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Biotechnological Production of Bioactive Compounds

Biotechnological Production of Bioactive Compounds Book
Author : Madan L. Verma,Anuj K. Chandel
Publisher : Elsevier
Release : 2019-07-20
ISBN : 0444643249
Language : En, Es, Fr & De

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Book Description :

Biotechnological Production of Bioactive Compounds provides insights on the most recent innovations, trends, concerns, solutions and practical challenges encountered in the fields of enzyme technology and nanobiotechnology for the production of bioactive materials with extra health benefits. As nanobiotechnology has improved the bioactive extraction process significantly, many bioactives, including bioflavonoids, omega-3 fatty acids, biopigments and low calorie sugar substitutes are a pivotal part of the food industry. The book highlights the production of extra health benefits “bioactives’’ from plants and microbes and explains how the extraction efficiency of bioactives molecules improves significantly with the recent advances in nanobiotechnology. Researchers in the fields of biochemical engineering, biotechnology, bioremediation, environmental sustainability and those in pharma industries will find the information in this book very helpful and illuminating. Outlines technological advances in bioactives extraction Covers bioflavonoids, biopigments, omega-3-fatty acids and low sugar substitutes Explains the mechanisms of Green cargo (biogenic nanoparticles) for the delivery of bioactive molecules

Biotechnology of Bioactive Compounds

Biotechnology of Bioactive Compounds Book
Author : Vijai Kumar Gupta,Maria G. Tuohy,Anthonia O'Donovan,Mohtashim Lohani
Publisher : John Wiley & Sons
Release : 2015-04-20
ISBN : 1118733495
Language : En, Es, Fr & De

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Book Description :

Bioactive compounds play a central role in high-value product development in the chemical industry. Bioactive compounds have been identified from diverse sources and their therapeutic benefits, nutritional value and protective effects in human and animal healthcare have underpinned their application as pharmaceuticals and functional food ingredients. The orderly study of biologically active products and the exploration of potential biological activities of these secondary metabolites, including their clinical applications, standardization, quality control, mode of action and potential biomolecular interactions, has emerged as one of the most exciting developments in modern natural medicine. Biotechnology of Bioactive Compounds describes the current stage of knowledge on the production of bioactive compounds from microbial, algal and vegetable sources. In addition, the molecular approach for screening bioactive compounds is also discussed, as well as examples of applications of these compounds on human health. The first half of the book comprises information on diverse sources of bioactive compounds, ranging from microorganisms and algae to plants and dietary foods. The second half of the book reviews synthetic approaches, as well as selected bioactivities and biotechnological and biomedical potential. The bioactive compounds profiled include compounds such as C-phycocyanins, glycosides, phytosterols and natural steroids. An overview of the usage of bioactive compounds as antioxidants and anti-inflammatory agents, anti-allergic compounds and in stem cell research is also presented, along with an overview of the medicinal applications of plant-derived compounds. Biotechnology of Bioactive Compounds will be an informative text for undergraduate and graduate students of bio-medicinal chemistry who are keen to explore the potential of bioactive natural products. It also provides useful information for scientists working in various research fields where natural products have a primary role.

Biotechnology of Natural Products

Biotechnology of Natural Products Book
Author : Wilfried Schwab,Bernd Markus Lange,Matthias Wüst
Publisher : Springer
Release : 2017-11-16
ISBN : 3319679031
Language : En, Es, Fr & De

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Book Description :

This text comprehensively covers the analysis, enzymology, physiology and genetics of valuable natural products used in the food industry that are attractive targets for biotechnological production. The focus is on the recent advances made to achieve this goal. This unique work is the first book to focus on biotechnological production of important natural products in food additives, fragrances and flavorings, and other bioactive compounds in food. The chapters offer a deep insight into modern research and the development of low molecular weight natural products. Biotechnology of Natural Products covers products in the Phenolic, Terpenoid, and Alkaloid categories, providing a full overview of the biotechnology of food additives and other low molecular weight natural products. Gene clustering and the evolution of pathways are covered, as well as future perspectives on the topic. Due to limited oil resources and increasing consumer demand for naturalness, bioprocesses are increasingly needed to meet these requirements. Novel sophisticated technologies have facilitated the elucidation of new chemical molecules, their biosynthetic pathways and biological functions. This book provides researchers with a full overview of the technologies and processes involved in the biotechnology of natural products.

