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Brain Targeted Drug Delivery System

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Brain Targeted Drug Delivery Systems

Brain Targeted Drug Delivery Systems Book
Author : Huile Gao,Xiaoling Gao
Publisher : Academic Press
Release : 2018-09-20
ISBN : 012814002X
Language : En, Es, Fr & De

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Book Description :

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain. Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers Discusses key points in developing brain targeting drug delivery systems Summarizes and presents currently available strategies for brain targeting drug delivery Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research

Recent Development in Brain Targeted Drug Delivery System

Recent Development in Brain Targeted Drug Delivery System Book
Author : Sanket Gandhi,Girish Jani,Jignasha Solanki
Publisher : LAP Lambert Academic Publishing
Release : 2012-06
ISBN : 9783659159107
Language : En, Es, Fr & De

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Book Description :

The brain is a delicate organ, and evolution built very efficient ways to protect it. Unfortunately, the same mechanisms that protect it against intrusive chemicals can also frustrate therapeutic interventions. Many existing pharmaceuticals are rendered ineffective in the treatment of cerebral diseases due to our inability to effectively deliver and sustain them within the brain. General methods that can enhance drug delivery to the brain are, therefore, of great interest. The clinical failure of much potentially effective therapeutics is often not due to a lack of drug potency but rather to shortcomings in the method by which the drug is delivered. In response to the insufficiency in conventional delivery mechanisms, aggressive research efforts have recently focused on the development of new strategies to more effectively deliver drug molecules to the CNS.

Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors

Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors Book
Author : Prashant Kesharwani,Umesh Gupta
Publisher : Academic Press
Release : 2018-04-20
ISBN : 0128122498
Language : En, Es, Fr & De

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Book Description :

Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors

Nanocarriers for Brain Targeting

Nanocarriers for Brain Targeting Book
Author : Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani
Publisher : CRC Press
Release : 2019-08-27
ISBN : 0429877536
Language : En, Es, Fr & De

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Book Description :

This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more. The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.

Nanomedicines for Brain Drug Delivery

Nanomedicines for Brain Drug Delivery Book
Author : Javier O. Morales,Pieter J. Gaillard
Publisher : Humana
Release : 2020-11-20
ISBN : 9781071608371
Language : En, Es, Fr & De

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Book Description :

This volume explores the latest research in central nervous system (CNS) targeted nanocarriers, methods for their synthesis, and its characterization process. Chapters in this book cover topics such as polymeric nanoparticles and liposomes; self-assembled peptide-based scaffolds for lesions of the nervous system; use of peptides as CNS drugs and as potential carriers to optimize brain-targeted delivery; ways to model and assess blood brain barrier absorption of drugs; and the role of neurodegeneration progress of nanomaterials and their potential toxicity concerns. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Thorough and cutting-edge, Nanomedicines for Brain Drug Delivery is a valuable resource that will help researchers guide and advance the field of nanomedicines for the brain and nervous system.

Direct Nose to Brain Drug Delivery

Direct Nose to Brain Drug Delivery Book
Author : Chandrakantsing Pardeshi,Eliana Souto
Publisher : Academic Press
Release : 2021-06-25
ISBN : 0128225238
Language : En, Es, Fr & De

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Book Description :

Direct Nose to Brain Drug Delivery: Mechanism, Technological Advances, Applications and Regulatory Updates provides the reader with precise knowledge about the strategies and approaches for enhanced nose to brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration, includes an overview on the toxicity aspects of the various materials used to develop the direct nose to brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. Direct Nose to Brain Drug Delivery: Mechanism, Technological Advances, Applications and Regulatory Updates is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems, and novel drug administration devices for the treatment of neuro-ailments. Explains the targeting approaches for enhanced brain targeting following intranasal drug administration Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose to brain Discusses pharmaceutical and biomedical applications after nose to brain delivery of therapeutic pharmaceuticals and biologicals

