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Bioreactor Modeling

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Bioreactor Modeling

Bioreactor Modeling Book
Author : Jerome Morchain
Publisher : Elsevier
Release : 2017-10-06
ISBN : 0081011660
Language : En, Es, Fr & De

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Book Description :

Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand, have the ability to modulate the rate of substrate assimilation. Moreover, the nature of the biochemical transformations results from a compromise between the needs of the cell and the available resources. This book revisits the modeling of bioreactors using a multi-scale approach. It addresses issues related to mixing, phase-to-phase transfers and the adaptation of microorganisms to variations in concentration, and explores the use of population balances for the simulation of bioreactors. By adopting a multidisciplinary perspective that draws on process engineering, fluid mechanics and microbiology, this book sheds new light on the particularity of bioprocesses in relation to physical and chemical phenomena. Presents a multiphase description of bioreactor modeling Includes a combination of concepts issued from different scientific fields to address a practical issue Provides a detailed description of the population balance concept as applied to biological systems Covers a set of illustrative examples of the interaction between hydrodynamics and biological response

Solid State Fermentation Bioreactors

Solid State Fermentation Bioreactors Book
Author : David A. Mitchell,Nadia Krieger,Marin Berovic
Publisher : Springer Science & Business Media
Release : 2006-08-02
ISBN : 3540312862
Language : En, Es, Fr & De

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Book Description :

This concise professional reference provides a fundamental framework for the design and operation of solid-state fermentation bioreactors, enabling researchers currently working at laboratory scale to scale up their processes. The authors survey bioreactor types in common use, and describe in depth how to plan a project, and model heat transfer phenomena. The book includes case studies, and a review of practical issues involved in bioreactor performance.

Computational Modeling in Biomechanics

Computational Modeling in Biomechanics Book
Author : Suvranu De,Farshid Guilak,Mohammad Mofrad
Publisher : Springer Science & Business Media
Release : 2010-03-10
ISBN : 9048135753
Language : En, Es, Fr & De

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Book Description :

Availability of advanced computational technology has fundamentally altered the investigative paradigm in the field of biomechanics. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum scales. Multiscale methods that link various scales are also being developed. While most applications require forward analysis, e.g., finding deformations and stresses as a result of loading, others involve determination of constitutive parameters based on tissue imaging and inverse analysis. This book provides a glimpse of the diverse and important roles that modern computational technology is playing in various areas of biomechanics including biofluids and mass transfer, cardiovascular mechanics, musculoskeletal mechanics, soft tissue mechanics, and biomolecular mechanics.

Bioreactor Systems for Tissue Engineering

Bioreactor Systems for Tissue Engineering Book
Author : Cornelia Kasper,Martijn van Griensven,Ralf Pörtner
Publisher : Springer Science & Business Media
Release : 2009-02-03
ISBN : 3540693564
Language : En, Es, Fr & De

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Book Description :

The editors of this special volume would first like to thank all authors for their excellent contributions. We would also like to thank Prof. Dr. Thomas Scheper, Dr. Marion Hertel and Ulrike Kreusel for providing the opportunity to compose this volume and Springer for organizational and technical support. Tissue engineering represents one of the major emerging fields in modern b- technology; it combines different subjects ranging from biological and material sciences to engineering and clinical disciplines. The aim of tissue engineering is the development of therapeutic approaches to substitute diseased organs or tissues or improve their function. Therefore, three dimensional biocompatible materials are seeded with cells and cultivated in suitable systems to generate functional tissues. Many different aspects play a role in the formation of 3D tissue structures. In the first place the source of the used cells is of the utmost importance. To prevent tissue rejection or immune response, preferentially autologous cells are now used. In particular, stem cells from different sources are gaining exceptional importance as they can be differentiated into different tissues by using special media and supplements. In the field of biomaterials, numerous scaffold materials already exist but new composites are also being developed based on polymeric, natural or xenogenic sources. Moreover, a very important issue in tissue en- neering is the formation of tissues under well defined, controlled and reprod- ible conditions. Therefore, a substantial number of new bioreactors have been developed.