Biotechnological Alternatives for Commercial and Sustainable Production of Bioactive Compounds from Medicinal Plants

Biotechnological Alternatives for Commercial and Sustainable Production of Bioactive Compounds from Medicinal Plants Book
Author : Maziah Mahmood
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biotechnological Alternatives for Commercial and Sustainable Production of Bioactive Compounds from Medicinal Plants book written by Maziah Mahmood, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biotechnological Production of Plant Secondary Metabolites

Biotechnological Production of Plant Secondary Metabolites Book
Author : Ilkay Erdogan Orhan
Publisher : Bentham Science Publishers
Release : 2012
ISBN : 1608051145
Language : En, Es, Fr & De

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Book Description :

Modern techniques have been developed to overcome problems associated with the extraction of natural products from plants. These techniques include production of secondary metabolites by biotechnological methods such as plant tissue culture and microbial

Marine Microbiology

Marine Microbiology Book
Author : Se-Kwon Kim
Publisher : John Wiley & Sons
Release : 2013-06-21
ISBN : 3527665277
Language : En, Es, Fr & De

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Book Description :

Deliberately breaking with the classical biology-centered description of marine organisms and their products, this reference emphasizes microbial technology over basic biology, setting it apart from its predecessors. As such, it systematically covers the technology behind high-value compounds for use as pharmaceuticals, nutraceuticals or cosmetics, from prospecting to production issues. Following a definition of the field, the book goes on to address all industrially important aspects of marine microbial biotechnology. The first main part contains a description of the major production organisms, from archaebacteria to cyanobacteria to algae and symbionts, including their genetic engineering. The remaining four parts look at commercially important compounds produced by these microorganisms together with their applications. Throughout, the emphasis is on technological considerations, and the future potential of these organisms or compound classes is discussed. A valuable and forward-looking resource for innovative biotechnologists in industry as well as in academia.

Biotechnological strategies for the conservation of medicinal and ornamental climbers

Biotechnological strategies for the conservation of medicinal and ornamental climbers Book
Author : Anwar Shahzad,Shiwali Sharma,Saeed A. Siddiqui
Publisher : Springer
Release : 2015-12-24
ISBN : 3319192884
Language : En, Es, Fr & De

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Book Description :

The book provides an overview on adoption of biotechnological approaches for the conservation, micropropagation, synseed production of various medicinal and ornamental climbers. The work includes a brief chapter on evolution and diversification of climbers. Other chapters give insights on protocols for in vitro propagation and synseed production of selected threatened medicinal and ornamental climbers. Informative chapter on the production of bioactive compound and their enhancement through genetic transformation and elicitation have been incorporated to cover latest advancement in the field of plant biotechnology. This book also explores the use of molecular marker technique for the desired improvement/magnification of medicinal and aesthetic value of climbing plants.

Recent Advancement in White Biotechnology Through Fungi

Recent Advancement in White Biotechnology Through Fungi Book
Author : Ajar Nath Yadav,Sangram Singh,Shashank Mishra,Arti Gupta
Publisher : Springer Nature
Release : 2019-10-01
ISBN : 3030255069
Language : En, Es, Fr & De

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Book Description :

Over the last decade considerable progress has been made in white biotechnology research and further major scientific and technological breakthroughs are expected in the future. The first large-scale industrial applications of modern biotechnology have been in the areas of food and animal feed production (agricultural/green biotechnology) and in pharmaceuticals (medical/red biotechnology). In contrast, the productions of bioactive compounds through fermentation or enzymatic conversion are known as industrial or white biotchnology. The fungi are ubiquitous in nature and have been sorted out from different habitats, including extreme environments (high temperature, low temperature, salinity and pH); and associated with plants (Epiphytic, Endophytic and Rhizospheric). The fungal strains are beneficial as well as harmful for human beings. The beneficial fungal strains may play important roles in the agricultural, industrial, and medical sectors. The fungal strains and its product (enzymes, bioactive compounds, and secondary metabolites) are very useful for industry (e.g., the discovery of penicillin from Penicillium chrysogenum). This discovery was a milestone in the development of white biotechnology as the industrial production of penicillin and antibiotics using fungi moved industrial biotechnology into the modern era, transforming it into a global industrial technology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors providing both high value nutraceutical and pharmaceutical products. The fungal strains and bioactive compounds also play an important role in environmental cleaning. This volume covers the latest research developments related to value-added products in white biotechnology through fungi.

