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Cancer Immunotherapy

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Cancer Immunotherapy Meets Oncology

Cancer Immunotherapy Meets Oncology Book
Author : Cedrik Michael Britten,Sebastian Kreiter,Mustafa Diken,Hans-Georg Rammensee
Publisher : Springer
Release : 2016-08-23
ISBN : 9783319381268
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.

Immunotherapy of Cancer

Immunotherapy of Cancer Book
Author : Yoshiyuki Yamaguchi
Publisher : Springer
Release : 2016-03-25
ISBN : 9784431550303
Language : En, Es, Fr & De

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Book Description :

This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted. With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.

Cancer Immunology

Cancer Immunology Book
Author : Nima Rezaei
Publisher : Springer Nature
Release : 2020-12-12
ISBN : 3030579492
Language : En, Es, Fr & De

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Book Description :

This book explains the immunology of organ-specific malignancies and discusses novel immunotherapy strategies for their treatment. Since the first, very successful edition of the book was published in 2015, a number of entirely new chapters have been included. The range of cancers considered has accordingly been extended, with coverage of the latest immunotherapy approaches for cancers in different organs. In addition, the original chapters have been updated to document the latest advances in immunotherapy for pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, bone tumors, central nervous tumors, lung cancer, genitourinary tract tumors, and breast cancer, among others. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and bench to bedside immunotherapy. Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors will be of special value to clinical immunologists, hematologists, and oncologists.

Cancer Immunotherapy

Cancer Immunotherapy Book
Author : David B. Teplow
Publisher : Academic Press
Release : 2019-08-03
ISBN : 0128165766
Language : En, Es, Fr & De

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Book Description :

Cancer Immunotherapy, Volume 165 in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to different approaches to cancer immunotherapy, with this release focusing on TNFR2 in cancer immunology and immunotherapy, From the Hellstrom paradox towards cancer cure, CAR T-cell treatment of T-cell malignancy , Immunotherapy of pancreatic cancer, Cancer stem cell immunology/immunotherapy, Cytokine release syndrome, Tumor cell-based mechanisms of resistance to immune attack, and Mushroom compounds in cancer immunotherapy. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Cancer Immunotherapy

Cancer Immunotherapy Book
Author : Tyler J. Curiel
Publisher : Springer Science & Business Media
Release : 2012-11-07
ISBN : 1461447321
Language : En, Es, Fr & De

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Book Description :

This work will provide a historical perspective on tumor immunotherapy, discuss fundamental mechanisms of failed tumor rejection, look at passive strategies to boost anti-tumor immunity, as well as have an in-depth look at active strategies to boost anti-tumor immunity.

Immunotherapy in Translational Cancer Research

Immunotherapy in Translational Cancer Research Book
Author : Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran
Publisher : John Wiley & Sons
Release : 2018-02-12
ISBN : 1118684524
Language : En, Es, Fr & De

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Book Description :

A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

Cancer Immunotherapy

Cancer Immunotherapy Book
Author : George C. Prendergast,Elizabeth M. Jaffee
Publisher : Academic Press
Release : 2013-06-04
ISBN : 0123946336
Language : En, Es, Fr & De

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Book Description :

There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease. Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication Drs. Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research Summarizes the latest insights into how immune escape defines an essential trait of cancer Includes numerous illustrations, including how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy and how reversing immune suppression by the tumor can cause tumor regression

Cancer Immunology

Cancer Immunology Book
Author : Nima Rezaei
Publisher : Springer Nature
Release : 2020
ISBN : 3030502872
Language : En, Es, Fr & De

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Book Description :

This translational, clinically oriented book describes in detail novel approaches to cancer immunotherapy, current strategies to target tumor immunosuppression, and prognostic biomarkers for personalized cancer treatments. Since the first, very successful edition of the book was published in 2015, the original chapters have been significantly updated and entirely new chapters are included on, for example, cancer immunoprevention, aptamer-mediated cancer gene therapy, haploidentical bone marrow transplantation for pediatric malignancies, and nanoimmunotherapy. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and cancer immunotherapy for organ-specific tumors. Cancer Immunology: Bench to Bedside Immunotherapy of Cancers will be of special value to clinical immunologists, hematologists, and oncologists.

Immunotherapy of Cancer

Immunotherapy of Cancer Book
Author : Mary L. Disis
Publisher : Springer Science & Business Media
Release : 2007-10-28
ISBN : 1597450111
Language : En, Es, Fr & De

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Book Description :

Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.

Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy

Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy Book
Author : Salem Chouaib,James Lorens
Publisher : Frontiers Media SA
Release : 2020-07-02
ISBN : 2889638170
Language : En, Es, Fr & De

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Book Description :

Download Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy book written by Salem Chouaib,James Lorens, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cancer Immunotherapy

Cancer Immunotherapy Book
Author : Claire Hearnden,Ed C. Lavelle
Publisher : Elsevier Inc. Chapters
Release : 2013-06-04
ISBN : 0128059176
Language : En, Es, Fr & De

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Book Description :

This chapter describes the types of adjuvants that are being investigated as potential cancer adjuvant candidates and those that are currently being used in vaccines against certain cancers.

NK Myeloid Cell Interactions in the Tumor Microenvironment Implications for Cancer Immunotherapy

NK Myeloid Cell Interactions in the Tumor Microenvironment  Implications for Cancer Immunotherapy Book
Author : Erik Wennerberg,Andreas Lundqvist,Yumeng Mao,Dimitrios Mougiakakos
Publisher : Frontiers Media SA
Release : 2021-09-08
ISBN : 2889712710
Language : En, Es, Fr & De

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Book Description :

Download NK Myeloid Cell Interactions in the Tumor Microenvironment Implications for Cancer Immunotherapy book written by Erik Wennerberg,Andreas Lundqvist,Yumeng Mao,Dimitrios Mougiakakos, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Resistance of Cancer Cells to CTL Mediated Immunotherapy

Resistance of Cancer Cells to CTL Mediated Immunotherapy Book
Author : Benjamin Bonavida,Salem Chouaib
Publisher : Springer
Release : 2015-06-20
ISBN : 3319178075
Language : En, Es, Fr & De

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Book Description :

This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.

Advances in Head and Neck Cancer Immunology and Immunotherapy

Advances in Head and Neck Cancer Immunology and Immunotherapy Book
Author : Rasha Abu-Eid,John E. Janik
Publisher : Frontiers Media SA
Release : 2019-06-19
ISBN : 2889458393
Language : En, Es, Fr & De

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Book Description :

Understanding the immunology of different cancers has led to great advances in developing cancer immunotherapies which are successfully used in generating effective anti-tumour immune responses. Head and neck cancers are no exception and various immunotherapies are now under study for the treatment of this diverse group of diseases. The articles in in this eBook provide a range of topics that highlight some of the latest advances in head and neck cancer immunology and immunotherapy. The authors of these articles provide their unique insight and expertise and suggest future directions for translational clinical research.

Optimal Control of Antigen Specific Antibody Interactions for Cancer Immunotherapy

Optimal Control of Antigen Specific Antibody Interactions for Cancer Immunotherapy Book
Author : Tazrin Ahmed
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

In the history of cancer treatment, the immunotherapy is considered to be the most promising treatment approach. The idea behind this breakthrough is to stimulate the patient's own immune system to recognize the cancer cells and destroy them. In this therapy, the antibodies are known to be powerful medications to activate the immune system in different ways. They circulate throughout the body until they discover a substance that body recognize as alien i.e. antigen and bind to them. Similarly, cancer cells often have molecules on their surface known as tumor-associated antigens. The researchers can design many clones of the antibody that only target a certain antigen type such as one found on tumors or cancer cells. Then, these are used as an effective drug for treating cancer. Thus, the antigen specific antibody interactions play a vital role in cancer immunotherapy. In this study, we propose a dynamic model to represent the population of antigens and antibodies in cancer patients; in particular we focus on the antigen-specific-antibody interactions to elicit an immune response that leads to the death of cancer cells. We formulate a terminal control problem where the schedule and doses of these antibodies are considered as control variables. The objective functional has been formulated as a measure of antigen population at the end of the treatment period. Pontryagin minimum principle (PMP) has been used to obtain the optimal control policies. For illustration, a series of numerical results is presented showing the effectiveness of immune therapy for cancer treatment corresponding to the different scenarios, choices of parameters and treatment periods. The results indicate that the control doses are followed by the emergence of antigen population. This approach would be potentially applicable to determine and prescribe the optimal doses and schedules for cancer patients.

Cancer Immunotherapy and Its Immunological Basis

Cancer Immunotherapy and Its Immunological Basis Book
Author : Yūichi Yamamura,Masayasu Kitagawa,Ichirō Azuma
Publisher : Unknown
Release : 1978
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Consists of the proceedings of international conference and symposia.

