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Botulinum Neurotoxin

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Botulinum Toxin E Book

Botulinum Toxin E Book Book
Author : Joseph Jankovic,Alberto Albanese,M. Zouhair Atassi,J. Oliver Dolly,Mark Hallett,Nathaniel H. Mayer
Publisher : Elsevier Health Sciences
Release : 2009-02-18
ISBN : 1437711197
Language : En, Es, Fr & De

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Book Description :

The new, therapeutically-focused Botulinum Toxin presents comprehensive, cross-disciplinary guidance on current practices, covering more than 100 non-cosmetic conditions that occur in neurology, physical medicine and rehabilitation, pain medicine, ophthalmology, gastroenterology, urology, orthopedics, and surgery. International contributors review the current understanding of the biology and cellular mechanisms along with relevant research so you can easily apply them to the pathophysiology of the numerous disorders that botulinum toxin is used to treat—such as botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. With discussions of the latest in approved treatment practices as well as new and emerging uses, you’ll get in-depth management guidance on the application of the toxin. Provides clinical applications of botulinum toxin for over 100 disorders for immediate access and easy reference during practice and treatment. Covers a broad array of hot topics, including botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. Focuses on approved uses with expert advice on thoroughly tested applications but also discusses new and emerging applications to expose you to additional treatment options. Presents the most comprehensive and up-to-date material available so you get all the information you need from this one resource. Offers the cross-disciplinary guidance of the best world-class expertise through an authoritative, international group of authors who demonstrate the applications of botulinum toxin across various specialties.

Botulinum Neurotoxin Injection Manual

Botulinum Neurotoxin Injection Manual Book
Author : Katharine E. Alter, MD,Nicole A. Wilson, PhD, MD
Publisher : Demos Medical Publishing
Release : 2014-12-15
ISBN : 1617052094
Language : En, Es, Fr & De

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Book Description :

The Essential Guide for Clinicians Who Prescribe and Inject BoNTs This is a detailed and practical guide to botulinum neurotoxin therapy (BoNT) and the wide range of applications for neurological and pain disorders. A unique reference source for new injectors and experienced clinicians alike, this indispensable manual provides information on dose, dilution, and indications for all four FDA-approved toxins in one handy text. Following a brief review of relevant pharmacology, the book provides product information and comparative distinctions between the four FDA-approved toxins (BotoxÆ, MyoblocÆ, XeominÆ, and DysportÆ), along with indications and doses for FDA-approved conditions, guidance techniques, and common and emerging clinical applications. The heart of the book is an injection manual, organized anatomically and by condition and covering all applications for medical treatment. For each condition or site, information is provided on typical muscle pattern or muscle groups involved, dosing guidelines and dilution for the applicable toxins, number of injection sites, and potential risks and benefits. Targeting techniques are organized in table format for quick retrieval. Anatomic illustrations and cross-sections are provided to orient injectors and help identify optimal insertion points. An appendix with useful clinical rating scales is also included. Key Features: Presents state-of-the-art information about current indications for all four FDA-approved botulinum neurotoxins Compares and contrasts the four toxins along with common and emerging clinical applications Provides dosing guidelines for various indications and injection sites for each muscle Includes anatomic drawings and cross-sections to illustrate muscle relationships and insertion points Serves as a practical, portable, how-to guide for new and experienced clinicians

Molecular Aspects of Botulinum Neurotoxin

Molecular Aspects of Botulinum Neurotoxin Book
Author : Keith A. Foster
Publisher : Springer
Release : 2014-07-08
ISBN : 1461494540
Language : En, Es, Fr & De

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Book Description :

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation with a focus on clinical application. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Clinical Applications of Botulinum Neurotoxin

Clinical Applications of Botulinum Neurotoxin Book
Author : Keith A. Foster
Publisher : Springer
Release : 2014-07-08
ISBN : 149390261X
Language : En, Es, Fr & De

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Book Description :

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Botulinum Neurotoxin and Tetanus Toxin

Botulinum Neurotoxin and Tetanus Toxin Book
Author : Lance Simpson
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0323141609
Language : En, Es, Fr & De

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Book Description :

