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Cardiac Regeneration And Repair

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Cardiac Regeneration and Repair Pathology and Therapies

Cardiac Regeneration and Repair  Pathology and Therapies Book
Author : Ren-Ke Li,Richard D. Weisel
Publisher : Woodhead Publishing
Release : 2017-11-13
ISBN : 9780081015766
Language : En, Es, Fr & De

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Book Description :

"Cardiac Regeneration and Repair, Volume One" reviews the pathology of cardiac injury and the latest advances in cell therapy. Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration, and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Chapters in part three move on to highlight novel stem cells for cardiac repair, including human embryonic stem cells and human pluripotent stem cells, and detail their current status and future potential for cardiac therapy. Finally, part four explores gene therapy, and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration. "Cardiac Regeneration and Repair, Volume One" is complemented by a second volume covering biomaterials and tissue engineering. Together, the two volumes of "Cardiac Regeneration and Repair" provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular functionHighlights new approaches to cell therapy for cardiac regeneration and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac functionExplores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration

Cardiac Regeneration and Repair

Cardiac Regeneration and Repair Book
Author : Ren-Ke Li,Richard D. Weisel
Publisher : Elsevier
Release : 2014-02-17
ISBN : 0857096710
Language : En, Es, Fr & De

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Book Description :

Cardiac Regeneration and Repair, Volume Two reviews the use of biomaterials, alone or combined with cell therapy, in providing tissue-engineered constructs to repair the injured heart and prevent or reverse heart failure. Part one explores the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Further chapters explore the use of biomaterials to enhance stem cell therapy for restoring ventricular function and generating stem cell-modified intravascular stents. Part two focuses on tissue engineering for cardiac repair, including chapters on decellularized biologic scaffolds, synthetic scaffolds, cell sheet engineering, maturation of functional cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro applications, and clinical considerations for cardiac tissue engineering. Finally, part three explores vascular remodeling, including chapters highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels. Cardiac Regeneration and Repair, Volume Two is complemented by an initial volume covering pathology and therapies. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Focuses on tissue engineering for cardiac repair including clinical considerations for cardiac tissue engineering Explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels

Cardiac Regeneration

Cardiac Regeneration Book
Author : Masaki Ieda,Wolfram-Hubertus Zimmermann
Publisher : Springer
Release : 2017-10-27
ISBN : 3319561065
Language : En, Es, Fr & De

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Book Description :

This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Cardiac Regeneration and Repair

Cardiac Regeneration and Repair Book
Author : Ren-Ke Li,Richard D. Weisel
Publisher : Woodhead Publishing
Release : 2014-01-22
ISBN : 9780857096586
Language : En, Es, Fr & De

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Book Description :

Heart disease is the leading cause of death in the UK and the United States. For those who survive heart disease, few victims recover completely. Cell therapies, tissue engineering, and biomaterials technologies have advanced and now offer the potential to reverse the damage caused by heart disease. Volume 1 of this important set provides comprehensive information on the pathology of heart disease and the cell therapies available. Opening chapters look at cardiac pathology and current therapies. Further chapters present gene and protein therapies for regeneration, cell therapies for cardiac regeneration, and clinical considerations of stem cell therapies.

Heart Regeneration

Heart Regeneration Book
Author : Anonim
Publisher : Unknown
Release : 2022-11-26
ISBN : 9814465259
Language : En, Es, Fr & De

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Book Description :

Download Heart Regeneration book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cardiac regeneration and repair

Cardiac regeneration and repair Book
Author : Ren-Ke Li,Richard D. Weisel
Publisher : Elsevier
Release : 2014-02-16
ISBN : 0857096702
Language : En, Es, Fr & De

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Book Description :

Cardiac Regeneration and Repair, Volume One reviews the pathology of cardiac injury and the latest advances in cell therapy. Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration, and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Chapters in part three move on to highlight novel stem cells for cardiac repair, including human embryonic stem cells and human pluripotent stem cells, and detail their current status and future potential for cardiac therapy. Finally, part four explores gene therapy, and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration. Cardiac Regeneration and Repair, Volume One is complemented by a second volume covering biomaterials and tissue engineering. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function Highlights new approaches to cell therapy for cardiac regeneration and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function Explores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration

Cardiovascular Regenerative Medicine

Cardiovascular Regenerative Medicine Book
Author : Vahid Serpooshan,Sean M. Wu
Publisher : Springer
Release : 2019-06-29
ISBN : 3030200477
Language : En, Es, Fr & De

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Book Description :

This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.

Concepts and Applications of Stem Cell Biology

Concepts and Applications of Stem Cell Biology Book
Author : Gabriela Rodrigues,Bernard A. J. Roelen
Publisher : Springer Nature
Release : 2020-06-30
ISBN : 3030439399
Language : En, Es, Fr & De

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Book Description :

This textbook will support graduate students with learning materials rich in the basic concepts of stem cell biology, in its most widespread and updated perspective. The chapters are conceived in a way for students to understand the meaning of pluripotency, the definition of embryonic stem cells and the formation of multicellular structures such as organoids together with the underlying principles of their epigenetic. This textbook also discusses adult stem cells and the potential use of these cells, in particular neural, mesenchymal, and several types of muscular cells, in biomedical research and clinical applications. This textbook represents a vital complement to the text on Essential Current Concepts of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.

