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Cardiac Electrophysiology From Cell To Bedside

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Cardiac Electrophysiology From Cell to Bedside E Book

Cardiac Electrophysiology  From Cell to Bedside E Book Book
Author : Douglas P. Zipes,Jose Jalife,William Gregory Stevenson
Publisher : Elsevier Health Sciences
Release : 2017-05-13
ISBN : 0323448887
Language : En, Es, Fr & De

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Book Description :

Rapid advancements in cardiac electrophysiology require today’s health care scientists and practitioners to stay up to date with new information both at the bench and at the bedside. The fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs. Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need, including the underlying basic science and the latest clinical advances in the field. An attractive full-color design features color photos, tables, flow charts, ECGs, and more. All chapters have been significantly revised and updated by global leaders in the field, including 19 new chapters covering both basic and clinical topics. New topics include advances in basic science as well as recent clinical technology, such as leadless pacemakers; catheter ablation as a new class I recommendation for atrial fibrillation after failed medical therapy; current cardiac drugs and techniques; and a new video library covering topics that range from basic mapping (for the researcher) to clinical use (implantations). Each chapter is packed with the latest information necessary for optimal basic research as well as patient care, and additional figures, tables, and videos are readily available online. New editor William G. Stevenson, highly regarded in the EP community, brings a fresh perspective to this award-winning text.

Cardiac Electrophysiology from Cell to Bedside

Cardiac Electrophysiology  from Cell to Bedside Book
Author : Douglas P. Zipes,Jose Jalife
Publisher : Elsevier Health Sciences
Release : 2013-10-25
ISBN : 145572856X
Language : En, Es, Fr & De

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Book Description :

Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world. Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more! Integrate the latest scientific understanding of arrhythmias with the newest clinical applications, to select the right treatment and management options for each patient. Stay current on the latest advancements and developments with sweeping updates and 52 NEW chapters - written by many new authors - on some of the hottest cardiology topics, such as new technologies for the study of the molecular structure of ion channels, molecular genetics, and the development of new imaging, mapping and ablation techniques. Get expert advice from Dr. Douglas P. Zipes - a leading authority in electrophysiology and editor of Braunwald's Heart Disease and the Heart Rhythm Journal - and Dr. Jose Jalife - a world-renowned leader and researcher in basic and translational cardiac electrophysiology. Access the full text online at Expert Consult, including supplemental text, figures, tables, and video clips. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should online access to the web site be discontinued.

Cardiac Electrophysiology

Cardiac Electrophysiology Book
Author : Douglas P. Zipes,José Jalife
Publisher : Saunders
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

In response to the many major recent developments in the field, the authors have completely updated this modern classic, making this edition the most significant revision yet. Practitioners will find all the state-of-the-art guidance they need to make informed, effective clinical decisions.

Cardiac Electrophysiology From Cell to Bedside E Book

Cardiac Electrophysiology  From Cell to Bedside E Book Book
Author : Douglas P. Zipes,Jose Jalife
Publisher : Elsevier Health Sciences
Release : 2013-10-11
ISBN : 1455770108
Language : En, Es, Fr & De

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Book Description :

Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world. Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more! Integrate the latest scientific understanding of arrhythmias with the newest clinical applications, to select the right treatment and management options for each patient. Stay current on the latest advancements and developments with sweeping updates and 52 NEW chapters - written by many new authors - on some of the hottest cardiology topics, such as new technologies for the study of the molecular structure of ion channels, molecular genetics, and the development of new imaging, mapping and ablation techniques. Get expert advice from Dr. Douglas P. Zipes - a leading authority in electrophysiology and editor of Braunwald’s Heart Disease and the Heart Rhythm Journal - and Dr. Jose Jalife - a world-renowned leader and researcher in basic and translational cardiac electrophysiology. Access the full text online at Expert Consult, including supplemental text, figures, tables, and video clips.

Zipes and Jalife s Cardiac Electrophysiology From Cell to Bedside

Zipes and Jalife s Cardiac Electrophysiology  From Cell to Bedside Book
Author : Jose Jalife, MD,William Gregory Stevenson, MD
Publisher : Elsevier
Release : 2021-12
ISBN : 9780323757454
Language : En, Es, Fr & De

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Book Description :

Fully updated from cover to cover, Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need-from new knowledge in basic science to the latest clinical advances in the field. Drs. José Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology. Packs each chapter with the latest information necessary for optimal basic research as well as patient care. Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices. Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation. Includes 47 new chapters covering both basic science and clinical topics. Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management. Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online. Recipient of a 2018 Highly Commended award from the British Medical Association. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Cardiac Electrophysiology From Cell to Bedside E Book

