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Carbonic Anhydrases As Biocatalysts

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Carbonic Anhydrases as Biocatalysts

Carbonic Anhydrases as Biocatalysts Book
Author : Claudiu T Supuran,Giuseppina De Simone
Publisher : Elsevier
Release : 2015-01-14
ISBN : 0444632638
Language : En, Es, Fr & De

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Book Description :

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes Identifies new targets for drug design studies Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications

Carbonic Anhydrases

Carbonic Anhydrases Book
Author : Claudiu T. Supuran,Alessio Nocentini
Publisher : Academic Press
Release : 2019-07-17
ISBN : 0128167459
Language : En, Es, Fr & De

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Book Description :

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health. Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs. Offers a full overview of CAs’ biochemical and structural features, as well as drug design and pharmacology of inhibitors and activators Provides a thorough update on the newly identified isoforms, modulating chemotypes, and innovative biomedical applications Describes the current biotechnological applications of CAs, including processes for CO2 capture Features chapter contributions from international leaders in CA biology, medicinal chemistry, and pharmacology

Carbonic Anhydrases and Metabolism

Carbonic Anhydrases and Metabolism Book
Author : Claudiu T. Supuran
Publisher : MDPI
Release : 2019-04-08
ISBN : 3038978000
Language : En, Es, Fr & De

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Book Description :

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient enzymes known in nature, due to the fact that the uncatalyzed hydration of CO2 is a very slow process and the physiological demands for its conversion to ionic, soluble species is very high. Inhibition of the CAs has pharmacological applications in many fields, such as antiglaucoma, anticonvulsant, antiobesity, and anticancer agents/diagnostic tools, but is also emerging for designing anti-infectives, i.e., antifungal, antibacterial, and antiprotozoan agents with a novel mechanism of action. Mitochondrial CAs are implicated in de novo lipogenesis, and thus selective inhibitors of such enzymes may be useful for the development of new antiobesity drugs. As tumor metabolism is diverse compared to that of normal cells, ultimately, relevant contributions on the role of the tumor-associated isoforms CA IX and XII in these phenomena have been published and the two isoforms have been validated as novel antitumor/antimetastatic drug targets, with antibodies and small-molecule inhibitors in various stages of clinical development. CAs also play a crucial role in other metabolic processes connected with urea biosynthesis, gluconeogenesis, and so on, since many carboxylation reactions catalyzed by acetyl-coenzyme A carboxylase or pyruvate carboxylase use bicarbonate, not CO2, as a substrate. In organisms other than mammals, e.g., plants, algae, and cyanobacteria, CAs are involved in photosynthesis, whereas in many parasites (fungi, protozoa), they are involved in the de novo synthesis of important metabolites (lipids, nucleic acids, etc.). The metabolic effects related to interference with CA activity, however, have been scarcely investigated. The present Special Issue of Metabolites aims to fill this gap by presenting the latest developments in the field of CAs and their role in metabolism.

The Carbonic Anhydrases Current and Emerging Therapeutic Targets

The Carbonic Anhydrases  Current and Emerging Therapeutic Targets Book
Author : W. Richard Chegwidden,Nicholas D. Carter
Publisher : Springer Nature
Release : 2021-12-01
ISBN : 303079511X
Language : En, Es, Fr & De

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Book Description :

This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.

Antiprotozoal Drug Development and Delivery

Antiprotozoal Drug Development and Delivery Book
Author : Alane Beatriz Vermelho,Claudiu T. Supuran
Publisher : Springer Nature
Release : 2022-06-24
ISBN : 3031068505
Language : En, Es, Fr & De

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Book Description :

This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates. The book will appeal not only to researchers, students and professionals interested in drug development to protozoan diseases, but also to medicinal chemists in general.

