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Molecular Aspects of Botulinum Neurotoxin

Molecular Aspects of Botulinum Neurotoxin Book
Author : Keith A. Foster
Publisher : Springer
Release : 2014-07-08
ISBN : 1461494540
Language : En, Es, Fr & De

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Book Description :

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation with a focus on clinical application. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Clinical Applications of Botulinum Neurotoxin

Clinical Applications of Botulinum Neurotoxin Book
Author : Keith A. Foster
Publisher : Springer
Release : 2014-07-08
ISBN : 149390261X
Language : En, Es, Fr & De

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Book Description :

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Botulinum Neurotoxin and Tetanus Toxin

Botulinum Neurotoxin and Tetanus Toxin Book
Author : Lance Simpson
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0323141609
Language : En, Es, Fr & De

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Book Description :

Botulinum Neurotoxin and Tetanus Toxin covers the mechanism of action, pathogenesis, and treatment of clostridial neurotoxins. The book is organized into four parts encompassing 18 chapters that discuss the origin, structure, pharmacology, toxicology, immunology, assays, and clinical issues of botulinum and tetanus neurotoxins. The introductory part of the book discusses the discovery and production of neurotoxins in various strains of Clostridium bacteria. This text also describes how specific bacteriophages and plasmids mediate the pathogenicity of some types of Clostridium botulinum and Clostridium tetani. The subsequent part provides an overview of issues related to toxin binding, including toxins that may serve as models for botulinum and tetanus neurotoxins. Discussions on the peripheral and central aspects of poisoning transport in the central nervous system and on the antagonistic drugs for clostridial neurotoxins are provided. The third part of the book addresses the antibodies against botulinum neurotoxin. Bioassay in mice and highly sensitive immunoassays, such as reversed passive hemagglutination, reversed passive latex agglutination, radioimmunoassay, and enzyme-linked immunosorbent assay, are presented. The concluding part covers the animal models for these toxins and discusses the diagnosis and treatment of botulism and tetanus in human. The clinical use of Clostridium botulinum toxin type A in ocular and neuromuscular disease is also examined. This book will be of value to protein chemists, microbiologists, virologists, pharmacologists, immunologists, and clinicians.

Botulinum Neurotoxin Injection Manual

Botulinum Neurotoxin Injection Manual Book
Author : Katharine E. Alter, MD,Nicole A. Wilson, PhD, MD
Publisher : Demos Medical Publishing
Release : 2014-12-15
ISBN : 1620700425
Language : En, Es, Fr & De

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Book Description :

This comprehensive yet practical guide covers botulinum toxin injections and the wide range of clinical applications for neurologic and other conditions. Intended as both as an introduction for new injectors and a handy reference guide for busy clinicians, the book opens with a brief review of pharmacology, product information and distinctions between the four toxins that are currently approved for use in the U.S. by the FDA, indications and doses for FDA-approved conditions, and accepted and emerging clinical applications. The remainder is an injection manual, organized anatomically and by condition and covering all applications. For each condition or site, information on typical muscle pattern or muscle groups involved, dosing guidelines and dilution for the applicable toxins, number of injection sites and targeting techniques are provided in table format for quick look-up. Anatomic illustrations and cross-sections appear on facing pages to orient injectors and help identify optimal insertion points. An appendix with useful clinical rating scales is also included.

Botulinum Neurotoxin for Head and Neck Disorders

Botulinum Neurotoxin for Head and Neck Disorders Book
Author : Andrew Blitzer,Brian E. Benson,Diana N. Kirke
Publisher : Georg Thieme Verlag
Release : 2020-05-23
ISBN : 1638536597
Language : En, Es, Fr & De

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Book Description :