Bioreactor System Design

Bioreactor System Design Book
Author : Juan A. Asenjo
Publisher : CRC Press
Release : 1994-11-17
ISBN : 9780824790028
Language : En, Es, Fr & De

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Book Description :

Describes the state-of-the-art techniques and methods involved in the design, operation, preparation and containment of bioreactor systems, taking into account the interrelated effects of variables associated with both upstream and downstream stages of the design process. The importance of the initial steps in the development of a bioprocess, such as strain and media selection, that have an overwhelming influence on all further operations, is emphasized.;This work is intended for biochemical, chemical and bioprocess engineers; biotechnologists; industrial biochemists; micro- and molecular biologists; food scientists; and upper-level undergraduate and graduate students in these disciplines.

An Introduction to Bioreactor Hydrodynamics and Gas Liquid Mass Transfer

An Introduction to Bioreactor Hydrodynamics and Gas Liquid Mass Transfer Book
Author : Enes Kadic,Theodore J. Heindel
Publisher : John Wiley & Sons
Release : 2014-03-14
ISBN : 1118869834
Language : En, Es, Fr & De

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Book Description :

Reviews and compares the major types of bioreactors, defines their pros and cons, and identifies research needs and figures of merit that have yet to be addressed Describes common modes of operation in bioreactors Covers the three common bioreactor types, including stirred-tank bioreactors, bubble column bioreactors, and airlift bioreactors Details less common bioreactors types, including fixed bed bioreactors and novel bioreactor designs Discusses advantages and disadvantages of each bioreactor and provides a procedure for optimal bioreactor selection based on current process needs Reviews the problems of bioreactor selection globally while considering all bioreactor options rather than concentrating on one specific bioreactor type

Bioreactors

Bioreactors Book
Author : Carl-Fredrik Mandenius
Publisher : John Wiley & Sons
Release : 2016-02-16
ISBN : 3527683372
Language : En, Es, Fr & De

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Book Description :

In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.

Bioreactors

Bioreactors Book
Author : Goutam Saha,Alok Barua,Satyabroto Sinha
Publisher : CRC Press
Release : 2017-12-01
ISBN : 1498736025
Language : En, Es, Fr & De

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Book Description :

Bioreactors: Animal Cell Culture Control for Bioprocess Engineering presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the "see-saw bioreactor," is ideal for the growth of cells with a sensitive membrane. The see-saw bioreactor derives its name from its principle of operation in which liquid columns in either limb of the reactor alternately go up and down. The working volume of the reactor is small, to within 15 L. However, it can easily be scaled up for large production in volume of cell mass in the drug and pharmaceutical industries. The authors describe the principle of operation of the see-saw bioreactor and how to automatically control the bioprocess. They discuss different control strategies as well as the thorough experimental research they conducted on this prototype bioreactor in which they applied a time delay control for yield maximization. To give you a complete understanding of the design and development of the see-saw bioreactor, the authors cover the mathematical model they use to describe the kinetics of fermentation, the genetic algorithms used for deriving the optimal time trajectories of the bioprocess variables, and the corresponding control inputs for maximizing the product yield. One chapter is devoted to the application of time delay control. Following a description of the bioreactor’s working setup in the laboratory, the authors sum up their investigation and define the future scope of work in terms of design, control, and software sensors.

Current Developments in Biotechnology and Bioengineering

Current Developments in Biotechnology and Bioengineering Book
Author : Ashok Pandey,Ranjna Sirohi,Christian Larroche,Mohammad Taherzadeh
Publisher : Elsevier
Release : 2022-08-26
ISBN : 0323984835
Language : En, Es, Fr & De

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Book Description :

Advances in Bioprocess Engineering, the latest release in the Current Developments in Biotechnology and Bioengineering series, provides a comprehensive overview of bioprocess systems, kinetics, bioreactor design, batch and continuous reactors and introduces key principles that enable bioprocess engineers to engage in analysis, optimization and design with consistent control over biological and chemical transformations. The bioprocessing sector is also updating its technologies with state-of-the art techniques to keep up with the rising demand of the industry and R&D. This book covers these aspects, taking readers through a step-by-step journey of bioprocessing while also guiding them towards a new era and future. Covers state-of-the-art, technological advancements in the field of bioprocessing Includes design and scale-up of bioreactors, monitoring and control systems, advances in upstream and downstream processing Includes design and development of fermentation processes such as the suitability of experimental design, full factorial, central composite design, Box-Behnken, Plackett-Burman, and more

Comprehensive Biotechnology

Comprehensive Biotechnology Book
Author : Anonim
Publisher : Elsevier
Release : 2019-07-17
ISBN : 0444640479
Language : En, Es, Fr & De