Cardiac Electrophysiology  From Cell to Bedside E Book Book
Author : Douglas P. Zipes,Jose Jalife
Publisher : Elsevier Health Sciences
Release : 2009-05-06
ISBN : 143772762X
Language : En, Es, Fr & De

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Book Description :

Cardiac Electrophysiology: From Cell to Bedside defines the entire state of current scientific and clinical knowledge in this subspecialty. In response to the many major recent developments in the field, Drs. Zipes and Jalife have completely updated this modern classic, making the 5th Edition the most significant revision yet. From our latest understanding of ion channels, molecular genetics, and cardiac electrical activity through newly recognized syndromes, unique needs of special patient populations, and new diagnostic and therapeutic options, you'll find all the state-of-the-art guidance you need to make informed, effective clinical decisions. What's more, a significantly restructured organization, a new full-color layout, and full-text online access make reference easier than ever. Integrates the latest scientific understanding of arrhythmias with the newest clinical applications, giving you an informed basis for choosing the right treatment and management options for each patient. Synthesizes the knowledge of preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world, giving you a well-rounded, expert grasp of every issue that affects your patient management. Contains 24 new chapters (listed below) as well as exhaustive updates throughout, to keep you current with new scientific knowledge, newly discovered arrhythmia syndromes, and new diagnostic and therapeutic techniques. Developmental Regulation of Cardiac Ion Channels Neural Mechanisms of Initiating and Maintaining Arrhythmias Single Nucleotide Polymorphisms and Acquired Cardiac Arrhythmias Inheritable Sodium Channel Diseases Inheritable Potassium Channel Diseases Inheritable Diseases of Intracellular Calcium Regulation Morphological Correlates of Atrial Arrhythmias Andersen-Tawil Syndrome Timothy Syndrome Progressive Cardiac Conduction Disease Sudden Infant Death Syndrome Arrhythmias in Patients with Neurologic Disorders Autonomic Testing Cardiac Resynchronization Therapy Energy Sources for Catheter Ablation Linear Lesions to Ablate Atrial Fibrillation Catheter Ablation of Ventricular Arrhythmias in Patients with Structural Heart Disease Catheter Ablation of Ventricular Arrhythmias in Patients without Structural Heart Disease Catheter Ablation in Patients with Congenital Heart Disease Features a completely new section on "Arrhythmias in Special Populations" that explores arrhythmias in athletes ... gender differences in arrhythmias ... arrhythmias in pediatric patients ... and sleep-disordered breathing and arrhythmias. Offers an attractive new full-color design featuring color photos, tables, flow charts, ECGs, and more, making clinically actionable information easy to find and absorb at a glance. Includes full-text online access via Expert Consult, making reference easier for busy practitioners.

Clinical Cardiac Electrophysiology

Clinical Cardiac Electrophysiology Book
Author : Demosthenes G. Katritsis,Fred Morady
Publisher : Elsevier
Release : 2021-02
ISBN : 9780323793384
Language : En, Es, Fr & De

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Book Description :

Offering a clear and consistent framework for recognition, diagnosis, and treatment of a wide range of cardiac arrhythmia disturbances, Clinical Cardiac Electrophysiology: A Practical Guide covers the fundamental analytical skills needed in this challenging area. This portable, highly accessible handbook focuses on the basics of clinical electrophysiology- how and when to perform an electrophysiology study as well as principles of ablation and other invasive therapies-all in a succinct and modern format. Focuses on using an effective, consistent, decision-making process in recognizing, diagnosing, and treating rhythm disturbances of the heart, including supraventricular tachycardias, atrial fibrillation, ventricular tachycardias, and other rapid or irregular heartbeats. Covers anatomic fundamentals of cardiac structures, clinical indications for electrophysiology studies, practicalities and methodology of performing an electrophysiology study, and problems encountered during the procedure. Includes quick clinical summaries and more than 180 illustrations: electrophysiology recordings, ECGs, cardiac anatomy, radiographic images, and electroanatomic maps. Discusses key topics such as mechanisms of arrhythmias, conventional and electroanatomic mapping systems, fundamentals of cardiac mapping, biophysics of catheter ablation, and much more. Offers real-world guidance on contemporary practice from leading cardiac electrophysiologists Drs. Demosthenes G Katritsis and Fred Morady, with input from a multinational team of electrophysiology fellows and cardiologists. Ideal as a stand-alone resource or used in conjunction with Dr. Douglas Zipes' renowned textbook, Cardiac Electrophysiology: From Cell to Bedside. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Electrocardiography of Arrhythmias A Comprehensive Review E Book