Biotechnological Production of Rosmarinic Acid and Ruscogenins

Biotechnological Production of Rosmarinic Acid and Ruscogenins Book
Author : Abbas Khojasteh
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyl lactic acid, is widely distributed in the plant kingdom, including Satureja khuzistanica, a threatened Iranian plant species. Interest in RA is growing due to its biological activities, including cognitive-enhancing effects, slowing the development of Alzheimer's disease, cancer chemoprotection and anti-inflammatory activity. In order to meet the increasing demand for this compound and preserve its natural sources, a new biotechnological platform based on cell suspension cultures of S. khuzistanica was developed. The results show that cell suspensions of this plant species synthesized high amounts of RA, which accumulated mainly inside the cells. In order to improve the system's biotechnological production, the effect of three elicitors, methyl jasmonate (MeJA), cyclodextrin (CD) and coronatine (COR) were tested. The obtained results demonstrate the effectiveness of MeJA and COR in improving the RA production of the S. khuzistanica cell cultures and also that the time course of growth and RA production can change with the age of the cell line and the number of subcultures. In contrast, the effects of CD were found to be insignificant. In this pipeline, the scale up of the biotechnological system to a benchtop bioreactor demonstrated the adaptability of the S. khuzistanica cell cultures to the scaling-up process and that the elicitors MeJA and COR also effectively improved the production at bioreactor level. Concerning the biological activity of S. khuzistanica, we demonstrated that an enriched RA extract was able to reduce the viability of cancer cell lines, increasing the sub-G0/G1 cell population and the activity of caspase-8 in MCF-7 cells, which suggests that S. khuzistanica extracts can induce apoptosis of MCF-7 cells through activation of the extrinsic pathway. In addition, our findings indicate that other compounds of the extract may act synergistically to potentiate the anticancer activity of RA.Similarly to S. khuzistanica, Ruscus aculeatus is a threatened medicinal plant. Its main bioactive components, the steroid saponins ruscogenin and neoruscogenin, have long been used in the treatment of hemorrhoids and varicose veins, but recently demonstrated activity against some types of cancer have stimulated interest in R. aculeatus extracts. Thus, plant cell biofactories could constitute an alternative to the whole plant as a source of these bioactive compounds. In our work, despite the in vitro recalcitrance of R. aculeatus, after many attempts in which we tested more than 70 different culture media, we developed friable R. aculeatus calli and their derived plant cell suspensions. Their ruscognenin production was compared with that of organized in vitro plantlet and root-rhizome cultures. Root-rhizomes showed a higher capacity for biomass and ruscogenin production than the cell suspensions and the yields were greatly improved by elicitation with COR, as in other plant in vitro cultures. The final total ruscogenin content was higher than 1800 mg g DW-1, after 4 weeks of culture. Although ruscogenins accumulate in plants mainly in the root-rhizome, it was demonstrated that the aerial part could play an important role in their biosynthesis, because production was higher in the whole plant than in the root-rhizome cultures. The most productive biotechnological system, COR-elicited root rhizome cultures, was scaled up to a benchtop bioreactor without losing its capacity for biomass and ruscogenin production." -- TDX.

Plant Biotechnology and Medicinal Plants

Plant Biotechnology and Medicinal Plants Book
Author : Mohamed Ramadan Rady
Publisher : Springer
Release : 2019-07-16
ISBN : 3030229297
Language : En, Es, Fr & De

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Book Description :

Plant tissue culture and advanced biotechnologies have proven to be influential tools that complement conventional breeding and accelerate development of many medicinal plants. Various approaches, such as pathway engineering, precursor feeding, transformation, elicitation with biotic and abiotic elicitors and scaling up in bioreactors, have been explored to improve the production of secondary metabolites from different medicinal plants. This book provides a comprehensive description of various studies, carried out on in vitro culture and hairy root cultures of Catharanthus roseus, Silybum marianum and Digitalis species which have been considered as alternative sources for the production of anti-tumour compounds, flavonolignans and cardenolides. Specific focus is on elicitation strategy for increasing production of bioactive compounds of C. roseus L., S. marianum and Digitalis species to overcome the constrains of conventional propagation. This book is valuable for researchers or students working on medicinal plants, phytochemistry, and plant tissue culture. It also serves as a reference for the pharmaceutical industry.

