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Biomedical Applications Of Microfluidic Devices

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Microfluidic Devices for Biomedical Applications

Microfluidic Devices for Biomedical Applications Book
Author : Xiujun James Li,Yu Zhou
Publisher : Woodhead Publishing
Release : 2021-08-09
ISBN : 0128227559
Language : En, Es, Fr & De

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Book Description :

Microfluidic Devices for Biomedical Applications, Second Edition provides updated coverage on the fundamentals of microfluidics, while also exploring a wide range of medical applications. Chapters review materials and methods, microfluidic actuation mechanisms, recent research on droplet microfluidics, applications in drug discovery and controlled-delivery, including micro needles, consider applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds, and cover the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. This book is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries. Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores a wide range of medical applications Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies Details applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and its role in developing tissue scaffolds, and stem cell engineering

Biomedical Applications of Microfluidic Devices

Biomedical Applications of Microfluidic Devices Book
Author : Michael R. Hamblin,Mahdi Karimi
Publisher : Academic Press
Release : 2020-11-12
ISBN : 0128187921
Language : En, Es, Fr & De

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Book Description :

Biomedical Applications of Microfluidic Devices introduces the subject of microfluidics and covers the basic principles of design and synthesis of actual microchannels. The book then explores how the devices are coupled to signal read-outs and calibrated, including applications of microfluidics in areas such as tissue engineering, organ-on-a-chip devices, pathogen identification, and drug/gene delivery. This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which are big drivers in biomedical engineering research. This book addresses the fundamental concepts and fabrication methods of microfluidic systems for those who want to start working in the area or who want to learn about the latest advances being made. The subjects covered are also an asset to companies working in this field that need to understand the current state-of-the-art. The book is ideal for courses on microfluidics, biosensors, drug targeting, and BioMEMs, and as a reference for PhD students. The book covers the emerging and most promising areas of biomedical applications of microfluidic devices in a single place and offers a vision of the future. Covers basic principles and design of microfluidics devices Explores biomedical applications to areas such as tissue engineering, organ-on-a-chip, pathogen identification, and drug and gene delivery Includes chemical applications in organic and inorganic chemistry Serves as an ideal text for courses on microfluidics, biosensors, drug targeting, and BioMEMs, as well as a reference for PhD students

Biomedical Applications for Microfluidic Devices

Biomedical Applications for Microfluidic Devices Book
Author : Wen Qiao
Publisher : Unknown
Release : 2013
ISBN : 9781303627866
Language : En, Es, Fr & De

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Book Description :

My thesis research has focused on the biomedical applications of microfluidic devices, including accommodating liquid intraocular lens, wirelessly powered dielectrophoresis microfluidic platform, and evaporative microarray for molecular in-vitro diagnosis. In the first part, I developed an accommodating intraocular lens that can largely improve cataract patients' living quality by enabling patients to focus on far distance as well as near distance. Compared to natural eyes, today's commercially available accommodating IOLs produce a much limited tuning range. The large performance gap is attributed to the fundamental difference between crystalline lens and the optic-shift IOLs in the operation principles. In the thesis we designed and made a fluidic IOL that can change its curvature as the crystalline lens does. Both mechanical performance and optical quality are tested under the physiological conditions of aged eyes, promising complete restoration of vision accommodation. In the second part, I reported the first microfluidic device integrated with a printed RF circuit so that the device can be wirelessly powered by a commerciallyavailable radio-frequency identification (RFID) reader. The device eliminates the need for wire attachments and external instrument, so the operators can use the device in essentially the same manner as they do with microscope slides. The integrated circuit can be fabricated on a flexible plastic substrate at very low cost using a roll-to-roll printing method. Electrical power at 13.56 MHz transmitted by a RFID reader is inductively coupled to the printed RFIC and converted into 10V DC (direct current) output, which provides sufficient power to drive a microfluidic device to manipulate biological particles such as beads and proteins via the DC dielectrophoresis (DC-DEP) effect. In the third part, I developed a mathematical model for microarray probe/target reaction. The analysis was based on any chemical reaction between target molecules suspended in solution react and probes immobilized on a solid substrate, so it can be used to analysis hybridization efficiency in genomic microarray, as well as binding efficiency in protein microarray. The model indicated that besides diffusion, electrical repelling force between negatively charged probe and target molecules is the main cause for low hybridization efficiency. Based on the model, we further proposed a novel evaporative microarray, which can reduce the target solution thickness down to 80 [mu]m and theoretically enrich the concentration of molecules up to 1000 fold before target/probe chemical reaction. Preliminary data demonstrated the feasibility of integration of evaporation with microarray using black silicon template.