Cancer Immunotherapy

Cancer Immunotherapy Book
Author : Freda K. Stevenson,Gianfranco di Genova,Christian H. Ottensmeier,Natalia Savelyeva
Publisher : Elsevier Inc. Chapters
Release : 2013-06-04
ISBN : 0128059117
Language : En, Es, Fr & De

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Book Description :

The goal of mobilizing the immune response against cancer in patients is ambitious, and, to even approach success, all the tools of modern genetics have been required. Tools are needed for three tasks: to profile cancer cells, to understand how they survive and proliferate, and to activate immune pathways able to circumvent tumor protective mechanisms and mediate successful attack. Gene-based vaccines incorporate tumor antigen sequences together with genes encoding molecules identified as critical for inducing responses. The vaccine backbones activate innate immunity and, provided T-cell help is co-induced, DNA vaccines overcome regulation and lead to high levels of CD8+ T-cell attack on tumors. Delivery of DNA vaccines to large animals and patients has required new thinking and strategies such as electroporation are now in the clinic. Clinically meaningful immune responses are being induced and the community is developing new ways of evaluating immune responses in patients and connecting these to clinical outcome.

MHC Class I Antigens In Malignant Cells

MHC Class I Antigens In Malignant Cells Book
Author : Natalia Aptsiauri,Angel Miguel Garcia-Lora,Teresa Cabrera
Publisher : Springer Science & Business Media
Release : 2013-02-26
ISBN : 1461465435
Language : En, Es, Fr & De

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Book Description :

Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. Precise identification of the mechanism leading to MHC class I defects will help to develop new personalized patient-tailored treatment protocols. There is significant new research on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer. In contrast, few data is available on the changes in MHC class I expression during the course of cancer immunotherapy, but the authors have recently made discoveries that show the progression or regression of a tumor lesion in cancer patients undergoing immunotherapy depends on the molecular mechanism responsible for the MHC class I alteration and not on the type of immunotherapy used. According to this notion, the nature of the preexisting MHC class I lesion in the cancer cell has a crucial impact on determining the final outcome of cancer immunotherapy. This SpringerBrief will present how MHC class 1 is expressed, explain its role in tumor progression, and its role in resistance to immunotherapy. ​

Cancer Immunotherapy

Cancer Immunotherapy Book
Author : Lauren M.F. Merlo,Laura Mandik-Nayak
Publisher : Elsevier Inc. Chapters
Release : 2013-06-04
ISBN : 0128058994
Language : En, Es, Fr & De

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Book Description :

B cells provide a variety of important functions to the adaptive immune system including antibody production, antigen presentation, and cytokine secretion, as well as being required for the development of proper lymphoid architecture. B cells originate in the bone marrow, where they mature and produce an initial diverse repertoire of non-self reactive B-cell receptors. After moving to the periphery, naïve B cells are presented with antigen by dendritic and other antigen-presenting cells. B cells that come in contact with and can recognize antigen become activated, expand, and further alter the B-cell receptor to improve antigen specificity through somatic hypermutation and affinity maturation. This B-cell receptor is subsequently secreted as active, mature antibody. Antibodies are able to recognize and bind to bacteria, viruses, and other antigens, initiating a cascade of processes that rid the body of pathogens.

Cancer Immunotherapy

Cancer Immunotherapy Book
Author : Marij J.P. Welters,Sjoerd H. van der Burg
Publisher : Elsevier Inc. Chapters
Release : 2013-06-04
ISBN : 0128059125
Language : En, Es, Fr & De

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Book Description :

Immunotherapy exploits the effector mechanisms of the immune system to combat cancer. A number of immunotherapeutic compounds are now firmly anchored in current treatment of cancer patients. For newly developed therapeutic entities, the study of the patient’s immune response to treatment remains an essential component of clinical trials. Under ideal circumstances, this analysis is accomplished by various laboratory assays that measure differences in wanted and unwanted immune parameters before, during, and after treatment, at both systemic and local levels, with the ultimate aim of identifying immune correlates of biological activity as well as clinical outcome. The biomarker identification process is assisted by a harmonization of assays and data reporting, because this enables a comparison of datasets obtained by testing similar therapeutic products in different trials. Moreover, a systematic use of the datasets to better understand the strengths, weaknesses and efficacy of various treatment modalities can guide decision making with regard to further clinical development, possibly encouraging investigators to move forward into larger trials or to further optimize immunotherapeutic compounds or approach. This chapter provides an overview of immunomonitoring principles to promote the clinical development of effective immunotherapeutics for cancer treatment.