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Bone Repair Biomaterials

Bone Repair Biomaterials Book
Author : J A Planell,S M Best,D Lacroix,A Merolli
Publisher : Elsevier
Release : 2009-08-26
ISBN : 1845696611
Language : En, Es, Fr & De

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Book Description :

Bone repair is a fundamental part of the rapidly expanding medical care sector and has benefited from many recent technological developments. With an increasing number of technologies available, it is vital that the correct technique is selected for specific clinical procedures. This unique book will provide a comprehensive review of the materials science, engineering principles and recent advances in this important area. The first part of the book reviews the fundamentals of bone repair and regeneration. Chapters in the second part discuss the science and properties of biomaterials used for bone repair such as metals, ceramics, polymers and composites. The final section of the book discusses clinical applications and considerations with chapters on such topics as orthopaedic surgery, tissue engineering, implant retrieval and ethics of bone repair biomaterials. With its distinguished editors and team of international contributors, Bone repair biomaterials is an invaluable reference for researchers and clinicians within the biomedical industry and academia. Provides a comprehensive review of the materials science, engineering principles and recent advances in this important area Reviews the fundamentals of bone repair and regeneration addressing social, economic and clinical challenges Examines the properties of biomaterials used for bone repair with specific chapters assessing metals, ceramics, polymers and composites

Bone Repair Biomaterials

Bone Repair Biomaterials Book
Author : Kendell Pawelec,J. A. Planell
Publisher : Woodhead Publishing
Release : 2018-11-29
ISBN : 0081024525
Language : En, Es, Fr & De

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Book Description :

Bone Repair Biomaterials: Regeneration and Clinical Applications, Second Edition, provides comprehensive reviews on materials science, engineering principles and recent advances. Sections review the fundamentals of bone repair and regeneration, discuss the science and properties of biomaterials used for bone repair, including metals, ceramics, polymers and composites, and discuss clinical applications and considerations, with chapters on such topics as orthopedic surgery, tissue engineering, implant retrieval, and ethics of bone repair biomaterials. This second edition includes more chapters on relevant biomaterials and a greatly expanded section on clinical applications, including bone repair applications in dental surgery, spinal surgery, and maxilo-facial and skull surgery. In addition, the book features coverage of long-term performance and failure of orthopedic devices. It will be an invaluable resource for researchers, scientists and clinicians concerned with the repair and restoration of bone. Provides a comprehensive review of the materials science, engineering principles and recent advances in this important area Presents new chapters on Surface coating of titanium, using bone repair materials in dental, spinal and maxilo-facial and skull surgery, and advanced manufacturing/3D printing Reviews the fundamentals of bone repair and regeneration, addressing social, economic and clinical challenges Examines the properties of biomaterials used for bone repair, with specific chapters assessing metals, ceramics, polymers and composites

Bone Substitute Biomaterials

Bone Substitute Biomaterials Book
Author : K. Mallick
Publisher : Elsevier
Release : 2014-08-05
ISBN : 0857099035
Language : En, Es, Fr & De

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Book Description :

Bone substitute biomaterials are fundamental to the biomedical sector, and have recently benefitted from extensive research and technological advances aimed at minimizing failure rates and reducing the need for further surgery. This book reviews these developments, with a particular focus on the desirable properties for bone substitute materials and their potential to encourage bone repair and regeneration. Part I covers the principles of bone substitute biomaterials for medical applications. One chapter reviews the quantification of bone mechanics at the whole-bone, micro-scale, and non-scale levels, while others discuss biomineralization, osteoductivization, materials to fill bone defects, and bioresorbable materials. Part II focuses on biomaterials as scaffolds and implants, including multi-functional scaffolds, bioceramics, and titanium-based foams. Finally, Part III reviews further materials with the potential to encourage bone repair and regeneration, including cartilage grafts, chitosan, inorganic polymer composites, and marine organisms. Provides a detailed and accurate overview of the bone substitute biomaterials, a fundamental part of the biomaterials and biomedical sector Provides readers with the principles of bone substitute biomaterials Reviews biomaterials for bone regeneration

Translating Biomaterials for Bone Graft

Translating Biomaterials for Bone Graft Book
Author : Joo L. Ong,Teja Guda
Publisher : CRC Press
Release : 2017-01-06
ISBN : 1315363518
Language : En, Es, Fr & De

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Book Description :

Translating Biomaterials for Bone Graft: Bench-top to Clinical Applications brings together the current translational research in bone tissue engineering, from design to application – from materials, drugs and biologic delivery used for bone graft applications to pre-clinical and clinical considerations. The book also discusses the regulatory approval pathways, which involves consideration of the class of devices; whether they are similar to existing solutions, minimal manipulation of donor tissue or completely novel materials, drugs and biologics. These considerations drive the ability to successfully transition the latest generations of bone graft materials into the clinics. Chapters come from materials scientists, clinicians, researchers, and consultants and provide a holistic understanding of the field. As such, the book is a state-of-the-art reference to bone therapies and should appeal to clinicians, scientists, as well as students interested in the current research and/or practices in the field of bone regeneration and restoration.