Actinobacteria Diversity and Biotechnological Applications

Actinobacteria  Diversity and Biotechnological Applications Book
Author : Bhim Pratap Singh,Vijai Kumar Gupta,Ajit Kumar Passari
Publisher : Elsevier
Release : 2018-02-01
ISBN : 0444639950
Language : En, Es, Fr & De

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Book Description :

Actinobacteria: Diversity and Biotechnological Applications: New and Future Developments in Microbial Biotechnology and Bioengineering, a volume in the series New and Future Developments in Microbial Biotechnology and Bioengineering series, offers the latest on the biotechnology of Kingdom actinobacteria, covering unique niches like their endosphere, rhizospheric soil and contaminated sites, etc. The book also covers the bioactive secondary metabolites obtained from actinobacteria and describes the application of microorganism (Actinobacteria) in plant growth promotion and in environmental cleanup. Finally, the book describes the biocontrol aspects of actinobacteria and how they can control fungal phytopathogens and the production of secondary metabolites. Includes an overview of all types of actinobacteria, source and enzymatic activity Lists various bioengineering methods for the production of these enzymes Reviews numerous industrial applications of actinobacteria, i.e., crop improvement, removal of heavy metals, etc. Offers unique coverage of the application of actinobacteria in bioremediation processes Explores the plant growth promoting potential of endophytic actinobacteria Describes biosynthetic potential genes associated with actinobacterial genome

Biotechnological Applications of Biodiversity

Biotechnological Applications of Biodiversity Book
Author : Joydeep Mukherjee
Publisher : Springer
Release : 2014-11-22
ISBN : 3662450976
Language : En, Es, Fr & De

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Book Description :

This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Recent Advancement in White Biotechnology Through Fungi

Recent Advancement in White Biotechnology Through Fungi Book
Author : Ajar Nath Yadav,Sangram Singh,Shashank Mishra,Arti Gupta
Publisher : Springer
Release : 2019-04-24
ISBN : 3030148467
Language : En, Es, Fr & De

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Book Description :

White biotechnology is industrial biotechnology dealing with various biotech products through applications of microbes. The main application of white biotechnology is commercial production of various useful organic substances, such as acetic acid, citric acid, acetone, glycerine, etc., and antibiotics like penicillin, streptomycin, mitomycin, etc., and value added product through the use of microorganisms especially fungi and bacteria. The value-added products included bioactive compounds, secondary metabolites, pigments and industrially important enzymes for potential applications in agriculture, pharmaceuticals, medicine and allied sectors for human welfare. In the 21st century, techniques were developed to harness fungi to protect human health (through antibiotics, antimicrobial, immunosuppressive agents, value-added products etc.), which led to industrial scale production of enzymes, alkaloids, detergents, acids, biosurfactants. The first large-scale industrial applications of modern biotechnology have been made in the areas of food and animal feed production (agricultural/green biotechnology) and pharmaceuticals (medical/red biotechnology). In contrast, the production of bio-active compounds through fermentation or enzymatic conversion is known industrial or white biotechnology. The beneficial fungal strains may play important role in agriculture, industry and the medical sectors. The beneficial fungi play a significance role in plant growth promotion, and soil fertility using both, direct (solubilization of phosphorus, potassium and zinc; production of indole acetic acid, gibberellic acid, cytokinin and siderophores) and indirect (production of hydrolytic enzymes, siderophores, ammonia, hydrogen cyanides and antibiotics) mechanisms of plant growth promotion for sustainable agriculture. The fungal strains and their products (enzymes, bio-active compounds and secondary metabolites) are very useful for industry. The discovery of antibiotics is a milestone in the development of white biotechnology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors, providing both high valued nutraceuticals and pharmaceutical products. The fungal strains and bio-active compounds also play important role in the environmental cleaning. This volume covers the latest research developments related to value-added products in white biotechnology through fungi.

Metabolic Engineering for Bioactive Compounds

Metabolic Engineering for Bioactive Compounds Book
Author : Vipin Chandra Kalia,Adesh Kumar Saini
Publisher : Springer
Release : 2017-10-07
ISBN : 9811055114
Language : En, Es, Fr & De

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Book Description :

This book comprehensively discusses the latest research in the area of metabolic engineering. Metabolic engineering solutions for bioactive compounds are now being derived by means of heterologous gene expression, in a wide range of organisms. The book provides an overview of the model systems being employed for metabolic manipulation to yield bioactive molecules, such as single-cell proteins, antibody generation, metabolites, proteases, chaperones, therapeutic proteins, nanomaterials, polymeric conjugates, dendrimers and nanoassemblies, Escherichia coli, Agrobacterium, Saccharomyces cerevisiae and cell lines, etc. In addition, it shares insights into the scope of these methods in the areas of prevention, diagnosis and treatment of diseases, e.g. immunotherapy for curing various diseases like cancer, allergies, autoimmune diseases, etc.