Mining Designing Mechanisms and Applications of Extremophilic Enzymes

Mining  Designing  Mechanisms and Applications of Extremophilic Enzymes Book
Author : Junpei Zhou,Massimiliano Fenice,Sunil Khare
Publisher : Frontiers Media SA
Release : 2021-12-29
ISBN : 2889718751
Language : En, Es, Fr & De

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Book Description :

Download Mining Designing Mechanisms and Applications of Extremophilic Enzymes book written by Junpei Zhou,Massimiliano Fenice,Sunil Khare, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biocatalysis

Biocatalysis Book
Author : Gonzalo de Gonzalo,Pablo Domínguez de María
Publisher : Royal Society of Chemistry
Release : 2017-11-02
ISBN : 1782626190
Language : En, Es, Fr & De

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Book Description :

Implementing biocatalytic strategies in an industrial setting is a challenging task, especially when commercial scale necessitates a balance between industrial need and economic viability. With invited contributions from a wide range of chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and the key aspects needed for economic success. Focussing on industry related issues, this book will be a useful tool for future research by both practitioners and academics.

Neutron Crystallography in Structural Biology

Neutron Crystallography in Structural Biology Book
Author : Anonim
Publisher : Academic Press
Release : 2020-02-22
ISBN : 0128192151
Language : En, Es, Fr & De

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Book Description :

Neutron Crystallography in Structural Biology, Volume 634, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this updated release include Fundamentals of neutron crystallography in structural biology, Large crystal growth for neutron protein crystallography, Prospects for membrane protein crystals in NMX, IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor, The macromolecular neutron diffractometer at the spallation neutron source, Current status and near future plan of neutron protein crystallography at J-PARC, Neutron macromolecular crystallography at the European spallation source, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on neutron crystallography in structural biology

Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis Book
Author : Peter Grunwald
Publisher : CRC Press
Release : 2019-06-27
ISBN : 1000020940
Language : En, Es, Fr & De

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Book Description :

This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, rare diseases, orphan drugs, the costs of drug development and therapies, and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions, carboxylesterase inhibitors for pharmaceutical applications, employment of inhibitors for the treatment of neurodegenerative diseases, use of engineered proteins, bioactive peptides, and fibrinolytic enzymes for thrombolytic therapy, and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore, it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance, computer-aided drug design for the identification of multi-target directed ligands, and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs.

Biocatalysis for Practitioners

Biocatalysis for Practitioners Book
Author : Gonzalo de Gonzalo,Iván Lavandera
Publisher : John Wiley & Sons
Release : 2021-04-13
ISBN : 3527824456
Language : En, Es, Fr & De

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Book Description :

This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.

Immobilized Biocatalysts

Immobilized Biocatalysts Book
Author : Peter Grunwald
Publisher : MDPI
Release : 2018-11-14
ISBN : 3038973181
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue "Immobilized Biocatalysts" that was published in Catalysts

Industrial Biocatalysis

Industrial Biocatalysis Book
Author : Peter Grunwald
Publisher : CRC Press
Release : 2014-12-11
ISBN : 9814463892
Language : En, Es, Fr & De

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Book Description :

Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts—with their environmentally friendly properties—are currently employed. Drivers are the big societal challenges resulting from concerns about the global climate change and the need for an assured energy supply. Modern biocatalysis relies to a large extent on the tremendous advances in the so-called omics techniques and the structural elucidation of biomolecules, which have led to synthetic biology and metabolic engineering as new research fields with high application potential for the rational design of enzymes and microbial production strains. In this book, renowned scientists discuss the actual developments in these research fields together with a variety of application-oriented topics.

Modern Biocatalysis

Modern Biocatalysis Book
Author : Gavin Williams,Mélanie Hall
Publisher : Royal Society of Chemistry
Release : 2018-05-31
ISBN : 178262726X
Language : En, Es, Fr & De

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Book Description :

The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current 'hot' topics in biocatalysis, where recent advances in research are defining new grounds in enzyme-catalyzed processes. With contributions from leading academics around the world, this book makes a ground-breaking contribution to this progressive field and is essential reading for graduates and researchers investigating (bio)catalysis, enzyme engineering, chemical biology, and synthetic biology.