Electrocardiography of Arrhythmias  A Comprehensive Review E Book Book
Author : Mithilesh Kumar Das,Douglas P. Zipes
Publisher : Elsevier Health Sciences
Release : 2021-01-22
ISBN : 0323809103
Language : En, Es, Fr & De

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Book Description :

Easy to read and abundantly illustrated, Electrocardiography of Arrhythmias: A Comprehensive Review, 2nd Edition, provides the core knowledge and clinical competencies you need to accurately interpret ECGs in preparation for cardiology boards and clinical practice. World-renowned cardiologists Mithilesh K. Das and Douglas P. Zipes offer a concise yet definitive review of all the ECG basics with realistic scenarios and detailed explanations for a wide range of ECG applications. Use this outstanding review tool alone or as a companion to Cardiac Electrophysiology: From Cell to Bedside. Provides a solid understanding of normal electrocardiograms and common abnormal findings, preparing you to accurately interpret ECGs and ace the ECG part of cardiology boards or the ABIM ICE ECG certifying exam. Contains realistic cases that simulate the clinical exam experience, and each ECG includes a brief clinical history in board format. Features more than 250 ECGs that demonstrate virtually any arrhythmia you’re likely to encounter. Includes new ECGs covering intracardiac electrophysiology, atrial fibrillation, ablation of many arrhythmias, arrhythmias associated with valvular surgery, idiopathic PVCs, arrhythmias associated with structural heart disease, ARVC, Brugada syndrome, and others. Covers key topics such as AV conduction abnormalities, complex atrial and ventricular arrhythmias, idiopathic ventricular tachycardia, and inherited arrhythmia syndromes.

Computational Cardiology

Computational Cardiology Book
Author : Frank B. Sachse
Publisher : Springer
Release : 2005-01-12
ISBN : 3540259260
Language : En, Es, Fr & De

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Book Description :

This book is devoted to computer-based modeling in cardiology, by taking an educational point of view, and by summarizing knowledge from several, commonly considered delimited areas of cardiac research in a consistent way. First, the foundations and numerical techniques from mathematics are provided, with a particular focus on the finite element and finite differences methods. Then, the theory of electric fields and continuum mechanics is introduced with respect to numerical calculations in anisotropic biological media. In addition to the presentation of digital image processing techniques, the following chapters deal with particular aspects of cardiac modeling: cardiac anatomy, cardiac electro physiology, cardiac mechanics, modeling of cardiac electro mechanics. This book was written for researchers in modeling and cardiology, for clinical cardiologists, and for advanced students.

Electrocardiography of Arrhythmias

Electrocardiography of Arrhythmias Book
Author : Mithilesh K. Das,Douglas P. Zipes
Publisher : Elsevier Health Sciences
Release : 2012
ISBN : 1437720293
Language : En, Es, Fr & De

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Book Description :

Electrocardiography of Arrhythmias: A Comprehensive Review equips you with the core knowledge and clinical competencies you need to accurately interpret electrocardiograms (ECG) and ace the ECG part of cardiology boards or the ABIM ICE ECG certifying exam. Co-written by world-renowned cardiologists Mithilesh K. Das and Douglas P. Zipes, this companion study guide to Cardiac Electrophysiology: From Cell to Bedside offers a concise yet definitive review of electrocardiography, complete with online access to the complete text and image collection at www.expertconsult.com, making this is the perfect review and exam prep tool. Obtain a realistic simulation of the actual exam experience. Each ECG is accompanied by a brief clinical history in board format. Review a full range of ECG images - from simple to complex - reflecting both common and rare conditions. Get the most from your board or certification prep by pairing this review with its parent text, Cardiac Electrophysiology: From Cell to Bedside, for detailed explanations and an enhanced learning experience. Take it with you! Access the fully searchable, complete text and image collection from any computer or mobile device at expertconsult.com Be prepared for the ECG section of cardiology boards or the ABIM ICE ECG certifying exam with this definitive review resource

Clinical Cardiac Electrophysiology E Book

Clinical Cardiac Electrophysiology   E Book Book
Author : Demosthenes G Katritsis,Fred Morady
Publisher : Elsevier Health Sciences
Release : 2021-02-02
ISBN : 0323793398
Language : En, Es, Fr & De

GET BOOK

Book Description :