Diamond based materials for biomedical applications

Diamond based materials for biomedical applications Book
Author : A. Karczemska
Publisher : Elsevier Inc. Chapters
Release : 2013-03-19
ISBN : 0128088079
Language : En, Es, Fr & De

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Book Description :

This chapter discusses the possibilities and advantages offered by the use of diamond materials in the fabrication of microfluidic devices. The correct choice of material with optimal properties is crucial in the design of modern microfluidic devices. The different applications of diamond materials in this field are reviewed, along with a discussion of recent development and future trends.

Biological Applications of Microfluidics

Biological Applications of Microfluidics Book
Author : Frank A. Gomez
Publisher : John Wiley & Sons
Release : 2008-02-15
ISBN : 0470074833
Language : En, Es, Fr & De

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Book Description :

Microfluidics-today's applications and tomorrow's potential Microfluidics has facilitated major biochemical application advancements in point-of-care diagnostics, bioterrorism detection, and drug discovery. There are numerous potential applications in biotechnology, pharmaceuticals, the life sciences, defense, public health, and agriculture. Microfluidic lab-on-a-chip (LOC) technologies represent a revolution in laboratory experimentation, bringing the benefits of miniaturization, integration, and automation to many research-based industries. Biological Applications of Microfluidics details recent advances in the biological applications of microfluidics, including cell sorting, DNA sequencing on a chip, microchip capillary electrophoresis, and synthesis on a microfluidic format. After an overview of microfluidics highlighting recent seminal works, it includes multiple chapters on: * Cell analysis on microfluidic devices * Chemical (enzymatic and non-enzymatic) reactions on microchips * Separations on microchips * Biomedical applications of microfluidics * Microfluidic fabrication * Hybrid microfluidic applications Microfluidics has incredible potential in a variety of areas. This book covers many recent advances, including microfabricated LOC technologies, advanced microfluidic tools, microfluidic culture platforms for stem cell and neuroscience research, a novel application of microfluidic LOC devices that facilitates fundamental research in proteomics that cannot be performed without miniaturization, the nano fountain pen, and more. With contributions from leading experts in chemistry, physics, bioengineering, material science, biomedicine, and other fields plus references at the end of each chapter to facilitate further study, this is an all-in-one, hands-on resource for analytical chemists and researchers. It is also an excellent resource for students studying analytical chemistry or biotechnology.

3D Printed Microfluidic Devices

3D Printed Microfluidic Devices Book
Author : Savas Tasoglu,Albert Folch
Publisher : MDPI
Release : 2019-01-10
ISBN : 3038974676
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue "3D Printed Microfluidic Devices" that was published in Micromachines

Development of Microfluidic Devices to Maintain and Interrogate Tissue Biopsies

Development of Microfluidic Devices to Maintain and Interrogate Tissue Biopsies Book
Author : Samantha Margaret Hattersley
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Development of Microfluidic Devices to Maintain and Interrogate Tissue Biopsies book written by Samantha Margaret Hattersley, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nanolithography

Nanolithography Book
Author : M Feldman
Publisher : Woodhead Publishing
Release : 2014-02-13
ISBN : 0857098756
Language : En, Es, Fr & De

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Book Description :

Integrated circuits, and devices fabricated using the techniques developed for integrated circuits, have steadily gotten smaller, more complex, and more powerful. The rate of shrinking is astonishing – some components are now just a few dozen atoms wide. This book attempts to answer the questions, “What comes next? and “How do we get there? Nanolithography outlines the present state of the art in lithographic techniques, including optical projection in both deep and extreme ultraviolet, electron and ion beams, and imprinting. Special attention is paid to related issues, such as the resists used in lithography, the masks (or lack thereof), the metrology needed for nano-features, modeling, and the limitations caused by feature edge roughness. In addition emerging technologies are described, including the directed assembly of wafer features, nanostructures and devices, nano-photonics, and nano-fluidics. This book is intended as a guide to the researcher new to this field, reading related journals or facing the complexities of a technical conference. Its goal is to give enough background information to enable such a researcher to understand, and appreciate, new developments in nanolithography, and to go on to make advances of his/her own. Outlines the current state of the art in alternative nanolithography technologies in order to cope with the future reduction in size of semiconductor chips to nanoscale dimensions Covers lithographic techniques, including optical projection, extreme ultraviolet (EUV), nanoimprint, electron beam and ion beam lithography Describes the emerging applications of nanolithography in nanoelectronics, nanophotonics and microfluidics

