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Bursting Neurons And Fading Memories

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Bursting Neurons and Fading Memories

Bursting Neurons and Fading Memories Book
Author : Michael R. D'Andrea
Publisher : Academic Press
Release : 2014-10-10
ISBN : 0128019883
Language : En, Es, Fr & De

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Book Description :

Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development. The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology A high-level text on AD pathology, and suggestions for progress in a stagnating field Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity

Intracellular Consequences of Amyloid in Alzheimer s Disease

Intracellular Consequences of Amyloid in Alzheimer s Disease Book
Author : Michael R. D'Andrea
Publisher : Academic Press
Release : 2016-02-21
ISBN : 012804330X
Language : En, Es, Fr & De

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Book Description :

Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death. Presents the latest research on the significance of intracellular amyloid as it relates to Alzheimer’s Addresses crucial questions about intracellular amyloid, including how if forms and enters neurons, its toxicity, if it triggers cell death, and how amyloid plaques are formed Examines the potential relationship between intracellular amyloid, plaques, and cognitive impairment in an effort to answer whether Alzheimer’s is initially a problem of amyloid, the neuron, or of the blood-brain barrier Seeks to help researchers generate additional alternative therapeutic opportunities to cure Alzheimer’s

Alzheimer s Turning Point

Alzheimer   s Turning Point Book
Author : Jack C. de la Torre
Publisher : Springer
Release : 2016-06-25
ISBN : 3319340573
Language : En, Es, Fr & De

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Book Description :

This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored. The author discusses in depth his proposal of the vascular hypothesis of Alzheimer's disease which has become a mother-lode for basic and clinical studies and a key approach to the prevention of this dementia.Alzheimer’s Turning Point offers professionals, students and those looking to learn more about this disorder a fresh clinical perspective of this devastating disease.

Glia in Health and Disease

Glia in Health and Disease Book
Author : Tania Spohr
Publisher : BoD – Books on Demand
Release : 2020-05-20
ISBN : 1789852536
Language : En, Es, Fr & De

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Book Description :

The book will highlight the role played by glial cells in the central and peripheral nervous systems in both healthy and unhealthy individuals. Among all processes involved, we will discuss the importance of the enteric nervous system in the control of gut homeostasis, in the interaction with the immune system, and its participation in pathological conditions such as metabolic syndrome. We will also look at the relevance of astrocytes during synaptic transmission and the regulation of plasticity by releasing gliotransmitters. Ultimately, we will highlight the influence of astrocytes during the development of a number of neurodegenerative diseases, such as multiple sclerosis and Alzheimer’s disease, focusing on how the serum levels of the astrocytic protein S100B can be used as a biomarker for clinical decisions.

From Neuron to Cognition Via Computational Neuroscience

From Neuron to Cognition Via Computational Neuroscience Book
Author : Michael A. Arbib,James J. Bonaiuto
Publisher : MIT Press
Release : 2016-11-11
ISBN : 0262034964
Language : En, Es, Fr & De

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Book Description :

A comprehensive, integrated, and accessible textbook presenting core neuroscientific topics from a computational perspective, tracing a path from cells and circuits to behavior and cognition.

Advances in Natural Computation

Advances in Natural Computation Book
Author : Licheng Jiao,Lipo Wang,Xinbo Gao,Jing Liu,Feng Wu
Publisher : Springer
Release : 2006-09-28
ISBN : 3540459022
Language : En, Es, Fr & De

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Book Description :

This is volume I of the proceedings of the Second International Conference on Natural Computation, ICNC 2006. After a demanding review process 168 carefully revised full papers and 86 revised short papers were selected from 1915 submissions for presentation in two volumes. This first volume includes 130 papers related to artificial neural networks, natural neural systems and cognitive science, neural network applications, as well as evolutionary computation: theory and algorithms.

Advances in Natural Computation

Advances in Natural Computation Book
Author : Licheng Jiao,Lipo Wang,Xinbo Gao,Jing Liu,Feng Wu
Publisher : Springer Science & Business Media
Release : 2006-09-19
ISBN : 3540459014
Language : En, Es, Fr & De

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Book Description :

This is volume I of the proceedings of the Second International Conference on Natural Computation, ICNC 2006. After a demanding review process 168 carefully revised full papers and 86 revised short papers were selected from 1915 submissions for presentation in two volumes. This first volume includes 130 papers related to artificial neural networks, natural neural systems and cognitive science, neural network applications, as well as evolutionary computation: theory and algorithms.

