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Cardiovascular Genome Editing

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Genome Editing

Genome Editing Book
Author : Kursad Turksen
Publisher : Springer
Release : 2016-08-09
ISBN : 3319341480
Language : En, Es, Fr & De

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Book Description :

This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions. Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.

Genome Editing

Genome Editing Book
Author : Kiran Musunuru
Publisher : Academic Press
Release : 2021-06-15
ISBN : 9780128234846
Language : En, Es, Fr & De

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Book Description :

Genome Editing: A Practical Guide to Research and Clinical Applications is geared towards investigators interested in learning how to use CRISPR-Cas9-based technologies, with a focus on cardiovascular research and clinical applications. Covering a range of topics from the basics of genome editing to design considerations, to assessments and applications, this reference allows readers to get started and establish a full workflow from the beginning of the project to its full completion. With worked examples drawn from real-life experiments, as well as troubleshooting and pitfalls to avoid, the book serves as an essential reference for researchers and investigators in both cardiovascular and biomedical research. Help readers familiarise with the variety of genome-editing approaches that are being applied in cardiovascular research and medicine, i.e., both research applications and clinical applications Understand the use of genome editing through worked examples (based on real-life experiments) in which CRISPR-Cas9 is employed, online tools to design CRISPR-Cas9 reagents, methods to interpret data from genome-editing experiments, the downsides of genome-editing technology - both the scientific and ethical pitfalls to avoid Written in an easy-to-follow manner, guiding readers from the design of the project to its completion Includes unpublished and new methods

Genome Editing and Engineering

Genome Editing and Engineering Book
Author : Krishnarao Appasani
Publisher : Cambridge University Press
Release : 2018-07-31
ISBN : 1107170370
Language : En, Es, Fr & De

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Book Description :

A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

Congestive Heart Failure and Cardiac Transplantation

Congestive Heart Failure and Cardiac Transplantation Book
Author : Daniel J. Garry,Robert F. Wilson,Zeev Vlodaver
Publisher : Springer
Release : 2017-06-01
ISBN : 3319445774
Language : En, Es, Fr & De

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Book Description :

This book is a comprehensive overview of heart failure and cardiac transplantation and integrates scientific and clinical information about the physiology, pathophysiology, diagnosis, and treatment of this disorder. Organized into five parts, it reviews the history and basic mechanisms of heart failure; etiology of heart failure; heart failure disease progression; advanced therapies for heart failure; and cardiac transplantation. The book presents basic concepts in the physiology, molecular biology, pathology, and epidemiology of the normal and failing heart; known causes of heart failure, such as right heart failure, valvular cardiomyopathy, molecular mechanisms of sarcomeric cardiomyopathies, and neuromuscular cardiomyopathy; cardiorenal syndrome; neurohormonal activation; cardiac resynchronization, ventricular assist devices; regenerative mechanisms; orthotopic heart transplantation; early and late management of the post-transplant patient; heart transplantation and antibody-mediated rejections; heart-lung transplantation; and cardiac xenotransplantation. Featuring contributions from leaders in the fields of heart failure, cardiac transplantation, cardiac pathology, and cardiovascular molecular research, Congestive Heart Failure and Cardiac Transplantation is a valuable compendium for cardiologists, cardiothoracic surgeons, researchers, trainees, and students.

Genome Engineering via CRISPR Cas9 System

Genome Engineering via CRISPR Cas9 System Book
Author : Vijai Singh,Pawan K. Dhar
Publisher : Academic Press
Release : 2020-02-18
ISBN : 0128181419
Language : En, Es, Fr & De

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Book Description :

Genome Engineering via CRISPR-Cas9 Systems presents a compilation of chapters from eminent scientists from across the globe who have established expertise in working with CRISPR-Cas9 systems. Currently, targeted genome engineering is a key technology for basic science, biomedical and industrial applications due to the relative simplicity to which they can be designed, used and applied. However, it is not easy to find relevant information gathered in a single source. The book contains a wide range of applications of CRISPR in research of bacteria, virus, algae, plant and mammalian and also discusses the modeling of drosophila, zebra fish and protozoan, among others. Other topics covered include diagnosis, sensor and therapeutic applications, as well as ethical and regulatory issues. This book is a valuable source not only for beginners in genome engineering, but also researchers, clinicians, stakeholders, policy makers, and practitioners interested in the potential of CRISPR-Cas9 in several fields. Provides basic understanding and a clear picture on how to design, use and implement the CRISPR-Cas9 system in different organisms Explains how to create an animal model for disease research and screening purposes using CRISPR Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, virology, bacteriology, molecular biology, neurology, cancer, industry, and many more

Encyclopedia of Cardiovascular Research and Medicine

Encyclopedia of Cardiovascular Research and Medicine Book
Author : N.A
Publisher : Elsevier
Release : 2017-11-27
ISBN : 012805154X
Language : En, Es, Fr & De

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Book Description :

Encyclopedia of Cardiovascular Research and Medicine offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine. Presents comprehensive coverage of every aspect of cardiovascular medicine and research Offers readers a broad, interdisciplinary overview of the concepts in cardiovascular research and medicine with applications across biomedical research Includes reputable, foundational content on genetics, cancer, immunology, cell biology and molecular biology Provides a multi-media enriched color-illustrated text with high quality images, graphs and tables.