Micro nanoparticle Synthesis by Microfluidic Devices for Biomedical Applications

Micro nanoparticle Synthesis by Microfluidic Devices for Biomedical Applications Book
Author : Lung-Hsin Hung
Publisher : Unknown
Release : 2007
ISBN : 9780549386438
Language : En, Es, Fr & De

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Book Description :

Microfluidic systems have advantages such as low sample consumption, fast reaction over conventional bench top processes and were demonstrated the abilities to generate high quality droplets and particles with narrow size distribution. Divided by material category, recent development of using microfluidic devices for semiconductor, metal, colloidal, and biomaterial particle synthesis were reviewed. Microfluidic systems were designed and fabricated accordingly by applications and upon surface modification for droplet generation and particle synthesis purpose. Poly (dimethylsiloxane) and solvent compatible thiolene adhesive were used as device materials, and soft lithography and molding method were utilized for fast device fabrication. Droplet generation and manipulation were demonstrated in microchannels with adjustable generation rate, size, ratio, and controllable droplet fusion and switch. Base on microfluidic systems and droplet technique, three methods, chemical reaction, solvent evaporation, solvent extraction were applied to generate cadmium sulfide and poly (lactide-co-glycolide) micro/nanoparticles. The sizes of synthesized particles range from 5nm (CdS) to 160mum (PLGA) in diameter with narrow size distribution. By utilizing microfluidic platforms more novel particle synthesis can be prepared and applied for drug delivery and biomedical applications.

Smart Polymers

Smart Polymers Book
Author : José Miguel García,Félix Clemente García,José Antonio Reglero Ruiz,Saúl Vallejos,Miriam Trigo-López
Publisher : Walter de Gruyter GmbH & Co KG
Release : 2022-01-19
ISBN : 1501522469
Language : En, Es, Fr & De

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Book Description :

Smart polymers react sharply to small changes in physical or chemical conditions and present an intelligent response to chemical stimuli (i.e., chemical species -including biomolecules-, pH, solvents, redox, stimuli that trigger controlled depolymerization) and physical stimuli (i.e., temperature, light, mechanical stress and electrical stimuli). For these reasons, the interest in smart polymers has recently increased exponentially, especially in biological stimuli (i.e., application of polymer-based biosensors, drug delivery, tissue engineering, precision medicine and cell therapy). This book offers a unique opportunity to review the physical-chemical fundamentals of smart polymers, and their behaviour. It also provides an excellent review of the main applications of smart polymers.

Cell Analysis on Microfluidics

Cell Analysis on Microfluidics Book
Author : Jin-Ming Lin
Publisher : Springer
Release : 2017-10-25
ISBN : 9811053944
Language : En, Es, Fr & De

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Book Description :

This book presents a detailed overview of the design, formatting, application, and development of microfluidic chips in the context of cell biology research, enumerating each element involved in microfluidics-based cell analysis, discussing its history, status quo, and future prospects, It also offers an extensive review of the research completed in the past decade, including numerous color figures. The individual chapters are based on the respective authors' studies and experiences, providing tips from the frontline to help researchers overcome bottlenecks in their own work. It highlights a number of cutting-edge techniques, such as 3D cell culture, microfluidic droplet technique, and microfluidic chip-mass spectrometry interfaces, offering a first-hand impression of the latest trends in the field and suggesting new research directions. Serving as both an elementary introduction and advanced guidebook, the book interests and inspires scholars and students who are currently studying microfluidics-based cell analysis methods as well as those who wish to do so.

Microfluidic Chip Capillary Electrophoresis Devices

Microfluidic Chip Capillary Electrophoresis Devices Book
Author : Ying Sing Fung,Qidan Chen,Fuying Du,Wenpeng Guo,Tongmei Ma,Zhou Nie,Hui Sun,Ruige Wu,Wenfeng Zhao
Publisher : CRC Press
Release : 2015-08-18
ISBN : 1482251655
Language : En, Es, Fr & De

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Book Description :

Capillary electrophoresis (CE) and microfluidic chip (MC) devices are relatively mature technologies, but this book demonstrates how they can be integrated into a single, revolutionary device that can provide on-site analysis of samples when laboratory services are unavailable. By introducing the combination of CE and MC technology, Microfluidic Ch

Micro Nano Technology Systems for Biomedical Applications

Micro Nano Technology Systems for Biomedical Applications Book
Author : Chih-Ming Ho
Publisher : Oxford University Press
Release : 2010-03-25
ISBN : 0191551384
Language : En, Es, Fr & De

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Book Description :