Biomimetic biomaterials

Biomimetic biomaterials Book
Author : K.A. Hing
Publisher : Elsevier Inc. Chapters
Release : 2013-09-30
ISBN : 012808815X
Language : En, Es, Fr & De

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Book Description :

This chapter reviews basic bone biology and bone graft technology to give an insight into the increasingly biomimetic approach being pursued in this field. Many current synthetic bone graft substitute materials have calcium phosphate chemistries reflecting the composition of bone mineral, and hierarchical pore structures similar to cancellous bone. Significant research effort has been devoted to understanding how slight variations in chemistry and pore structure impact a graft material’s ability to support or stimulate bone healing. It appears that the best results are obtained when a graft chemistry or structure is designed to mimic the natural tissue.

Use of Biomaterial Particulates in Bone Repair

Use of Biomaterial Particulates in Bone Repair Book
Author : Moses Taurayi Mushipe
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Use of Biomaterial Particulates in Bone Repair book written by Moses Taurayi Mushipe, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomaterials in Orthopedics

Biomaterials in Orthopedics Book
Author : Michael J. Yaszemski
Publisher : CRC Press
Release : 2003-10-17
ISBN : 9780824756864
Language : En, Es, Fr & De

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Book Description :

Written by respected experts in the field, Biomaterials in Orthopedics discusses bioabsorbable biomaterials for bone repair, nondegradable materials in orthopaedics and delivery systems. Topics in this text include biocompatibility and the biomaterial/tissue interface; self-reinforced bioabsorbable devices and guided regeneration; bone substitutes,

A Tissue Regeneration Approach to Bone and Cartilage Repair

A Tissue Regeneration Approach to Bone and Cartilage Repair Book
Author : Hala Zreiqat,Colin R. Dunstan,Vicki Rosen
Publisher : Springer
Release : 2014-12-05
ISBN : 3319132660
Language : En, Es, Fr & De

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Book Description :

Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration. Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues. This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.

Biomaterials for Bone Regeneration

Biomaterials for Bone Regeneration Book
Author : P. Dubruel,S. Van Vlierberghe
Publisher : Elsevier
Release : 2014-06-09
ISBN : 0857098101
Language : En, Es, Fr & De

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Book Description :

Novel Biomaterials for Bone Regeneration provides a comprehensive review of currently available biomaterials and how they can be applied in bone regeneration. In recent decades, there has been a shift from the idea of using biomaterials as passive substitutes for damaged bones towards the concept of biomaterials as aids for the regeneration of a host's own bone tissue. This has generated an important field of research and a range of technological developments. Part one of this book discusses a wide range of materials, including calcium phosphate cements, hydrogels, biopolymers, synthetic polymers, and shape memory polymers. Part two then turns to the processing and surface modification of biomaterials, as well as how biomaterials can be evaluated both for their mechanical properties and for immunocompatibility with the host. Finally, part three covers a variety of cellular approaches, and production and delivery of biomaterials for bone regeneration. Chapters also consider the potential of electromagnetic and ultrasonic stimulation of biomaterials to aid in the regenerative process. Novel Biomaterials for Bone Regeneration represents an important resource for academics, clinicians, and industry professionals working in the area of biomedical materials, providing them with both an overview of the current state-of-the-art, and an indication of potential future developments. Provides comprehensive coverage of novel materials, techniques, and applications of biomaterials for bone regeneration Provides vital information on the various types of materials used in bone regeneration Discusses processing, modification, and evaluation techniques of biomaterials, and looks at cellular approaches and stimulation of biomaterials for bone regeneration

Mineralized Collagen Bone Graft Substitutes

Mineralized Collagen Bone Graft Substitutes Book
Author : Xiu-Mei Wang,Zhi-Ye Qiu,Helen Cui
Publisher : Woodhead Publishing
Release : 2019-04-18
ISBN : 0081027397
Language : En, Es, Fr & De