Neural Nets and Chaotic Carriers

Neural Nets and Chaotic Carriers Book
Author : Peter Whittle
Publisher : World Scientific Publishing Company
Release : 2010
ISBN : 9781848165915
Language : En, Es, Fr & De

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Book Description :

Neural Nets and Chaotic Carriers develops rational principles for the design of associative memories, with a view to applying these principles to models with irregularly oscillatory operation so evident in biological neural systems, and necessitated by the meaninglessness of absolute signal levels. Design is based on the criterion that an associative memory must be able to cope with 'fading data', i.e., to form an inference from the data even as its memory of that data degrades. The resultant net shows striking biological parallels. When these principles are combined with the Freeman specification of a neural oscillator, some remarkable effects emerge. For example, the commonly-observed phenomenon of neuronal bursting appears, with gamma-range oscillation modulated by a low-frequency square-wave oscillation (the escapement 'oscillation'). Bridging studies and new results of artificial and biological neural networks, the book has a strong research character. It is, on the other hand, accessible to non-specialists for its concise exposition on the basics.

Reservoir Computing

Reservoir Computing Book
Author : Kohei Nakajima
Publisher : Springer Nature
Release : 2021-10-18
ISBN : 9811316872
Language : En, Es, Fr & De

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Book Description :

Download Reservoir Computing book written by Kohei Nakajima, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Advances in Neural Information Processing Systems 13

Advances in Neural Information Processing Systems 13 Book
Author : Todd K. Leen,Thomas G. Dietterich,Volker Tresp
Publisher : MIT Press
Release : 2001
ISBN : 9780262122412
Language : En, Es, Fr & De

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Book Description :

The proceedings of the 2000 Neural Information Processing Systems (NIPS) Conference.The annual conference on Neural Information Processing Systems (NIPS) is the flagship conference on neural computation. The conference is interdisciplinary, with contributions in algorithms, learning theory, cognitive science, neuroscience, vision, speech and signal processing, reinforcement learning and control, implementations, and diverse applications. Only about 30 percent of the papers submitted are accepted for presentation at NIPS, so the quality is exceptionally high. These proceedings contain all of the papers that were presented at the 2000 conference.

Neural Nets and Chaotic Carriers

Neural Nets and Chaotic Carriers Book
Author : Peter Whittle
Publisher : World Scientific
Release : 2010-07-29
ISBN : 1908977957
Language : En, Es, Fr & De

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Book Description :

Neural Nets and Chaotic Carriers develops rational principles for the design of associative memories, with a view to applying these principles to models with irregularly oscillatory operation so evident in biological neural systems, and necessitated by the meaninglessness of absolute signal levels. Design is based on the criterion that an associative memory must be able to cope with “fading data”, i.e., to form an inference from the data even as its memory of that data degrades. The resultant net shows striking biological parallels. When these principles are combined with the Freeman specification of a neural oscillator, some remarkable effects emerge. For example, the commonly-observed phenomenon of neuronal bursting appears, with gamma-range oscillation modulated by a low-frequency square-wave oscillation (the “escapement oscillation”). Bridging studies and new results of artificial and biological neural networks, the book has a strong research character. It is, on the other hand, accessible to non-specialists for its concise exposition on the basics. Contents:Opening and Themes:Introduction and AspirationsOptimal Statistical ProceduresLinear Links and Nonlinear Knots: The Basic Neural NetBifurcations and ChaosAssociative and Storage Memories:What is a Memory? The Hamming and Hopfield NetsCompound and ‘Spurious’ TracesPreserving Plasticity: A Bayesian ApproachThe Key Task: The Fixing of Fading Data. Conclusions IPerformance of the Probability-Maximising AlgorithmOther Memories — Other ConsiderationsOscillatory Operation and the Biological Model:Neuron Models and Neural MassesFreeman Oscillators — Solo and in ConcertAssociative Memories Incorporating the Freeman OscillatorOlfactory Comparisons. Conclusions IITransmission Delays Readership: Professionals and graduates in areas associated with artificial neural networks. Keywords:Neural Nets;Associative Memory;Freeman Oscillator;Neuronal Bursting;Olfactory System

Knobil and Neill s Physiology of Reproduction

Knobil and Neill s Physiology of Reproduction Book
Author : Tony M. Plant,Anthony J. Zeleznik
Publisher : Academic Press
Release : 2014-11-15
ISBN : 012397769X
Language : En, Es, Fr & De

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Book Description :