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Book Description :

Comprehensive Biotechnology, Third Edition unifies, in a single source, a huge amount of information in this growing field. The book covers scientific fundamentals, along with engineering considerations and applications in industry, agriculture, medicine, the environment and socio-economics, including the related government regulatory overviews. This new edition builds on the solid basis provided by previous editions, incorporating all recent advances in the field since the second edition was published in 2011. Offers researchers a one-stop shop for information on the subject of biotechnology Provides in-depth treatment of relevant topics from recognized authorities, including the contributions of a Nobel laureate Presents the perspective of researchers in different fields, such as biochemistry, agriculture, engineering, biomedicine and environmental science

Biological Reaction Engineering

Biological Reaction Engineering Book
Author : Elmar Heinzle,Irving J. Dunn,John Ingham,Jiří E. Přenosil
Publisher : John Wiley & Sons
Release : 2021-04-26
ISBN : 3527325247
Language : En, Es, Fr & De

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Book Description :

This practical book presents the modeling of dynamic biological engineering processes in a readily comprehensible manner, using the unique combination of simplified fundamental theory and direct hands-on computer simulation. The mathematics is kept to a minimum, and yet the 60 examples illustrate almost every aspect of biological engineering science, with each one described in detail, including the model equations. The programs are written in the modern user-friendly simulation language Berkeley Madonna, which can be run on both Windows PC and Power-Macintosh computers. Madonna solves models comprising many ordinary differential equations using very simple programming, including arrays. It is so powerful that the model parameters may be defined as "sliders", which allow the effect of their change on the model behavior to be seen almost immediately. Data may be included for curve fitting, and sensitivity or multiple runs may be performed. The results can be viewed simultaneously on multiple-graph windows or by using overlays. The examples can be varied to fit any real situation, and the suggested exercises provide practical guidance. The extensive teaching experience of the authors is reflected in this well-balanced presentation, which is suitable for the teacher, student, biochemist or the engineer.

The Prospect of Industry 5 0 in Biomanufacturing

The Prospect of Industry 5 0 in Biomanufacturing Book
Author : Pau Loke Show,Kit Wayne Chew,Tau Chuan Ling
Publisher : CRC Press
Release : 2021-07-02
ISBN : 1000407411
Language : En, Es, Fr & De

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Book Description :

This is the first book to present the idea of Industry 5.0 in biomanufacturing and bioprocess engineering, both upstream and downstream. The Prospect of Industry 5.0 in Biomanufacturing details the latest technologies and how they can be used efficiently and explains process analysis from an engineering point of view. In addition, it covers applications and challenges. FEATURES Describes the previous Industrial Revolution, current Industry 4.0, and how new technologies will transition toward Industry 5.0 Explains how Industry 5.0 can be applied in biomanufacturing Demonstrates new technologies catered to Industry 5.0 Uses worked examples related to biological systems This book enables readers in industry and academia working in the biomanufacturing engineering sector to understand current trends and future directions in this field.

Techno economics and Life Cycle Assessment of Bioreactors

Techno economics and Life Cycle Assessment of Bioreactors Book
Author : Puranjan Mishra,Lakhveer Singh,Pooja Ghosh
Publisher : Elsevier
Release : 2022-06-24
ISBN : 0323885837
Language : En, Es, Fr & De

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Book Description :

Techno-economics and Life Cycle Assessment of Bioreactors: Post-Covid19 Waste Management Approach covers the emerging trends in bioreactor research, including techno-economics and life cycle assessment perspectives, both key considerations in making the anaerobic-digestion process technically feasible, economically viable and environmentally sustainable. The book is divided into three sections, with an introductory chapter on the impact of COVID-19 on existing practices of waste and resource management. Sections cover advances in bioreactor development for enhanced valorization of waste, the techno-economics of the different bioreactor systems, the life cycle assessment of bioreactors, their methodological challenges and future perspectives. Providing a holistic overview of bioreactors and taking into account recent trends in their design, the chapters also highlight the advances needed to manage COVID-19 waste in a sustainable manner. With contributions from leading experts in bioreactor and life cycle assessment, this book will be an invaluable reference source for academics working on anaerobic digesters and energy sustainability, as well as for research and development professionals in the renewable energy industry, and scientists and engineers working on clean and efficient energy generation from wastes. Reinforces our understanding of the basic concepts and applications of bioreactors Includes a comprehensive evaluation of “Techno-economics and “Environmental impact analysis through a life cycle assessment approach Covers bioreactor advancements and a prognosis for the maximum utilization of waste for the increase transformation of waste to wealth Enables the broad range spectrum of potential technological and environmental impacts occurring across product generation