Plant derived Bioactives

Plant derived Bioactives Book
Author : Mallappa Kumara Swamy
Publisher : Springer Nature
Release : 2020-05-11
ISBN : 9811517614
Language : En, Es, Fr & De

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Book Description :

Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, Plant-derived Bioactives: Chemistry and Mode of Action, discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, Plant-derived Bioactives: Production, Properties and Therapeutic Applications, explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of innovative new drugs.

Recent Advancement in White Biotechnology Through Fungi

Recent Advancement in White Biotechnology Through Fungi Book
Author : Ajar Nath Yadav,Shashank Mishra,Sangram Singh,Arti Gupta
Publisher : Springer
Release : 2019-03-08
ISBN : 303010480X
Language : En, Es, Fr & De

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Book Description :

White biotechnology, or industrial biotechnology as it is also known, refers to the use of living cells and/or their enzymes to create industrial products that are more easily degradable, require less energy, create less waste during production and sometimes perform better than products created using traditional chemical processes. Over the last decade considerable progress has been made in white biotechnology research, and further major scientific and technological breakthroughs are expected in the future. Fungi are ubiquitous in nature and have been sorted out from different habitats, including extreme environments (high temperature, low temperature, salinity and pH), and may be associated with plants (epiphytic, endophytic and rhizospheric). The fungal strains are beneficial as well as harmful for human beings. The beneficial fungal strains may play important roles in the agricultural, industrial, and medical sectors. The fungal strains and their products (enzymes, bioactive compounds, and secondary metabolites) are very useful for industry (e.g., the discovery of penicillin from Penicillium chrysogenum). This discovery was a milestone in the development of white biotechnology as the industrial production of penicillin and antibiotics using fungi moved industrial biotechnology into the modern era, transforming it into a global industrial technology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors, providing both high value nutraceutical and pharmaceutical products. The fungal strains and bioactive compounds also play an important role in environmental cleaning. This volume covers the latest developments and research in white biotechnology with a focus on diversity and enzymes.

Natural Bio active Compounds

Natural Bio active Compounds Book
Author : Mohd Sayeed Akhtar,Mallappa Kumara Swamy,Uma Rani Sinniah
Publisher : Springer Nature
Release : 2019-09-22
ISBN : 9811371547
Language : En, Es, Fr & De

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Book Description :

Bioactive compounds produced by natural sources, such as plants, microbes, endophytic fungi, etc., can potentially be applied in various fields, including agriculture, biotechnology and biomedicine. Several bioactive compounds have proved to be invaluable in mediating plant-microbe interactions, and promoting plant growth and development. Due to their numerous health-promoting properties, these compounds have been widely used as a source of medication since ancient times. However, there is an unprecedented need to meet the growing demand for natural bioactive compounds in the flavor and fragrance, food, and pharmaceutical industries. Moreover, discovering new lead molecules from natural sources is essential to overcoming the rising number of new diseases. In this regard, natural bioactive compounds hold tremendous potential for new drug discovery. Therefore, this field of research has become a vital area for researchers interested in understanding the chemistry, biosynthetic mechanisms, and pharmacological activities of these bioactive metabolites. This book describes the basics of bioactive plant compounds, their chemical properties, and their pharmacological biotechnological properties with regard to various human diseases and applications in the drug, cosmetics and herbal industries. It offers a valuable asset for all students, educators, researchers, and healthcare experts involved in agronomy, ecology, crop science, molecular biology, stress physiology, and natural products.

The Lychee Biotechnology

The Lychee Biotechnology Book
Author : Manoj Kumar,Vivek Kumar,Ram Prasad,Ajit Varma
Publisher : Springer
Release : 2017-03-27
ISBN : 9811036446
Language : En, Es, Fr & De

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Book Description :

This book provides systematic information on the lychee and modern tools to promote its sustainable growth and development. Including dedicated chapters on the evolution and diversification of the lychee, it highlights its genetic makeup and reciprocal exogenous factors, addressing the narrow genetic pool and lack of natural biodiversity. It also discusses issues related to post-harvest losses and robust approaches at the commercial level. Further, the book offers insights on in vitro propagation methods and prospective transgenic approaches for selected lychee cultivars. Chapters on the production of bioactive compounds and their enhancement through genetic transformation and elicitation are also included, reflecting the latest advances in the field of lychee biotechnology. Lastly, the book explores the use of molecular marker techniques to achieve the desired improvements in fruit trees’ medicinal and aesthetic value.