The Fourth Edition of Knobil & Neill continues to serve as a reference aid for research, to provide the historical context to current research, and most importantly as an aid for graduate teaching on a broad range of topics in human and comparative reproduction. In the decade since the publication of the last edition, the study of reproductive physiology has undergone monumental changes. Chief among these advances are in the areas of stem cell development, signaling pathways, the role of inflammation in the regulatory processes in the various tissues, and the integration of new animal models which have led to a greater understanding of human disease. The new edition synthesizes all of this new information at the molecular, cellular, and organismal levels of organization and present modern physiology a more understandable and comparative context. The Fourth Edition has been extensively revised, reflecting new fundamental advancements in this rapidly advancing field. Provides a common language for researchers across the fields of physiology, endocrinology, and biology to discuss their understanding of reproduction. Saves academic researchers time in quickly accessing the very latest details on reproductive physiology, as opposed to searching through thousands of journal articles.

Biological and Artificial Intelligence Environments

Biological and Artificial Intelligence Environments Book
Author : Bruno Apolloni,Maria Marinaro,Roberto Tagliaferri
Publisher : Springer Science & Business Media
Release : 2007-11-04
ISBN : 1402034326
Language : En, Es, Fr & De

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Book Description :

Reports the proceedings of the 15th Italian workshop on neural networks issued by the Italian Society on Neural Networks SIREN. This volume contains papers in various fields, such as Pattern Recognition, Stochastic Optimization, Learning, Granular Computing, and more, with a bias toward bioinformatics operational applications.

Nature Inspired Problem Solving Methods in Knowledge Engineering

Nature Inspired Problem Solving Methods in Knowledge Engineering Book
Author : José Mira,José R. Álvarez
Publisher : Springer
Release : 2007-06-23
ISBN : 3540730559
Language : En, Es, Fr & De

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Book Description :

The second of a two-volume set, this book constitutes the refereed proceedings of the Second International Work-Conference on the Interplay between Natural and Artificial Computation, IWINAC 2007, held in La Manga del Mar Menor, Spain in June 2007. It contains all the contributions connected with biologically inspired methods and techniques for solving AI and knowledge engineering problems in different application domains.

Neuroscience for Clinicians

Neuroscience for Clinicians Book
Author : Eduardo E. Benarroch
Publisher : Oxford University Press
Release : 2021
ISBN : 0190948892
Language : En, Es, Fr & De

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Book Description :

"The aim of this book is to provide the clinician with a comprehensive and clinical relevant survey of emerging concepts on the organization and function of the nervous system and neurologic disease mechanisms, at the molecular, cellular and system levels. The content of is based on the review of information obtained from recent advances in genetic, molecular and cell biology techniques, electrophysiological recordings, brain mapping, and mouse models, emphasizing the clinical and possible therapeutic implications. Many chapters of this book contain information that will be relevant not only clinical neurologists but also to psychiatrists and physical therapists. The scope includes the mechanisms and abnormalities of DNA/RNA metabolism, proteostasis, vesicular biogenesis, and axonal transport and mechanisms of neurodegeneration; the role of the mitochondria in cell function and death mechanisms; ion channels, neurotransmission and mechanisms of channelopathies and synaptopathies; the functions of astrocytes, oligodendrocytes and microglia and their involvement in disease; the local circuits and synaptic interactions at the level of the cerebral cortex, thalamus, basal ganglia, cerebellum, brainstem and spinal cord transmission regulating sensory processing, behavioral state and motor functions; the peripheral and central mechanisms of pain and homeostasis; and networks involved in emotion, memory, language, and executive function"--

Aging

Aging Book
Author : Harold Cox
Publisher : McGraw-Hill/Dushkin
Release : 2007
ISBN : 9780073397290
Language : En, Es, Fr & De

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Book Description :

This Twentieth Edition of ANNUAL EDITIONS: AGING 07/08 provides convenient, inexpensive access to current articles selected from the best of the public press. Organizational features include: an annotated listing of selected World Wide Web sites; an annotated table of contents; a topic guide; a general introduction; brief overviews for each section; a topical index; and an instructor’s resource guide with testing materials. USING ANNUAL EDITIONS IN THE CLASSROOM is offered as a practical guide for instructors. ANNUAL EDITIONS titles are supported by our student website, www.mhcls.com/online.

