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Biophysical Mass Spectrometry

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Mass Spectrometry in Biophysics

Mass Spectrometry in Biophysics Book
Author : Igor A. Kaltashov,Stephen J. Eyles
Publisher : John Wiley & Sons
Release : 2005-05-06
ISBN : 0471705160
Language : En, Es, Fr & De

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Book Description :

The first systematic summary of biophysical mass spectrometrytechniques Recent advances in mass spectrometry (MS) have pushed the frontiersof analytical chemistry into the biophysical laboratory. As aresult, the biophysical community's acceptance of MS-based methods,used to study protein higher-order structure and dynamics, hasaccelerated the expansion of biophysical MS. Despite this growing trend, until now no single text has presentedthe full array of MS-based experimental techniques and strategiesfor biophysics. Mass Spectrometry in Biophysics expertly closesthis gap in the literature. Covering the theoretical background and technical aspects of eachmethod, this much-needed reference offers an unparalleled overviewof the current state of biophysical MS. Mass Spectrometry inBiophysics begins with a helpful discussion of general biophysicalconcepts and MS-related techniques. Subsequent chaptersaddress: * Modern spectrometric hardware * High-order structure and dynamics as probed by various MS-basedmethods * Techniques used to study structure and behavior of non-nativeprotein states that become populated under denaturingconditions * Kinetic aspects of protein folding and enzyme catalysis * MS-based methods used to extract quantitative information onprotein-ligand interactions * Relation of MS-based techniques to other experimental tools * Biomolecular properties in the gas phase Fully referenced and containing a helpful appendix on the physicsof electrospray mass spectrometry, Mass Spectrometry in Biophysicsalso offers a compelling look at the current challenges facingbiomolecular MS and the potential applications that will likelyshape its future.

Mass Spectrometry in Structural Biology and Biophysics

Mass Spectrometry in Structural Biology and Biophysics Book
Author : Igor A. Kaltashov,Stephen J. Eyles
Publisher : John Wiley & Sons
Release : 2012-04-03
ISBN : 0470937793
Language : En, Es, Fr & De

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Book Description :

With its detailed and systematic coverage of the current state of biophysical mass spectrometry (MS), here is one of the first systematic presentations of the full experimental array of MS-based techniques used in biophysics, covering both fundamental and practical issues. The book presents a discussion of general biophysical concepts and a brief overview of traditional biophysical techniques before outlining the more advanced concepts of mass spectrometry. The new edition gives an up-to-date and expanded coverage of experimental methodologies and a clear look at MS-based methods for studying higher order structures and biopolymers. A must for researchers in the field of biophysics, structural biology, and protein chemistry.

Biophysical Methods for Biotherapeutics

Biophysical Methods for Biotherapeutics Book
Author : Tapan K. Das
Publisher : Wiley
Release : 2014-04-28
ISBN : 0470938439
Language : En, Es, Fr & De

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Book Description :

With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development. • Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods • Chapters organized according to the sequential nature of the drug development process • Helps formulation, analytical, and bioanalytical scientists in pharma and biotech better understand and usestrengths and limitations of biophysical methods • Explains how to use biophysical methods, the information obtained, and what needs to be presented in a regulatory filing, assess impact on quality and immunogenicity • With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.

Methods in Modern Biophysics

Methods in Modern Biophysics Book
Author : Bengt Nölting
Publisher : Springer Science & Business Media
Release : 2013-03-09
ISBN : 3662053675
Language : En, Es, Fr & De

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Book Description :

Incorporating dramatic recent advances, "Methods in Modern Biophysics" presents a fresh and timely introduction to modern biophysical methods. This innovative text surveys and explains the ten key biophysical methods, including those related to biophysical nanotechnology, scanning probe microscopy, X-ray crystallography, ion mobility spectrometry, mass spectrometry, and proteomics. Containing much information previously unavailable in tutorial form, "Methods in Modern Biophysics" employs worked examples and more than 260 illustrations to fully detail the techniques and their underlying mechanisms. The book was written for advanced undergraduate and graduate students, postdocs, researchers, lecturers and professors in biophysics, biochemistry, general biology and related fields.

