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Cell Based Liver Regeneration

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Cell Based Liver Regeneration

Cell Based Liver Regeneration Book
Author : Hala Gabr,Wael Abo El-Kheir
Publisher : Academic Press
Release : 2021-10-01
ISBN : 0128223413
Language : En, Es, Fr & De

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Book Description :

Stem cell therapy is a fast-growing field of medicine with remarkable prospects in a broad spectrum of diseases. Cell-Based Liver Regeneration: Current Aspects and Future Approaches addresses the full spectrum of regenerative medicine in liver diseases. Coverage will include the basic science, current research and a comprehensive review of clinical trials conducted in the field. The book will discuss the various types of stem cells for liver regeneration, presenting the advantages and disadvantages of each type. A review of all aspects of implanting stem cell therapy for the liver, such as: choosing the cell type, the source, laboratory manipulation, dose, route and follow-up. The book concludes with a full discussion of the current clinical trials involving cellular therapy in liver regeneration. Cell-Based Liver Regeneration: Current Aspects and Future Approaches is written for stem cell biologists, liver biologists, hepatologists and graduate students by authors with extensive knowledge in basic, pre-clinical and clinical stem cell research. Introduces basic concepts of liver regeneration Discusses the various types of stem cells used in liver regeneration Explores published and ongoing clinical trials involving cellular therapy in liver regeneration

Liver Regeneration

Liver Regeneration Book
Author : Dieter Häussinger
Publisher : Walter de Gruyter
Release : 2011
ISBN : 3110250780
Language : En, Es, Fr & De

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Book Description :

Understanding the mechanisms involved in liver regeneration is of crucial importance for clinical medicine, not only regarding carcinogenesis and diabetes treatment, but also for the use of stem cells for cell therapy and liver surgery. This graduate-level text provides an overview of the current state of knowledge of the molecular mechanisms of liver regeneration. Hepatic stem cells are introduced and the important players involved in regeneration such as oval cells, bone marrow and stellate cells are reviewed. The cell signaling pathways that initiate liver regeneration and regulate the switch between proliferation and apoptosis are presented and the role of liver stem cells in tumorigenesis is discussed. The book also treats the epigenetic regulation of liver stem cells and the roles of inflammation and angiogenesis in liver regeneration. This compact overview of the fascinating regenerative capacity of the liver will be of interest to graduate students and post-docs in molecular biology, biochemistry and medicine.

Stem Cell and Liver Regeneration

Stem Cell and Liver Regeneration Book
Author : K. Okita
Publisher : Springer Science & Business Media
Release : 2004
ISBN : 9784431401995
Language : En, Es, Fr & De

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Book Description :

Cellular therapy with liver stem cells and their progeny, including bone marrow cells, is a promising new approach that will contribute significantly to the treatment of liver diseases. The existence of the liver stem cell had long been debated, but it is now generally accepted that the liver contains cells with stem-like properties and that these cells can be activated to proliferate and differentiate into mature hepatocytes under certain conditions. There is also a substantial body of evidence to suggest that oval cells are involved in liver regeneration as they differentiate into hepatocytes and biliary cells. This book is a collection of work on stem cell and liver regeneration, initially delivered at the 14th Yamaguchi (Japan) Symposium on Liver Disease. Its nine chapters present the most recent data about basic and clinical research in hepatology in Japan and other countries, providing a valuable resource for researchers and practitioners alike.

Bioengineering Liver Transplantation

Bioengineering Liver Transplantation Book
Author : Luc J.W. Van der Laan,Bart Spee,Monique M. A. Verstegen
Publisher : MDPI
Release : 2019-11-19
ISBN : 3039217445
Language : En, Es, Fr & De

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Book Description :

The aim of this Special Issue is to review, understand, and evaluate new and exciting opportunities from the field on regenerative medicine, biomaterials, and stem cell research for the bioengineering of human liver grafts that can be applied for transplantation and personalized treatment of end-stage liver disease.The development of culture conditions for long-term expansion of LGR5+ intestinal stem cells as crypt-villus structures demonstrated the feasibility of deriving complex, organ-like structures in vitro from primary adult tissues, including the liver. Moreover, human pluripotent stem cells (hPSCs) can be applied to generate functionally maturated liver and bile duct epithelial cells.In this Special Issue, we welcome reviews and original papers focussing on hepatic cell sources, including adult hepatic stem cells, organoids, fetal and induced pluripotent stem cells, and primary cells (i.e., hepatocytes, cholangiocytes, and endothelial cells) and how these cells can be applied in tissue engineering strategies to generate implantable and personalized liver grafts. Potential topics include, but are not limited to, the following: liver tissue engineering, liver regeneration, graft repair, liver stem cells and organoids, bio-scaffolds, and 3D printing.We invite you to contribute original research papers, as well as comprehensive reviews, aligned with these themes, to advance and improve the actual state-of-the-art in liver bioengineering and providing new opportunities for the imminent medical problem of organ and tissue shortage for transplantation.