Nanotechnology Methods for Neurological Diseases and Brain Tumors

Nanotechnology Methods for Neurological Diseases and Brain Tumors Book
Author : Yasemin Gürsoy Özdemir,Sibel Bozdag Pehlivan,Emine Sekerdag
Publisher : Academic Press
Release : 2017-07-14
ISBN : 0128038004
Language : En, Es, Fr & De

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Book Description :

Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer’s, Parkinson’s and stroke, those that bypass the blood/brain barrier. The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery. In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors. Comprehensive guide for up-to-date views on the latest advances in targeted treatment strategies for brain tumors and neurological diseases Designed with a multidisciplinary approach that links neurology, neuro-oncology and nanoscience to drug delivery to the brain with an emphasis on the blood-brain-barrier Written in a language that makes it easy to understand nanotechnology drug delivery techniques Presents a unique book that also covers advanced treatment approaches of neurological diseases and brain tumors

Exploitation of P glycoprotein at the Blood Brain Barrier for Targeted Drug Delivery

Exploitation of P glycoprotein at the Blood Brain Barrier for Targeted Drug Delivery Book
Author : Lindsey Anne Crawford
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Drug development for the central nervous system (CNS) has struggled to reach clinical approval. One reason many drugs do not advance into clinical applications is their low uptake in the CNS due to the blood brain barrier (BBB). Targeted drug delivery to the CNS has been well-studied for over 30 years, and recently has been focused on methods of BBB disruption (e.g., focused ultrasound), circumvention (e.g., convection enhanced delivery) or exploitation (e.g., receptor mediated targeting). Receptor mediated targeting is a method of active transport across the BBB by exploiting endogenous receptorligand interactions. The work outlined in this dissertation has studied a novel drug delivery method for receptor mediated targeting through the exploitation of P-glycoprotein (P-gp). P-gp is naturally overexpressed at the BBB and therefore makes an attractive target for CNS drug delivery. It was hypothesized that this new approach to CNS delivery could be accomplished by creating a polymeric nanoparticle delivery system with a P-gp substrate as a targeting moiety. The work focused on the development of a polylactide (PLA) nanoparticle containing a surfacetethered polyethylene glycol (PEG) linker terminated with rhodamine as a P-gp targeting moiety. Rhodamine dyes are a well-known class of P-gp substrates and the two used in this study, rhodamine 6G (Rho6G) and rhodamine 123 (Rho123) show high and moderate affinity to P-gp, respectively. Due to the novelty of this system, the PEG-Rho linker was first assessed in vitro to determine if it was still capable of interacting with P-gp as a substrate. It was evident that the conjugates of PEG-Rho still remained P-gp substrates; therefore, the PLA-PEG nanoparticle was developed to assess targeting of the drug delivery system in vivo. Before targeting efficiency could be measured in vivo a nanoparticle detection method was needed. The autofluorescence of various tissues poses a problem when considering nanoparticle detection by fluorescence in vivo. Therefore, the time resolved fluorescent properties of europium chelates were utilized to overcome autofluorescence challenges. Europium chelates continue to emit photons microseconds after excitation, whereas the autofluorescent molecules in tissues emit photons for only nanoseconds. By measuring photon emittance at microsecond timescales following excitation, the autofluorescent background was eliminated allowing sensitive detection of the nanoparticles in vivo. Once the Rho-PEG-PLA nanoparticle was synthesized and a detection method to track and quantify the particles in vivo was developed, the targeting efficiency of the systems was assessed. In a mouse model, Rho6G-PEG-PLA nanoparticles accumulated 2.6 times greater in the brain than untargeted control mPEG-PLA nanoparticles. Using a P-gp knockout mouse, the accumulation of Rho6G-PEG-PLA nanoparticles was shown to significantly decrease in the brain compared to the wild type mouse. Thus the conclusion was made that Rho6G-PEG-PLA nanoparticles can actively target P-gp at the BBB and can enhance the accumulation of drug delivery nanoparticles in the CNS.