Novel Materials for Carbon Dioxide Mitigation Technology

Novel Materials for Carbon Dioxide Mitigation Technology Book
Author : Bryan Morreale,Fan Shi
Publisher : Elsevier
Release : 2015-06-01
ISBN : 0444632611
Language : En, Es, Fr & De

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Book Description :

Materials for Carbon Dioxide Mitigation Technology offers expert insight and experience from recognized authorities in advanced material development in carbon mitigation technology and constitutes a comprehensive guide to the selection and design of a wide range of solvent/sorbent/catalyst used by scientists globally. It appeals to chemical scientists, material scientists and engineers, energy researchers, and environmental scientists from academia, industry, and government in their research directed toward greener, more efficient carbon mitigation processes. Emphasizes material development for carbon mitigation technologies rather than regulations Provides a fundamental understanding of the underpinning science as well as technological approaches to implement carbon capture, utilization and storage technologies Introduces the driving force behind novel materials, their performance and applications for carbon dioxide mitigation Contains figures, tables and an abundance of examples clearly explaining the development, characterization and evaluation of novel carbon mitigation materials Includes hundreds of citations drawing on the most recent published works on the subject Provides a wealth of real-world examples, illustrating how to bridge nano-scale materials to bulk carbon mitigation properties

Biocatalysis in Green Solvents

Biocatalysis in Green Solvents Book
Author : Pedro Lozano
Publisher : Academic Press
Release : 2022-08-02
ISBN : 032391425X
Language : En, Es, Fr & De

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Book Description :

Biocatalysis in Green Solvents offers a pragmatic overview and instruction in biocatalysis and enzymology of green solvents for sustainable industries and medicine, running from concept to application. Here, international experts in the field discuss structure-function relationships of enzymes in ionic liquids (ILs) and examine how enzymes act as selective catalysts for fine biochemical synthesis in non-aqueous environments. Several integral green biochemical processes of biocatalytic transformation and pure product separation are described in detail. Application focused chapters discuss the role of biocatalysis in creating and implementing deep eutectic solvents, biomass derived solvents, sub and supercritical fluids, carbon dioxide biphasic systems, and enzymatic membrane reactors, as well as applying these biocatalytic processes in drug discovery and production. Examines the structure-function relationships of enzymes in ionic liquids and biocatalytic processes for various applications across industry and medicine Includes clear instruction in core green biochemical processes—of (bio)catalytic transformation—and pure product separation Features chapter contributions from international experts across academia and industry

Essentials of Chemical Biology

Essentials of Chemical Biology Book
Author : Andrew D. Miller,Julian Tanner
Publisher : John Wiley & Sons
Release : 2013-05-03
ISBN : 1118687833
Language : En, Es, Fr & De

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Book Description :

“This excellent work fills the need for an upper-level graduate course resource that examines the latest biochemical, biophysical, and molecular biological methods for analyzing the structures and physical properties of biomolecules... This reviewer showed [the book] to several of his senior graduate students, and they unanimously gave the book rave reviews. Summing Up: Highly recommended...” CHOICE Chemical biology is a rapidly developing branch of chemistry, which sets out to understand the way biology works at the molecular level. Fundamental to chemical biology is a detailed understanding of the syntheses, structures and behaviours of biological macromolecules and macromolecular lipid assemblies that together represent the primary constituents of all cells and all organisms. The subject area of chemical biology bridges many different disciplines and is fast becoming an integral part of academic and commercial research. This textbook is designed specifically as a key teaching resource for chemical biology that is intended to build on foundations lain down by introductory physical and organic chemistry courses. This book is an invaluable text for advanced undergraduates taking biological, bioorganic, organic and structural chemistry courses. It is also of interest to biochemists and molecular biologists, as well as professionals within the medical and pharmaceutical industry. Key Features: A comprehensive introduction to this dynamic area of chemistry, which will equip chemists for the task of understanding and studying the underlying principles behind the functioning of biological macro molecules, macromolecular lipid assemblies and cells. Covers many basic concepts and ideas associated with the study of the interface between chemistry and biology. Includes pedagogical features such as: key examples, glossary of equations, further reading and links to websites. Clearly written and richly illustrated in full colour.