Control in Bioprocessing

Control in Bioprocessing Book
Author : Pablo A. López Pérez,Ricardo Aguilar López,Ricardo Femat
Publisher : John Wiley & Sons
Release : 2020-03-10
ISBN : 1119296323
Language : En, Es, Fr & De

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Book Description :

Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation and the Use of Sensors is divided into three sections. Part I, Mathematical preliminaries and overview of the control and monitoring of bioprocess, provides a general overview of the control and monitoring of bioprocesses, and introduces the mathematical framework necessary for the analysis and characterization of bioprocess dynamics. Part II, Observability and control concepts, presents the observability concepts which form the basis of design online estimation algorithms (software sensor) for bioprocesses, and reviews controllability of these concepts, including automatic feedback control systems. Part III, Software sensors and observer-based control schemes for bioprocesses, features six application cases including dynamic behavior of 3-dimensional continuous bioreactors; observability analysis applied to 2D and 3D bioreactors with inhibitory and non-inhibitory models; and regulation of a continuously stirred bioreactor via modeling error compensation. Applicable across all areas of bioprocess engineering, including food and beverages, biofuels and renewable energy, pharmaceuticals and nutraceuticals, fermentation systems, product separation technologies, wastewater and solid-waste treatment technology, and bioremediation Provides a clear explanation of the mass-balance–based mathematical modelling of bioprocesses and the main tools for its dynamic analysis Offers industry-based applications on: myco-diesel for implementing "quality" of observability; developing a virtual sensor based on the Just-In-Time Model to monitor biological control systems; and virtual sensor design for state estimation in a photocatalytic bioreactor for hydrogen production Control in Bioengineering and Bioprocessing is intended as a foundational text for graduate level students in bioengineering, as well as a reference text for researchers, engineers, and other practitioners interested in the field of estimation and control of bioprocesses.

The Control Handbook three volume set

The Control Handbook  three volume set  Book
Author : William S. Levine
Publisher : CRC Press
Release : 2018-10-08
ISBN : 1420073672
Language : En, Es, Fr & De

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Book Description :

At publication, The Control Handbook immediately became the definitive resource that engineers working with modern control systems required. Among its many accolades, that first edition was cited by the AAP as the Best Engineering Handbook of 1996. Now, 15 years later, William Levine has once again compiled the most comprehensive and authoritative resource on control engineering. He has fully reorganized the text to reflect the technical advances achieved since the last edition and has expanded its contents to include the multidisciplinary perspective that is making control engineering a critical component in so many fields. Now expanded from one to three volumes, The Control Handbook, Second Edition brilliantly organizes cutting-edge contributions from more than 200 leading experts representing every corner of the globe. They cover everything from basic closed-loop systems to multi-agent adaptive systems and from the control of electric motors to the control of complex networks. Progressively organized, the three volume set includes: Control System Fundamentals Control System Applications Control System Advanced Methods Any practicing engineer, student, or researcher working in fields as diverse as electronics, aeronautics, or biomedicine will find this handbook to be a time-saving resource filled with invaluable formulas, models, methods, and innovative thinking. In fact, any physicist, biologist, mathematician, or researcher in any number of fields developing or improving products and systems will find the answers and ideas they need. As with the first edition, the new edition not only stands as a record of accomplishment in control engineering but provides researchers with the means to make further advances.