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Book Description :

Mineralized Collagen Bone Graft Substitutes presents a comprehensive study of biomimetic mineralized collagen, synthesized in vitro, a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the clinical use of this novel material, the book provides a complete examination, from bench to bedside. Chapters discuss natural bone and familiar biomaterials for bone repair, the preparation and safety of mineralized collagen, products made of mineralized collagen, and present clinical case studies. This book is an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. Provides a deep analysis of synthetic collagen, from bench to bedside Systematically examines the structure, principles, properties, biomimetic synthesis and characterization of mineralized collagen for bone repair Includes case studies that look at a range of clinical bone repair applications of Mineralized collagen and their clinical results

Influence of Calcitriol on the Differentiation of Osteoblasts on Biomaterials for Bone Repair and Development of a Three dimensional in Vitro Model of Biomaterial Vascularization

Influence of Calcitriol on the Differentiation of Osteoblasts on Biomaterials for Bone Repair and Development of a Three dimensional in Vitro Model of Biomaterial Vascularization Book
Author : Sebastian Wilfried Schotten
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Influence of Calcitriol on the Differentiation of Osteoblasts on Biomaterials for Bone Repair and Development of a Three dimensional in Vitro Model of Biomaterial Vascularization book written by Sebastian Wilfried Schotten, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fabrication and Characterization of Remineralized Bone Matrices RBM for Use as Bone Tissue Engineering Substrates

Fabrication and Characterization of Remineralized Bone Matrices  RBM  for Use as Bone Tissue Engineering Substrates Book
Author : Matthew Alan Soicher
Publisher : Unknown
Release : 2013
ISBN : 9781303792656
Language : En, Es, Fr & De

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Book Description :

Incidence rates of bone fractures are on the rise due to an aging population, and nearly 10% of fractures fail to heal without exogenous treatment. With limitations on current clinical treatments, there is growing demand for the development of effective new therapies; bone tissue engineering (BTE) represents a promising approach to address the problem of healing bone defects. Biomaterials are a critical component of tissue engineering strategies aimed at treating skeletal defects. In order to best facilitate or stimulate bone healing, biomaterials should demonstrate a number of key traits including biocompatibility, osteoinductivity, and osteoconductivity. Additionally, since bone is a load-bearing tissue, biomaterials used in bone defect applications should have sufficient mechanical properties to maintain structure and function when placed into a defect site. A range of materials have been used in BTE with varying degrees of success, although natural polymers - specifically the demineralized bone matrix (DBM) - exhibit osteoinductive properties and have been shown to contribute to bone healing. However, poor mechanical properties leave DBM primarily as filler or support material in clinical applications. Additionally, natural tissues must be decellularized and sterilized prior to clinical use, processes that can alter their efficacy. Therefore, we set out to modify the mechanical properties of DBM by incorporating a stiff mineral phase within the bulk of the collagenous matrix without compromising the structure and function of the native tissue. The initial work in this dissertation was aimed at designing, building, and testing a unique automated system to reproducibly remineralize DBM. By exposing the DBM to solutionscontaining different mineral ions - a process we termed alternate solution immersion, or ASI - we demonstrated the ability to nucleate and grow mineral within the DBM, fabricating remineralized bone matrices (RBM). These RBM contained approximately 40% mineral by volume, and were significantly stiffer compared to the DBM starting material. We then set out to characterize the mineral formed via our ASI process. Multiple analysis techniques, including FTIR, identified the mineral as brushite, a biocompatible, FDA approved material used as a bone repair substrate. After confirming the formation of a stiff, biocompatible mineral, we set out to improve the safety of the material by reducing immunological concerns via an antigen removal (AR) step. However we noticed an unintended consequence: following AR treatment the ASI process resulted in more mineral and stiffer RBM compared to matrices that did not experience AR treatment. One potential mechanism of action identified was the removal of a number of non-collagenous proteins (NCPs) known to act as inhibitors of mineralization both in vivo and in vitro. Finally, we designed an in vitro cell culture experiment to assess the ability of RBM to support the survival and differentiation of an important progenitor cell source, bone marrow-derived mesenchymal stromal cells (MSCs). We cultured MSCs on RBM, DBM, and PLG scaffolds. RBM demonstrated a tendency for improved cell adhesion and better seeding efficiency compared to the other scaffold materials. DNA content on RBM was increased nearly 10-fold compared to other groups after 3 weeks in culture. Additionally, MSCs cultured on both RBM and DBM had increased osteogenic gene expression after 1 and 2 weeks, exhibiting increases in both early and late osteogenic marker genes. These data, coupled with increased mechanical properties and demonstrated biocompatibility following ASI-remineralization, indicate RBM is an attractive substrate for further study regarding BTE applications.

