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Bursting Neurons And Fading Memories

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Bursting Neurons and Fading Memories

Bursting Neurons and Fading Memories Book
Author : Michael R. D'Andrea
Publisher : Academic Press
Release : 2014-10-10
ISBN : 0128019883
Language : En, Es, Fr & De

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Book Description :

Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development. The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology A high-level text on AD pathology, and suggestions for progress in a stagnating field Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity

Intracellular Consequences of Amyloid in Alzheimer s Disease

Intracellular Consequences of Amyloid in Alzheimer s Disease Book
Author : Michael R. D'Andrea
Publisher : Academic Press
Release : 2016-02-21
ISBN : 012804330X
Language : En, Es, Fr & De

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Book Description :

Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death. Presents the latest research on the significance of intracellular amyloid as it relates to Alzheimer’s Addresses crucial questions about intracellular amyloid, including how if forms and enters neurons, its toxicity, if it triggers cell death, and how amyloid plaques are formed Examines the potential relationship between intracellular amyloid, plaques, and cognitive impairment in an effort to answer whether Alzheimer’s is initially a problem of amyloid, the neuron, or of the blood-brain barrier Seeks to help researchers generate additional alternative therapeutic opportunities to cure Alzheimer’s

Alzheimer s Turning Point

Alzheimer   s Turning Point Book
Author : Jack C. de la Torre
Publisher : Springer
Release : 2016-06-25
ISBN : 3319340573
Language : En, Es, Fr & De

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Book Description :

This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored. The author discusses in depth his proposal of the vascular hypothesis of Alzheimer's disease which has become a mother-lode for basic and clinical studies and a key approach to the prevention of this dementia.Alzheimer’s Turning Point offers professionals, students and those looking to learn more about this disorder a fresh clinical perspective of this devastating disease.

Glia in Health and Disease

Glia in Health and Disease Book
Author : Tania Spohr
Publisher : BoD – Books on Demand
Release : 2020-05-20
ISBN : 1789852536
Language : En, Es, Fr & De

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Book Description :

The book will highlight the role played by glial cells in the central and peripheral nervous systems in both healthy and unhealthy individuals. Among all processes involved, we will discuss the importance of the enteric nervous system in the control of gut homeostasis, in the interaction with the immune system, and its participation in pathological conditions such as metabolic syndrome. We will also look at the relevance of astrocytes during synaptic transmission and the regulation of plasticity by releasing gliotransmitters. Ultimately, we will highlight the influence of astrocytes during the development of a number of neurodegenerative diseases, such as multiple sclerosis and Alzheimer’s disease, focusing on how the serum levels of the astrocytic protein S100B can be used as a biomarker for clinical decisions.

From Neuron to Cognition Via Computational Neuroscience

From Neuron to Cognition Via Computational Neuroscience Book
Author : Michael A. Arbib,James J. Bonaiuto
Publisher : MIT Press
Release : 2016-11-11
ISBN : 0262034964
Language : En, Es, Fr & De

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Book Description :

A comprehensive, integrated, and accessible textbook presenting core neuroscientific topics from a computational perspective, tracing a path from cells and circuits to behavior and cognition.

Advances in Natural Computation

Advances in Natural Computation Book
Author : Licheng Jiao,Lipo Wang,Xinbo Gao,Jing Liu,Feng Wu
Publisher : Springer Science & Business Media
Release : 2006-09-19
ISBN : 3540459014
Language : En, Es, Fr & De

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Book Description :

This is volume I of the proceedings of the Second International Conference on Natural Computation, ICNC 2006. After a demanding review process 168 carefully revised full papers and 86 revised short papers were selected from 1915 submissions for presentation in two volumes. This first volume includes 130 papers related to artificial neural networks, natural neural systems and cognitive science, neural network applications, as well as evolutionary computation: theory and algorithms.

Knobil and Neill s Physiology of Reproduction

Knobil and Neill s Physiology of Reproduction Book
Author : Tony M. Plant,Anthony J. Zeleznik
Publisher : Academic Press
Release : 2014-11-15
ISBN : 012397769X
Language : En, Es, Fr & De

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Book Description :

The Fourth Edition of Knobil & Neill continues to serve as a reference aid for research, to provide the historical context to current research, and most importantly as an aid for graduate teaching on a broad range of topics in human and comparative reproduction. In the decade since the publication of the last edition, the study of reproductive physiology has undergone monumental changes. Chief among these advances are in the areas of stem cell development, signaling pathways, the role of inflammation in the regulatory processes in the various tissues, and the integration of new animal models which have led to a greater understanding of human disease. The new edition synthesizes all of this new information at the molecular, cellular, and organismal levels of organization and present modern physiology a more understandable and comparative context. The Fourth Edition has been extensively revised, reflecting new fundamental advancements in this rapidly advancing field. Provides a common language for researchers across the fields of physiology, endocrinology, and biology to discuss their understanding of reproduction. Saves academic researchers time in quickly accessing the very latest details on reproductive physiology, as opposed to searching through thousands of journal articles.

Annual Editions

Annual Editions Book
Author : Karen L. Freiberg
Publisher : McGraw-Hill/Dushkin
Release : 2003-11
ISBN : 9780072862294
Language : En, Es, Fr & De

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Book Description :

This updated thirty-second edition gives you a variety of carefully selected articles from the best of the public press, including magazines, newspapers, and journals. Topics covered include genetic and parental influences on development, development during infancy and early childhood and many others.