Annual Editions

Annual Editions Book
Author : Karen L. Freiberg
Publisher : McGraw-Hill/Dushkin
Release : 2002-12
ISBN : 9780072548198
Language : En, Es, Fr & De

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Book Description :

This annually updated reader is a compilation of carefully selected articles from magazines, newspapers, and journals. Topics covered include genetic and parental influences on development, development during infancy and early childhood and many others. This title is supported by Dushkin Online (www.dushkin.com/online/), a student Web site that provides study support and tools and links to related Web sites.

The Light

The Light Book
Author : J. Powers
Publisher : iUniverse
Release : 2007-01
ISBN : 0595423949
Language : En, Es, Fr & De

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Book Description :

In a cosmos where the physical constants of nature are fine tuned to unimaginable precision to permit the existence of life, the giant US/Chinese radio telescope on the far side of the moon detects no technological civilizations. Why? Fantasies of space travel to the stars and cheap limitless energy have, by the mid-21st century, proven to be just that. Fantasies. Upon this stage appears an American Indian woman in the grip of a delusion that her son is Quetzalcoatl, an ancient Meso-American God whom she has pursued in devotion across the centuries. A teacher at the shabby Apache Indian reservation elementary school recognizes the boy as probably the greatest mathematical genius in human history. A shaman senses in the man the reality of myth and fulfillment of ancient prophecy. None comprehend the staggering dimensions of his true destiny. The Light is a psychedelic adventure of a genius who must choose between surrender to delusion, or freedom from superstition and madness to fall in love and live his own life as the greatest particle physicist of his age. In so doing he unleashes forces that give substance to ancient myths and challenge the limits of human imagination.

Annual Editions Aging

Annual Editions  Aging Book
Author : Harold Cox
Publisher : McGraw-Hill/Dushkin
Release : 2006-04
ISBN : 9780073516141
Language : En, Es, Fr & De

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Book Description :

Using an interdisciplinary approach, provides current articles selected from the best of the public press, including articles from medicine, nursing, psychology, sociology, social work, and the biological sciences.

Neurovision Neural bases of binocular vision and coordination and their implications in visual training programs

Neurovision  Neural bases of binocular vision and coordination and their implications in visual training programs Book
Author : Olivier A. Coubard
Publisher : Unknown
Release : 2015-10-12
ISBN : 2889196550
Language : En, Es, Fr & De

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Book Description :

Binocular vision is achieved by five neurovisual systems originating in the retina but varying in their destination within the brain. Two systems have been widely studied: the retino-tectal or retino-collicular route, which subserves an expedient and raw estimate of the visual scene through the magnocellular pathway, and the retino-occipital or retino-cortical route, which allows slower but refined analysis of the visual scene through the parvocellular pathway. But there also exist further neurovisual systems: the retino-hypothalamic, retino-pretectal, and accessory optic systems, which play a crucial role in vision though they are less understood. The retino-pretectal pathway projecting onto the pretectum is critical for the pupillary or photomotor reflex. The retino-hypothalamic pathway projecting onto the suprachiasmatic nucleus regulates numerous behavioral and biological functions as well as circadian rhythms. The accessory optic system targeting terminal lateral, medial and dorsal nuclei through the paraoptic fasciculus plays a role in head and gaze orientation as well as slow movements. Taken together, these neurovisual systems involve 60% of brain activity, thus highlighting the importance of vision in the functioning and regulation of the central nervous system. But vision is first and foremost action, which makes perception impossible without movement. Binocular coordination is a prerequisite for binocular fusion of the object of interest on the two foveas, thus ensuring visual perception. The retino-collicular pathway is sufficient to elicit reflexive eye movements with short latencies. Thanks to its motor neurons, the superior colliculus activates premotor neurons, which themselves activate motor neurons of the oculomotor, trochlear and abducens nuclei. At a higher level, a cascade of neural mechanisms participates in the control of decisional eye movements. The superior colliculus is controlled by the substancia nigra pars reticulata, which is itself gated by subcortical structures such as the dorsal striatum. The superior colliculus is also inhibited by the dorsolateral prefrontal cortex through a direct prefrontotectal tract. Cortical areas are crucial for the triggering of eye movements: the frontal eye field, supplementary eye field, and parietal eye field. Finally the cerebellum maintains accuracy. The focus of the present research topic, entitled Neural bases of binocular vision and coordination and their implications in visual training programs, is to review the most recent findings in brain imaging and neurophysiology of binocular vision and coordination in humans and animals with frontally-placed eyes. The emphasis is put on studies that enable transfer of knowledge toward visual training programs targeting visual field defects (e.g., hemianopia) and binocular functional disorders (e.g., amblyopia).