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Carbonic Anhydrases As Biocatalysts

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Carbonic Anhydrases as Biocatalysts

Carbonic Anhydrases as Biocatalysts Book
Author : Claudiu T Supuran,Giuseppina De Simone
Publisher : Elsevier
Release : 2015-01-14
ISBN : 0444632638
Language : En, Es, Fr & De

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Book Description :

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes Identifies new targets for drug design studies Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications

Carbonic Anhydrases

Carbonic Anhydrases Book
Author : Claudiu Supuran,Alessio Nocentini
Publisher : Academic Press
Release : 2019-07-17
ISBN : 0128167459
Language : En, Es, Fr & De

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Book Description :

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health. Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs. Offers a full overview of CAs’ biochemical and structural features, as well as drug design and pharmacology of inhibitors and activators Provides a thorough update on the newly identified isoforms, modulating chemotypes, and innovative biomedical applications Describes the current biotechnological applications of CAs, including processes for CO2 capture Features chapter contributions from international leaders in CA biology, medicinal chemistry, and pharmacology

Carbonic Anhydrases and Metabolism

Carbonic Anhydrases and Metabolism Book
Author : Claudiu T. Supuran
Publisher : MDPI
Release : 2019-04-08
ISBN : 3038978000
Language : En, Es, Fr & De

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Book Description :

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient enzymes known in nature, due to the fact that the uncatalyzed hydration of CO2 is a very slow process and the physiological demands for its conversion to ionic, soluble species is very high. Inhibition of the CAs has pharmacological applications in many fields, such as antiglaucoma, anticonvulsant, antiobesity, and anticancer agents/diagnostic tools, but is also emerging for designing anti-infectives, i.e., antifungal, antibacterial, and antiprotozoan agents with a novel mechanism of action. Mitochondrial CAs are implicated in de novo lipogenesis, and thus selective inhibitors of such enzymes may be useful for the development of new antiobesity drugs. As tumor metabolism is diverse compared to that of normal cells, ultimately, relevant contributions on the role of the tumor-associated isoforms CA IX and XII in these phenomena have been published and the two isoforms have been validated as novel antitumor/antimetastatic drug targets, with antibodies and small-molecule inhibitors in various stages of clinical development. CAs also play a crucial role in other metabolic processes connected with urea biosynthesis, gluconeogenesis, and so on, since many carboxylation reactions catalyzed by acetyl-coenzyme A carboxylase or pyruvate carboxylase use bicarbonate, not CO2, as a substrate. In organisms other than mammals, e.g., plants, algae, and cyanobacteria, CAs are involved in photosynthesis, whereas in many parasites (fungi, protozoa), they are involved in the de novo synthesis of important metabolites (lipids, nucleic acids, etc.). The metabolic effects related to interference with CA activity, however, have been scarcely investigated. The present Special Issue of Metabolites aims to fill this gap by presenting the latest developments in the field of CAs and their role in metabolism.

Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis Book
Author : Peter Grunwald
Publisher : CRC Press
Release : 2019-06-27
ISBN : 1000020940
Language : En, Es, Fr & De

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Book Description :

This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, rare diseases, orphan drugs, the costs of drug development and therapies, and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions, carboxylesterase inhibitors for pharmaceutical applications, employment of inhibitors for the treatment of neurodegenerative diseases, use of engineered proteins, bioactive peptides, and fibrinolytic enzymes for thrombolytic therapy, and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore, it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance, computer-aided drug design for the identification of multi-target directed ligands, and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs.

Green Solvents for Organic Synthesis

Green Solvents for Organic Synthesis Book
Author : V. K. Ahluwalia,Ranbir S. Varma
Publisher : Alpha Science International, Limited
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Solvents play an important role in organic synthesis. Most of the common organic solvents which have been used for organic synthesis include benzene, chloroform, toluene, carbon tetrachloride etc. Most of these are volatile (VOC) and have undesirable properties like toxicity or being harmful to the environment or may be obtained from non renewable petroleum sources. This book describes some of the most important green solvents, their merits and demerits. These green solvents include water, supercritical carbon dioxide, ionic liquids, polyethylene glycol and its solutions and the Florous Phase Technique. A large number of representative synthetic applications for each of the green solvents are described.

Studies with the Enzyme Carbonic Anhydrase

Studies with the Enzyme  Carbonic Anhydrase Book
Author : Harold Bernard Reisman
Publisher : Unknown
Release : 1959
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Studies with the Enzyme Carbonic Anhydrase book written by Harold Bernard Reisman, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Carbon Dioxide Activation by Metal Complexes

Carbon Dioxide Activation by Metal Complexes Book
Author : Arno Behr
Publisher : Vch Pub
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Carbon Dioxide Activation by Metal Complexes book written by Arno Behr, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Ullmann s biotechnology and biochemical engineering

Ullmann s biotechnology and biochemical engineering Book
Author : Wiley-VCH Staff
Publisher : Unknown
Release : 2007-08-03
ISBN : 9783527316038
Language : En, Es, Fr & De

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Book Description :

The one-stop resource for all those involved in the biochemical and biotechnological industries. Based on the latest online edition of Ullmann's Encyclopedia of Industrial Chemistry containing articles never seen before in print, this ready reference meets the need for a detailed survey of the biochemical fundamentals and techniques as well as their applications in biochemical engineering and biobased production.

