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Botulinum Neurotoxin

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Botulinum Neurotoxin Injection Manual

Botulinum Neurotoxin Injection Manual Book
Author : Katharine E. Alter, MD,Nicole A. Wilson, PhD, MD
Publisher : Demos Medical Publishing
Release : 2014-12-15
ISBN : 1620700425
Language : En, Es, Fr & De

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Book Description :

This comprehensive yet practical guide covers botulinum toxin injections and the wide range of clinical applications for neurologic and other conditions. Intended as both as an introduction for new injectors and a handy reference guide for busy clinicians, the book opens with a brief review of pharmacology, product information and distinctions between the four toxins that are currently approved for use in the U.S. by the FDA, indications and doses for FDA-approved conditions, and accepted and emerging clinical applications. The remainder is an injection manual, organized anatomically and by condition and covering all applications. For each condition or site, information on typical muscle pattern or muscle groups involved, dosing guidelines and dilution for the applicable toxins, number of injection sites and targeting techniques are provided in table format for quick look-up. Anatomic illustrations and cross-sections appear on facing pages to orient injectors and help identify optimal insertion points. An appendix with useful clinical rating scales is also included.

Clinical Applications of Botulinum Neurotoxin

Clinical Applications of Botulinum Neurotoxin Book
Author : Keith A. Foster
Publisher : Springer
Release : 2014-07-08
ISBN : 149390261X
Language : En, Es, Fr & De

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Book Description :

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Botulinum Neurotoxin and Tetanus Toxin

Botulinum Neurotoxin and Tetanus Toxin Book
Author : Lance Simpson
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0323141609
Language : En, Es, Fr & De

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Book Description :

Botulinum Neurotoxin and Tetanus Toxin covers the mechanism of action, pathogenesis, and treatment of clostridial neurotoxins. The book is organized into four parts encompassing 18 chapters that discuss the origin, structure, pharmacology, toxicology, immunology, assays, and clinical issues of botulinum and tetanus neurotoxins. The introductory part of the book discusses the discovery and production of neurotoxins in various strains of Clostridium bacteria. This text also describes how specific bacteriophages and plasmids mediate the pathogenicity of some types of Clostridium botulinum and Clostridium tetani. The subsequent part provides an overview of issues related to toxin binding, including toxins that may serve as models for botulinum and tetanus neurotoxins. Discussions on the peripheral and central aspects of poisoning transport in the central nervous system and on the antagonistic drugs for clostridial neurotoxins are provided. The third part of the book addresses the antibodies against botulinum neurotoxin. Bioassay in mice and highly sensitive immunoassays, such as reversed passive hemagglutination, reversed passive latex agglutination, radioimmunoassay, and enzyme-linked immunosorbent assay, are presented. The concluding part covers the animal models for these toxins and discusses the diagnosis and treatment of botulism and tetanus in human. The clinical use of Clostridium botulinum toxin type A in ocular and neuromuscular disease is also examined. This book will be of value to protein chemists, microbiologists, virologists, pharmacologists, immunologists, and clinicians.

Molecular Aspects of Botulinum Neurotoxin

Molecular Aspects of Botulinum Neurotoxin Book
Author : Keith A. Foster
Publisher : Springer
Release : 2014-07-08
ISBN : 1461494540
Language : En, Es, Fr & De

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Book Description :

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation with a focus on clinical application. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Botulinum toxins in dermatology

Botulinum toxins in dermatology Book
Author : Joel L. Cohen
Publisher : John Wiley & Sons
Release : 2013
ISBN : 1444338250
Language : En, Es, Fr & De

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Book Description :

Download Botulinum toxins in dermatology book written by Joel L. Cohen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Botulinum Neurotoxins for Head and Neck Disorders

Botulinum Neurotoxins for Head and Neck Disorders Book
Author : Andrew Blitzer,Brian E. Benson,Joel Guss
Publisher : Thieme
Release : 2012-03-28
ISBN : 1604065869
Language : En, Es, Fr & De

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Book Description :

