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Cellular And Animal Models In Human Genomics Research

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Cellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research Book
Author : Anonim
Publisher : Academic Press
Release : 2019-07-30
ISBN : 012816574X
Language : En, Es, Fr & De

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Book Description :

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

Cancer Genomics

Cancer Genomics Book
Author : Jason N. Berman,Priscilla P.L. Chiu,Graham Dellaire
Publisher : Elsevier Inc. Chapters
Release : 2013-11-21
ISBN : 0128061057
Language : En, Es, Fr & De

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Book Description :

Genome-wide association (GWA) studies and tumor-specific epigenome, transcriptome and genome sequencing projects are generating an ever-growing list of susceptibility alleles, as well as putative gain- and loss-of-function gene mutations associated with cancer. These genetic changes ultimately need to be validated to determine their contribution to the initiation, progression and likelihood of treatment response for various cancers. The bottle-neck is no longer obtaining sequence data or completion of the GWA studies, but rather the ability efficiently to validate candidate genes identified by these projects. In vivo studies in animal models are the “gold standard” for validation of these candidate drivers and modifiers of cancer. Furthermore, once a gene product or molecular pathway has been validated as playing an important role in the development or progression of cancer, animal models provide the necessary preclinical data for evaluation of the efficacy and toxicity of new therapeutics targeting that gene or pathway. As such, animal models play an essential role in cancer research by facilitating the translation of genomic discoveries into preclinical studies that precede new targeted therapies for cancer. In this chapter, we will discuss vertebrate and invertebrate animal models as they apply to cancer genomics, as well as key technologies employed. In particular, we will focus on the use of murine and zebrafish human tumor xenografts and transgenic models.

Animal Biotechnology

Animal Biotechnology Book
Author : Ashish S. Verma,Anchal Singh
Publisher : Academic Press
Release : 2020-06-11
ISBN : 0128117257
Language : En, Es, Fr & De

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Book Description :

Animal Biotechnology: Models in Discovery and Translation, Second Edition, provides a helpful guide to anyone seeking a thorough review of animal biotechnology and its application to human disease and welfare. This updated edition covers vital fundamentals, including animal cell cultures, genome sequencing analysis, epigenetics and animal models, gene expression, and ethics and safety concerns, along with in-depth examples of implications for human health and prospects for the future. New chapters cover animal biotechnology as applied to various disease types and research areas, including in vitro fertilization, human embryonic stem cell research, biosensors, enteric diseases, biopharming, organ transplantation, tuberculosis, neurodegenerative disorders, and more. Highlights the latest biomedical applications of genetically modified and cloned animals, with a focus on cancer and infectious diseases Offers first-hand accounts of the use of biotechnology tools, including molecular markers, stem cells, animal cultures, tissue engineering, ADME and CAM Assay Includes case studies that illustrate safety assessment issues, ethical considerations, and intellectual property rights associated with the translation of animal biotechnology studies

Animal Models and Human Reproduction

Animal Models and Human Reproduction Book
Author : Heide Schatten,Gheorghe M. Constantinescu
Publisher : John Wiley & Sons
Release : 2017-01-13
ISBN : 1118881346
Language : En, Es, Fr & De

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Book Description :

Our knowledge of reproductive biology has increased enormously in recent years on cellular, molecular, and genetic levels, leading to significant breakthroughs that have directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems. Animal Models and Human Reproduction presents a comprehensive reference that reflects the latest scientific research being done in human reproductive biology utilizing domestic animal models. Chapters on canine, equine, cow, pig, frog, and mouse models of reproduction reflect frontier research in placental biology, ovarian function and fertility, non-coding RNAs in gametogenesis, oocyte and embryo metabolism, fertilization, cryopreservation, signal transduction pathways, chromatin dynamics, epigenetics, reproductive aging, and inflammation. Chapters on non-human primate models also highlight recent advancements into such issues as human in vitro fertilization (IVF) and assisted reproductive technologies (ART). This book offers animal scientists, reproductive biology scientists, clinicians and practitioners, invaluable insights into a wide range of issues at the forefront of human reproductive health.