Botulinum Neurotoxin and Tetanus Toxin covers the mechanism of action, pathogenesis, and treatment of clostridial neurotoxins. The book is organized into four parts encompassing 18 chapters that discuss the origin, structure, pharmacology, toxicology, immunology, assays, and clinical issues of botulinum and tetanus neurotoxins. The introductory part of the book discusses the discovery and production of neurotoxins in various strains of Clostridium bacteria. This text also describes how specific bacteriophages and plasmids mediate the pathogenicity of some types of Clostridium botulinum and Clostridium tetani. The subsequent part provides an overview of issues related to toxin binding, including toxins that may serve as models for botulinum and tetanus neurotoxins. Discussions on the peripheral and central aspects of poisoning transport in the central nervous system and on the antagonistic drugs for clostridial neurotoxins are provided. The third part of the book addresses the antibodies against botulinum neurotoxin. Bioassay in mice and highly sensitive immunoassays, such as reversed passive hemagglutination, reversed passive latex agglutination, radioimmunoassay, and enzyme-linked immunosorbent assay, are presented. The concluding part covers the animal models for these toxins and discusses the diagnosis and treatment of botulism and tetanus in human. The clinical use of Clostridium botulinum toxin type A in ocular and neuromuscular disease is also examined. This book will be of value to protein chemists, microbiologists, virologists, pharmacologists, immunologists, and clinicians.

Botulinum Neurotoxin A Multifunctional Protein for the Development of New Therapeutics

Botulinum Neurotoxin  A Multifunctional Protein for the Development of New Therapeutics Book
Author : Elena Fonfria
Publisher :
Release : 2018
ISBN :
Language : En, Es, Fr & De

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Book Description :

Botulinum neurotoxin (BoNT) is a major therapeutic agent licensed in neurological indications such as dystonia and spasticity. In recent years, its use has steadily increased in other neurological areas and new therapeutic areas and also in the aesthetic setting. Paradoxically, BoNT is also the causative agent of the disease botulism and a potential bioterrorism toxin. The BoNT family of toxins comprised more than 40 individual members, classified into 7 serotypes and are produced by Gram-positive obligate anaerobic bacteria. BoNTs are enzymatic multi-modular proteins with a complex multistep mechanism of action. Their target site is at peripheral neurons, particularly the neuromuscular junction, at which they inhibit acetylcholine neurotransmission. Despite intense activity in the BoNT field, today there are still gaps in knowledge both in clinical practice and in basic research. The discovery of the structure-function of BoNT and its domains has allowed rational design of new features using molecular engineering. The diversity of BoNT molecules, both natural and engineered, is an invaluable pool from which to design future new therapeutics with unique pharmacological properties for current and novel indications.

Botulinum Neurotoxins

Botulinum Neurotoxins Book
Author : Andreas Rummel,Thomas Binz
Publisher : Springer Science & Business Media
Release : 2012-12-14
ISBN : 3642335705
Language : En, Es, Fr & De

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Book Description :

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

The Use of Botulinum Neurotoxin Type A in Aesthetics

The Use of Botulinum Neurotoxin Type A in Aesthetics Book
Author : N.A
Publisher :
Release : 2017
ISBN :
Language : En, Es, Fr & De

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Book Description :

Abstract : BACKGROUND: The most common aesthetic procedure performed worldwide is the injection of botulinum neurotoxin Type A (BoNT-A). Aesthetic providers must fully comprehend the objective scientific data, theoretical mechanisms of action, and differences between brands of BoNT-A. OBJECTIVE: To determine and review the relevant clinical postulates for the use of botulinum toxin in aesthetics. MATERIALS AND METHODS: The BoNT-A clinical postulates presented here discuss how each brand of BoNT-A acts identically, how the molecular potency may vary between the different products, how patient age, gender, genetics, and muscle mass cause variation in toxin receptor number and density, and how both practitioner and patient can affect toxin distribution. RESULTS: A total of 8 clinical postulates have been identified that are key to understanding the use of botulinum toxin in aesthetics and to obtaining the best clinical results. CONCLUSION: All of these factors affect the potential efficacy of the injected toxin and hence the aesthetic results obtained.