In daily life, we are accustomed to working with length scales of feet or meters, but the building blocks from which our bodies are constructed are many orders of magnitude smaller. The technologies that are being developed to intervene at these minute scales have the potential to improve human health and significantly enrich our lives. Revolutionary micro/nano technology platforms have led to dramatic advances in sample preparation, analysis and cell culture. From the 1990s through to the very beginning of the twenty-first century, the focus was on the development of manufacturing technologies. Through elegant design and sophisticated fabrication, the micro- to nano-scale manipulation of fluids and particles has become routine. Since then, it has become possible to control molecular interactions at device surfaces, and optical manipulation, imaging and sensing techniques can also be incorporated. Micro/nano technology platforms are already being used to study and direct biological processes at the cellular and sub-cellular level, and to detect disease with greater sensitivity and specificity. The challenges and excitement in the near future will be in engineering these sophisticated, multifunctional devices to seamlessly interface with complex biological systems. Providing a clear guide that moves from molecules through devices to systems, this book reviews fundamental aspects of microfluidic devices, including fabrication, surface property control, pressure-driven and electrokinetic flow, and functions such as fluid mixing, particle sorting and molecular separations. The integration of optical and plasmonic imaging, optoelectronic tweezers for single particle manipulation, and optical and electrical signal transduction methods for biosensing are shown to provide extraordinary capabilities for bioanalytical and biomedical applications. These represent key areas of research that will lead to the next generation of micro/nano-based systems. Anyone working in this fast-changing field will benefit from this comprehensive review of the latest thinking, while researchers will find much to inspire and direct their work.

Micro and Nanostructured Microfluidic Devices for Localized Protein Immobilization and Other Biomedical Applications

Micro  and Nanostructured Microfluidic Devices for Localized Protein Immobilization and Other Biomedical Applications Book
Author : Steidle, Nicole E.
Publisher : KIT Scientific Publishing
Release : 2014-12-23
ISBN : 3731502976
Language : En, Es, Fr & De

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Book Description :

Download Micro and Nanostructured Microfluidic Devices for Localized Protein Immobilization and Other Biomedical Applications book written by Steidle, Nicole E., available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Micro and Nanotechnology Enabled Applications for Portable Miniaturized Analytical Systems

Micro  and Nanotechnology Enabled Applications for Portable Miniaturized Analytical Systems Book
Author : Sabu Thomas,Mazaher Ahmadi,Tuan Anh Nguyen,Abbas Afkhami,Tayyebeh Madrakian
Publisher : Elsevier
Release : 2021-10-12
ISBN : 0128237287
Language : En, Es, Fr & De

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Book Description :

Micro- and Nanotechnology Enabled Applications for Portable Miniaturized Analytical Systems outlines the basic principles of miniaturized analytical devices, such as spectrometric, separation, imaging and electrochemical miniaturized instruments. Concepts such as smartphone-enabled miniaturized detection systems and micro/nanomachines are also reviewed. Subsequent chapters explore the emerging application of these mobile devices for miniaturized analysis in various fields, including medicine and biomedicine, environmental chemistry, food chemistry, and forensic chemistry. This is an important reference source for materials scientists and engineers wanting to understand how miniaturization techniques are being used to create a range of efficient, sustainable electronic and optical devices. Miniaturization describes the concept of manufacturing increasingly smaller mechanical, optical, and electronic products and devices. These smaller instruments can be used to produce micro- and nanoscale components required for analytical procedures. A variety of micro/nanoscale materials have been synthesized and used in analytical procedures, such as sensing materials, sorbents, adsorbents, catalysts, and reactors. The miniaturization of analytical instruments can be applied to the different steps of analytical procedures, such as sample preparation, analytical separation, and detection, reducing the total cost of manufacturing the instruments and the needed reagents and organic solvents. Outlines how miniaturization techniques can be used to create new optical and electronic micro- and nanodevices Explores major application areas, including biomedicine, environmental science and security Assesses the major challenges of using miniaturization techniques

Drug Delivery Devices and Therapeutic Systems

Drug Delivery Devices and Therapeutic Systems Book
Author : Eric Chappel
Publisher : Academic Press
Release : 2020-11-07
ISBN : 0128198397
Language : En, Es, Fr & De

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Book Description :

Drug Delivery Devices and Therapeutic Systems examines the current technology and innovations moving drug delivery systems (DDS) forward. The book provides an overview on the therapeutic use of drug delivery devices, including design, applications, and a description of the design of each device. While other books focus on the therapy, the primary emphasis in this book is on current technologies for DDS applications, including microfluidics, nanotechnology, biodegradable hydrogel and microneedles, with a special emphasis on wearable DDS. As part of the Developments in Biomedical Engineering and Bioelectronics series, this book is written by experts in the field and informed with information directly from manufacturers. Pharmaceutical scientists, medical researchers, biomedical engineers and clinical professionals will find this an essential reference. Provides essential information on the most recent drug delivery systems available Explains current technology and its applications to drug delivery Contains contributions from biomedical engineers, pharmaceutical scientists and manufacturers