Frontiers in Stem Cell and Regenerative Medicine Research

Frontiers in Stem Cell and Regenerative Medicine Research Book
Author : Atta-ur- Rahman ,Shazia Anjum
Publisher : Bentham Science Publishers
Release : 2017-10-17
ISBN : 1681085526
Language : En, Es, Fr & De

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Book Description :

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. The seventh volume of this series features reviews on roles of mesenchymal stem cells and biomaterials in cartilage regeneration in vivo, liver regeneration, cardiogenesis and magnetic nanoparticles for regenerative therapy.

Cell Transplantation

Cell Transplantation Book
Author : Anonim
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cell Transplantation book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America Book
Author : National Academy of Sciences (U.S.)
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Proceedings of the National Academy of Sciences of the United States of America book written by National Academy of Sciences (U.S.), available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Liver Regeneration

Liver Regeneration Book
Author : Udayan M. Apte
Publisher : Academic Press
Release : 2015-08-13
ISBN : 0128004312
Language : En, Es, Fr & De

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Book Description :

Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications presents cutting-edge information on liver regeneration research through an integrated, systems-wide perspective. The book addresses discoveries on hepatic progenitor cells, liver regeneration after chemical damage, and liver regeneration as a prime therapy for liver failure and disease. By addressing the urgent need for translating basic research findings into clinically relevant modalities and potential therapeutic applications, the book provides the data needed to improve liver patient management. Hundreds of full-color, graphic photographs and illustrations underline key elements and show researchers and students important aspects of liver transplantation, immunofluorescence, and other techniques used in liver regeneration. Summarizes current liver regeneration studies and discussions on expected discoveries Provides an overview of standard scientific and cutting-edge technologies to study liver regeneration Presents details on the molecular mechanisms that affect liver regeneration Highly illustrated, with hundreds of full-color, graphic photographs and illustrations to enhance the learning process

Experimental Biology and Medicine

Experimental Biology and Medicine Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Experimental Biology and Medicine book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cellular Transplantation

Cellular Transplantation Book
Author : Craig Halberstadt,Dwaine F. Emerich
Publisher : Academic Press
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. This book features: . Detailed description of clinical trials in cell transplantation . Review of current therapeutic approaches . Coverage of the broad range of diseases addressed by cell therapeutics . Discussion of stem cell biology and its role in transplantation About the editors Dwaine Emerich is Vice President of Research and Chief Scientific Officer for LCT BioPharma, having previously held the same position at Sertoli Technologies Inc. He has also held the position of Director of Biological Research at Alkermes Inc. and CytoTherapeutics Inc. His research interests include cell transplantation, drug delivery, nanotechnology and tissue engineering. Craig Halberstadt is the Director of Tissue Engineering at the Carolinas Medical Center in Charlotte, North Carolina. With prior positions at Desmos, Inc. and Advanced Tissue Sciences, his research focuses on cell transplantation, cell/biomaterial interactions, and in vivo reconstruction of new tissues.

Regenerative Medicine Stem Cells and the Liver

Regenerative Medicine  Stem Cells and the Liver Book
Author : David C. Hay
Publisher : CRC Press
Release : 2012-04-12
ISBN : 1466513853
Language : En, Es, Fr & De

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Book Description :

The regenerative capacity of the liver has been recognized for centuries, but when it is overwhelmed by insulting stimuli or is chronically damaged, its regenerative capability is substantially reduced or lost. Researchers have been working to find solutions to cure failing human liver function. Given the ability of stem cells to self- renew and differentiate into specialized cell liver types, they represent an attractive strategy to replace lost liver function. This book begins by outlining the complex nature of human liver disease and proceeds to examine the potential that stem cell-based approaches have to offer.