Offering a clear and consistent framework for recognition, diagnosis, and treatment of a wide range of cardiac arrhythmia disturbances, Clinical Cardiac Electrophysiology: A Practical Guide covers the fundamental analytical skills needed in this challenging area. This portable, highly accessible handbook focuses on the basics of clinical electrophysiology— how and when to perform an electrophysiology study as well as principles of ablation and other invasive therapies—all in a succinct and modern format. Focuses on using an effective, consistent, decision-making process in recognizing, diagnosing, and treating rhythm disturbances of the heart, including supraventricular tachycardias, atrial fibrillation, ventricular tachycardias, and other rapid or irregular heartbeats. Covers anatomic fundamentals of cardiac structures, clinical indications for electrophysiology studies, practicalities and methodology of performing an electrophysiology study, and problems encountered during the procedure. Includes quick clinical summaries and more than 180 illustrations: electrophysiology recordings, ECGs, cardiac anatomy, radiographic images, and electroanatomic maps. Discusses key topics such as mechanisms of arrhythmias, conventional and electroanatomic mapping systems, fundamentals of cardiac mapping, biophysics of catheter ablation, and much more. Offers real-world guidance on contemporary practice from leading cardiac electrophysiologists Drs. Demosthenes G Katritsis and Fred Morady, with input from a multinational team of electrophysiology fellows and cardiologists. Ideal as a stand-alone resource or used in conjunction with Dr. Douglas Zipes’ renowned textbook, Cardiac Electrophysiology: From Cell to Bedside.

Cardiac Electrophysiology Methods and Models

Cardiac Electrophysiology Methods and Models Book
Author : Daniel C. Sigg,Paul A. Iaizzo,Yong-Fu Xiao,Bin He
Publisher : Springer Science & Business Media
Release : 2010-09-11
ISBN : 9781441966582
Language : En, Es, Fr & De

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Book Description :

Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.

Interventional Electrophysiology

Interventional Electrophysiology Book
Author : Igor Singer
Publisher : Lippincott Williams & Wilkins
Release : 2001
ISBN : 0781723337
Language : En, Es, Fr & De

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Book Description :

This thoroughly updated Second Edition is a comprehensive, practical g uide to all current techniques and procedural aspects of interventiona l electrophysiology. A leading international group of experts describe s in depth the procedures and techniques, the rationale for their use, and the available alternatives. Complementing the text are more than 600 illustrations, including spatially oriented "how-to" line drawings, radiographs, and conceptual diagrams. This edition features an exten sively updated program of illustrations and includes the latest inform ation on dual chamber defibrillators, atrial defibrillators and ablati on techniques, and ablation and catheters.

Heart Disease

Heart Disease Book
Author : Eugene Braunwald
Publisher : W.B. Saunders Company
Release : 1997
ISBN : 9780721656649
Language : En, Es, Fr & De

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Book Description :

This two-volume reference on heart disease ranges from examination and circulatory function to diseases of the heart, and broader perspectives on heart disease and cardiologic practice. This edition includes 23 new chapters, covering such topics as coronary heart diseases in women, and thrombosis.

Clinical Arrhythmology and Electrophysiology

Clinical Arrhythmology and Electrophysiology Book
Author : Ziad F. Issa,John Michael Miller,Douglas P. Zipes
Publisher : Elsevier Health Sciences
Release : 2009
ISBN : 1416059989
Language : En, Es, Fr & De

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Book Description :

With its unique, singular focus on the clinical aspect of cardiac arrhythmias, Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald's Heart Disease makes it easy to apply today's most up-to-date guidelines for diagnosis and treatment. An expert author team provides clear, clinically focused guidance on all types of cardiac arrhythmias, including practical techniques for managing complex patients. Find the information you need quickly with a consistent organization in all chapters, written to a template that shows every arrhythmia type in a similar manner. Access the fully searchable contents online at www.expertconsult.com, in addition to downloadable images and dynamic video clips. Fully understand the rationale for treatment of specific arrhythmias with practical techniques that are grounded in the most recent basic science. Stay up to date with new chapters on molecular mechanisms of cardiac electrical activity, cardiac ion channels, ventricular tachycardia in nonischemic dilated cardiomyopathy, epicardial ventricular tachycardia, ventricular arrhythmias in hypertrophic cardiomyopathy, ventricular arrhythmias in inherited channelopathies, ventricular arrhythmias in congenital heart disease, atrial arrhythmias in congenital heart disease, and complications of catheter ablation of cardiac arrhythmias. View videos of 27 key techniques online, including optical mapping of reentrant ventricular arrhythmias, 3-dimensional mapping of arrhythmias using different mapping and navigation modalities, and fluoroscopy images illustrating techniques for electrophysiologic catheter positioning, atrial septal puncture, and pericardial access. Gain a new understanding of hot topics such as mechanisms of arrhythmias, electrophysiologic testing, mapping and navigation modalities, ablation energy sources, sinus node dysfunction, conduction disturbances, atrial tachyarrhythmias, preexcitation syndromes and all types of ventricular and supraventricular tachycardias. Tackle the clinical management of cardiac arrhythmias with confidence with the most up-to-date guidance from the experts you trust. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Basic Cardiac Electrophysiology for the Clinician