In Vitro and In Vivo Tools in Drug Delivery Research for Optimum Clinical Outcomes

In Vitro and In Vivo Tools in Drug Delivery Research for Optimum Clinical Outcomes Book
Author : Ambikanandan Misra,Aliasgar Shahiwala
Publisher : CRC Press
Release : 2018-06-22
ISBN : 1351368710
Language : En, Es, Fr & De

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Book Description :

This book covers the essentials of drug delivery research and provides a unique forum for scientific experimental methods that are exclusively focused by the in-vitro, ex-vivo, and in-vivo methodologies of drug delivery research and felicitates translational research. The book includes recent and novel approaches in evaluation methods of transdermal, nasal, ocular, oral and intraoral, gastro-retentive, colon-targeted, and brain-targeted drug delivery systems. Providing up to date and comprehensive information, this text is invaluable to students, teachers, scientists, and others employed in the field of drug delivery.

Stochastic Modeling and Simulations of Targeted Drug Delivery Across Blood brain Barrier Using Nanoparticles

Stochastic Modeling and Simulations of Targeted Drug Delivery Across Blood brain Barrier Using Nanoparticles Book
Author : Hua Deng
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The existence of the blood-brain barrier (BBB) makes the treatment of brain diseases and cancers significantly challenging. The BBB strictly regulates the transport of molecules from the blood side into the brain parenchyma. Delivery of drug-loaded nanoparticle (NP) across BBB through receptor-mediated transcytosis (RMT) has been a promising strategy to overcome the obstacle. But the optimal design of nanoparticle for effective delivery across BBB is still a daunting task. The successful transport of nanoparticles across BBB through RMT is a complex and multi-stage process. The understanding of the mechanism of RMT is critical for the future drug delivery system.Firstly, the designed nanoparticle should be internalized at the blood side through endocytosis. Among which, the receptor dependent clathrin-mediated endocytosis (CME) is one of the most important pathways for the delivery of nanoparticles. In our study, we have built a stochastic computational model to investigate the CME based on Metropolis Monte Carlo simulations. The model systematically incorporates the ligand-receptor interactions, development of clathrin-coated pit (CCP) and membrane deformation during the CME. We also studied the influences of key designing parameters such as particle size and ligand density as well as membrane mechanical property on the CME. Secondly, to effectively deliver NPs across BBB, it is important not only enter the cell from the blood side but also release the cargo on the brain side. Different from CME, the exocytosis is proposed to be strongly regulated by the activity of actin filaments. Therefore, we developed a model for the exocytosis by considering the effect of actin tension and force. Combining the CME and exocytosis models together, we studied the overall impact of designing parameters on the whole transcytosis.Lastly, though most current nanocarriers designed in lab and clinical trials are spherical, the advancing of nanofabrication techniques enables the manufacturing of various shaped nanoparticles mimicking the viruses and bacteria in nature. The designing of nonspherical nanoparticle is of significant meaning for the future drug delivery system. Therefore, we extended our model to investigate the designing factors and overall transcytosis effectiveness of ellipsoidal nanoparticles in comparison to its spherical counterparts.

Nanocarriers for Brain Targeting

Nanocarriers for Brain Targeting Book
Author : Taylor & Francis Group
Publisher : Apple Academic Press
Release : 2021-03-31
ISBN : 9781774634127
Language : En, Es, Fr & De

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Book Description :

This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more. The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.

Membranes and Barriers

Membranes and Barriers Book
Author : Anonim
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Membranes and Barriers book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Carbon Nanotubes for Targeted Drug Delivery

Carbon Nanotubes for Targeted Drug Delivery Book
Author : Md Saquib Hasnain,Amit Kumar Nayak
Publisher : Springer Nature
Release : 2019-11-08
ISBN : 9811509107
Language : En, Es, Fr & De

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Book Description :

This book provides a detailed introduction to carbon nanotubes (CNTs) for targeted drug delivery. After a brief overview of the classification, preparation, and characterization of carbon nanotubes, it focuses on their use in targeted drug delivery. It presents CNTs for brain targeting, ocular targeting, cancer targeting, and lymphatic targeting, as well as antibody therapy. The book also includes chapters on carbon nanotubes for controlled drug delivery, transdermal drug delivery, solubility enhancement, vaccine delivery, gene delivery, and as quantum dots. Last but not least, it addresses the absorption and transportation of CNTs, toxicity and regulatory considerations, as well as clinical trials and the market status of CNTs. The book offers a comprehensive, self-contained reference guide, with all topics covered concisely and with the help of figures, tables and flowcharts.