Cardiovascular Engineering A Protective Approach

Cardiovascular Engineering  A Protective Approach Book
Author : Shu Liu
Publisher : McGraw Hill Professional
Release : 2020-06-12
ISBN : 1260457656
Language : En, Es, Fr & De

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Book Description :

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Cardiovascular engineering principles and practices with a focus on disease prevention Aimed at advanced students taking cardiovascular, regenerative, and tissue engineering courses, Cardiovascular Engineering: A Protective Approach explores applications of protective engineering strategies and technologies to common cardiovascular disorders. A protective approach to cardiovascular engineering involves studying the naturally occurring mechanisms that protect molecules, cells, and organs from injury and dysfunction. The goal is to use this understanding to design and develop engineering-based therapeutic strategies and technologies that prevent cardiovascular injury and disease. Readers will learn the fundamental and applied aspects of cardiovascular engineering. Coverage includes: • Foundations of cardiovascular protective engineering • Development of the heart, blood vessels, and blood cells • Stem cells and regeneration • Structure and function of the heart and blood vessels • Cytokines and growth factors in cardiovascular disease • Mechanisms of disease • Systems protective mechanisms against injury • Protective engineering strategies • Systemic hypertension • Atherosclerosis and arterial aneurysms • Ischemic heart disease and ischemic stroke • Cardiomyopathies and congenital heart disease

Establishment of a PRKAG2 Cardiac Syndrome Disease Model and Mechanism Study Using Human Induced Pluripotent Stem Cells

Establishment of a PRKAG2 Cardiac Syndrome Disease Model and Mechanism Study Using Human Induced Pluripotent Stem Cells Book
Author : N.A
Publisher :
Release : 2018
ISBN :
Language : En, Es, Fr & De

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Book Description :

Abstract: PRKAG2 cardiac syndrome is a distinct form of human cardiomyopathy characterized by cardiac hypertrophy, ventricular pre-excitation and progressive cardiac conduction disorder. However, it remains unclear how mutations in the PRKAG2 gene give rise to such a complicated disease. To investigate the underlying molecular mechanisms, we generated disease-specific hiPSC-derived cardiomyocytes from two brothers both carrying a heterozygous missense mutation c.905G>A (R302Q) in the PRKAG2 gene and further corrected the R302Q mutation with CRISPR-Cas9 mediated genome editing. Disease-specific hiPSC-cardiomyocytes recapitulated many phenotypes of PRKAG2 cardiac syndrome including cellular enlargement, electrophysiological irregularities and glycogen storage. In addition, we found that the PRKAG2-R302Q mutation led to increased AMPK activities, resulting in extensive glycogen deposition and cardiomyocyte hypertrophy. Finally we confirmed that disrupted phenotypes of PRKAG2 cardiac syndrome caused by the specific PRKAG2-R302Q mutation can be alleviated by small molecules inhibiting AMPK activity and be rescued with CRISPR-Cas9 mediated genome correction. Our results showed that disease-specific hiPSC-CMs and genetically-corrected hiPSC-cardiomyocytes would be a very useful platform for understanding the pathogenesis of, and testing autologous cell-based therapies for, PRKAG2 cardiac syndrome. Abstract : Graphical abstract Highlights: Patient-specific hiPSC-CM model of PRKAG2 cardiac syndrome is successfully generated. Patient-specific hiPSC-CMs recapitulate critical properties of the PRKAG2 cardiac syndrome in vitro . PRKAG2-R302Q mutation increases AMPK activity, leading to extensive glycogen deposition in hiPSC-CMs. Patient-specific hiPSC-CMs provide a new way to study the pathogenesis of PRKAG2 cardiac syndrome. CRISPR-Cas9 mediated genome correction can rescue the phenotypes of PRKAG2 cardiac syndrome.

