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Brain Targeted Drug Delivery System

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Brain Targeted Drug Delivery Systems

Brain Targeted Drug Delivery Systems Book
Author : Huile Gao,Xiaoling Gao
Publisher : Academic Press
Release : 2018-09-20
ISBN : 012814002X
Language : En, Es, Fr & De

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Book Description :

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain. Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers Discusses key points in developing brain targeting drug delivery systems Summarizes and presents currently available strategies for brain targeting drug delivery Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research

Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors

Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors Book
Author : Prashant Kesharwani,Umesh Gupta
Publisher : Academic Press
Release : 2018-04-20
ISBN : 0128122498
Language : En, Es, Fr & De

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Book Description :

Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors

Direct Nose to Brain Drug Delivery

Direct Nose to Brain Drug Delivery Book
Author : Chandrakantsing Pardeshi,Eliana B. Souto
Publisher : Academic Press
Release : 2021-06-01
ISBN : 0128225238
Language : En, Es, Fr & De

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Book Description :

Direct Nose to Brain Drug Delivery: Mechanism, Technological Advances, Applications and Regulatory Updates provides the reader with precise knowledge about the strategies and approaches for enhanced nose to brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration, includes an overview on the toxicity aspects of the various materials used to develop the direct nose to brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. Direct Nose to Brain Drug Delivery: Mechanism, Technological Advances, Applications and Regulatory Updates is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems, and novel drug administration devices for the treatment of neuro-ailments. Explains the targeting approaches for enhanced brain targeting following intranasal drug administration Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose to brain Discusses pharmaceutical and biomedical applications after nose to brain delivery of therapeutic pharmaceuticals and biologicals

Nanotechnology Methods for Neurological Diseases and Brain Tumors

Nanotechnology Methods for Neurological Diseases and Brain Tumors Book
Author : Yasemin Gürsoy Özdemir,Sibel Bozdag Pehlivan,Emine Sekerdag
Publisher : Academic Press
Release : 2017-07-14
ISBN : 0128038004
Language : En, Es, Fr & De

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Book Description :

Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer’s, Parkinson’s and stroke, those that bypass the blood/brain barrier. The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery. In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors. Comprehensive guide for up-to-date views on the latest advances in targeted treatment strategies for brain tumors and neurological diseases Designed with a multidisciplinary approach that links neurology, neuro-oncology and nanoscience to drug delivery to the brain with an emphasis on the blood-brain-barrier Written in a language that makes it easy to understand nanotechnology drug delivery techniques Presents a unique book that also covers advanced treatment approaches of neurological diseases and brain tumors

Nanocarriers for Brain Targeting

Nanocarriers for Brain Targeting Book
Author : Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani
Publisher : CRC Press
Release : 2019-08-05
ISBN : 0429877544
Language : En, Es, Fr & De

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Book Description :

This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more. The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.

Nanoparticles for Brain Drug Delivery

Nanoparticles for Brain Drug Delivery Book
Author : Carla Vitorino,Andreia Jorge,Alberto A. C. C. Pais
Publisher : Jenny Stanford Publishing
Release : 2021-01-28
ISBN : 9789814877312
Language : En, Es, Fr & De

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Book Description :

In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. The book encompasses general aspects pertaining to fundamental development, including tripartite in silico-in vitro-in vivo approaches. It also covers a diversity of nanomedicines applied in treatment and/or diagnosis and monitoring of CNS disorders. Aspects concerning their translation from the bench to clinical practice are also seamlessly discussed. This book will inspire readers to discover possible approaches to holistically delivering drugs into the brain. Edited by Carla Vitorino, Andreia Jorge and Alberto Pais, this book will appeal to anyone involved in nanomedicine, pharmaceutics, neurological and cancer therapies, drug delivery research and computational and regulatory sciences.

In Vitro and In Vivo Tools in Drug Delivery Research for Optimum Clinical Outcomes

In Vitro and In Vivo Tools in Drug Delivery Research for Optimum Clinical Outcomes Book
Author : Ambikanandan Misra,Aliasgar Shahiwala
Publisher : CRC Press
Release : 2018-06-22
ISBN : 1351368729
Language : En, Es, Fr & De

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Book Description :

This book covers the essentials of drug delivery research and provides a unique forum for scientific experimental methods that are exclusively focused by the in-vitro, ex-vivo, and in-vivo methodologies of drug delivery research and felicitates translational research. The book includes recent and novel approaches in evaluation methods of transdermal, nasal, ocular, oral and intraoral, gastro-retentive, colon-targeted, and brain-targeted drug delivery systems. Providing up to date and comprehensive information, this text is invaluable to students, teachers, scientists, and others employed in the field of drug delivery.

Biomedical Index to PHS supported Research pt A Subject access A H

Biomedical Index to PHS supported Research  pt  A  Subject access A H Book
Author : Anonim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomedical Index to PHS supported Research pt A Subject access A H book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nanomedicines for Brain Drug Delivery

Nanomedicines for Brain Drug Delivery Book
Author : Javier O. Morales,Pieter J. Gaillard
Publisher : Humana
Release : 2020-11-20
ISBN : 9781071608371
Language : En, Es, Fr & De

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Book Description :

This volume explores the latest research in central nervous system (CNS) targeted nanocarriers, methods for their synthesis, and its characterization process. Chapters in this book cover topics such as polymeric nanoparticles and liposomes; self-assembled peptide-based scaffolds for lesions of the nervous system; use of peptides as CNS drugs and as potential carriers to optimize brain-targeted delivery; ways to model and assess blood brain barrier absorption of drugs; and the role of neurodegeneration progress of nanomaterials and their potential toxicity concerns. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Thorough and cutting-edge, Nanomedicines for Brain Drug Delivery is a valuable resource that will help researchers guide and advance the field of nanomedicines for the brain and nervous system.