The most comprehensive, state-of-the-art guide available on the use of botulinum neurotoxin for head & neck disorders! Senior author Andrew Blitzer is an internationally renowned pioneer on the use of botulinum neurotoxin for functional disorders, with unparalleled expertise on this topic. Joined by esteemed co-editors Brian Benson and Diana Kirke, with multidisciplinary contributors, Botulinum Neurotoxin for Head and Neck Disorders Second Edition fills a gap in the medical literature. The unique textbook focuses on the use of botulinum neurotoxins for functional disorders of the head and neck, though with some aesthetic indications. The second edition reflects the latest advances and understanding of existing and emerging applications for botulinum neurotoxins, including new treatment paradigms, revised pharmacology, and an updated review of the literature in all chapters. Twenty superbly illustrated chapters cover the management of hyperfunctional, pain, and hypersecretory syndromes of the head and neck. Hyperfunctional motor disorders are discussed in chapters focused on blepharospasm, facial dystonia, Meige syndrome, oromandibular dystonia, spasmodic dysphonia (laryngeal dystonia), and cervical dystonia. Specific treatment approaches for pain are addressed in chapters on migraine and chronic daily tension headaches, temporomandibular disorders, and trigeminal neuralgia. The treatment of autonomic nervous system disorders is covered in chapters dedicated to Frey syndrome, facial hyperhydrosis, and sialorrhea. Key Features A 30-year review of spasmodic dysphonia data includes new insights encompassing comprehensive treatment, management and outcomes results, and neuropathophysiology A new chapter details the emerging role of botulinum neurotoxin to treat radiation-induced spasm and pain Updates on the management of palatal myoclonus, temporomandibular joint disorder, and sialorrhea An impressive compendium of professional injection videos, including a new video on sialorrhea and an updated migraine video Clinical pearls throughout the book focus on best practices, how to avoid pitfalls, and achieving the most optimal outcomes This is a must-have resource for otolaryngologists–head and neck surgeons, neurologists, dentists, pain specialists, physical medicine and rehabilitation specialists, and others health professionals who use botulinum neurotoxin to treat motor, sensory, and autonomic disorders of the head and neck region. This book includes complimentary access to a digital copy on https://medone.thieme.com.

Botulinum Toxin E Book

Botulinum Toxin E Book Book
Author : Joseph Jankovic,Alberto Albanese,M. Zouhair Atassi,J. Oliver Dolly,Mark Hallett,Nathaniel H. Mayer
Publisher : Elsevier Health Sciences
Release : 2009-02-18
ISBN : 1437711197
Language : En, Es, Fr & De

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Book Description :

The new, therapeutically-focused Botulinum Toxin presents comprehensive, cross-disciplinary guidance on current practices, covering more than 100 non-cosmetic conditions that occur in neurology, physical medicine and rehabilitation, pain medicine, ophthalmology, gastroenterology, urology, orthopedics, and surgery. International contributors review the current understanding of the biology and cellular mechanisms along with relevant research so you can easily apply them to the pathophysiology of the numerous disorders that botulinum toxin is used to treat—such as botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. With discussions of the latest in approved treatment practices as well as new and emerging uses, you’ll get in-depth management guidance on the application of the toxin. Provides clinical applications of botulinum toxin for over 100 disorders for immediate access and easy reference during practice and treatment. Covers a broad array of hot topics, including botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. Focuses on approved uses with expert advice on thoroughly tested applications but also discusses new and emerging applications to expose you to additional treatment options. Presents the most comprehensive and up-to-date material available so you get all the information you need from this one resource. Offers the cross-disciplinary guidance of the best world-class expertise through an authoritative, international group of authors who demonstrate the applications of botulinum toxin across various specialties.

Botulinum Neurotoxins

Botulinum Neurotoxins Book
Author : Andreas Rummel,Thomas Binz
Publisher : Springer Science & Business Media
Release : 2012-12-14
ISBN : 3642335705
Language : En, Es, Fr & De

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Book Description :

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

Manual of Botulinum Toxin Therapy

Manual of Botulinum Toxin Therapy Book
Author : Daniel Truong,Mark Hallett,Dirk Dressler,Christopher Zachary
Publisher : Cambridge University Press
Release : 2014-01-23
ISBN : 1107025354
Language : En, Es, Fr & De

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Book Description :

"This book tries to answer many of the questions posed above with the contributions of a team of international experts. As in the first edition, the emphasis in this book is on technique, so it is richly endowed with illustrations concerning accurate access techniques to help physicians become facile and fully competent"--Provided by publisher.