Learn expert injection techniques with this multimedia reference guide to the therapeutic uses of botulinum neurotoxin Containing detailed injection instructions, Botulinum Neurotoxin for Head and Neck Disorders and the associated how-to videos offer otolaryngologists, neurologists, pain specialists, and others a complete guide to the management of motor, sensory and autonomic disorders of the head and neck region with botulinum neurotoxin. It covers treatment methods for conditions ranging from hyperfunctional motor disorders (dystonia, tremor, dysphagia), to afferent pain disorders (temporomandibular joint disorder, migraine, trigeminal neuralgia) to autonomic disorders (hypersalivation, Frey's syndrome). In each of the indications, the written material reviews the effects of the toxin on the nervous system, central pain thresholds, and central motor pathways. Special Features: Reviews the pharmacology, indications, mechanisms of action, and technique for each use of botulinum neurotoxin Provides detailed information on the anatomy, treatment methods, follow-up care, and possible complications for each disorder Includes online access to professionally produced videos in which Dr. Blitzer demonstrates injection techniques for the disorders in the book Contains vivid, full color illustrations and photographs that clarify information in the text Focusing specifically on injection techniques for the therapeutic uses of botulinum neurotoxin for treating head and neck disorders, this manual fills an important gap in the literature. It gives clinicians current, authoritative, and in-depth information on administering botulinum neurotoxin most effectively for the head and neck disorders of their patients.

Manual of Botulinum Toxin Therapy

Manual of Botulinum Toxin Therapy Book
Author : Daniel Truong,Mark Hallett,Dirk Dressler,Christopher Zachary
Publisher : Cambridge University Press
Release : 2014-01-23
ISBN : 1107025354
Language : En, Es, Fr & De

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Book Description :

"This book tries to answer many of the questions posed above with the contributions of a team of international experts. As in the first edition, the emphasis in this book is on technique, so it is richly endowed with illustrations concerning accurate access techniques to help physicians become facile and fully competent"--Provided by publisher.

Botulinum Toxin in Clinical Dermatology

Botulinum Toxin in Clinical Dermatology Book
Author : Anthony V. Benedetto
Publisher : CRC Press
Release : 2006-01-13
ISBN : 0203495055
Language : En, Es, Fr & De

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Book Description :

Botulinum Toxin in Clinical Dermatology explores botulinum toxin, from its early recognition as a food borne toxin to its current form as a pharmaceutical injectible. This high quality, well-illustrated, practical manual presents the latest on the clinical use of the different types of botulinum toxins available and presents in a clear and concise way all the pertinent and up-to-date information on how to inject botulinum toxin and avoid complications. Packed with clinical photographs and scientific drawings, each chapter addresses a different aspect of the topic. This is the most comprehensive and authoritative reference for cosmetic injections of botulinum toxin for removal of facial and neck wrinkles.

Botulinum Neurotoxins

Botulinum Neurotoxins Book
Author : Andreas Rummel,Thomas Binz
Publisher : Springer
Release : 2015-01-29
ISBN : 9783642448898
Language : En, Es, Fr & De

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Book Description :

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

Botulinum and Tetanus Neurotoxins

Botulinum and Tetanus Neurotoxins Book
Author : B.R. DasGupta
Publisher : Springer Science & Business Media
Release : 2013-11-11
ISBN : 1475795424
Language : En, Es, Fr & De

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Book Description :

Three days in Madison have thoroughly modified my view on clostridial neurotoxins. While still realizing the numerous activating, modifying and protective inputs, I cannot judge the meaningfulness of the meeting impartially. Neither may the reader expect a complete summary of all presentations. Collected in this volume, they speak for themselves without requiring an arbiter. Instead I shall write down my very personal opinions as a researcher who has studied clostridial neurotoxins for nearly 25 years. Comparable conferences have been rare during this time. A comprehensive symposium 4 on C. botulinum neurotoxins has been organized at Ft. Detrick. International conferences on tetanus have been held regularly under the auspices of the Wodd Health Organization. One or maximally two days of these meetings have been devoted to tetanus toxin and its actions whereas the sponsor and the majority of the participants have been interested mainly in epidemiology, prevention and treatment of tetanus as a disease (see refs. 5,6). Some aspects of clostridial neurotoxins have been addressed in the context of bacterial toxins, in particular in the biennial European workshops. 1-3,7,8 The Madison meeting differed from the previous ones in three aspects. First, it covered both tetanus and botulinum neurotoxins. The fusion was justified because of their huge similarities in primary structure, in their mode of action and in their cellular targets. Second, the meeting was not limited to toxins but drew some lines on which modern neurobiology might proceed.

Botulinum Toxin Treatment in Surgery Dentistry and Veterinary Medicine

Botulinum Toxin Treatment in Surgery  Dentistry  and Veterinary Medicine Book
Author : Bahman Jabbari
Publisher : Springer Nature
Release : 2020-10-06
ISBN : 3030506916
Language : En, Es, Fr & De

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Book Description :

All books on the market which have been written on the subject of botulinum toxin therapy focus on treatment of hyperactive movement disorders, autonomic dysfunction (bladder, sweat and salivary glands) and some pain indications (migraine). Reference to pre-or post -surgical indications are brief and often out-dated. No book has information on dentistry or veterinary medicine. This book provides up-to-date information on botulinum toxin therapy in surgical fields. It is also the only book in the market that provides information on botulinum toxin therapy in dentistry and veterinary medicine, furnishing the latest information. Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine appeals to many disciplines including surgery, dentistry and veterinary medicines well as appealing to neurologists and internists.