Index Medicus

Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Journal of Cell Biology

The Journal of Cell Biology Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-

DNA and Cell Biology

DNA and Cell Biology Book
Author : Anonim
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download DNA and Cell Biology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Regeneration of Liver and Kidney

Regeneration of Liver and Kidney Book
Author : Nancy L. R. Bucher,Ronald A. Malt
Publisher : Unknown
Release : 1971
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Regeneration of Liver and Kidney book written by Nancy L. R. Bucher,Ronald A. Malt, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Emerging Trends in Cell and Gene Therapy

Emerging Trends in Cell and Gene Therapy Book
Author : Michael K. Danquah,Ram I. Mahato
Publisher : Springer Science & Business Media
Release : 2013-06-14
ISBN : 162703417X
Language : En, Es, Fr & De

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Book Description :

Examples from various organs and diseases illustrate the potential benefit obtained when both therapeutic approaches are combined with delivery strategies. Representing the combined effort of several leading international research and clinical experts, this book, Emerging Trends in Cell and Gene Therapy, provides a complete account on and brings into sharp focus current trends and state-of-the-art in important areas at the interface of cell- and gene-based therapies. This book addresses the current fragmented understanding regarding these two research areas and fills the vast unmet educational need and interest of both students and researchers in academia and industry. Main features of the book: · Biological aspects of stem cell sources, differentiation and engineering. · Application of microfluidics to study stem cell dynamics · Potential clinical application of stem cells and gene therapy to specific human disease. · Utilization of biomaterials and stem cells in regenerative medicine with particular emphasis on spinal cord repair, ligament and bone tissue engineering. · Biomimetic multiscale topography for cell alignment.

Liver Lung and Heart Regeneration

Liver  Lung and Heart Regeneration Book
Author : Phuc Van Pham
Publisher : Springer
Release : 2016-12-10
ISBN : 3319466933
Language : En, Es, Fr & De

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Book Description :

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in liver, lung and heart regeneration. All chapters are contributed by pre-eminent scientists in the field and covers such topics as cell therapy in the treatment of cirrhosis and other liver, heart and lung diseases, characteristics of hepatic progenitor cells, future directions of the discussed therapies and much more. Liver, Lung and Heart Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Muse Cells

Muse Cells Book
Author : Mari Dezawa
Publisher : Springer
Release : 2018-11-27
ISBN : 4431568476
Language : En, Es, Fr & De

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Book Description :

This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications—for example, in acute myocardial infarction, stroke, skin injuries and ulcers, renal failure, and liver disease. An important technical chapter provides a practical and precise protocol for the isolation of Muse cells, which will enable readers to use Muse cells in their own research. In offering fascinating insights into the strategic organization of the body’s reparative function and explaining how full utilization of Muse cells may significantly enhance the effectiveness of MSC treatment, the book will be of high value for Ph.D. students, postdocs, basic researchers, clinical doctors, and industrial developers.

Liver Regeneration and Carcinogenesis

Liver Regeneration and Carcinogenesis Book
Author : Gerard Meurant
Publisher : Elsevier
Release : 1995-09-27
ISBN : 9780080535548
Language : En, Es, Fr & De

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Book Description :

Because of its marked capacity to regenerate and the ability of chemical carcinogens and viruses to ready transform hepatocytes, the liver has been used extensively as a model for investigating the molecular mechanisms of cellular proliferation and carcinogenesis. Recently, striking advances have occured in the understanding of hepatocyte growth regulation and the manner in which chemical agents and viruses alter these normal growth regulatory pathways in liver carcinogenesis. This explosion of information has occured in a multitude of researh disciplines. This book brings together current findings in a coherent manner, from a molecular point of view. Three sections cover in detail the areas of liver regeneration, liver carcinogenesis, and liver tumor therapy. The contributors are pioneers and leaders in this field. * Logical organization of material in three detailed and comprehensive sections: liver regeneration, liver carcinogenesis, and liver tumor treatment * Contributors are pioneers and leaders in the field * There are currently no books on this subject on the market * Research focus is at the molecular level

Artificial Liver Support

Artificial Liver Support Book
Author : G. Brunner,F. W. Schmidt
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642966292
Language : En, Es, Fr & De

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Book Description :

The regenerative capacity of the liver cell is almost unlimited. Therefore after acute liver damage, be it viral, toxic, hypoxic, or surgical in origin, restitutio ad integrum is the usual outcome. In two forms of liver disease, however, this is not the case: in fulmi nant hepatic failure, liver regeneration often is not fast enough to keep the organism alive; in end-stage cirrhosis, regeneration is dis turbed by a hypertrophic architecture of fibrotic tissue. For these extreme forms of liver disease and for critical situations before and after liver surgery, artificial liver support is needed. This book contains the latest results in this area of research pre sented by scientists from allover the world at an international symposium held in Celle, Germany, June 2-4, 1980. Exciting new methods like continuous membrane plasma sepa ration and liver cell transplantation into the spleen have been de veloped. The older methods of hemoperfusion and dialysis have been improved. Enzymological methods and liver transplantation have made good progress. We hope that this volume will help the clinician in his decision-making and stimulate ingenious new re search for the benefit of our liver patients.