Cardiovascular and Pulmonary Physical Therapy Third Edition

Cardiovascular and Pulmonary Physical Therapy  Third Edition Book
Author : William DeTurk,Lawerence Cahalin
Publisher : McGraw Hill Professional
Release : 2018-01-12
ISBN : 1259837963
Language : En, Es, Fr & De

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Book Description :

A comprehensive, up-to-date textbook spanning the entire scope of cardiovascular and pulmonary practice A Doody’s Core Title for 2019! Cardiovascular and Pulmonary Physical Therapy, Third Edition reflects the broadest possible spectrum of cardiovascular and pulmonary practice and draws upon the expertise of a carefully selected team of world-renowned contributors. This internationally acclaimed text reviews must-know background knowledge, thoroughly explains exercise principles, cites the best evidence, and integrates the American Physical Therapy Association’s approved practice patterns into the chapter content. Learn how to apply principles to practice in any setting with: • The Guide to Physical Therapy Practice integrated throughout, with an entire chapter devoted to its history and use • Preferred practice patterns for cardiovascular and pulmonary physical therapy form the core of eight chapters are used as springboards to describe interventions and outcomes • Case studies in practice pattern chapters allow you to experience the proper application of the practice patterns • The patient-client management model is used in the case studies with appropriate test, measures, and interventions selected from the practice patterns and applied to the patient • “International Perspectives” provide a way to gain insight into the global practice of physical therapy • Evidence-based and peer reviewed published material is included to help you develop specific intervention regimens • Online access to case-based exercises, video clips illustrating technical psychomotor skills, and demonstrations of cardiac and pulmonary physical exams

Clinical Genetics in Nursing Practice

Clinical Genetics in Nursing Practice Book
Author : Felissa R. Lashley, PhD, RN, FABMGG
Publisher : Springer Publishing Company
Release : 2005-04-15
ISBN : 9780826123671
Language : En, Es, Fr & De

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Book Description :

Designated a Doody's Core Title! The third edition of this award-winning text provides new and updated knowledge about genetics issues relevant to nursing practice. Read in sequence or used as a reference, this is a comprehensive overview of how genetics affetcs the care that nurses provide. In addition to a summary of basic human genetics and discussion of the Human Genome Project, this new edition includes the latest research findings and implications about inheritance, major genetic disorders (cytogenetics or chromosomal, inherited biochemical, and congenital anomalies), and genetics in twin studies. A consideration of the ethical impact of genetics on society and future generations, as well as information on assisted reproduction round out the overview. Includes over 100 illustrations and photos of specific genetic disorders; tables and figures on the distribution of disease; and an extensive appendix listing associations, organizations, and websites relevant to genetics.

Molecular Basis of Cardiovascular Disease

Molecular Basis of Cardiovascular Disease Book
Author : Kenneth R. Chien
Publisher :
Release : 1999
ISBN :
Language : En, Es, Fr & De

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Book Description :

Covering the molecular basis of heart disease, this text evaluates topics such as genetic mapping approaches in inherited cardiovascular disorders, and driving mechanisms in the transition from cardiac hypertrophy to heart failure.

Cardiac Sodium Channel Disorders An Issue of Cardiac Electrophysiology Clinics

Cardiac Sodium Channel Disorders  An Issue of Cardiac Electrophysiology Clinics  Book
Author : Hugues Abriel
Publisher : Elsevier Health Sciences
Release : 2015-09-01
ISBN : 0323326412
Language : En, Es, Fr & De

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Book Description :

The sodium channel, a ubiquitous member of the cardiac, neural, and muscular conduction systems, has been implicated in the pathogenesis of an array of human diseases. Mutations associated with the cardiac sodium channel are responsible for a wide spectrum of disorders. The cardiac sodium channel and associated disorders are comprehensively examined in this issues of the Cardiac Electrophysiology Clinics.

Application of Genetics and Genomics in Poultry Science

Application of Genetics and Genomics in Poultry Science Book
Author : Xiaojun Liu
Publisher : BoD – Books on Demand
Release : 2018-09-05
ISBN : 1789236304
Language : En, Es, Fr & De

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Book Description :

Genetics and genomics in poultry have been the most rapidly advancing subjects since the completion of the chicken genome sequence in 2004 and have been extensively used to understand the genetic determinants of complex traits. This book intends to provide readers with a comprehensive overview of the current progress in the application of genetic and genomic science in the poultry field. The contents cover genetic variation detection, selection methods for breeding, transgenesis and genome editing, genetic basis of disease resistance, control of gene expression and regulation, reproduction and meat quality, etc. The book should prove useful to researchers and students working in related fields.

Translational Cardiometabolic Genomic Medicine

Translational Cardiometabolic Genomic Medicine Book
Author : Annabelle Rodriguez-Oquendo
Publisher : Academic Press
Release : 2015-09-07
ISBN : 0128004746
Language : En, Es, Fr & De

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Book Description :

Translational Cardiometabolic Genomic Medicine, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases. This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis. It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets. Provides comprehensive research on translational genomic medicine Explains state-of-the-art genome editing for stem cells and mouse models with significant relevance to human cardiometabolic disease Includes discussions on the functional effects of single nucleotide polymorphisms and cardiometabolic diseases, stratified by sex and race Encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome

Fast Forward Investing How to Profit from AI Driverless Vehicles Gene Editing Robotics and Other Technologies Reshaping Our Lives