Biochemistry of Foods and the Biocatalysts

Biochemistry of Foods and the Biocatalysts Book
Author : Ishak I. Shahied
Publisher : Unknown
Release : 1977
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The chemistry of foods; Water in foods; Lipids; Carbohydrates; Proteins; Flavonoids; Flavors in foods; Vegetables and fruits; Milk; Cereal chemistry; The chemistry of vitamins; Vitamin A; Vitamin D; Vitamin E; Vitamin K; Vitamin C; Thiamin (B1); Riboflavin (B2); Niacin; Pantothenic acid; Biotin; Pyridozine (B6); Vitamin B12; Folic acid; The chemistry of minerals; Minerals; Calcium; Phosphorus; Sodium; Potassium; Magnesium; The trace elements; Iron; Copper; Zinc; Manganese; Molybdenum; Cobalt; Selenium; Fluorine; Chromium; Physiology and biochemical reactioons of the hormones; Catecholamines; Hormones of the posterior pituitary; Hormones of the anterior pituitary; Adrenocorticotropic hormone (ACTH); Growth hormone (GH); Prolactin; Thyroid hormones; Parathyroid hormone; Insulin; Glucagon; Gonadotropic and sex hormones; Adrenal cortex hormones; Gastrointestinal hormones.

British Abstracts

British Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1952
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download British Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Yale Journal of Biology and Medicine

The Yale Journal of Biology and Medicine Book
Author : Anonim
Publisher : Unknown
Release : 1937
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Yale Journal of Biology and Medicine book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Applied Biocatalysis in Specialty Chemicals and Pharmaceuticals

Applied Biocatalysis in Specialty Chemicals and Pharmaceuticals Book
Author : American Chemical Society Division Of Biochemical,Badal C. Saha,David Charles Demirjian,American Chemical Society. Division of Biochemical Technology,American Chemical Society. Meeting
Publisher : Amer Chemical Society
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Written for a wide variety of biotechnologists, this book provides a major review of the state-of-the-art in bioethanol production technologies, enzymatic biomass conversion, and biodiesel. It also provides a detailed explanation of a breakthrough in photosynthetic water splitting which could result in a doubling of the efficiency of solar energy conversion by green plants. The book covers production of lactic acid, succinic acid, 1,3-propanediol, 2,3-butanediol, and polyhydroxybutyrate and xylitol. It also includes a chapter on synthesis-gas fermentation.

Biocatalysis

Biocatalysis Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biocatalysis book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Characterization and Application of Biocatalysts in Extreme Environments

Characterization and Application of Biocatalysts in Extreme Environments Book
Author : Peter Christopher Michels
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Characterization and Application of Biocatalysts in Extreme Environments book written by Peter Christopher Michels, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Technological Applications of Biocatalysts

Technological Applications of Biocatalysts Book
Author : Open Universiteit (Heerlen, Netherlands)
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book builds upon a knowledge of the properties of enzymes and shows how these important catalysts can be used in industry. The central theme demonstrates how proteins, especially enzymes and immunoglobins can be isolated, characterised and produced on a large scale. Specific examples are given and both practical and theoretical aspects are examined. Applications for a wide range of metabolites are described with particular emphasis on the design, performance and production of biosensors. * Step-by-step logical development * Student centered learning style * Texts planned by both industry and academia The need for a cost effective training scheme for new and existing staff at all levels has been met by the University of Greenwich (formerly Thames Polytechnic) and the Open University of the Netherlands. As part of the European Community Education and Technology Training initiative (COMETT) and in conjunction with a number of other leading UK and European universities, they are developing BIOTOL, a training scheme in biotechnology using open learning materials, which will provide tailor-made courses, flexible in content, pace and place. 'This is a particularly useful learning resource for people wanting to broaden their knowledge in biotechnology either informally or by extending their formal education in MScs and similar courses.' - Journal of Chemical Tech & Biotechnology, July 1995

Current Research in Britain

Current Research in Britain Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Current Research in Britain book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

General Physiology

General Physiology Book
Author : Bradley Titus Scheer
Publisher : Unknown
Release : 1953
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The physicochemical foundations of life; The chemical dynamics of life; Energy transformation in cells and organisms; The development of organisms; The integration of the organism.

Gas Oil Coal and Environmental Biotechnology II

Gas  Oil  Coal  and Environmental Biotechnology II Book
Author : Cavit Akin,Jared R. W. Smith
Publisher : Inst of Gas Technology
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Gas Oil Coal and Environmental Biotechnology II book written by Cavit Akin,Jared R. W. Smith, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Industrial Pharmaceutical Biotechnology

Industrial Pharmaceutical Biotechnology Book
Author : Heinrich Klefenz
Publisher : Wiley-VCH
Release : 2002-04-22
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume focuses on pharmaceutical biotechnology as a key area of life sciences. The complete range of concepts, processes and technologies of biotechnology is applied in modern industrial pharmaceutical research, development and production. The results of genome sequencing and studies of biological-genetic function are combined with chemical, micro-electronic and microsystem technology to produce medical devices and diagnostic biochips. A multitude of biologically active molecules is expanded by additional novel structures created with newly arranged gene clusters and bio-catalytic chemical processes. New organisational structures in the co-operation of institutes, companies and networks enable faster knowledge and product development and immediate application of the results of research and process development. This book is the ideal source of information for scientists and engineers in research and development, for decision-makers in biotech, pharma and chemical corporations, as well as for research institutes, but also for founders of biotech companies and people working for venture capital corporations.