Aging

Aging Book
Author : Harold Cox
Publisher : Dushkin Publishing Group
Release : 2005-07
ISBN : 9780073515939
Language : En, Es, Fr & De

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Book Description :

This eighteenth edition of ANNUAL EDITIONS: AGING (2006 UPDATE) provides convenient, inexpensive access to current articles selected from the best of the public press. Organizational features include: an annotated listing of selected World Wide Web sites; an annotated table of contents; a topic guide; a general introduction; brief overviews for each section; a topical index; and an instructor’s resource guide with testing materials. USING ANNUAL EDITIONS IN THE CLASSROOM is offered as a practical guide for instructors. ANNUAL EDITIONS titles are supported by our student website, www.dushkin.com/online.

Annual Editions Aging

Annual Editions  Aging Book
Author : Harold Cox
Publisher : McGraw-Hill/Dushkin
Release : 2006-04
ISBN : 9780073516141
Language : En, Es, Fr & De

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Book Description :

Using an interdisciplinary approach, provides current articles selected from the best of the public press, including articles from medicine, nursing, psychology, sociology, social work, and the biological sciences.

Annual Editions

Annual Editions Book
Author : Harold Cox
Publisher : McGraw-Hill/Dushkin
Release : 2004-08
ISBN : 9780073012551
Language : En, Es, Fr & De

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Book Description :

These public press articles were chosen because they address the most relevant and current problems in the area of aging. A variety of divergent views on the appropriate solutions to these problems is presented. The well-illustrated articles are written by gerontologists, educators, researchers, and writers. The articles provide an effective and useful perspective on today's important topics in the study of aging. This title is supported by the student website, Dushkin Online (www.dushkin.com/online).

Annual Editions Aging 08 09

Annual Editions  Aging 08 09 Book
Author : Harold Cox
Publisher : McGraw-Hill/Dushkin
Release : 2008-03-17
ISBN : 9780073397603
Language : En, Es, Fr & De

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Book Description :

This Twenty-First Edition of ANNUAL EDITIONS: AGING provides convenient, inexpensive access to current articles selected from the best of the public press. Organizational features include: an annotated listing of selected World Wide Web sites; an annotated table of contents; a topic guide; a general introduction; brief overviews for each section; a topical index; and an instructor’s resource guide with testing materials. USING ANNUAL EDITIONS IN THE CLASSROOM, ISBN 0073301906, is offered as a practical guide for instructors. ANNUAL EDITIONS titles are supported by our student website, www.mhcls.com/online.

Newsweek

Newsweek Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Newsweek book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neural Nets and Chaotic Carriers

Neural Nets and Chaotic Carriers Book
Author : Peter Whittle
Publisher : World Scientific
Release : 2010
ISBN : 1848165900
Language : En, Es, Fr & De

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Book Description :

Neural Nets and Chaotic Carriers develops rational principles for the design of associative memories, with a view to applying these principles to models with irregularly oscillatory operation so evident in biological neural systems, and necessitated by the meaninglessness of absolute signal levels.Design is based on the criterion that an associative memory must be able to cope with ?fading data?, i.e., to form an inference from the data even as its memory of that data degrades. The resultant net shows striking biological parallels. When these principles are combined with the Freeman specification of a neural oscillator, some remarkable effects emerge. For example, the commonly-observed phenomenon of neuronal bursting appears, with gamma-range oscillation modulated by a low-frequency square-wave oscillation (the ?escapement oscillation?). Bridging studies and new results of artificial and biological neural networks, the book has a strong research character. It is, on the other hand, accessible to non-specialists for its concise exposition on the basics.

Society for Neuroscience Abstracts

Society for Neuroscience Abstracts Book
Author : Society for Neuroscience. Annual Meeting
Publisher : Unknown
Release : 1981
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Society for Neuroscience Abstracts book written by Society for Neuroscience. Annual Meeting, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Make It Stick

Make It Stick Book
Author : Peter C. Brown
Publisher : Harvard University Press
Release : 2014-04-14
ISBN : 0674419383
Language : En, Es, Fr & De

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Book Description :

Drawing on cognitive psychology and other fields, Make It Stick offers techniques for becoming more productive learners, and cautions against study habits and practice routines that turn out to be counterproductive. The book speaks to students, teachers, trainers, athletes, and all those interested in lifelong learning and self-improvement.

CSA Neurosciences Abstracts

CSA Neurosciences Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download CSA Neurosciences Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Science Reporter

Science Reporter Book
Author : Anonim
Publisher : Unknown
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Science Reporter book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Body Book

The Body Book Book
Author : Anonim
Publisher : Workman Publishing Company
Release : 1992
ISBN : 9781563052989
Language : En, Es, Fr & De

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Book Description :

Facts and explanations about the various body systems, plus information on vaccines, tears, and many other relevant topics.

Consciousness and the Brain

Consciousness and the Brain Book
Author : Stanislas Dehaene
Publisher : Penguin
Release : 2014-01-30
ISBN : 0698151402
Language : En, Es, Fr & De

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Book Description :

WINNER OF THE 2014 BRAIN PRIZE From the acclaimed author of Reading in the Brain, a breathtaking look at the new science that can track consciousness deep in the brain How does our brain generate a conscious thought? And why does so much of our knowledge remain unconscious? Thanks to clever psychological and brain-imaging experiments, scientists are closer to cracking this mystery than ever before. In this lively book, Stanislas Dehaene describes the pioneering work his lab and the labs of other cognitive neuroscientists worldwide have accomplished in defining, testing, and explaining the brain events behind a conscious state. We can now pin down the neurons that fire when a person reports becoming aware of a piece of information and understand the crucial role unconscious computations play in how we make decisions. The emerging theory enables a test of consciousness in animals, babies, and those with severe brain injuries. A joyous exploration of the mind and its thrilling complexities, Consciousness and the Brain will excite anyone interested in cutting-edge science and technology and the vast philosophical, personal, and ethical implications of finally quantifying consciousness. From the Trade Paperback edition.