Hyperhidrosis and Botulinum Toxin in Dermatology

Hyperhidrosis and Botulinum Toxin in Dermatology Book
Author : Oliver Philip Kreyden,Roland Böni,Günter Burg
Publisher : Karger Medical and Scientific Publishers
Release : 2002
ISBN : 3805573065
Language : En, Es, Fr & De

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Book Description :

In this publication a comprehensive overview on the pathophysiology and treatment of hyperhidrosis with a focus on the new therapy with botulinum toxin is given by renowned experts from Europe and the USA. In the first part the pathophysiology of hyperhidrosis, rare forms of sweating and their symptoms, as well as the different topical and surgical treatments for focal hyperhidrosis are discussed. The second part deals with botulinum toxin. Besides a historic survey of the drug the reader is introduced to the pharmacological particularities and the different modalities of treatment for focal hyperhidrosis. Complications and side effects of the therapy are presented as well. The final chapter is reserved for other dermatological indications like anal fissure and wrinkles.

Manual of Botulinum Toxin Therapy

Manual of Botulinum Toxin Therapy Book
Author : Daniel Truong,Dirk Dressler,Mark Hallett,Christopher Zachary
Publisher : Cambridge University Press
Release : 2014-01-23
ISBN : 1107654335
Language : En, Es, Fr & De

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Book Description :

Fully updated throughout, the second edition of the Manual of Botulinum Toxin Therapy provides practical guidance on the use of Botox in a wide variety of disorders. New chapters have been added on the use of botulinum toxin in wound healing, in focal hand dystonia and in thoracic outlet syndrome, as well as others. There are new chapters on the use of botulinum toxins in conjunction with ultrasound guidance. Using clear line-drawings the Manual describes the relevant injection sites for each condition and gives comparative dosage tables for the various formulations of toxins used in different muscle groups. Throughout the emphasis is on technique and the book can be used as both a teaching aid and in bedside guidance. The manual will be of use to neurologists, otolaryngologists, urologists, ophthalmologists, dermatologists, internists, pain management specialists, rehabilitation specialists and plastic surgeons, and any other clinicians discovering the potential of botulinum toxin.

Botulinum Toxin in Clinical Dermatology

Botulinum Toxin in Clinical Dermatology Book
Author : Anthony V. Benedetto
Publisher : CRC Press
Release : 2006-01-13
ISBN : 0203495055
Language : En, Es, Fr & De

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Book Description :

Botulinum Toxin in Clinical Dermatology explores botulinum toxin, from its early recognition as a food borne toxin to its current form as a pharmaceutical injectible. This high quality, well-illustrated, practical manual presents the latest on the clinical use of the different types of botulinum toxins available and presents in a clear and concise way all the pertinent and up-to-date information on how to inject botulinum toxin and avoid complications. Packed with clinical photographs and scientific drawings, each chapter addresses a different aspect of the topic. This is the most comprehensive and authoritative reference for cosmetic injections of botulinum toxin for removal of facial and neck wrinkles.

Botulinum Toxin Dosing Manual

Botulinum Toxin Dosing Manual Book
Author : Katharine E. Alter, MD,Nicole A. Wilson, PhD, MD
Publisher : Springer Publishing Company
Release : 2020-12-15
ISBN : 0826147666
Language : En, Es, Fr & De

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Book Description :

Configured for quick point-of-care consult, Botulinum Toxin Dosing Manual is the must-have resource for practitioners and trainees at any level. This practical compendium provides comprehensive information on applications and dosing guidelines for all four FDA-approved toxins, and also includes agency-approved indications and ranges for Canada, the UK, and selected EU countries. Detailed botulinum toxin (or neurotoxin) (BoNT) dosage information is presented in an easy-to-navigate table format. The tables are organized by clinical indication along with each agency-approved dosage where available and the published dosage ranges per treatment session and per structure injected. Covering applications for neurological, urological, neurosecretory, and pain conditions with side-by-side product dosing comparisons, the guide allows clinicians to quickly calculate the dosage of a given BoNT product for a particular indication and/or structure and choose the best option for treatment. Anatomical illustrations are provided at the end of the book to enhance the localization of muscles and other target structures during the injection planning process. This handy manual is indispensable for new injectors and experienced clinicians alike, who need to stay current with the ever-expanding indications and dosage recommendations to create effective treatment plans for their patients. Key Features: Up-to-date guidelines and dosage ranges for FDA-approved botulinum toxins and applications for adults and children; includes agency-approved ranges for Canada, the UK, and EU Current information on published dosage ranges from studies for FDA-approved botulinum toxins fit for adults and children for most clinical applications Information organized in user-friendly table format to speed dosage calculation for clinicians treating patients with BoNT Published dosing recommendations for a wide variety of indications by muscle or group, dilution, injection sites, and more Anatomic drawings illustrate muscle relationships and insertion points