Octacalcium Phosphate Biomaterials

Octacalcium Phosphate Biomaterials Book
Author : Gerard Insley,Osamu Suzuki
Publisher : Woodhead Publishing
Release : 2019-11-20
ISBN : 0081025122
Language : En, Es, Fr & De

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Book Description :

Octacalcium Phosphate Biomaterials: Past, Present and Future is a comprehensive study of octacalcium phosphate (OCP), a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the use of OCP as a scaffold material, this book explores its potential to deliver improved clinical results. Early chapters in the book discuss OCP's effects on bone cell activity, cellular interactions and their role in bone formation, repair and replacement. Later chapters cover topics such as drug delivery, synthesis methodologies and future analysis techniques. This will be an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. OCP is known to be a pre-cursor to hydroxyapatite in the human biomineralization process that forms bone and tooth enamel. Research studies that have emerged in recent years suggest OCP's tremendous potential as a bioactive material. Contains comprehensive, up-to-date information on the basic science, including physical, chemical and biological properties Presents the clinical potential of octacalcium phosphate biomaterials Provides a reference point for new research and increased activity in the area of next generation smarter biomaterials for hard tissue repair and regeneration

Engineered Bone

Engineered Bone Book
Author : Herve Petite
Publisher : CRC Press
Release : 2005-08-15
ISBN : 149871353X
Language : En, Es, Fr & De

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Book Description :

This book addresses relevant issues that tissue-engineering researchers must consider when planning new strategies, especially in the bone and cartilage field. It describes transcription factors that are essential in bone development, and deals with bone healing.

Mineralized Collagen for Bone Repair

Mineralized Collagen for Bone Repair Book
Author : Fu-Zhai Cui,Yun Cui,Hi-Ye Qiu
Publisher : Woodhead Publishing
Release : 2019-01-15
ISBN : 9780081027172
Language : En, Es, Fr & De

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Book Description :

Mineralized Collagen for Bone Repair presents a comprehensive study of biomimetic mineralized collagen, synthesized in vitro, a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the clinical use of this novel material, the book provides a complete examination, from bench to bedside. Chapters discuss natural bone and familiar biomaterials for bone repair, the preparation and safety of mineralized collagen, products made of mineralized collagen, and present clinical case studies. This book is an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. Provides a deep analysis of synthetic collagen, from bench to bedside Systematically examines the structure, principles, properties, biomimetic synthesis and characterization of mineralized collagen for bone repair Includes case studies that look at a range of clinical bone repair applications of Mineralized collagen and their clinical results

Bone Biomaterials Beyond

Bone  Biomaterials   Beyond Book
Author : Antonio Barone,Ulf Nannmark
Publisher : Edra Masson
Release : 2014-04-01T00:00:00+02:00
ISBN : 8821437590
Language : En, Es, Fr & De

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Book Description :

The introduction of osseointegrated dental implants soon 50 years ago has indeed revolutionized dentistry. The scientific evaluation of their use has shown good and increasingly successful treatment outcomes. A prerequisite though is the availability of sufficient bone volumes to ensure integration and acceptable aesthetic results. In this book various surgical techniques, using different augmentation materials, are described and explained. The aim has been to highlight minimally invasive surgical techniques, which leads to less risk of morbidity and reduces treatment time. Readers will enjoy a comprehensive atlas providing some practical advices for every day surgical practice based on solid scientific evidence.

Biomaterials for Drug Delivery and Tissue Engineering Volume 662

Biomaterials for Drug Delivery and Tissue Engineering  Volume 662 Book
Author : Surya Mallapragada,Mark Tracy,Balaji Narasimhan,Richard Korsmeyer,Edith Mathiowitz
Publisher : Materials Research Society
Release : 2001-09-14
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The MRS Symposium Proceeding series is an internationally recognised reference suitable for researchers and practitioners.