Targeted Drug Delivery

Targeted Drug Delivery Book
Author : Rudolph L. Juliano
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642758622
Language : En, Es, Fr & De

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Book Description :

The chapters in this volume describe a powerful emerging approach for the therapy of disease. Targeted drug delivery, that is control of the kinetic behavior, tissue distribution, and subcellular localization of pharmaco logically active agents, offers an important means for improving the efficacy of a wide variety of drug therapies. This is particularly true for therapeutic approaches based on newer agents which are the products of recombinant DNA research. These agents, be they peptides, proteins, or oligonucleotides, tend to be larger, more complex, and less stable than traditional drugs. Thus they stand to benefit most from drug delivery systems which can protect them from premature degradation and which can carry them to critical target sites in the body. This volume examines several important aspects of the current state of drug delivery research; it also attempts to project future directions for this field. Successful approaches to drug targeting are based, first of all, on a sophisticated understanding of the biological barriers encountered by the drug-carrier complex as it moves from the portal of administration to the ultimate target site. A second aspect of successful drug delivery is appro priate matching of the disease entity with the pharmacologically active substance and with the delivery system. Thus it is important to be aware of the variety of delivery technologies which currently exist and to be sensitive to their strengths and limitations.

Carbon Nanotubes for Targeted Drug Delivery

Carbon Nanotubes for Targeted Drug Delivery Book
Author : Md Saquib Hasnain,Amit Kumar Nayak
Publisher : Springer Nature
Release : 2019-11-08
ISBN : 9811509107
Language : En, Es, Fr & De

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Book Description :

This book provides a detailed introduction to carbon nanotubes (CNTs) for targeted drug delivery. After a brief overview of the classification, preparation, and characterization of carbon nanotubes, it focuses on their use in targeted drug delivery. It presents CNTs for brain targeting, ocular targeting, cancer targeting, and lymphatic targeting, as well as antibody therapy. The book also includes chapters on carbon nanotubes for controlled drug delivery, transdermal drug delivery, solubility enhancement, vaccine delivery, gene delivery, and as quantum dots. Last but not least, it addresses the absorption and transportation of CNTs, toxicity and regulatory considerations, as well as clinical trials and the market status of CNTs. The book offers a comprehensive, self-contained reference guide, with all topics covered concisely and with the help of figures, tables and flowcharts.

Surface Modification of Nanoparticles for Targeted Drug Delivery

Surface Modification of Nanoparticles for Targeted Drug Delivery Book
Author : Yashwant V Pathak
Publisher : Springer
Release : 2019-03-11
ISBN : 3030061159
Language : En, Es, Fr & De

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Book Description :

This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics nano-particles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nanoparticles and also allows the nano particles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection essential information with various applications of surface modification of nanoparticles and their disease specific applications for therapeutic purposes.

The Blood Brain Barrier BBB

The Blood Brain Barrier  BBB  Book
Author : Gert Fricker,Melanie Ott,Anne Mahringer
Publisher : Springer
Release : 2014-10-24
ISBN : 3662437872
Language : En, Es, Fr & De

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Book Description :

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Drug Discovery Handbook

Drug Discovery Handbook Book
Author : Shayne C. Gad
Publisher : Wiley-Interscience
Release : 2005-07-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

THE FIRST COMPREHENSIVE GUIDE TO THE METHODS AND TECHNIQUES OF DRUG DISCOVERY The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.

Alkenes Advances in Research and Application 2012 Edition

Alkenes   Advances in Research and Application  2012 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-12-26
ISBN : 1464991308
Language : En, Es, Fr & De

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Book Description :

Alkenes—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Alkenes. The editors have built Alkenes—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Alkenes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Alkenes—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Brain Drug Targeting

Brain Drug Targeting Book
Author : William M. Pardridge
Publisher : Cambridge University Press
Release : 2001-05-31
ISBN : 9780521800778
Language : En, Es, Fr & De

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Book Description :

This challenging 2001 book reviews modern neurotherapeutics from the point of view of drug targeting.

The Virginia Journal of Science

The Virginia Journal of Science Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Virginia Journal of Science book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Discovery Technologies

Drug Discovery Technologies Book
Author : Colin Roy Clark
Publisher : Ellis Horwood
Release : 1990
ISBN : 9780470216040
Language : En, Es, Fr & De

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Book Description :

Download Drug Discovery Technologies book written by Colin Roy Clark, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Resistance in Epilepsy

Drug Resistance in Epilepsy Book
Author : Novartis Foundation
Publisher : Wiley-Blackwell
Release : 2002-04-26
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Drug resistance in epilepsy is an important clinical problem. About 20% of patients diagnosed as having epilepsy fail to respond to prescribed antiepileptic drugs and continue to have seizures. But despite the size of the problem, remarkably little attention has been paid to the biological basis of refractory epilepsy. Recent work has shown that brain tissue from some patients with epilepsy shows increased expression of a protein that mediates drug resistance in cancer, P glycoprotein. But while resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken with some success, resistance in epilepsy has only just begun to be addressed. This novel book brings together, for the first time, epilepsy researchers and oncologists, with a view to stimulating further work on drug resistance in epilepsy. Successfully bridging the two fields, the stimulating discussions contained in this book should be of great interest to those working on cancer resistance and refractory epilepsy alike.