Biophysical Characterization of Proteins in Developing Biopharmaceuticals

Biophysical Characterization of Proteins in Developing Biopharmaceuticals Book
Author : Damian J. Houde,Steven A. Berkowitz
Publisher : Elsevier
Release : 2019-11-13
ISBN : 0444641742
Language : En, Es, Fr & De

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Book Description :

Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly employed in the biopharmaceutical industry. This book will help today’s industrial scientists plan a career in this industry and successfully implement these biophysical methodologies. This updated edition has been fully revised, with new chapters focusing on the use of chromatography and electrophoresis and the biophysical characterization of very large biopharmaceuticals. In addition, best practices of applying statistical analysis to biophysical characterization data is included, along with practical issues associated with the concept of a biopharmaceutical’s developability and the technical decision-making process needed when dealing with biophysical characterization data. Presents basic protein characterization methods and tools applicable to (bio)pharmaceutical research and development Highlights the capabilities and limitations of each technique Discusses the underlining science of each tool Empowers industrial biophysical chemists by providing a roadmap for applying biophysical tools Outlines the needs for new characterization and analytical tools in the biopharmaceutical industry

Introduction to Biomolecular Structure and Biophysics

Introduction to Biomolecular Structure and Biophysics Book
Author : Gauri Misra
Publisher : Springer
Release : 2017-09-07
ISBN : 9811049688
Language : En, Es, Fr & De

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Book Description :

This comprehensive book presents a modern concept in biophysics based on recently published research. It highlights various aspects of the biophysical fundamentals and techniques that are currently used to study different physical properties of biomolecules, and relates the biological phenomenon with the underlying physical concepts. The content is divided into nine chapters summarizing the structural details of proteins, including recently discovered novel folds, higher order structures of nucleic acids, as well as lipids and the physical forces governing the macromolecular interactions which are essential for the various biological processes. It also provides insights into the recent advances in biophysical techniques including Hydrogen Deuterium Exchange with Mass Spectrometry (HDX-MS), Small angle X-ray scattering (SAXS) and Cryo Electron Microscopy (cryo EM), supplemented with interesting experimental data. It is a valuable reference resource for anyone with a desire to gain a better understanding of the fundamentals of biophysical concepts and techniques of important biomolecules.

Indian Journal of Biochemistry Biophysics

Indian Journal of Biochemistry   Biophysics Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Indian Journal of Biochemistry Biophysics book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Annual Review of Biophysics and Biophysical Chemistry

Annual Review of Biophysics and Biophysical Chemistry Book
Author : Donald M. Engelman
Publisher : Unknown
Release : 1988-06
ISBN : 9780824318178
Language : En, Es, Fr & De

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Book Description :

Download Annual Review of Biophysics and Biophysical Chemistry book written by Donald M. Engelman, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Hydrogen Exchange Mass Spectrometry of Proteins

Hydrogen Exchange Mass Spectrometry of Proteins Book
Author : David D. Weis
Publisher : John Wiley & Sons
Release : 2016-03-21
ISBN : 1118616499
Language : En, Es, Fr & De

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Book Description :

Hydrogen exchange mass spectrometry is widely recognized for its ability to probe the structure and dynamics of proteins. The application of this technique is becoming widespread due to its versatility for providing structural information about challenging biological macromolecules such as antibodies, flexible proteins and glycoproteins. Although the technique has been around for 25 years, this is the first definitive book devoted entirely to the topic. Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods and Applications brings into one comprehensive volume the theory, instrumentation and applications of Hydrogen Exchange Mass Spectrometry (HX-MS) - a technique relevant to bioanalytical chemistry, protein science and pharmaceuticals. The book provides a solid foundation in the basics of the technique and data interpretation to inform readers of current research in the method, and provides illustrative examples of its use in bio- and pharmaceutical chemistry and biophysics In-depth chapters on the fundamental theory of hydrogen exchange, and tutorial chapters on measurement and data analysis provide the essential background for those ready to adopt HX-MS. Expert users may advance their current understanding through chapters on methods including membrane protein analysis, alternative proteases, millisecond hydrogen exchange, top-down mass spectrometry, histidine exchange and method validation. All readers can explore the diversity of HX-MS applications in areas such as ligand binding, membrane proteins, drug discovery, therapeutic protein formulation, biocomparability, and intrinsically disordered proteins.

Biophysical Chemistry

Biophysical Chemistry Book
Author : Alan Cooper
Publisher : Royal Society of Chemistry
Release : 2011
ISBN : 1849730814
Language : En, Es, Fr & De

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Book Description :

This book will be ideal for early undergraduates studying chemical or physical sciences and will act as a basis for more advanced study.