New Strategies for Improving the Biotechnological Production of Pharmaceuticals and Biopharmaceuticals in Plant Cell and Organ Cultures

New Strategies for Improving the Biotechnological Production of Pharmaceuticals and Biopharmaceuticals in Plant Cell and Organ Cultures Book
Author : Diego Alberto Hidalgo Martínez
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"The thesis is presented as a compendium of publications and includes six different sections: General Introduction, Objectives, Results, General Discussion, Conclusions and References. The General Introduction summarizes the state of the art of Plant Cell and Organ Cultures (Plant Biofactories) and their applications for the pipeline production of Cosme-, Pharma- and Biopharmaceuticals. Objectives describes the overall aim of the PhD thesis, as well as the specific goals of each chapter of the Results section. The five chapters of the Results section are based on published scientific articles in ISI journals, where the PhD candidate is always the first author and in each article and when possible according with the editorial rules, it is mentioned that it forms part of his PhD thesis. Each chapter clearly refers to a particular goal of Plant Biofactories employed for the production of biologically active high added-value compounds. Briefly: a)Chapter 1 aims to demonstrate the effectiveness of plant in vitro cultures of Centella asiatica for the production of centellosides in optimized conditions by adding elicitors and potential precursors. Centellosides are widely utilized for their therapeutical properties and C. asiatica cell lines are also currently applied as cosmetic ingredients. b)Chapter 2 focuses on the biotechnological production of t-resveratrol, a bioactive compound found in wine and other foods, in engineered hairy roots of tobacco. The study aims to demonstrate the power of metabolic engineering tools for designing new organisms with modified metabolic capacities and their utility for the production of scarcely distributed plant compounds. c)Chapter 3 provides a paradigmatic example of how a metabolic pathway can be extended in a host organism by means of metabolic engineering tools. Silybum marianum cell cultures, which have the natural ability to produce polyphenol silymarins, are shown to have a previously unexplored capacity for the heterologous production of t-resveratrol, a new polyphenol in this plant species. d)Chapter 4 aims to demonstrate the broad capacity of plant cells for bioconverting exogenous substrates to target products, showing that tobacco hairy roots and their derived cell cultures can biotransform t-resveratrol into the more active metabolites t-piceatannol and t-pterostilbene, both high added-value compounds scarcely distributed in nature. e)Chapter 5 describes the production of the truncated human tissue plasminogen activator (K2S) in tobacco cell cultures derived from transplastomic plants, aiming to avoid the disadvantages of biopharmaceutical production in field transgenic crops. The Discussion section includes a general discussion of the main results obtained and described in the five chapters of the PhD thesis in the context of recent studies and the objectives of the thesis. In the Conclusions section, the main conclusions derived from the results reported in the five chapters are briefly summarized. The References include the complete references of all the articles cited in the general sections of the PhD thesis." -- TDX

Production of Biomass and Bioactive Compounds Using Bioreactor Technology

Production of Biomass and Bioactive Compounds Using Bioreactor Technology Book
Author : Kee-Yoeup Paek,Hosakatte Niranjana Murthy,Jian-Jiang Zhong
Publisher : Springer
Release : 2014-09-30
ISBN : 9401792232
Language : En, Es, Fr & De

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Book Description :

The bioactive compounds of plants have world-wide applications in pharmaceutical, nutraceutical and food industry with a huge market. In this book, a group of active researchers have addressed on the most recent advances in plant cell and organ cultures for the production of biomass and bioactive compounds using bioreactors. Tremendous efforts have been made to commercialize the production of plant metabolites by employing plant cell and organ cultures in bioreactors. This book emphasizes on the fundamental topics like designing of bioreactors for plant cell and organ cultures, various types of bioreactors including stirred tank, airlift, photo-bioreactor, disposable bioreactor used for plant cell and organ cultures and the advantages and disadvantages of bioreactor cultures. Various strategies for biomass production and metabolite accumulation have been discussed in different plant systems including Korean/Chinese ginseng, Siberian ginseng, Indian ginseng, Echinacea, St. John’s wort, Noni, Chinese licorice, Caterpillar fungus and microalgae. Researches on the industrial application of plant cells and organs with future prospects as well as the biosafety of biomass produced in bioreactors are also described. The topics covered in this book, such as plant cell and organ cultures, hairy roots, bioreactors, bioprocess techniques, will be a valuable reference for plant biotechnologists, plant biologists, pharmacologists, pharmacists, food technologists, nutritionists, research investigators of healthcare industry, academia, faculty and students of biology and biomedical sciences. The multiple examples of large-scale applications of cell and organ cultures will be useful and significant to industrial transformation and real commercialization.