Heart Regeneration

Heart Regeneration Book
Author : Felix B. Engel
Publisher : World Scientific
Release : 2012
ISBN : 9814299804
Language : En, Es, Fr & De

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Book Description :

This title presents the major advances of the last decade in the field of cardiac regeneration.

Cardiovascular Regeneration and Stem Cell Therapy

Cardiovascular Regeneration and Stem Cell Therapy Book
Author : Annarosa Leri,Piero Anversa,William H. Frishman
Publisher : John Wiley & Sons
Release : 2008-04-15
ISBN : 0470994304
Language : En, Es, Fr & De

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Book Description :

This book is the definitive reference on two of the most exciting areas of cardiovascular research – myocardial regeneration and stem cell therapy – for the treatment of disease. Edited by pioneers in the area, with contributions from every major investigator worldwide, it covers: The biology of stem cells The actions of stem cells from the bone marrow, the heart, and embryos on the normal restorative and repair functions of the heart and blood vessels How stem cells could contribute to myocardial recovery in the face of injury and aging How adjuvant therapy with growth factors might enhance stem cell activity in regeneration and repair Clinical applications and clinical experiences This fully referenced publication presents the current state of knowledge in both basic science and clinical practice, and is an essential reference for scientists, students, and clinicians.

Stem Cells and Cardiac Regeneration

Stem Cells and Cardiac Regeneration Book
Author : Rosalinda Madonna
Publisher : Springer
Release : 2015-12-29
ISBN : 9783319254258
Language : En, Es, Fr & De

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Book Description :

This book provides an update of recent advances in the basic and clinical applications of cell-based therapies for myocardial repair and regeneration in ischemic heart disease (IHD) and heart failure (HF). The first sections of the book illuminate basic aspects of stem cells such as definitions, isolation criteria and characterization of embryonic and adult stem cells, as well as pluripotent stem cells and tissue specific progenitor and stem cells. In the following section, the text examines the role of critical regulators of stem cell differentiation in myocardial regeneration, that include circadian rhythyms, microRNAs, epigenetics, microvescicles, and exosomes. The text concludes with a review of the use of stem/progenitor cells in cardiac regeneration and discuss current controversies, unresolved issues, challenges, and future directions. Stem Cells and Cardiac Regeneration is addressed to a wide audience consisting of cardiologists, clinicians, and research scientists, who will learn new concepts in cardiovascular regeneration and repair with special focus on molecular mechanisms and therapeutic potential for cardiovascular regeneration.

Principles of Regenerative Medicine

Principles of Regenerative Medicine Book
Author : Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
Publisher : Academic Press
Release : 2010-12-16
ISBN : 9780123814234
Language : En, Es, Fr & De

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Book Description :

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Innovative Medicine

Innovative Medicine Book
Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publisher : Springer
Release : 2015-10-13
ISBN : 4431556516
Language : En, Es, Fr & De

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Book Description :

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Organ Repair and Regeneration

Organ Repair and Regeneration Book
Author : Giuseppe Orlando,Shaf Keshavjee
Publisher : Academic Press
Release : 2021-01-14
ISBN : 0128194529
Language : En, Es, Fr & De

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Book Description :

Organ Repair and Regeneration: Preserving Organs in the Regenerative Medicine Era encompasses updates on all organs, from the kidneys, to the lungs, liver, pancreas, intestines, and beyond. Chapters cover the pathophysiology of ischemia-reperfusion, repairing organs with MSC, repairing cardiac allografts in situ, and much more. The book conceptualizes the idea that the modern approach to organ preservation is ante literam, a form of organ repair and regeneration which, per se, is referred to as a field of health sciences under the umbrella of regenerative medicine. This book demonstrates the merging of regenerative medicine and organ transplantation. Covers all aspects of organ preservation, repair and regeneration Addresses the repair of organs that experience an Ischemia/Reperfusion (I/R) injury, those that are intended for transplantation, and specific issues related to each organ Presented by editors and authors who are physicians, surgeons and researchers in the field of organ transplantation and regenerative medicine

Cardiac Tissue Engineering

Cardiac Tissue Engineering Book
Author : Milica Radisic,Lauren D. Black III
Publisher : Humana Press
Release : 2014-07-29
ISBN : 9781493910465
Language : En, Es, Fr & De

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Book Description :

Cardiac Tissue Engineering: Methods and Protocols presents a collection of protocols on cardiac tissue engineering from pioneering and leading researchers around the globe. These include methods and protocols for cell preparation, biomaterial preparation, cell seeding, and cultivation in various systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Tissue Engineering: Methods and Protocols highlights the major techniques, both experimental and computational, for the study of cardiovascular tissue engineering.