Botulinum Toxin in Urology

Botulinum Toxin in Urology Book
Author : Michael B. Chancellor,Christopher P. Smith
Publisher : Springer Science & Business Media
Release : 2011-06-24
ISBN : 9783642035807
Language : En, Es, Fr & De

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Book Description :

Bladder injection of onabotulinumtoxinA for the treatment of urinary incontinence due to neurogenic detrusor overactivity has recently been approved by regulatory agencies in several EU countries and by the FDA in the United States. This is the first book to focus on the practical application of botulinum toxin (BoNT) in the genitourinary tract. It covers in detail applications of BoNT in the bladder and the prostate and pelvic floor, with reviews of the latest clinical series and techniques in both adults and children. Appendices containing easy-to-read instructions for patients undergoing bladder and prostate BoNT injections are included, in addition to procedural guidelines for nursing staff. The book is written in a concise, clinically relevant style by two leading pioneers in the field, who were the first to undertake comprehensive basic research into the mechanisms underlying the efficacy and potential uses of BoNT within the lower urinary tract.

Botulinum Neurotoxins and Nervous System

Botulinum Neurotoxins and Nervous System Book
Author : Siro Luvisetto
Publisher : MDPI
Release : 2020-11-06
ISBN : 303943456X
Language : En, Es, Fr & De

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Book Description :

This book collects 25 scientific articles from laboratories around the world, all of which use botulinum neurotoxins as the main protagonists of their studies. The use of botulinum neurotoxin in medicine, following its ability to inhibit the effects of various disorders of different etiology on the human organism, constitutes the main topic of each article presented here. This book, which is aimed at both students and medical professionals, attempts to summarize current knowledge about the use of botulinum toxin as a therapeutic agent in many diseases, ranging from spasticity to tremor, form motor dysfunction after stroke to neuropathic pain, from hyperactive muscle to migraine, and so on. Thanks to its simplified writing, accessible to an audience who may not be familiar with the mysteries of science, readers will get new insights into this biological toxin and its multiple applications, not simply relegated to its historical use to correct of face wrinkles. Both review and research articles are presented, not only concerning animal studies, but also clinical reports. This book will provide an up-to-date picture of the state-of-the-art of the possible development of novel applications of botulinum neurotoxins for future therapeutic purposes.

Characterization and Stabilization of Clostridium Botulinum Neurotoxin for Medical Use

Characterization and Stabilization of Clostridium Botulinum Neurotoxin for Medical Use Book
Author : Michael Charles Goodnough
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Characterization and Stabilization of Clostridium Botulinum Neurotoxin for Medical Use book written by Michael Charles Goodnough, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Botulinum Neurotoxin Production by Clostridium Botulinum Strain Loch Maree

Botulinum Neurotoxin Production by Clostridium Botulinum Strain Loch Maree Book
Author : Sherly Bellevue
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Botulinum Neurotoxin Production by Clostridium Botulinum Strain Loch Maree book written by Sherly Bellevue, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Botulinum Neurotoxin

Botulinum Neurotoxin Book
Author : Chong-Tae Kim
Publisher : Elsevier
Release : 2021-05-28
ISBN : 9780323697156
Language : En, Es, Fr & De

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Book Description :

A practical, how-to guide for both new and experienced clinicians, Botulinum Neurotoxin: A Guide to Motor Point Injections identifies the correct motor points for botulinum neurotoxin (BoNT) injections for non-cosmetic purposes such as muscle dystonia, muscle spasticity, teeth grinding, or drooling. Dr. Chong-Tae Kim expertly guides readers through the efficient blocking of neurotransmitters using BoNT, identifying target muscles and clearly demonstrating how to identify optimal insertion points. Covers both the upper and lower extremities and how to select target muscles for specific deformities. Includes illustrations and photographs to illustrate muscle relationships and correct insertion points. Uses consistent labelling and coding throughout to provide an easy-to-follow, image-guided approach. Presents information in two parts: Part 1 covers BoNT injections to individual motor points of muscles of the face, neck, trunk, and extremities, along with superb visual guidance. Part 2 discusses how to select target muscles for BoNT injections to treat deformities caused by muscle hyperactivity. Consolidates today's available information on this timely topic into a single, convenient resource