Characterization of Biomaterials

Characterization of Biomaterials Book
Author : Samit K. Nandi,Subhasish Biswas
Publisher : Elsevier Inc. Chapters
Release : 2013-03-12
ISBN : 012807101X
Language : En, Es, Fr & De

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Book Description :

The use of biomaterials has become indispensable in modern medicine that includes primarily for the restoration of function as well as drug carriers. Biomaterials developed for bone, cartilage, ligament, tendon, skeletal muscle, dental, and other musculoskeletal applications almost always necessitate mechanical properties characterization to guarantee that they are robust enough for their in vivo functionality. In addition, mechanical conditioning often has a direct consequence on cellular behaviors such as differentiation, extracellular matrix production, migration, and proliferation. There is imperative necessity to get real-time data of tissue development in vivo in response to various biomechanical stimuli such as tension/compression, bending, torsion, and steady or dynamic fluid flow of construct that allows experimental protocol changes to be made early. In vitro characterization is unable to exhibit the tissue response to materials, instead being limited to the response of individual cell lines or primary cells taken from animals. Considering the wide and ever-increasing use of biomaterials in different fields of veterinary and medical sciences with its effective use in emerging fields, the characterization in respect to cellular response in the living system and its effect thereafter for leading a physiologic life, a comprehensive understanding have to be developed in totality. Further, implant safety such as avoidance of adverse tissue reaction and resistance to wear and corrosion are of high clinical significance for implants used in long-term clinical situations. The characterization along with related factors like histological, histomorphological, biochemical, radiological, scanning and transmission electron microscopic, fluorochrome labelling, biomechanical, micro-CT analysis, immunohistochemistry in orthopaedic and soft tissue surgery have been tried to elucidate with emphasis on in vivo applications of biomaterials. Amid various characterization parameters, histology is one of the most important tools to assess cellular reactions in the implant–tissue interface that can be carried out by both undecalcified and decalcified bone specimens. Histomorphometry can directly help in quantitative measurement (percentage) of newly formed bone in the implanted scaffold using semiautomatic image analysis software and also sometimes determines the host's vascularization. Histochemistry can be used to observe connective tissue ingrowth within the scaffold. The morphology and the proliferating cells can be evaluated by immunohistochemical technique. Biochemical markers like serum calcium, phosphorus, alkaline phosphatase, and osteocalcin help in evaluating the progress of healing and tartrate-resistant acid phosphatase for determining the osteoclasts activity. To understand the mechanisms of unusual bone remodelling, a number of different fluorescent stains like calcein green, tetracycline, alizarin red derivatives and xylenol orange have been developed to detect and quantify bone mineralization. Angiogenesis within the scaffold can be observed and quantified by angiography, osteomedullography, micro-CT, immunostaining with von Willebrand factor stain and intravital microscopy. Biomechanical testing is essential for quantitative assessment of implant integration and contact percentage between implant materials with the host tissue and can be performed by pull-out or push-out tests. Surface analysis and the interaction with bone tissue can be best detected by scanning electron microscopy. Non-invasive techniques include radiological, micro-CT analysis, densitometry study and ultrasound elasticity imaging (UEI). Radiological study helps to assess the union at the host bone–implant interfaces during the follow-up period and should be carried out at regular and calculated interval. Micro-CT is also a non-invasive technique and has great potential in characterization of biomaterials in regard to pore size and spatial distribution of newly formed bone together with quantitative information. Densitometric evaluation is helpful for estimating bone mineral content and density. UEI provides more information of scaffold degradation and tissue development. Finally, targeted delivery system needs quantitative measurements of biodistributable materials which can be best accomplished by computed tomography (CT), fluorescence imaging, inductively coupled atomic emission spectroscopy, inductively coupled plasma-mass spectrometry, micro-positron emission tomography, MRI imaging, and radiography. This chapter is primarily on hands-on experience in surgical manipulation of different biomaterials like hydroxyapatite, tricalcium phosphate, bioactive glass, metals, chitosan, as well as natural coralline hydroxyapatite. Different characterization techniques elaborated in this chapter can show a road map to the researchers, scientists, teachers and readers in this field of biomaterials to understand fundamental aspects of materials and related tissue response to the system in vivo. It can also provide clues for further research in the future towards this emerging field.

Integrated Biomaterials in Tissue Engineering

Integrated Biomaterials in Tissue Engineering Book
Author : Murugan Ramalingam
Publisher : John Wiley & Sons
Release : 2012-04-03
ISBN : 1118311981
Language : En, Es, Fr & De

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Book Description :

"Integrated Biomaterials in Tissue Engineering" features all aspects from fundamental principles to current technological advances in biomaterials at the macro/micro/nano/molecular scales suitable for tissue engineering and regenerative medicine. The book is unique as it provides all important aspects dealing with the basic science involved in structure and properties, techniques and technological innovations in material processing and characterizations, and applications of biomaterials in tissue engineering and regenerative medicine.