New Techniques in Biophysics and Cell Biology

New Techniques in Biophysics and Cell Biology Book
Author : Roger H. Pain,Basil J. Smith
Publisher : Unknown
Release : 1973
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download New Techniques in Biophysics and Cell Biology book written by Roger H. Pain,Basil J. Smith, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Synthesis and Biophysical Studies of Novel Vancomycin Derivatives

Synthesis and Biophysical Studies of Novel Vancomycin Derivatives Book
Author : Uma N. Sundram
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Synthesis and Biophysical Studies of Novel Vancomycin Derivatives book written by Uma N. Sundram, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biophysical Studies of the Effects of Environmental Toxins on Alpha synuclein

Biophysical Studies of the Effects of Environmental Toxins on Alpha synuclein Book
Author : Blanca A. Silva
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biophysical Studies of the Effects of Environmental Toxins on Alpha synuclein book written by Blanca A. Silva, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biophysical Electron Microscopy

Biophysical Electron Microscopy Book
Author : P. W. Hawkes,Ugo Valdrè
Publisher : Unknown
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book is an essential text for all biologists, biophysicists, and medical doctors who apply techniques of electron microscopy. Biologists and physicists have written the book in close collaboration so as to describe and explain these techniques in an accessible manner to a wide audience. This volume will have the double effect of encouraging biologists to experiment with techniques they have not yet tried and of inviting physicists to turn their skills to some of the unsolved problems of the biological specimen.

Introduction to Biophysical Methods for Protein and Nucleic Acid Research

Introduction to Biophysical Methods for Protein and Nucleic Acid Research Book
Author : Jay A. Glasel,Murray P. Deutscher
Publisher : Academic Press
Release : 1995-11-20
ISBN : 9780080534985
Language : En, Es, Fr & De

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Book Description :

The first of its kind, Introduction to Biophysical Methods for Protein and Nucleic Acid Research serves as a text for the experienced researcher and student requiring an introduction to the field. Each chapter presents a description of the physical basis of the method, the type of information that may be obtained with the method, how data should be analyzed and interpreted and, where appropriate, practical tips about procedures and equipment. Key Features * Modern Use of Mass Spectroscopy * NMR Spectroscopy * Molecular Modeling and Graphics * Macintosh and DOS/Windows 3.x disks

Studies of Iron Homeostasis in Saccharomyces Cerevisiae and Biophysical Characterization of Tomato Chloroplast Superoxide Dismutase

Studies of Iron Homeostasis in Saccharomyces Cerevisiae and Biophysical Characterization of Tomato Chloroplast Superoxide Dismutase Book
Author : Amir Liba
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Studies of Iron Homeostasis in Saccharomyces Cerevisiae and Biophysical Characterization of Tomato Chloroplast Superoxide Dismutase book written by Amir Liba, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Modern Biophysical Chemistry

Modern Biophysical Chemistry Book
Author : Peter Jomo Walla
Publisher : John Wiley & Sons
Release : 2014-09-22
ISBN : 3527337733
Language : En, Es, Fr & De

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Book Description :

This updated and up-to-date version of the first edition continues with the really interesting stuff to spice up a standard biophysics and biophysical chemistry course. All relevant methods used in current cutting edge research including such recent developments as super-resolution microscopy and next-generation DNA sequencing techniques, as well as industrial applications, are explained. The text has been developed from a graduate course taught by the author for several years, and by presenting a mix of basic theory and real-life examples, he closes the gap between theory and experiment. The first part, on basic biophysical chemistry, surveys fundamental and spectroscopic techniques as well as biomolecular properties that represent the modern standard and are also the basis for the more sophisticated technologies discussed later in the book. The second part covers the latest bioanalytical techniques such as the mentioned super-resolution and next generation sequencing methods, confocal fluorescence microscopy, light sheet microscopy, two-photon microscopy and ultrafast spectroscopy, single molecule optical, electrical and force measurements, fluorescence correlation spectroscopy, optical tweezers, quantum dots and DNA origami techniques. Both the text and illustrations have been prepared in a clear and accessible style, with extended and updated exercises (and their solutions) accompanying each chapter. Readers with a basic understanding of biochemistry and/or biophysics will quickly gain an overview of cutting edge technology for the biophysical analysis of proteins, nucleic acids and other biomolecules and their interactions. Equally, any student contemplating a career in the chemical, pharmaceutical or bio-industry will greatly benefit from the technological knowledge presented. Questions of differing complexity testing the reader's understanding can be found at the end of each chapter with clearly described solutions available on the Wiley-VCH textbook homepage under: www.wiley-vch.de/textbooks

Biochemistry and Biophysics in Food Research

Biochemistry and Biophysics in Food Research Book
Author : James Muil Leitch,Douglas N. Rhodes
Publisher : Unknown
Release : 1963
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biochemistry and Biophysics in Food Research book written by James Muil Leitch,Douglas N. Rhodes, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Handbook of Biochemistry and Biophysics

The Handbook of Biochemistry and Biophysics Book
Author : Henry Clarence Damm,Paige K. Besch
Publisher : Unknown
Release : 1966
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Purpose of the book is to keep professionals abreast of the rapidly advancing and changing technology of biochemistry and biophysics.