Dynamics of the Chemostat

Dynamics of the Chemostat Book
Author : Abdelhamid Ajbar,Khalid Alhumaizi
Publisher : CRC Press
Release : 2011-08-09
ISBN : 1439867143
Language : En, Es, Fr & De

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Book Description :

A ubiquitous tool in mathematical biology and chemical engineering, the chemostat often produces instabilities that pose safety hazards and adversely affect the optimization of bioreactive systems. Singularity theory and bifurcation diagrams together offer a useful framework for addressing these issues. Based on the authors’ extensive work in this field, Dynamics of the Chemostat: A Bifurcation Theory Approach explores the use of bifurcation theory to analyze the static and dynamic behavior of the chemostat. Introduction The authors first survey the major work that has been carried out on the stability of continuous bioreactors. They next present the modeling approaches used for bioreactive systems, the different kinetic expressions for growth rates, and tools, such as multiplicity, bifurcation, and singularity theory, for analyzing nonlinear systems. Application The text moves on to the static and dynamic behavior of the basic unstructured model of the chemostat for constant and variable yield coefficients as well as in the presence of wall attachment. It then covers the dynamics of interacting species, including pure and simple microbial competition, biodegradation of mixed substrates, dynamics of plasmid-bearing and plasmid-free recombinant cultures, and dynamics of predator–prey interactions. The authors also examine dynamics of the chemostat with product formation for various growth models, provide examples of bifurcation theory for studying the operability and dynamics of continuous bioreactor models, and apply elementary concepts of bifurcation theory to analyze the dynamics of a periodically forced bioreactor. Using singularity theory and bifurcation techniques, this book presents a cohesive mathematical framework for analyzing and modeling the macro- and microscopic interactions occurring in chemostats. The text includes models that describe the intracellular and operating elements of the bioreactive system. It also explains the mathematical theory behind the models.

Food Industry Wastes

Food Industry Wastes Book
Author : Maria R. Kosseva,C.A. Kent
Publisher : Elsevier Inc. Chapters
Release : 2013-01-31
ISBN : 0128058919
Language : En, Es, Fr & De

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Book Description :

Download Food Industry Wastes book written by Maria R. Kosseva,C.A. Kent, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Modern Solid State Fermentation

Modern Solid State Fermentation Book
Author : Hongzhang Chen
Publisher : Springer Science & Business Media
Release : 2013-03-22
ISBN : 9400760434
Language : En, Es, Fr & De

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Book Description :

“Modern Solid State Fermentation: Theory and Practice” covers state-of-the-art studies in the field of solid state fermentation (SSF). In terms of different characteristics of microbial metabolites, this book catalogs SSF into two main parts: anaerobic and aerobic SSF. Based on the principles of porous media and strategies of process control and scale-up, which are introduced in the book, it not only presents a well-founded explanation of essence of solid state fermentation, but also their influence on microbial physiology. In addition, due to the rapid development of this field in recent years, inert support solid state fermentation is also examined in detail. At last, the modern solid state fermentation technology platform is proposed, which will be used in solid biomass bioconversion. This book is intended for biochemists, biotechnologists and process engineers, as well as researchers interested in SSF. Dr. Hongzhang Chen is a Professor at Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China.

Industrial Biotechnology

Industrial Biotechnology Book
Author : Christoph Wittmann
Publisher : John Wiley & Sons
Release : 2017-03-06
ISBN : 3527341811
Language : En, Es, Fr & De

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Book Description :

The latest volume in the Advanced Biotechnology series provides an overview of the main product classes and platform chemicals produced by biotechnological processes today, with applications in the food, healthcare and fine chemical industries. Alongside the production of drugs and flavors as well as amino acids, bio-based monomers and polymers and biofuels, basic insights are also given as to the biotechnological processes yielding such products and how large-scale production may be enabled and improved. Of interest to biotechnologists, bio and chemical engineers, as well as those working in the biotechnological, chemical, and food industries.

Bioreactor Design Fundamentals

Bioreactor Design Fundamentals Book
Author : Norton G. McDuffie
Publisher : Butterworth-Heinemann
Release : 2013-10-22
ISBN : 1483221083
Language : En, Es, Fr & De

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Book Description :

Bioreactor Design Fundamentals presents the development in the bioreactor field. This book discusses the applications of biological kinetics and thermodynamics. Organized into seven chapters, this book begins with an overview of the design of biological reactors that involves determining operating conditions, sizing the reactor, controlling temperature and sterility, and controlling operating variables. This text then examines the significance of pH considerations in biological reactor and process design. Other chapters consider enzyme kinetics and the equations most commonly used as models for overall enzyme kinetics. This book discusses as well the mass transfer rates in bioreactors, which are significant because of their effects on some chemical reaction rates in transformations by enzymes or by living cells. The final chapter deals with the ideal state of the continuous stirred-tank reactors (CSTRs). This book is a valuable resource for biochemical engineers and industrial microbiologists.