Treatments from Toxins

Treatments from Toxins Book
Author : Keith Alan Foster,Peter Hambleton,Clifford C. Shone
Publisher : CRC Press
Release : 2006-11-02
ISBN : 1420004158
Language : En, Es, Fr & De

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Book Description :

As little as two decades ago, deliberately injecting botulinum toxin into patients would have seemed foolhardy at best and criminal at worst. The increased clinical use of botulinum toxins has expanded the body of knowledge available on the structure and function of these proteins. This knowledge can be applied to topics as varied as therapies based on the endopeptidase activity of the toxins, vaccine development, protection against botulism, and vectors for neuronal drug delivery. Based on recent scientific and clinical information from top international authorities, Treatments from Toxins: The Therapeutic Potential of Clostridial Neurotoxins reviews the status of current research and development and identifies significant developments. Drawing on their vast experience in this field, the editors present the basic background of the bacteriology and genetics of the neurotoxigenic clostridia, a history of the discovery of the neurotoxins, and an overview of the tetanus and botulism diseases. The chapters detailing common medical applications of the toxins cover side effects and novel uses, including neuronal drug delivery strategies, and provide a fresh look at what can still be achieved. They also explore the toxins as potential threat agents and the advent of the therapeutic use of botulinum toxins. Highlighting the pitfalls, successes, and challenges that exist when engineering complex proteins, the book brings together the clinical and theoretical worlds. It presents a broad overview of the current status of botulinum research and its clinical applications.

Analysis of Type A Botulinum Neurotoxin Expression in Clostridium Botulinum

Analysis of Type A Botulinum Neurotoxin Expression in Clostridium Botulinum Book
Author : Sean S. Dineen
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Analysis of Type A Botulinum Neurotoxin Expression in Clostridium Botulinum book written by Sean S. Dineen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Botulinum Neurotoxin Complex

Botulinum Neurotoxin Complex Book
Author : Jiarong Flora Chen
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Botulinum Neurotoxin Complex book written by Jiarong Flora Chen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Botulinum Neurotoxin for Head and Neck Disorders

Botulinum Neurotoxin for Head and Neck Disorders Book
Author : Andrew Blitzer,Brian Benson,Diana Kirke
Publisher : Unknown
Release : 2020
ISBN : 9781684200955
Language : En, Es, Fr & De

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Book Description :

The most comprehensive, state-of-the-art guide available on the use of botulinum neurotoxin for head & neck disorders! Senior author Andrew Blitzer is an internationally renowned pioneer on the use of botulinum neurotoxin for functional disorders, with unparalleled expertise on this topic. Joined by esteemed co-editors Brian Benson and Diana Kirke, with multidisciplinary contributors, Botulinum Neurotoxin for Head and Neck Disorders Second Edition fills a gap in the medical literature. The unique textbook focuses on the use of botulinum neurotoxins for functional disorders of the head and neck, though with some aesthetic indications. The second edition reflects the latest advances and understanding of existing and emerging applications for botulinum neurotoxins, including new treatment paradigms, revised pharmacology, and an updated review of the literature in all chapters. Twenty superbly illustrated chapters cover the management of hyperfunctional, pain, and hypersecretory syndromes of the head and neck. Hyperfunctional motor disorders are discussed in chapters focused on blepharospasm, facial dystonia, Meige syndrome, oromandibular dystonia, spasmodic dysphonia (laryngeal dystonia), and cervical dystonia. Specific treatment approaches for pain are addressed in chapters on migraine and chronic daily tension headaches, temporomandibular disorders, and trigeminal neuralgia. The treatment of autonomic nervous system disorders is covered in chapters dedicated to Frey syndrome, facial hyperhydrosis, and sialorrhea. Key Features A 30-year review of spasmodic dysphonia data includes new insights encompassing comprehensive treatment, management and outcomes results, and neuropathophysiology A new chapter details the emerging role of botulinum neurotoxin to treat radiation-induced spasm and pain Updates on the management of palatal myoclonus, temporomandibular joint disorder, and sialorrhea An impressive compendium of professional injection videos, including a new video on sialorrhea and an updated migraine video Clinical pearls throughout the book focus on best practices, how to avoid pitfalls, and achieving the most optimal outcomes This is a must-have resource for otolaryngologists-head and neck surgeons, neurologists, dentists, pain specialists, physical medicine and rehabilitation specialists, and others health professionals who use botulinum neurotoxin to treat motor, sensory, and autonomic disorders of the head and neck region. This book includes complimentary access to a digital copy on https://medone.thieme.com.