Botulinum Toxin Therapy

Botulinum Toxin Therapy Book
Author : Scott M. Whitcup,Mark Hallett
Publisher : Springer Nature
Release : 2021-01-05
ISBN : 303066306X
Language : En, Es, Fr & De

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Book Description :

In a rapidly progressing field, Botulinum Toxin Therapy provides both clinicians and basic researchers with the latest science on the structure and function of botulinum toxins and the use of these toxins to treat a wide variety of diseases. Part 1 of the book reviews the basic science of botulinum toxins including advances in our understanding of the molecular structure and mechanism of action of botulinum toxins. This section also discusses the manufacturing and formulation of botulinum toxins for clinical use and the development of novel therapeutic toxins for the future. Part 2 reviews the use of botulinum toxins in clinical practice. It discusses the clinical pharmacology of botulinum toxin drugs and their use in a wide variety of clinical conditions including headache, spasticity, pain, disorders of the genitourinary and gastrointestinal tract, strabismus, and medical aesthetics.

Botulinum Toxin

Botulinum Toxin Book
Author : Nikolay Serdev
Publisher : BoD – Books on Demand
Release : 2018-12-19
ISBN : 1789841356
Language : En, Es, Fr & De

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Book Description :

The aim of this book is to ensure a safe understanding and use of botulinum toxin in medicine. Known indications, contraindications, diversity, comparative effects between subtypes, limits, allergies, treatments, adverse reactions, nonresponsiveness, and new investigations will be described. Botulinum toxin can be currently used in nearly every specialty. The main areas in this book are cosmetics and dermatology, as well as dentistry, urology, masseter hypertrophy, chronic pain treatment, and others. The important aim is formation of the knowledge of anatomy, muscles to be treated and their function, risk factors, brand names, associations with operations, and other treatments.

Botulinum Neurotoxins and Nervous System

Botulinum Neurotoxins and Nervous System Book
Author : Siro Luvisetto
Publisher : MDPI
Release : 2020-11-06
ISBN : 303943456X
Language : En, Es, Fr & De

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Book Description :

This book collects 25 scientific articles from laboratories around the world, all of which use botulinum neurotoxins as the main protagonists of their studies. The use of botulinum neurotoxin in medicine, following its ability to inhibit the effects of various disorders of different etiology on the human organism, constitutes the main topic of each article presented here. This book, which is aimed at both students and medical professionals, attempts to summarize current knowledge about the use of botulinum toxin as a therapeutic agent in many diseases, ranging from spasticity to tremor, form motor dysfunction after stroke to neuropathic pain, from hyperactive muscle to migraine, and so on. Thanks to its simplified writing, accessible to an audience who may not be familiar with the mysteries of science, readers will get new insights into this biological toxin and its multiple applications, not simply relegated to its historical use to correct of face wrinkles. Both review and research articles are presented, not only concerning animal studies, but also clinical reports. This book will provide an up-to-date picture of the state-of-the-art of the possible development of novel applications of botulinum neurotoxins for future therapeutic purposes.

Botulinum Toxin E Book

Botulinum Toxin E Book Book
Author : Alastair Carruthers,Jean Carruthers
Publisher : Elsevier Health Sciences
Release : 2012-09-26
ISBN : 1455737763
Language : En, Es, Fr & De

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Book Description :

This title in the PROCEDURES IN COSMETIC DERMATOLOGY SERIES presents up-to-the-minute, practical guidance on botulinum toxin injection techniques shaping today's practice. Succinctly written and lavishly illustrated, it focuses on procedural how-to's and offers step-by-step advice on proper techniques, pitfalls, and tricks of the trade—so you can refine and hone your skills...and expand your surgical repertoire. You'll find current, to-the-point guidance on the cosmetic use of the toxin — edited by pioneers in the field, Drs. Jean and Alastair Carruthers. Implement the newest procedures into your practice immediately and confidently—with the outstanding guidance you'll find in this volume of the PROCEDURES IN COSMETIC DERMATOLOGY SERIES. Covers the hottest topics—including botox aesthetics, facial treatments, neck treatment, adjunctive treatment, pain relief, and facial asymmetry—all in one concise, accessible volume. Features a wealth of color illustrations and photographs that depict cases as they present in practice. Discusses common pitfalls and emphasizes how to optimize outcomes, enabling readers to improve their technique. Highlights emerging topics in the field, with guidance on the newest developments in cosmetic surgery. Includes a comprehensive, instructional DVD containing video clips of techniques and procedures as well as the experts' hints and tips. Use of fillers in combination with Botox to better sculpt the lower face Coverage of new fillers like Juvederm, Evolence, Radiesse and Perlane to keep you on the cutting edge New and expanded coverage of periocular treatment Highest quality video footage of procedures on the bonus DVD

Botulinum Toxin Treatment in Surgery Dentistry and Veterinary Medicine

Botulinum Toxin Treatment in Surgery  Dentistry  and Veterinary Medicine Book
Author : Bahman Jabbari
Publisher : Springer Nature
Release : 2020-10-06
ISBN : 3030506916
Language : En, Es, Fr & De

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Book Description :

All books on the market which have been written on the subject of botulinum toxin therapy focus on treatment of hyperactive movement disorders, autonomic dysfunction (bladder, sweat and salivary glands) and some pain indications (migraine). Reference to pre-or post -surgical indications are brief and often out-dated. No book has information on dentistry or veterinary medicine. This book provides up-to-date information on botulinum toxin therapy in surgical fields. It is also the only book in the market that provides information on botulinum toxin therapy in dentistry and veterinary medicine, furnishing the latest information. Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine appeals to many disciplines including surgery, dentistry and veterinary medicines well as appealing to neurologists and internists.

Hyperhidrosis and Botulinum Toxin in Dermatology

Hyperhidrosis and Botulinum Toxin in Dermatology Book
Author : Oliver Philip Kreyden,Roland Böni,Günter Burg
Publisher : Karger Medical and Scientific Publishers
Release : 2002
ISBN : 3805573065
Language : En, Es, Fr & De

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Book Description :

In this publication a comprehensive overview on the pathophysiology and treatment of hyperhidrosis with a focus on the new therapy with botulinum toxin is given by renowned experts from Europe and the USA. In the first part the pathophysiology of hyperhidrosis, rare forms of sweating and their symptoms, as well as the different topical and surgical treatments for focal hyperhidrosis are discussed. The second part deals with botulinum toxin. Besides a historic survey of the drug the reader is introduced to the pharmacological particularities and the different modalities of treatment for focal hyperhidrosis. Complications and side effects of the therapy are presented as well. The final chapter is reserved for other dermatological indications like anal fissure and wrinkles.

Botulinum Toxin in Urology

Botulinum Toxin in Urology Book
Author : Michael B. Chancellor,Christopher P. Smith
Publisher : Springer Science & Business Media
Release : 2011-06-24
ISBN : 3642035809
Language : En, Es, Fr & De

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Book Description :

Bladder injection of onabotulinumtoxinA for the treatment of urinary incontinence due to neurogenic detrusor overactivity has recently been approved by regulatory agencies in several EU countries and by the FDA in the United States. This is the first book to focus on the practical application of botulinum toxin (BoNT) in the genitourinary tract. It covers in detail applications of BoNT in the bladder and the prostate and pelvic floor, with reviews of the latest clinical series and techniques in both adults and children. Appendices containing easy-to-read instructions for patients undergoing bladder and prostate BoNT injections are included, in addition to procedural guidelines for nursing staff. The book is written in a concise, clinically relevant style by two leading pioneers in the field, who were the first to undertake comprehensive basic research into the mechanisms underlying the efficacy and potential uses of BoNT within the lower urinary tract.

Botulinum and Tetanus Neurotoxins

Botulinum and Tetanus Neurotoxins Book
Author : B.R. DasGupta
Publisher : Springer Science & Business Media
Release : 2013-11-11
ISBN : 1475795424
Language : En, Es, Fr & De

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Book Description :

Three days in Madison have thoroughly modified my view on clostridial neurotoxins. While still realizing the numerous activating, modifying and protective inputs, I cannot judge the meaningfulness of the meeting impartially. Neither may the reader expect a complete summary of all presentations. Collected in this volume, they speak for themselves without requiring an arbiter. Instead I shall write down my very personal opinions as a researcher who has studied clostridial neurotoxins for nearly 25 years. Comparable conferences have been rare during this time. A comprehensive symposium 4 on C. botulinum neurotoxins has been organized at Ft. Detrick. International conferences on tetanus have been held regularly under the auspices of the Wodd Health Organization. One or maximally two days of these meetings have been devoted to tetanus toxin and its actions whereas the sponsor and the majority of the participants have been interested mainly in epidemiology, prevention and treatment of tetanus as a disease (see refs. 5,6). Some aspects of clostridial neurotoxins have been addressed in the context of bacterial toxins, in particular in the biennial European workshops. 1-3,7,8 The Madison meeting differed from the previous ones in three aspects. First, it covered both tetanus and botulinum neurotoxins. The fusion was justified because of their huge similarities in primary structure, in their mode of action and in their cellular targets. Second, the meeting was not limited to toxins but drew some lines on which modern neurobiology might proceed.

Botulinum Toxins in Clinical Aesthetic Practice Second Edition

Botulinum Toxins in Clinical Aesthetic Practice  Second Edition Book
Author : Anthony Benedetto
Publisher : CRC Press
Release : 2011-01-18
ISBN : 1841847550
Language : En, Es, Fr & De

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Book Description :

Well illustrated with high-quality photographs, Botulinum Toxins in Clinical Aesthetic Practice has proven itself a premier guide to the clinical use of different types of botulinum toxins for both esthetic and medical purposes. This second edition retains all the features that made its predecessor so successful, including detailed anatomic drawings, a review of the different formulations available, and specimen forms. This edition has been revised and updated throughout and features additional new material on medico-legal considerations and psychological and cultural factors that may affect the intentions of patients and the results that can be achieved.

Botulinum toxins in dermatology

Botulinum toxins in dermatology Book
Author : Joel L. Cohen
Publisher : John Wiley & Sons
Release : 2013
ISBN : 1444338250
Language : En, Es, Fr & De

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Book Description :

Download Botulinum toxins in dermatology book written by Joel L. Cohen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Handbook of Botulinum Toxins for Aesthetic Indications

Handbook of Botulinum Toxins for Aesthetic Indications Book
Author : Kenneth Beer
Publisher : JP Medical Ltd
Release : 2015-10-24
ISBN : 1909836001
Language : En, Es, Fr & De

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Book Description :

Botox continues to be the number one cosmetic procedure performed worldwide. Physicians from a wide range of specialties – not just dermatologists but also OBGYNs, primary care practitioners and ophthalmologists – are eager to learn from results-focused educational material written by leading practitioners. Most botox books focus solely on injection technique. Handbook of Botulinum Toxins for Aesthetic Indications: Theory and Practice describes current techniques, but focuses on securing optimum results in different patient types, e.g. patients of different ethnicities, patients with thick skin, heavy brows, and so on. In addition, the book covers hot topics such as the use of new types of neurotoxins, the problem of counterfeit products, and combining neurotoxins with other modalities such as fillers and lasers. Edited by a recognized educator in this area, and taking a unique problem-based approach, Handbook of Botulinum Toxins for Aesthetic Indications gives practical guidance on the use of different strategies in different patient types to ensure the best possible aesthetic results. Unique, practical emphasis on treatment strategies for different patient types Includes coverage of new neurotoxins recently approved for use Highly illustrated with colour photographs and detailed drawings showing injection sites and technique Written by well-known educators in dermatologic surgery

Botulinum Neurotoxin Complex

Botulinum Neurotoxin Complex Book
Author : Jiarong Flora Chen
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Botulinum Neurotoxin Complex book written by Jiarong Flora Chen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.