Fast Forward Investing  How to Profit from AI  Driverless Vehicles  Gene Editing  Robotics  and Other Technologies Reshaping Our Lives Book
Author : Jon Markman
Publisher : McGraw Hill Professional
Release : 2018-11-02
ISBN : 1260132226
Language : En, Es, Fr & De

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Book Description :

Invest in the future! Everything you need to capitalize on the tech revolution Our lives are on the verge of being reshaped by advanced technology. Fast Forward Investing provides the knowledge and insight you need to build and maintain your portfolio accordingly. Author Jon D. Markman is a veteran tech investor, money manager, and award-winning author of the popular daily newsletter Tech Trend Trader. There’s no one more qualified to help you design a portfolio that extracts huge profits from the shares of public technology companies and helps you augment your gains with conviction during stretches of high volatility. In Fast Forward Investing, Markman describes what to expect, when to expect it, and how to profit in impending technological and economic revolution. Revealing the most important companies in the industry that are right now building platforms and competitive advantages that will disrupt and transform their markets, he shows which trends are important and provides detailed guidance for staying ahead of the curve. Radical advances in data collection and analytics, artificial intelligence and raw computing power are changing human history. And it’s happening with sharp advances at incredible speed. Make sure you’re at the tip of the spear with Fast Forward Investing.

Antitargets and Drug Safety

Antitargets and Drug Safety Book
Author : Laszlo Urban,Vinod Patel,Roy J. Vaz
Publisher : John Wiley & Sons
Release : 2015-02-23
ISBN : 3527673660
Language : En, Es, Fr & De

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Book Description :

With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing on hepatotoxicity in drug safety, cardiovascular toxicity and signaling effects via kinase and GPCR anti-targets. In the final section, several case studies of recently developed drugs illustrate how to prevent anti-target effects and how big pharma deals with them if they occur. The more recent field of systems pharmacology has gained prominence and this is reflected in chapters dedicated to the utility in deciphering and modeling anti-targets. The final chapter is concerned with those compounds that inadvertently elicit CNS mediated adverse events, including a pragmatic description of ways to mitigate these types of safety risks. Written as a companion to the successful book on antitargets by Vaz and Klabunde, this new volume focuses on recent progress and new classes, methods and case studies that were not previously covered.

Cardiovascular Genomics

Cardiovascular Genomics Book
Author : Keith DiPetrillo
Publisher : Humana
Release : 2009-09-25
ISBN :
Language : En, Es, Fr & De

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Book Description :

The first section of this guide provides methods for cardiovascular phenotyping of rodent models; the second section covers bioinformatic integration of phenotypde data with genome-wide genotype and expression data. Chapters include step-by-step protocols.

It s Complicated

It s Complicated Book
Author : Jeff Hsu
Publisher :
Release : 2013
ISBN :
Language : En, Es, Fr & De

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Book Description :

Coronary artery disease (CAD) and atrial fibrillation (AF) are two common complex diseases of the heart that both have strong genetic components. Although genome wide association studies in humans and genetic mapping studies in mouse models have identified genomic loci associated with these diseases, the functional genetic variants and the mechanisms by which they alter disease susceptibility are largely unknown. In this thesis we use mouse models and human atrial tissues to perform functional genomic studies to gain insight into these disease associated loci, with the central hypothesis that many disease associated variants function by regulating the expression of nearby genes. The major methods used in these studies are transcriptome profiling by expression microarrays and RNA sequencing followed by rigorous statistical analysis. Transcript expression can be considered as an intermediate phenotype to disease susceptibility; and, the identification of genetic variants that alter transcript expression may lead to the mechanism of disease association. In the first study we performed an intercross between AKR and DBA/2 inbred mouse lines to identify and replicate atherosclerosis modifier genes. Quantitative trait loci (QTL) for atherosclerosis on chromosome 2, 15, and 17 were replicated between studies. We quantified whole-genome expression of bone marrow derived macrophages and endothelial cells and found that much of the gene expression was under genetic control, including at the atherosclerosis QTLs, and that this was genetic regulation of gene expression was reproducible between experiments. In the second study we identified genes that are regulated differentially in macrophages from these two mouse strains upon cholesterol loading. We found that the atherosclerosis resistant strain had much higher up regulation of genes in the lysosomal pathway. Combining these two studies, we identified several atherosclerosis candidate modifier genes, such as \textit{Sys1}. In the third study we quantified the differences in gene expression between human left and right atria using RNA sequencing and found many genes differentially expressed at loci associated with AF in genome-wide association studies. In addition we identified a long non-coding RNA adjacent to \textit{PITX2}, at the locus with that has the highest association with AF. In the future these loci can be studied further using reporter assays to identify the causal variant as well as using genomic editing techniques to study the gene regulatory mechanism.