Botulinum Toxin Treatment of Pain Disorders

Botulinum Toxin Treatment of Pain Disorders Book
Author : Bahman Jabbari
Publisher : Springer
Release : 2015-03-23
ISBN : 1493925016
Language : En, Es, Fr & De

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Book Description :

This book provides an authoritative overview of botulinum neurotoxin (BoNT) treatment menus for 14 pain categories with an evidence based literature review on each pain disorder, illustrative figures along with brief video clips showing the techniques and patient interviews. Introductory chapters cover basic information about the mechanism, function and the analgesic effects of the BoNTs based on the data derived from animal studies. Clinical chapters define pain in conditions such as post-herpetic and post-traumatic neuralgias, plantar fasciitis, low back pain, post-surgical pain syndromes and migraine in detail, provide discussion of current modes of treatment and updated information on BoNT therapy. Each chapter also includes illustrative case histories. Botulinum Toxin Treatment of Pain Disorders will prove an invaluable resource for clinicians and researchers involved in the treatment of pain disorders including neurologists, pain medicine specialists, anesthesiologists, internists, those conducting research in pharmacology and toxicology as well as students in these areas.

Botulinum Neurotoxin for Head and Neck Disorders

Botulinum Neurotoxin for Head and Neck Disorders Book
Author : Andrew Blitzer,Brian Benson,Diana Kirke
Publisher :
Release : 2020
ISBN : 9781684200955
Language : En, Es, Fr & De

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Book Description :

The most comprehensive, state-of-the-art guide available on the use of botulinum neurotoxin for head & neck disorders! Senior author Andrew Blitzer is an internationally renowned pioneer on the use of botulinum neurotoxin for functional disorders, with unparalleled expertise on this topic. Joined by esteemed co-editors Brian Benson and Diana Kirke, with multidisciplinary contributors, Botulinum Neurotoxin for Head and Neck Disorders Second Edition fills a gap in the medical literature. The unique textbook focuses on the use of botulinum neurotoxins for functional disorders of the head and neck, though with some aesthetic indications. The second edition reflects the latest advances and understanding of existing and emerging applications for botulinum neurotoxins, including new treatment paradigms, revised pharmacology, and an updated review of the literature in all chapters. Twenty superbly illustrated chapters cover the management of hyperfunctional, pain, and hypersecretory syndromes of the head and neck. Hyperfunctional motor disorders are discussed in chapters focused on blepharospasm, facial dystonia, Meige syndrome, oromandibular dystonia, spasmodic dysphonia (laryngeal dystonia), and cervical dystonia. Specific treatment approaches for pain are addressed in chapters on migraine and chronic daily tension headaches, temporomandibular disorders, and trigeminal neuralgia. The treatment of autonomic nervous system disorders is covered in chapters dedicated to Frey syndrome, facial hyperhydrosis, and sialorrhea. Key Features A 30-year review of spasmodic dysphonia data includes new insights encompassing comprehensive treatment, management and outcomes results, and neuropathophysiology A new chapter details the emerging role of botulinum neurotoxin to treat radiation-induced spasm and pain Updates on the management of palatal myoclonus, temporomandibular joint disorder, and sialorrhea An impressive compendium of professional injection videos, including a new video on sialorrhea and an updated migraine video Clinical pearls throughout the book focus on best practices, how to avoid pitfalls, and achieving the most optimal outcomes This is a must-have resource for otolaryngologists-head and neck surgeons, neurologists, dentists, pain specialists, physical medicine and rehabilitation specialists, and others health professionals who use botulinum neurotoxin to treat motor, sensory, and autonomic disorders of the head and neck region. This book includes complimentary access to a digital copy on https://medone.thieme.com.