Nanomaterials for Biocatalysis

Nanomaterials for Biocatalysis Book
Author : Guillermo R. Castro,Ashok Kumar,Tuan Anh Nguyen,Xianghui Qi,Ghulam Yasin
Publisher : Elsevier
Release : 2021-10-12
ISBN : 0128244372
Language : En, Es, Fr & De

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Book Description :

Nanomaterials for Biocatalysis explains the fundamental design concepts and emerging applications of nanoscale biocatalysts, such as bioconversions, bioelectronics, biosensors, biocomputing and therapeutic applications. Nano-biocatalysts refers to the incorporation of enzymes into nanomaterials. These enzyme-enhanced nanocarriers have many advantages, including low mass transfer limitation, high enzyme capacity, better stabilization, and the formation of single-enzyme nanoparticles. Smart nanocontainers have been developed for the smart release of their embedded active substances. These smart releases can be obtained by using smart coatings as their outer nanoshells. In addition, these nanocontainers could protect the enzymes from chemical or metabolic alterations on their delivering pathways towards the target. This is an important reference source for materials scientists and chemical engineers who want to know more about how nanomaterials are being used for biocatalysis applications. Explains the major fabrication techniques and applications of nanobiocatalysts Shows how nanobiocatalysts are used in a variety of environmental and biomedical sectors Assesses the major challenges associated with the widespread manufacture of nanobiocatalysts

Carbon Utilization

Carbon Utilization Book
Author : Malti Goel,M. Sudhakar
Publisher : Springer
Release : 2017-03-28
ISBN : 9811033528
Language : En, Es, Fr & De

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Book Description :

This book provides in-depth information on topics relating to anthropogenic carbon dioxide utilization processes. Presenting a collection of state-of-the-art scientific reviews and research perspectives on carbon management strategies of relevance to the energy industry, it features contributions by leading scientists and technocrats across 19 chapters as an Indian contribution In the energy industry, new processes for carbon dioxide removal and recycling are developing quickly, and it is in this context that the book provides an opportunity to review the current status of and promote efforts to achieve effective carbon capture and management. The contents presented here will prove useful to researchers, students, industry experts, scientists and policymakers alike.

Biocatalysis

Biocatalysis Book
Author : Peter Grunwald
Publisher : World Scientific Publishing Company
Release : 2017-08-04
ISBN : 1783269103
Language : En, Es, Fr & De

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Book Description :

In this Completely Revised and Extended Edition with a significantly enhanced content, all Chapters have been updated considering relevant literature and recent developments until 2016 together with application oriented examples with a focus on Industrial Biocatalysis. Newly treated topics comprise among others systems metabolic engineering approaches, metagenome screening, new tools for pathway engineering, and de-novo computational design as actual research areas in biocatalysis. Information about different aspects of RNA technologies, and completely new Chapters on 'Fluorescent Proteins' and 'Biocatalysis and Nanotechnology' are also included.

Enzyme or Whole Cell Immobilization for Efficient Biocatalysis Focusing on Novel Supporting Platforms and Immobilization Techniques

Enzyme or Whole Cell Immobilization for Efficient Biocatalysis  Focusing on Novel Supporting Platforms and Immobilization Techniques Book
Author : Wen-Yong Lou,Jun Ge,Changzhu Wu,Jesús Fernández Lucas
Publisher : Frontiers Media SA
Release : 2021-04-21
ISBN : 288966709X
Language : En, Es, Fr & De

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Book Description :

Download Enzyme or Whole Cell Immobilization for Efficient Biocatalysis Focusing on Novel Supporting Platforms and Immobilization Techniques book written by Wen-Yong Lou,Jun Ge,Changzhu Wu,Jesús Fernández Lucas, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.