Animal Models of Speech and Language Disorders

Animal Models of Speech and Language Disorders Book
Author : Santosh A. Helekar
Publisher : Springer Science & Business Media
Release : 2013-10-17
ISBN : 1461484006
Language : En, Es, Fr & De

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Book Description :

Basic research over the last decade or two has uncovered similarities between speech, especially its sensori-motor aspects, and vocal communication in several non-human species. The most comprehensive studies so far have been conducted in songbirds. Songbirds offer us a model system to study the interactions between developmental or genetic predispositions and tutor-dependent influences, on the learning of vocal communication. Songbird research has elucidated cellular and molecular mechanisms underlying learning and production of vocal patterns, perception of vocal sounds, vocal motor control and vocal neuromotor plasticity. More recently, the entire genome of the songbird zebra finch has been sequenced. These discoveries, along with the identification of several genes implicated in familial human speech and language disorders, have made it possible to look for analogues of speech and language dysfunction in zebra finches, at least at the perceptual and sensori-motor levels. Two approaches in particular have led us closer to the development of animal models of human speech conditions, namely developmental stuttering and a familial verbal dyspraxia associated with a mutation in the gene for the transcription factor FoxP2. Work on other animals that show developmental sensori-motor learning of vocal sounds used for communication have also shown significant progress, leading to the possibility of development of models of speech and language dysfunction in them. Among mammals, the principal ones include dolphins and whales. In non-human primates, while vocal learning per se is not very prominent, investigations on their communicative abilities have thrown some light on the rudiments of language. These considerations make the publication of a book focused on animal models of speech and language disorders, detailing the overall investigative approach of neurobehavioral studies in animals capable of vocal communication and learned vocalizations, a much-needed and worthwhile project. It would serve as a unifying review of research in this new multidisciplinary frontier, spanning the molecular to the behavioral, for clinicians and researchers, as well as a teaching resource for advanced speech pathology and neuroscience students. This book will also be the first of its kind.

CRISPR in Animals and Animal Models

CRISPR in Animals and Animal Models Book
Author : Anonim
Publisher : Academic Press
Release : 2017-11-10
ISBN : 0128125071
Language : En, Es, Fr & De

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Book Description :

CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics of interest in this updated volume include a section on CRISPR history, The genome editing revolution, Programming CRISPR and its applications, CRISPR Delivery methods, CRISPR libraries and screening, CRISPR investigation in haploid cells, CRISPR in the generation of transgenic animals, CRISPR therapeutics, and Promising strategies and present challenges. Accessible to students and researchers alike Written by leading authorities in the field

Mouse Models of Human Cancer

Mouse Models of Human Cancer Book
Author : Eric C. Holland
Publisher : Wiley-Liss
Release : 2004-08-27
ISBN : 047144460X
Language : En, Es, Fr & De

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Book Description :

Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

Handbook of Models for Human Aging

Handbook of Models for Human Aging Book
Author : P. Michael Conn
Publisher : Elsevier
Release : 2011-04-28
ISBN : 9780080460062
Language : En, Es, Fr & De

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Book Description :

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

Animal Models in Biomedical Research

Animal Models in Biomedical Research Book
Author : Cynthia Petrie Smith
Publisher : Unknown
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Animal Models in Biomedical Research book written by Cynthia Petrie Smith, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

From Animal Models to Human Genetics

From Animal Models to Human Genetics Book
Author : Karsten Conrad
Publisher : Unknown
Release : 2004
ISBN : 9783899671483
Language : En, Es, Fr & De

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Book Description :

Download From Animal Models to Human Genetics book written by Karsten Conrad, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mouse Models of Human Blood Cancers

Mouse Models of Human Blood Cancers Book
Author : Shaoguang Li
Publisher : Springer Science & Business Media
Release : 2008-12-19
ISBN : 9780387691329
Language : En, Es, Fr & De

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Book Description :

In this book, Dr. Li and his author team plan to emphasize why mouse models are useful in vivo systems for understanding disease mechanisms and developing therapeutic strategies in blood cancers. The authors do not intend to cover all types of blood cancers; instead, they will focus on some major ones such as leukemias and lymphomas. However, the authors will try to cover as much as they can the cancer types and point out that many blood cancers need to be studied in mouse disease models although they are still not available at present. A major focus in the book will be to show what we can or cannot learn from mouse disease models and to also show the critical contributions of mouse models in therapeutic drug development.

CRISPR in Animals and Animal Models

CRISPR in Animals and Animal Models Book
Author : Raul Torres-Ruiz,Sandra Rodriguez-Perales
Publisher : Academic Press
Release : 2017-11
ISBN : 9780128125069
Language : En, Es, Fr & De

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Book Description :

CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics of interest in this updated volume include a section on CRISPR history, The genome editing revolution, Programming CRISPR and its applications, CRISPR Delivery methods, CRISPR libraries and screening, CRISPR investigation in haploid cells, CRISPR in the generation of transgenic animals, CRISPR therapeutics, and Promising strategies and present challenges. Accessible to students and researchers alike Written by leading authorities in the field

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2017-06-20
ISBN : 0128096993
Language : En, Es, Fr & De

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Book Description :

Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases

Model Organisms in Drug Discovery

Model Organisms in Drug Discovery Book
Author : Pamela M. Carroll,Kevin Fitzgerald
Publisher : John Wiley & Sons
Release : 2004-04-21
ISBN : 047087130X
Language : En, Es, Fr & De

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Book Description :

Fruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which "define" humans are conserved in Drosophila, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems. Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future. Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future. This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease Book
Author : JoEllen Welsh
Publisher : Elsevier Inc. Chapters
Release : 2013-05-29
ISBN : 012807230X
Language : En, Es, Fr & De

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Book Description :

Breast cancer is one of the most frequently diagnosed malignancies, and despite extensive molecular and cellular research, the mortality rate remains high. Preclinical testing of new strategies to prevent the emergence of invasive disease and to effectively treat existing disease is dependent on appropriate in vivo models. The challenges with modeling breast cancer in animals include species differences in mammary gland development and sensitivity to carcinogens as well as the molecular heterogeneity of human breast cancer. This chapter focuses on the plethora of animal models that have been developed in rodents, including chemically induced protocols, transplantable and graft models, and transgenic and knockout approaches. Although no single model is suitable for all research purposes, genomic profiling has enabled the identification of rodent tumors that display molecular similarity to specific subtypes of human breast cancer. Practical aspects and key issues involved in choosing an animal model are discussed, along with the advantages and limitations of the most commonly utilized rodent models of breast cancer.

Animal Models in Biomedical Research

Animal Models in Biomedical Research Book
Author : Anonim
Publisher : DIANE Publishing
Release : 1993-07
ISBN : 9781568069241
Language : En, Es, Fr & De

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Book Description :

Download Animal Models in Biomedical Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

What Will We Do If We Don t Experiment on Animals

What Will We Do If We Don t Experiment on Animals  Book
Author : Jean Swingle Greek,C. Ray Greek
Publisher : Trafford Publishing
Release : 2004
ISBN : 1412020581
Language : En, Es, Fr & De

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Book Description :

Drs. Greek have written 2 books on why using animals as models for humans is not the best way to conduct medical research and drug testing. During their lectures and debates, the most commonly asked question was, "Well. What will we use if we don't use animals?" What Will We Do If We Don't Experiment On Animals? Medical Research for the Twenty-first Century is the answer to that question. Drs. Greek explain briefly why one species cannot predict drug response for another and describe what research and testing methods should be used today instead of animals. They also describe where our biomedical research dollars should be spent if we are to have cures for cancer, AIDS, and Alzheimer's. This book will appeal to science-trained and general audiences, animal lovers and science readers, public policy analysts, students, patients and patient support groups, and government watchdog groups. What Will We Do If We Don't Experiment On Animals? Medical Research for the Twenty-first Century takes medical research out of the nineteenth and into the 21st century.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease Book
Author : Lina Badimon,Laura Casani,Gemma Vilahur
Publisher : Elsevier Inc. Chapters
Release : 2013-05-29
ISBN : 0128072008
Language : En, Es, Fr & De

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Book Description :

Experimental approaches to understand the pathophysiology of atherosclerosis and thrombosis involve the combination of both cellular and animal approaches. Animals have been instrumental in biomedical research in order to provide a better understanding on the mechanisms that have already been outlined in in vitro studies. Atherosclerosis studies were firstly carried out in rodents using diet-induced atherosclerosis approaches. However, these diets were un-physiological and the developed lesions were often limited in size, composition, and location largely differing from humans. During the last years, with the advent of molecular genetics and genetic manipulation techniques, the development of gene-engineered animals has allowed an explosion in the number of models resulting in a tremendous progress in the understanding of both atherosclerosis and thrombosis. However, direct translation from rodents to humans has to be taken with caution because of the well-reported species-related differences. Although there is no known animal model for human disease, large animal models have demonstrated better suitability for translation to humans. For instance swine, a species that spontaneously develops atherosclerosis and thrombosis, are more closely mimics of the macrovascular-related thrombotic complications found in humans. This book chapter provides an in depth overview of the currently available small and large animal modelsof atherosclerosis and thrombosis and examinestheir applicability for translational research purposes as well as highlights species-related differences with humans.

Animal Models for Human Cancer Volume 69

Animal Models for Human Cancer  Volume 69 Book
Author : Marianne I. Martic-Kehl,Pius August Schubiger,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
Publisher : John Wiley & Sons
Release : 2016-08-15
ISBN : 3527339973
Language : En, Es, Fr & De

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Book Description :

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long-term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.

Animal Models of Human Disease

Animal Models of Human Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2011-03-04
ISBN : 0123848792
Language : En, Es, Fr & De

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Book Description :

Animal experiments have contributed much to our understanding of mechanisms of disease and are important for determining new therapies. This volume reviews the latest research and developments in this field. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields