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Bone Substitute Biomaterials

Bone Substitute Biomaterials Book
Author : K. Mallick
Publisher : Elsevier
Release : 2014-08-05
ISBN : 0857099035
Language : En, Es, Fr & De

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Book Description :

Bone substitute biomaterials are fundamental to the biomedical sector, and have recently benefitted from extensive research and technological advances aimed at minimizing failure rates and reducing the need for further surgery. This book reviews these developments, with a particular focus on the desirable properties for bone substitute materials and their potential to encourage bone repair and regeneration. Part I covers the principles of bone substitute biomaterials for medical applications. One chapter reviews the quantification of bone mechanics at the whole-bone, micro-scale, and non-scale levels, while others discuss biomineralization, osteoductivization, materials to fill bone defects, and bioresorbable materials. Part II focuses on biomaterials as scaffolds and implants, including multi-functional scaffolds, bioceramics, and titanium-based foams. Finally, Part III reviews further materials with the potential to encourage bone repair and regeneration, including cartilage grafts, chitosan, inorganic polymer composites, and marine organisms. Provides a detailed and accurate overview of the bone substitute biomaterials, a fundamental part of the biomaterials and biomedical sector Provides readers with the principles of bone substitute biomaterials Reviews biomaterials for bone regeneration

Bone Biomaterials Beyond

Bone  Biomaterials   Beyond Book
Author : Antonio Barone,Ulf Nannmark
Publisher : Edra Masson
Release : 2014-04-01T00:00:00+02:00
ISBN : 8821437590
Language : En, Es, Fr & De

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Book Description :

The introduction of osseointegrated dental implants soon 50 years ago has indeed revolutionized dentistry. The scientific evaluation of their use has shown good and increasingly successful treatment outcomes. A prerequisite though is the availability of sufficient bone volumes to ensure integration and acceptable aesthetic results. In this book various surgical techniques, using different augmentation materials, are described and explained. The aim has been to highlight minimally invasive surgical techniques, which leads to less risk of morbidity and reduces treatment time. Readers will enjoy a comprehensive atlas providing some practical advices for every day surgical practice based on solid scientific evidence.

Bone Grafts and Bone Substitutes

Bone Grafts and Bone Substitutes Book
Author : Aziz Nather
Publisher : World Scientific
Release : 2005-09-01
ISBN : 9814481475
Language : En, Es, Fr & De

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Book Description :

This book provides the latest updates on the major challenges of bridging large bone defects, where options range from autografts, “tissue engineered bone”, biomaterials (hydroxyapatite, polycaprolactone and third generation biomaterials) to prostheses. Emphasis has been made on bone tissue engineering, the current state-of-the-art in this field, problems encountered with cell culture technology, scaffolds and bone growth factors (including genomics) and the use of gene therapy for the application of bone growth factors. Attention has also been given to the use of bone autografts. It also covers the use of biomaterials and prostheses as other options for reconstruction. Clinical applications, in addition to the basic science, are also included throughout the discussions. Contents:Basic Science of BoneAutograftsAllograftsGenomicsBone Tissue EngineeringGrowth FactorsCeramicsProstheses Readership: Undergraduate students, graduate students, researchers and lecturers in bone tissue engineering, bone growth factors, biomaterials, autografts, allografts, prostheses, as well as orthopaedic surgeons, plastic and reconstructive surgeons, maxillo-facial surgeons and tissue bank operators. Keywords:Bone Grafts;Bone Substitutes;Basic Science;Clinical Applications;Bone Tissue Engineering;Bone Growth Factor;Genomics;Bone Gene Therapy;BiomaterialsKey Features:Latest updates on the major challenges of bridging large bone defects, including state-of-the-art optionsClinical applications highlighted

Biomimetic biomaterials

Biomimetic biomaterials Book
Author : K.A. Hing
Publisher : Elsevier Inc. Chapters
Release : 2013-09-30
ISBN : 012808815X
Language : En, Es, Fr & De

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Book Description :

This chapter reviews basic bone biology and bone graft technology to give an insight into the increasingly biomimetic approach being pursued in this field. Many current synthetic bone graft substitute materials have calcium phosphate chemistries reflecting the composition of bone mineral, and hierarchical pore structures similar to cancellous bone. Significant research effort has been devoted to understanding how slight variations in chemistry and pore structure impact a graft material’s ability to support or stimulate bone healing. It appears that the best results are obtained when a graft chemistry or structure is designed to mimic the natural tissue.

Octacalcium Phosphate Biomaterials

Octacalcium Phosphate Biomaterials Book
Author : Gerard Insley,Osamu Suzuki
Publisher : Woodhead Publishing
Release : 2019-11-20
ISBN : 0081025122
Language : En, Es, Fr & De

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Book Description :

Octacalcium Phosphate Biomaterials: Past, Present and Future is a comprehensive study of octacalcium phosphate (OCP), a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the use of OCP as a scaffold material, this book explores its potential to deliver improved clinical results. Early chapters in the book discuss OCP's effects on bone cell activity, cellular interactions and their role in bone formation, repair and replacement. Later chapters cover topics such as drug delivery, synthesis methodologies and future analysis techniques. This will be an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. OCP is known to be a pre-cursor to hydroxyapatite in the human biomineralization process that forms bone and tooth enamel. Research studies that have emerged in recent years suggest OCP's tremendous potential as a bioactive material. Contains comprehensive, up-to-date information on the basic science, including physical, chemical and biological properties Presents the clinical potential of octacalcium phosphate biomaterials Provides a reference point for new research and increased activity in the area of next generation smarter biomaterials for hard tissue repair and regeneration

Biomaterials in Orthopedics

Biomaterials in Orthopedics Book
Author : Michael J. Yaszemski
Publisher : CRC Press
Release : 2003-10-17
ISBN : 082475686X
Language : En, Es, Fr & De

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Book Description :

Written by respected experts in the field, Biomaterials in Orthopedics discusses bioabsorbable biomaterials for bone repair, nondegradable materials in orthopaedics and delivery systems. Topics in this text include biocompatibility and the biomaterial/tissue interface; self-reinforced bioabsorbable devices and guided regeneration; bone substitutes,

Mineralized Collagen Bone Graft Substitutes

Mineralized Collagen Bone Graft Substitutes Book
Author : Xiu-Mei Wang,Zhi-Ye Qiu,Helen Cui
Publisher : Woodhead Publishing
Release : 2019-04-18
ISBN : 0081027397
Language : En, Es, Fr & De

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Book Description :

Mineralized Collagen Bone Graft Substitutes presents a comprehensive study of biomimetic mineralized collagen, synthesized in vitro, a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the clinical use of this novel material, the book provides a complete examination, from bench to bedside. Chapters discuss natural bone and familiar biomaterials for bone repair, the preparation and safety of mineralized collagen, products made of mineralized collagen, and present clinical case studies. This book is an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. Provides a deep analysis of synthetic collagen, from bench to bedside Systematically examines the structure, principles, properties, biomimetic synthesis and characterization of mineralized collagen for bone repair Includes case studies that look at a range of clinical bone repair applications of Mineralized collagen and their clinical results

Translating Biomaterials for Bone Graft

Translating Biomaterials for Bone Graft Book
Author : Joo L. Ong,Teja Guda
Publisher : CRC Press
Release : 2017-01-06
ISBN : 1315363518
Language : En, Es, Fr & De

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Book Description :

Translating Biomaterials for Bone Graft: Bench-top to Clinical Applications brings together the current translational research in bone tissue engineering, from design to application – from materials, drugs and biologic delivery used for bone graft applications to pre-clinical and clinical considerations. The book also discusses the regulatory approval pathways, which involves consideration of the class of devices; whether they are similar to existing solutions, minimal manipulation of donor tissue or completely novel materials, drugs and biologics. These considerations drive the ability to successfully transition the latest generations of bone graft materials into the clinics. Chapters come from materials scientists, clinicians, researchers, and consultants and provide a holistic understanding of the field. As such, the book is a state-of-the-art reference to bone therapies and should appeal to clinicians, scientists, as well as students interested in the current research and/or practices in the field of bone regeneration and restoration.

Clinical Applications of Biomaterials

Clinical Applications of Biomaterials Book
Author : Gurbinder Kaur
Publisher : Springer
Release : 2017-06-07
ISBN : 331956059X
Language : En, Es, Fr & De

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Book Description :

This book examines the most novel and state-of-the-art applications of biomaterials, with chapters that exemplify approaches with targeted drug delivery, diabetes, neurodegenerative diseases and cranioplasty implants. Expert contributors analyze biomaterials such as calcium phosphate, sol-gel and quenched glasses, metallic and polymer implants, bioactive glass, and polymer composites while also covering important areas such as the soft tissue replacement, apatites, bone regeneration and cell encapsulation. This book is appropriate for biomedical engineers, materials scientists, and clinicians who are seeking to implement the most advanced approaches and technologies with their patients.

Learning from Nature How to Design New Implantable Biomaterials From Biomineralization Fundamentals to Biomimetic Materials and Processing Routes

Learning from Nature How to Design New Implantable Biomaterials  From Biomineralization Fundamentals to Biomimetic Materials and Processing Routes Book
Author : Rui L. Reis,S. Weiner
Publisher : Springer Science & Business Media
Release : 2005-12-29
ISBN : 140202648X
Language : En, Es, Fr & De

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Book Description :

The development of materials for any replacement or regeneration application should be based on the thorough understanding of the structure to be substituted. This is true in many fields, but particularly exigent in substitution and regeneration medicine. The demands upon the material properties largely depend on the site of application and the function it has to restore. Ideally, a replacement material should mimic the living tissue from a mechanical, chemical, biological and functional point of view. Of course this is much easier to write down than to implement in clinical practice. Mineralized tissues such as bones, tooth and shells have attracted, in the last few years, considerable interest as natural anisotropic composite structures with adequate mechanical properties. In fact, Nature is and will continue to be the best materials scientist ever. Who better than nature can design complex structures and control the intricate phenomena (processing routes) that lead to the final shape and structure (from the macro to the nano level) of living creatures? Who can combine biological and physico-chemical mechanisms in such a way that can build ideal structure-properties relationships? Who, else than Nature, can really design smart structural components that respond in-situ to exterior stimulus, being able of adapting constantly their microstructure and correspondent properties? In the described philosophy line, mineralized tissues and biomineralization processes are ideal examples to learn-from for the materials scientist of the future.

Natural and Cell derived Matrices as Biomaterials in Bone Regeneration

Natural  and Cell derived Matrices as Biomaterials in Bone Regeneration Book
Author : Jenna N. Harvestine
Publisher : Unknown
Release : 2018
ISBN : 9780438930759
Language : En, Es, Fr & De

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Book Description :

With over 2 million bone graft procedures ever year, bone is the second most transplanted material behind blood. However, limited tissue supply and post-operative concerns for donor site pain and morbidity motivate alternative strategies to drive bone regeneration. Mesenchymal stem cells (MSCs) are found within multiple tissue compartments in the postnatal organism, making them widely accessible for autologous cell therapy and a promising alternative to bone grafts. However, loss of osteogenic phenotype, poor cell viability, and insufficient vasculature infiltration after implantation challenge clinical application of tissue engineered constructs. Cell-derived extracellular matrix (ECM), is a biomimetic platform that provides a natural niche to promote trophic factor secretion, cell adhesion, survival, and osteogenic differentiation. We hypothesized a cell-secreted ECM would select endothelial and stem/progenitor cell populations from tissue aspirates to enhance cell survival and instruct cell function, resulting in improved osteogenic potential. First, we hypothesized MSC-derived ECM-coated scaffolds would enhance osteogenic differentiation and bone formation by culture expanded bone marrow-derived MSCs. Human MSCs cultured on ECM-coated scaffolds exhibited increased metabolic activity and decreased apoptosis compared to uncoated scaffolds. In short-term culture, MSCs on ECM-coated substrates secreted more proangiogenic factors while maintaining markers of osteogenic differentiation. Upon implantation, we detected improved survival of MSCs on ECM-coated scaffolds over 3 weeks. Histological evaluation revealed enhanced cellularization and osteogenic differentiation in ECM-coated scaffolds compared to controls. To determine whether the bioactivity of cell-secreted ECM was dependent on cell source, we assessed the osteogenic response of human stromal vascular fraction (SVF) on ECMs secreted by bone marrow-derived mesenchymal stem cells (MSCs) as well as adipose stem/stromal cells (ASCs) and human dermal fibroblasts (HDFs). Mass spectrometry analysis identified 278, 225, and 150 distinct proteins within MSC-, ASC-, and HDF-derived ECMs, respectively, suggesting that stromal cell-derived ECMs are more complex than HDF-derived ECMs which contained nearly 50% fewer distinct proteins. Regardless of ECM source, SVF deposited over 8- and 1.3-fold more calcium compared to tissue culture plastic (TCP) and collagen-coated controls, respectively. Flow cytometry confirmed that SVF cultured on ECM retained CD31 and CD34 positive cell populations better than TCP confirming a role for accessory cells in osteogenic differentiation by tissue aspirates. In addition to lipoaspirates, bone marrow aspirates (BMA) contain a rich source of cells for use in several clinical indications including bone repair. However, progenitor cells such as MSCs account for a small fraction of nucleated cells in BMA, requiring extensive in vitro culture for expansion. We hypothesized that cell-secreted ECM could be used to sequester MSCs and accessory cells from BMA for bone regeneration. To generate 3D implantable constructs, BMA was resuspended in media with or without type I collagen or ECM and injected into a perfusion bioreactor system. Compared to uncoated scaffolds, we observed a 30- and 143- fold increase in MSCs when fresh BMA was cultured on collagen- or ECM-coated scaffolds, respectively. Upon subcutaneous implantation, ECM-coated scaffolds promoted cell survival and early vascularization, yet bone formation was comparable across all implant groups, suggesting additional osteogenic cues are necessary. To determine if osteogenic pre-conditioning would improve the bone forming potential of BMA, cells were perfused on ECM-coated scaffold for either 20 hours or 14 days to generate naïve and pre-conditioned constructs, respectively. Naïve constructs secreted high levels of pro-angiogenic growth factors, while pre-conditioned cells exhibited an osteogenic phenotype and scaffolds contained more MSCs and endothelial cells. Constructs were implanted into 3.5 mm defects made in the calvariae of nude rats then monitored for vascular invasion and bone formation over 10 weeks. Vascular infiltration into pre-conditioned implants occurred rapidly over the first 14 days, resulting in greater vessel density compared to naïve implants which peaked at 28 days. Early advantages in vessel formation correlated to increased bone volume and tissue mineral density in pre-conditioned implants at 10 weeks confirming the synergy between angiogenesis and bone formation. Collectively, this dissertation describes the capacity of cell-secreted ECM to sequester, maintain, and direct osteogenic differentiation by two clinically investigated tissue aspirates for bone tissue engineering. Novel strategies that augment bone repair using autologous tissues address a critically unmet need and have direct implications to improve current standards of care at the forefront of orthopaedic regenerative medicine.

Developments and Applications of Calcium Phosphate Bone Cements

Developments and Applications of Calcium Phosphate Bone Cements Book
Author : Changsheng Liu,Hongyan He
Publisher : Springer
Release : 2017-10-20
ISBN : 9811059756
Language : En, Es, Fr & De

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Book Description :

This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications.

Stratified Bone Graft Technique with Biomaterials

Stratified Bone Graft Technique with Biomaterials Book
Author : Josu00e9 Eduardo De
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The different biomaterials that are a disposition of the clinician at present, are displacing the gold standard that involves the graft only of autologous bone. The technique of stratification involves the combination of different biomaterials with different origins and characteristics in order to achieve greater similarity with the graft receiving zone. Factors such as vascularization, and intrinsic properties of the material such as grain, porosity and resorption will influence the success of the technique. (Matu00e9 et al. 2013). Aim: To verify the effectiveness of a stratified technique of bone grafting to create a more adequate response of the receiving environment and a replacement of bone of higher quality. Six American Fox Hound dogs weighing 12-15 kg were used for this study. All protocols were carried out under the supervision of the Veterinary Service of the University and with the approval of the own ethics committee. The interventions were performed under sedation and general anesthesia and with local infiltrative anesthesia. The pieces P3 and M1 were extracted in each hemimandu00edbula, leaving a time of healing of 2 months; After which 3 defects were made in each hemimandibula with a total of 36 for the study by means of a 3.5 mm diameter trephine. Three study groups were created. Group A: autologous-porcine-synthetic stratified and Group B: porcine and Group C: autogenous. The porcine material used was Osteobiol by Tecnoss MP3 (Torino, ITALY) and the synthetic material was a combination of 60% HA and B-TCP 40% self-synthesis. An evolutionary collagen membrane was used as membrane barrier. Tecnoss (Torino, ITALY). Histological and histomorphometric analysis of the analyzed samples were performed after 12 weeks of healing.: In all the cases analyzed, from the histological point of view, a greater similarity with natural bone has been found in those cases in which a stratified technique has been used in comparison with those cases in which only a porcine biomaterial has been used. With neoformation and stabilization patterns of neoformed bone more similar to the receptor site. No healing responses or abnormal inflammation have been observed in any of the treated cases. From the point of view of the histomorphometric analysis, greater values ;of new bone formation have been found in all cases treated with a stratified graft in relation to the graft of a single layer of porcine origin. Similarly, graft adaptation rates and reabsorption and neoformation relationships were more similar to natural bone.With the limitations of an experimental animal study it can be concluded that the stratified graft technique achieves more similar results to autologous bone than a single layer technique and allows to overcome the stumbling block of autologous bone limitation in morbidity and volume.

Innovative Bioceramics in Translational Medicine II

Innovative Bioceramics in Translational Medicine II Book
Author : Andy H. Choi
Publisher : Springer Nature
Release : 2022-05-27
ISBN : 9811674396
Language : En, Es, Fr & De

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Book Description :

Download Innovative Bioceramics in Translational Medicine II book written by Andy H. Choi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biocomposites and Hybrid Biomaterials of Calcium Orthophosphates with Polymers

Biocomposites and Hybrid Biomaterials of Calcium Orthophosphates with Polymers Book
Author : Sergey V. Dorozhkin
Publisher : CRC Press
Release : 2018-09-29
ISBN : 0429799799
Language : En, Es, Fr & De

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Book Description :

This title gives an overview of composites and biocomposites. It discusses the history of CaPO4/ /polymer biocomposites and hybrid biomaterials, as well as analyzing the latest developments in the field. It also covers bioactivity and biodegradation of CaPO4-based biomaterials.

Dental Implants and Bone Grafts Materials and Biological Issues

Dental Implants and Bone Grafts Materials and Biological Issues Book
Author : Hamdam Alghamdi,John Jansen
Publisher : Woodhead Publishing
Release : 2019-10-15
ISBN : 0081024789
Language : En, Es, Fr & De

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Book Description :

Dental Implants and Bone Grafts: Materials and Biological Issues brings together cutting-edge research to provide detailed coverage of biomaterials for alveolar bone replacement and reconstruction, enabling scientists and clinicians to gain a thorough knowledge of advances and applications in this field. As tooth loss and alveolar bony defects are common and pose a significant health problem in dental clinics, this book deals with timely topics, including alveolar bone structures and properties, mechanical function, pathological changes, material issues, reviews of biomaterials and tissue engineering for dental implants, design and surface modification, biological interaction and biocompatibility of dental implants, and new frontiers. This book is a highly valuable resource for scientists, clinicians and implantologists interested in the complex alveolar bone system and biomaterial and regenerative strategies for its reconstruction. Focuses on the structure, function and pathology of alveolar bone system Considers the issues involved in selecting alveolar bone biomaterials (dental implants and bone grafts) Discusses the requirements for optimal dental implant osseointegration and alveolar bone replacements/reconstruction Explains the biological basis of interactions between alveolar bone and biomaterials

Biomaterials for Bone Tissue Engineering

Biomaterials for Bone Tissue Engineering Book
Author : José A. Sanz-Herrera
Publisher : MDPI
Release : 2020-05-27
ISBN : 3039289659
Language : En, Es, Fr & De

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Book Description :

Bone tissue engineering aims to develop artificial bone substitutes that partially or totally restore the natural regeneration capability of bone tissue lost under circumstances of injury, significant defects, or diseases such as osteoporosis. In this context, biomaterials are the keystone of the methodology. Biomaterials for bone tissue engineering have evolved from biocompatible materials that mimic the physical and chemical environment of bone tissue to a new generation of materials that actively interacts with the physiological environment, accelerating bone tissue growth. Mathematical modelling and simulation are important tools in the overall methodology. This book presents an overview of the current investigations and recent contributions in the field of bone tissue engineering. It includes several successful examples of multidisciplinary collaboration in this transversal area of research. The book is intended for students, researchers, and professionals of a number of disciplines, such as engineering, mathematics, physics, chemistry, biomedicine, biology, and veterinary. The book is composed of an editorial section and 16 original research papers authored by leading researchers of this discipline from different laboratories across the world

The Use of Bone Substitutes in Spine Surgery

The Use of Bone Substitutes in Spine Surgery Book
Author : R. Gunzburg,M. Szpalski,N. Passuti,M. Aebi
Publisher : Springer Science & Business Media
Release : 2002
ISBN : 9783540426875
Language : En, Es, Fr & De

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Book Description :

Spinal arthrodesis is a generally accepted procedure for the management of patients with a variety of spinal disor ders. The primary goal for spinal fusion is to eliminate the instability of the spine, often caused by trauma, deformity, tumor, inflammation or infection, and common degenera tive deterioration of the motion segments. In many clini FRA paw', cal situations, the optimal solution in restoring the spine's integrity is through surgical intervention. There are many techniques of spinal fusion applicable to the lumbar spine. Posterior (PLIF) and anterior lumbar interbody fusion (ALIF) have been developed and employed to address PLlI' po . . . . . these concerns alone or in combination with various inter nal fixation devices. The anterior column is often recon structed with metallic intervertebral cages or biological Fig. ! Femoral ring allograft (FRA) and posterior lumbar inter implants (allograft or autograft bone) [16, 31]. body fusion (PLlF) spacers The success of every spine fusion procedure depends on the phenomenon of bone healing. Whether the healing process occurs depends on many factors, including the type This paper aims to provide a review of the two newly of biological graft, host factors, technique, and the rigidity developed biological cages, the femoral ring allograft of the particular surgical construct. Bone grafts serve two (FRA) spacer and the posterior lumbar interbody fusion main functions: they provide for the synthesis of new bone (PLIF) spacer (Fig. 1).

Marine Biomaterials

Marine Biomaterials Book
Author : Se-Kwon Kim
Publisher : CRC Press
Release : 2013-04-11
ISBN : 1466505656
Language : En, Es, Fr & De

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Book Description :

Oceans are an abundant source of diverse biomaterials with potential for an array of uses. Marine Biomaterials: Characterization, Isolation and Applications brings together the wide range of research in this important area, including the latest developments and applications, from preliminary research to clinical trials. The book is divided into four parts, with chapters written by experts from around the world. Biomaterials described come from a variety of marine sources, such as fish, algae, microorganisms, crustaceans, and mollusks. Part I covers the isolation and characterization of marine biomaterials—bioceramics, biopolymers, fatty acids, toxins and pigments, nanoparticles, and adhesive materials. It also describes problems that may be encountered in the process as well as possible solutions. Part II looks at biological activities of marine biomaterials, including polysaccharides, biotoxins, and peptides. Chapters examine health benefits of the biomaterials, such as antiviral activity, antidiabetic properties, anticoagulant and anti-allergic effects, and more. Part III discusses biomedical applications of marine biomaterials, including nanocomposites, and describes applications of various materials in tissue engineering and drug delivery. Part IV explores commercialization of marine-derived biomaterials—marine polysaccharides and marine enzymes—and examines industry perspectives and applications. This book covers the key aspects of available marine biomaterials for biological and biomedical applications, and presents techniques that can be used for future isolation of novel materials from marine sources.

Clinical Applications of Bone Allografts and Substitutes

Clinical Applications of Bone Allografts and Substitutes Book
Author : Glyn O. Phillips
Publisher : World Scientific
Release : 2005
ISBN : 9812563431
Language : En, Es, Fr & De

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Book Description :

Although bone allografts were first utilized by McEwen in orthopaedic surgery in 1881, progress since then has been sporadic. With the growth of tissue banks and the greater availability of safe and sterile bone grafts, the pace has now quickened; in 2004, more than one million such grafts were used in the USA alone. However, the practice generally remained a ?cottage industry? well into the latter part of the 20th century. This volume provides an international expert evaluaton of the current use of bone, bone substitutes and related allografts, and describes up-to-date practices and clinical results in particular procedures. It will provide a ready reference for readers wishing to carry out an initial survey of the subject.