts and discussion questions are included with the text to actively integrate written content and engage students using multisensory teaching methods. Key Features Presents a concise, visual and interactive presentation of a challenging subject Designed specifically to accommodate a semester-long course Contains numerous illustrations depicting fetal development and physiology of the different body systems Each chapter contains reflective questions and other interactive learning resources Incorporates genetics and pathophysiologic correlations Meets the nationally-recognized accreditation requirements for APN physiology coursework

Oxford Textbook of Medicine Cardiovascular Disorders

Oxford Textbook of Medicine  Cardiovascular Disorders Book
Author : David Warrell,Timothy Cox,John Firth,Jeremy Dwight
Publisher : Oxford University Press
Release : 2016-06-03
ISBN : 0192512501
Language : En, Es, Fr & De

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Book Description :

The Oxford Textbook of Medicine: Cardiovascular Disorders is selected from the cardiology section of the renowned Oxford Textbook of Medicine. An authoritative resource on heart disease and beautifully illustrated in full colour, it is an essential guide to best practice in managing and preventing a wide variety of cardiovascular disorders. Chapters on arrhythmias, acute coronary syndromes and cardiac surgery have been completely revised and updated, together with new chapters on blood vessels and the endothelium, cardiac physiology, syncope and palpitations, and cardio-renal syndrome. Heart failure and heart disease in pregnancy are thoroughly treated, while imaging chapters evaluate the latest techniques and illustrate all clinical features with detailed images. In 46 finely crafted chapters with clear essentials, experts in cardiovascular disease review the essentials of diagnosis, guidelines and practice and provide a wealth of practical advice for use in clinical situations. In addition, background information on epidemiology, pathogenesis and pathophysiology encourages a fuller understanding of conditions, and more than 350 full colour images help with diagnosis. This essential reference tool supports all medical professionals seeking a general outline of treatment and prevention of cardiovascular disorders, and fills the gap between undergraduate teaching texts and specialist texts for cardiologists. Cardiologists and general physicians will find it immensely valuable when diagnosing and managing heart disease in their day-to-day practice. It is also of usefor trainees in cardiology and general medicine, especiallythose interested in applied cardiovascular pathophysiology.

Tandon s Textbook of Cardiology

Tandon   s Textbook of Cardiology Book
Author : Dorairaj Prabhakaran,Raman Krishna Kumar,Nitish Naik
Publisher : Wolters kluwer india Pvt Ltd
Release : 2019-01-17
ISBN : 9388696166
Language : En, Es, Fr & De

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Book Description :

An authoritative, comprehensive, and accessible cardiology textbook that caters to the needs of trainees and practicing cardiologists. Cardiovascular disease is now the largest contributor to global mortality. Low and middle income countries. (Lmics) presently bear the brunt of this global epidemic, accounting for over three quarters of cardiovascular deaths and 90% of these deaths under 70 years of age. The experience and expertise of health professionals in these countries will therefore be the principal determinant of global success in countering and curbing the global cardiovascular epidemic in the coming decades. This book covers the fundamentals of cardiology in depth, to provide conceptual clarity, and delves into specific cardiovascular disorders with detailed descriptions that range from aetiology and pathophysiology to evidence informed approaches to diagnosis and management. It does all of this by blending contextual relevance with uncompromising academic rigor.

Research in Computational Molecular Biology

Research in Computational Molecular Biology Book
Author : Russell Schwartz
Publisher : Springer Nature
Release : 2020-04-20
ISBN : 3030452573
Language : En, Es, Fr & De

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Book Description :

This book constitutes the proceedings of the 24th Annual Conference on Research in Computational Molecular Biology, RECOMB 2020, held in Padua, Italy, in May 2020. The 13 regular and 24 short papers presented were carefully reviewed and selected from 206 submissions. The papers report on original research in all areas of computational molecular biology and bioinformatics.