Advanced Drug Delivery

Advanced Drug Delivery Book
Author : Ashim Mitra,Chi H. Lee,Kun Cheng
Publisher : John Wiley & Sons
Release : 2013-08-26
ISBN : 1118662849
Language : En, Es, Fr & De

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Book Description :

Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to datewith the state of the science, presenting the basics, formulationstrategies, and therapeutic applications of advanced drug delivery.The book demonstrates how core concepts of pharmaceutical sciences,chemistry, and molecular biology can be combined and applied inorder to spark novel ideas to design and develop advanced drugdelivery systems for the treatment of a broad range of humandiseases. Advanced Drug Delivery features contributions from aninternational team of pharmaceutical scientists. Chapters reflect athorough review and analysis of the literature as well as theauthors' firsthand experience developing drug delivery systems. Thebook is divided into four parts: Part I, Introduction and Basics of Advanced DrugDelivery, explores physiological barriers, stability,transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offerstested and proven strategies for advanced delivery of both smallmolecules and macromolecules Part III, Translational Research of Advanced DrugDelivery, focuses on regulatory considerations andtranslational applications of advanced drug delivery systems forthe treatment of cardiovascular diseases, cancer, sexuallytransmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery inEmerging Research Areas, examines stem cell research,cell-based therapeutics, tissue engineering, and molecularimaging Each chapter provides objectives and assessment questions tohelp readers grasp key concepts and assess their knowledge as theyprogress through the book. Advanced Drug Delivery is recommended for graduates andupper-level undergraduates in the pharmaceutical sciences who needa solid foundation in the basics. It is also recommended forpharmaceutical professionals who want to take advantage of new andemerging applications in advanced drug delivery systems.

Nanoparticulate Drug Delivery Systems

Nanoparticulate Drug Delivery Systems Book
Author : Raj K. Keservani,Anil K. Sharma
Publisher : CRC Press
Release : 2019-01-23
ISBN : 1351137247
Language : En, Es, Fr & De

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Book Description :

Focusing on nanoparticulate nanocarriers and recent advances in the field of drug delivery, the volume begins with chapters that provide an informative introduction to polymeric nanoparticles—their general physicochemical features and characteristics, their applications in drug delivery systems, and the challenges involved. Specific applications are discussed, with attention paid to treatment of particular diseases and disorders and the targeting of specific organs. Part 2 looks at more specific applications and techniques of nanoparticulate nanocarriers for drug delivery, such as the use of magnetic nanoparticles, gold nanoparticles in therapeutics, and superparamagnetic iron oxide nanoparticles (SPIONs) for the treatment of cancer. Part 3 discusses lipid-based nanoparticulates for various applications, including skin care. The last section of the book explores some of the newer nanoarchitectures, including dendrimers in gene delivery and carbon nanotubes for drug delivery. Together, the insightful research presented here provides valuable information for those involved in this area, including scientists and researchers and faculty and upper-level students, as well as for industry professionals.

Targeted Drug Delivery Concepts and Design

Targeted Drug Delivery   Concepts and Design Book
Author : Padma V. Devarajan,Sanyog Jain
Publisher : Springer
Release : 2014-12-08
ISBN : 3319113550
Language : En, Es, Fr & De

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Book Description :

This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Nanoparticles for Brain Drug Delivery

Nanoparticles for Brain Drug Delivery Book
Author : Carla Vitorino,Andreia Jorge,Alberto A.C.C. Pais
Publisher : CRC Press
Release : 2021-03-16
ISBN : 1000245632
Language : En, Es, Fr & De

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Book Description :

In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. The book encompasses general aspects pertaining to fundamental development, including tripartite in silico–in vitro–in vivo approaches. It also covers a diversity of nanomedicines applied in treatment and/or diagnosis and monitoring of CNS disorders. Aspects concerning their translation from the bench to clinical practice are also seamlessly discussed. This book will inspire readers to discover possible approaches to holistically delivering drugs into the brain. Edited by Carla Vitorino, Andreia Jorge and Alberto Pais, this book will appeal to anyone involved in nanomedicine, pharmaceutics, neurological and cancer therapies, drug delivery research and computational and regulatory sciences.