Biomaterials for Cardiac Regeneration

Biomaterials for Cardiac Regeneration Book
Author : Erik J. Suuronen,Marc Ruel
Publisher : Springer
Release : 2014-11-12
ISBN : 3319109723
Language : En, Es, Fr & De

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Book Description :

This book offers readers a comprehensive biomaterials-based approach to achieving clinically successful, functionally integrated vasculogenesis and myogenesis in the heart. Coverage is multidisciplinary, including the role of extracellular matrices in cardiac development, whole-heart tissue engineering, imaging the mechanisms and effects of biomaterial-based cardiac regeneration, and autologous bioengineered heart valves. Bringing current knowledge together into a single volume, this book provides a compendium to students and new researchers in the field and constitutes a platform to allow for future developments and collaborative approaches in biomaterials-based regenerative medicine, even beyond cardiac applications.

Nanomedicine for Ischemic Cardiomyopathy

Nanomedicine for Ischemic Cardiomyopathy Book
Author : Morteza Mahmoudi, PhD
Publisher : Academic Press
Release : 2020-05-20
ISBN : 012817434X
Language : En, Es, Fr & De

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Book Description :

Nanomedicine for Ischemic Cardiomyopathy: Progress, Opportunities, and Challenges provides an overview on the recent advances in diagnostic and treatment of ischemic cardiomyopathy diseases including myocardial infarction. Shortcomings of the current methods and how nanomedicine can address those obstacles in the field are discussed including the limitations of newly developed cell therapy approaches to clinical translation and how nanomedicine may overcome crucial issues and facilitate the successful and efficient clinical translation of cell therapy. Biomolecular therapy is also explored as another powerful approach for regeneration of heart tissue including available methods and systematic delivery of biomolecules using nanocarriers to the injured part of myocardium through active targeting. Finally, coverage of major tissue engineering advances for myocardial regeneration, including use of epicardial nanostructured patches for regeneration of injured epicardium and the highly conductive patches for enhancing cross talks between the cardiomyocytes, is explored. This concise, yet rigorous coverage, of the field of cardiac nanotechnology outlines the innovative and necessary role of nanomedicine in regenerative medicine for cardiac repair allowing researchers, clinicians, and nanotechnologists to examine the strengths and limitations of current findings and predict future trends to advance the applications of nanotechnology in cardiovascular biomedical research. Introduces concepts of the unique capacities of cardiac-nanotechnology Points to potential and promising applications of engineering nanotechnologies on revolutionizing cell therapy and biomolecular therapy approaches for cardiac regeneration Bridges the knowledge gap between cardiologists and cardiac regenerative nanomedicine experts

Advanced Therapies for Cardiac Regeneration

Advanced Therapies for Cardiac Regeneration Book
Author : Valeria Chiono,Ipsita Roy,Monica Boffito,Irene Carmagnola,Susanna Sartori
Publisher : Frontiers Media SA
Release : 2021-04-13
ISBN : 2889666956
Language : En, Es, Fr & De

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Book Description :

The Research Topic is organized in the framework of the project BIORECAR (grant number: 772168; http://www.biorecar.polito.it/index.html)

Molecular Approaches to Heart Failure Therapy

Molecular Approaches to Heart Failure Therapy Book
Author : Gerd Hasenfuss
Publisher : Springer Science & Business Media
Release : 2000
ISBN : 9783798512368
Language : En, Es, Fr & De

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Book Description :

G. HASENFUSS, E. MARBAN Heart failure embodies the central irony of modern medicine. As we have become increasingly adept at treating the major proximate causes of death in Western society, we have effectively converted acute illness into chronic malady. The last twenty years have witnessed a revolution in the treatment of acute coronary syndromes, myocardial infarction in particular. Patients who reach the hospital now have every expectation of leaving alive, but not necessarily well. Our ability to blunt the edge of ischemic insults has en­ gendered new problems: a new cohort of patients whose hearts function well enough to enable short-term survival, but at the cost of decreased ex­ ercise tolerance, dyspnea and increased long-term mortality. The irony is compounded by our increasingly sophisticated pharmacopeia for the treat­ ment of heart failure, which, by slowing the progression of ventricular dys­ function, has created a chronic illness. The fact of its chronicity makes heart failure no less deadly. In symptomatic patients, mortality exceeds 5-10% per year even with the best contemporary therapy. Not all heart failure is ischemic, of course, but the final common phenotype is eerily concordant regardless of the proximate cause. No wonder, then, that heart failure is the leading cause of hospitalization in America and in Western Europe and that the prevalence of the disease continues to rise. Drugs have indeed revolutionized heart failure therapy, ACE inhibitors and beta-adrenergic blockers having the most outstanding records to date.

Etiology and Morphogenesis of Congenital Heart Disease

Etiology and Morphogenesis of Congenital Heart Disease Book
Author : Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi
Publisher : Springer
Release : 2016-06-24
ISBN : 4431546286
Language : En, Es, Fr & De

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Book Description :

This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.