Basic Cardiac Electrophysiology for the Clinician Book
Author : Jose Jalife,Mario Delmar,Justus Anumonwo,Omer Berenfeld,Jerome Kalifa
Publisher : John Wiley & Sons
Release : 2011-08-24
ISBN : 144436037X
Language : En, Es, Fr & De

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Book Description :

This book translates fundamental knowledge in basic cardiac electrophysiology from the bench to the bedside. Revised and updated for its second edition, the text offers new coverage of the molecular mechanisms of ion channel behavior and its regulation, complex arrhythmias, and the broadening roles of devices and ablation. Clear, straightforward explanations are illustrated by plentiful diagrams to make the material accessible to the non-specialist.

Heart Cell Communication in Health and Disease

Heart Cell Communication in Health and Disease Book
Author : Walmor C. de Mello,Michiel J. Janse
Publisher : Springer Science & Business Media
Release : 1997-12-31
ISBN : 9780792380528
Language : En, Es, Fr & De

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Book Description :

In Heart Cell Communication in Health and Disease an extensive review of different aspects of heart cell communication is presented. The book starts with the fundamental concept that cardiac cells are communicated, and then proceeds to the role of gap junctions in heart development, the molecular biology of gap junctions, the biophysics of the intercellular channels, the control of junctional conductance and the influence of gap junctions on impulse propagation. This is the first time that a single volume has described cell communication in the normal heart and under different pathological conditions such as heart failure, coronary disease, myocardial ischemia and cardiac arrhythmias. In this way the process of cell communication is analyzed at different levels of complexity, providing the reader with a wide view of this field and its relevance to cardiology.

Cardiac Drug Safety

Cardiac Drug Safety Book
Author : Matthew J. Killeen
Publisher : World Scientific
Release : 2012
ISBN : 9814317454
Language : En, Es, Fr & De

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Book Description :

At present, over 120 medications have been withdrawn from the major global pharmaceutical markets due to potentially lethal unwanted effects on the heart, namely ventricular fibrillation. With recent FDA guidelines recommending stringent testing of new pharmaceuticals on the heart, the importance of cardiac electrophysiology is affecting an increasing number of professionals in a range of industries. This book will equip readers with a clear and solid foundation in the fundamentals of electrophysiology and pharmacology of the heart, explore clinical disorders and treatments and relate this to the research and development of new medicines.Representing an integrative bench to bedside approach to understanding this critical drug safety phenomenon, this book begins with a comprehensive review of the mechanisms responsible for drug-induced arrhythmia, followed by an in-depth discussion of the current preclinical and clinical recording techniques. Additionally, a complete assessment of current methods to stratify cardiac risk in drug development is included. Most importantly, the book develops and outlines the novel strategies and key frameworks that increase the cardiac drug safety and drive down the risk of novel biopharmaceutical products in the future. Contents: Physiology of the Heart; Introduction to Electrophysiology: History, Ion Channels, Important Concepts; Electrophysiology of the Heart; Studying Cardiac Electrophysiology in the Laboratory and Clinic; Electrical Disorders of the Heart: From Cell to Bedside; The Impact of Cardiac Electrophysiology on Drug Development: History, Current Tests (Regulations, Requirements) and Their Shortcomings; Case Studies; The Future of Cardiac Drug Safety: Strategies to Reduce Risk and Ensure Continued Safety.

Clinical Cardiac Electrophysiology

Clinical Cardiac Electrophysiology Book
Author : Mark E. Josephson
Publisher : Lippincott Williams & Wilkins
Release : 2008
ISBN : 9780781777391
Language : En, Es, Fr & De

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Book Description :

Fully revised and updated, Dr. Josephson's classic text provides a thorough understanding of the mechanisms of cardiac arrhythmias and the therapeutic interventions used to treat arrhythmias. This edition has a new full-color design, and a companion Web site offers the fully searchable text.

Cardiac Arrhythmias

Cardiac Arrhythmias Book
Author : Gregory Y. H. Lip,John Godtfredsen
Publisher : Mosby Incorporated
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Efficiently covers all common and uncommon arrhythmias; focuses on day-to-day issues faced in clinical practice, thoroughly describing pathogenesis, clinical presentation, ECG interpretation and diagnosis; offers in-depth, evidence-based appraisals of the latest electrophysiologic, pharmacologic, and surgical therapies; and presents all of this vital information in an accessible format using color photographs, line drawings, tables, and flow charts.