Neurotoxicity of Nanomaterials and Nanomedicine

Neurotoxicity of Nanomaterials and Nanomedicine Book
Author : Xinguo Jiang,Huile Gao
Publisher : Academic Press
Release : 2016-10-03
ISBN : 0128046201
Language : En, Es, Fr & De

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Book Description :

Neurotoxicity of Nanomaterials and Nanomedicine presents an overview of the exciting research in neurotoxicity and nanomaterials. Nanomaterials have been extensively used in medicine, including diagnosis probes, drug carriers, and embedded materials. While some have been approved for clinical use, most nanomaterials are waiting to be transferred from lab to clinic. However, the toxicity is a main barrier that restricts the translation. This comprehensive book includes chapters on the most commonly used individual nanoparticles, with information on the applications, neurotoxicity, and related mechanisms of each, providing the most in-depth and current information available. The book examines the pathways that nanomaterials enter into, and eliminate, from the brain, along with the strategies that could reduce the neurotoxicity of nanomaterials. Providing a background to the subject, detailed information, and ideas for future directions in research, the book is essential for students and researchers in toxicology, and for those in medicine, neurology, pharmacology, pharmaceutical science, and materials science who are researching nanomaterials. Presents a thorough discussion of the most common nanoparticles in the brain and their neurotoxicology Includes the most common nanoparticles, their applications, and mechanisms Provides one of the first books to focus on nanomedicine and neurotoxicity

Teaching an Old Drug New Tricks

Teaching an Old Drug New Tricks Book
Author : Zachary Nielson Warnken
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A major barrier to the treatment of central nervous system delivery is the ability to target drug delivery to the brain. The brain is protected by the blood-brain barrier, making it difficult for both small and especially large molecule drugs to reach their sight of action. With recent advancements in high throughput screening, some already marketed drugs have been found to be active in treating central nervous system diseases such as glioblastoma multiforme (GBM), however, some of these drugs are insufficient in their current forms to reach the brain and treat the disease. Nasal drug delivery is a promising route of delivery for treating central nervous system disease as it has shown the ability to directly transport drugs to the brain, bypassing the blood-brain barrier. Critical aspects to using nasal drug delivery to treat central nervous system diseases are the ability to target the formulation to specific sites in the nasal cavity as well as the ability of formulations to drive transport to the brain. In addition to nasal drug delivery, some drugs can benefit from improvements in bioavailability orally to increase brain exposure. Amorphous solid dispersions are a technique widely used to improve the bioavailability of the poorly-water soluble drugs however they are limited in their use for highly lipophilic drugs due to drug loading limitations. This research focuses on better understanding nasal drug delivery to leverage ways to better target sites in the nasal cavity. In addition to this targeting research, research that supports the in vitro tests for analyzing and assessing nasal drug delivery devices has been performed. Personalized nasal drug delivery in 3D-printed casts is shown to be a superior method for targeting a particular region of the nasal cavity due to the variation in individual’s nasal geometry. A large focus of the research has been to repurpose atovaquone for the treatment of glioblastoma. This research provides evidence of the benefits a new formulation strategy which incorporates a spontaneously emulsifying component into the classical amorphous solid dispersion to overcome its limitations with the highly lipophilic nature of atovaquone. The improved formulation alongside results showing activity of atovaquone against GBM present a promising repurposing strategy for atovaquone to be used in the treatment of GBM

Nanocarriers for Brain Targeting

Nanocarriers for Brain Targeting Book
Author : Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani
Publisher : CRC Press
Release : 2019-08-05
ISBN : 0429877544
Language : En, Es, Fr & De

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Book Description :

This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more. The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.