Cellular and Molecular Biology of Atherosclerosis

Cellular and Molecular Biology of Atherosclerosis Book
Author : Antonio M Jr Gotto
Publisher : Unknown
Release : 1992-03-24
ISBN : 9781447119104
Language : En, Es, Fr & De

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Book Description :

Download Cellular and Molecular Biology of Atherosclerosis book written by Antonio M Jr Gotto, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cell and Tissue Based Molecular Pathology E Book

Cell and Tissue Based Molecular Pathology E Book Book
Author : Raymond R. Tubbs,Mark H. Stoler
Publisher : Elsevier Health Sciences
Release : 2008-09-22
ISBN : 1437719481
Language : En, Es, Fr & De

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Book Description :

This volume in the Foundations in Diagnostic Pathology Series packs today's most essential cell and tissue base molecular pathology into a compact, high-yield format! It focuses on the state of the art in practical validated molecular diagnostics as applied across the fields of surgical pathology and cytology. With an emphasis on current, clinically valid, and diagnostically important applications today and in the near future, you can be assured you’re getting the most up-to-date, authoritative coverage available. Its pragmatic, well-organized approach, nearly 250 full-color illustrations, and at-a-glance boxes and tables make the information you need easy to access. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice! Offers detailed discussions on today’s technologies to help you select the best test for case evaluation. Presents recognized molecular pathologists who convey the most current information, keeping you on the cusp of your field. Features nearly 250 full-color illustrations that present important pathologic features, enabling you to form a differential diagnosis and compare your findings with actual cases. Uses a consistent, user-friendly format, including at-a-glance boxes and tables for easy reference.

Mechanisms of Vascular Disease

Mechanisms of Vascular Disease Book
Author : Robert Fitridge
Publisher : Springer Nature
Release : 2020-07-30
ISBN : 3030436837
Language : En, Es, Fr & De

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Book Description :

This extensively revised third edition provides a practically applicable guide to the pathophysiology, assessment and management of vascular disorders encountered in vascular surgical practice. It features detailed information on the latest developments in the pathophysiology of conditions including atherosclerosis, multi-organ failure, limb compartment syndromes and Raynaud’s phenomenon in a clear easy to digest format. Disorders such as reperfusion injuries, vasculitides, and aortic dissection are covered. Furthermore, key topics in vascular and endovascular practice such as radiation biology and radiation safety are also detailed. Each chapter contains a set of learning objectives and key references, enabling the reader to quickly identify key points. Mechanisms of Vascular Disease: A Textbook for Vascular Specialists comprehensively covers a variety of common and unusual pathophysiologies encountered in vascular surgery, and is an ideal resource for both the trainee, and practicing clinical vascular surgeon seeking an up-to-date resource on the topic.

From Genetics to Gene Therapy

From Genetics to Gene Therapy Book
Author : David S. Latchman
Publisher : Taylor & Francis
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Distinguished scientists provide an overview of the molecular pathology of human disease. Each chapter provides an analysis of the molecular biological approaches to individual diseases, such as leukaemia, cardiovascular disease and cancer, and includes a

Congestive Heart Failure and Cardiac Transplantation

Congestive Heart Failure and Cardiac Transplantation Book
Author : Daniel J. Garry,Robert F. Wilson,Zeev Vlodaver
Publisher : Springer
Release : 2017-06-01
ISBN : 3319445774
Language : En, Es, Fr & De

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Book Description :

This book is a comprehensive overview of heart failure and cardiac transplantation and integrates scientific and clinical information about the physiology, pathophysiology, diagnosis, and treatment of this disorder. Organized into five parts, it reviews the history and basic mechanisms of heart failure; etiology of heart failure; heart failure disease progression; advanced therapies for heart failure; and cardiac transplantation. The book presents basic concepts in the physiology, molecular biology, pathology, and epidemiology of the normal and failing heart; known causes of heart failure, such as right heart failure, valvular cardiomyopathy, molecular mechanisms of sarcomeric cardiomyopathies, and neuromuscular cardiomyopathy; cardiorenal syndrome; neurohormonal activation; cardiac resynchronization, ventricular assist devices; regenerative mechanisms; orthotopic heart transplantation; early and late management of the post-transplant patient; heart transplantation and antibody-mediated rejections; heart-lung transplantation; and cardiac xenotransplantation. Featuring contributions from leaders in the fields of heart failure, cardiac transplantation, cardiac pathology, and cardiovascular molecular research, Congestive Heart Failure and Cardiac Transplantation is a valuable compendium for cardiologists, cardiothoracic surgeons, researchers, trainees, and students.

Advanced Concepts in Endocarditis

Advanced Concepts in Endocarditis Book
Author : Michael S. Firstenberg
Publisher : Unknown
Release : 2018-09-12
ISBN : 1789236266
Language : En, Es, Fr & De

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Book Description :

Download Advanced Concepts in Endocarditis book written by Michael S. Firstenberg, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.