Micro and Nanomanipulation Tools

Micro  and Nanomanipulation Tools Book
Author : Yu Sun,Xinyu Liu
Publisher : John Wiley & Sons
Release : 2015-09-10
ISBN : 3527690255
Language : En, Es, Fr & De

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Book Description :

Combining robotics with nanotechnology, this ready reference summarizes the fundamentals and emerging applications in this fascinating research field. This is the first book to introduce tools specifically designed and made for manipulating micro- and nanometer-sized objects, and presents such examples as semiconductor packaging and clinical diagnostics as well as surgery. The first part discusses various topics of on-chip and device-based micro- and nanomanipulation, including the use of acoustic, magnetic, optical or dielectrophoretic fields, while surface-driven and high-speed microfluidic manipulation for biophysical applications are also covered. In the second part of the book, the main focus is on microrobotic tools. Alongside magnetic micromanipulators, bacteria and untethered, chapters also discuss silicon nano- and integrated optical tweezers. The book closes with a number of chapters on nanomanipulation using AFM and nanocoils under optical and electron microscopes. Exciting images from the tiniest robotic systems at the nano-level are used to illustrate the examples throughout the work. A must-have book for readers with a background ranging from engineering to nanotechnology.

Micro Nano Devices for Blood Analysis

Micro Nano Devices for Blood Analysis Book
Author : Rui A. Lima,Graça Minas,Susana Catarino
Publisher : MDPI
Release : 2019-12-03
ISBN : 3039218247
Language : En, Es, Fr & De

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Book Description :

The development of micro- and nanodevices for blood analysis is an interdisciplinary subject that demands the integration of several research fields, such as biotechnology, medicine, chemistry, informatics, optics, electronics, mechanics, and micro/nanotechnologies. Over the last few decades, there has been a notably fast development in the miniaturization of mechanical microdevices, later known as microelectromechanical systems (MEMS), which combine electrical and mechanical components at a microscale level. The integration of microflow and optical components in MEMS microdevices, as well as the development of micropumps and microvalves, have promoted the interest of several research fields dealing with fluid flow and transport phenomena happening in microscale devices. Microfluidic systems have many advantages over their macroscale counterparts, offering the ability to work with small sample volumes, providing good manipulation and control of samples, decreasing reaction times, and allowing parallel operations in one single step. As a consequence, microdevices offer great potential for the development of portable and point-of-care diagnostic devices, particularly for blood analysis. Moreover, the recent progress in nanotechnology has contributed to its increasing popularity, and has expanded the areas of application of microfluidic devices, including in the manipulation and analysis of flows on the scale of DNA, proteins, and nanoparticles (nanoflows). In this Special Issue, we invited contributions (original research papers, review articles, and brief communications) that focus on the latest advances and challenges in micro- and nanodevices for diagnostics and blood analysis, micro- and nanofluidics, technologies for flow visualization, MEMS, biochips, and lab-on-a-chip devices and their application to research and industry. We hope to provide an opportunity to the engineering and biomedical community to exchange knowledge and information and to bring together researchers who are interested in the general field of MEMS and micro/nanofluidics and, especially, in its applications to biomedical areas.

Microfluidic Devices with Integrated Biosensors for Biomedical Applications

Microfluidic Devices with Integrated Biosensors for Biomedical Applications Book
Author : César Alejandro Parra Cabrera,Josep Samitier i Martí,Universitat de Barcelona. Departament d'Electrònica
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Microfluidic Devices with Integrated Biosensors for Biomedical Applications book written by César Alejandro Parra Cabrera,Josep Samitier i Martí,Universitat de Barcelona. Departament d'Electrònica, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nanomaterials and Their Biomedical Applications

Nanomaterials and Their Biomedical Applications Book
Author : Tuhin Subhra Santra,Loganathan Mohan
Publisher : Springer Nature
Release : 2021-04-16
ISBN : 9813362529
Language : En, Es, Fr & De

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Book Description :

This book highlights the evolution of, and novel challenges currently facing, nanomaterials science, nanoengineering, and nanotechnology, and their applications and development in the biological and biomedical fields. It details different nanoscale and nanostructured materials syntheses, processing, characterization, and applications, and considers improvements that can be made in nanostructured materials with their different biomedical applications. The book also briefly covers the state of the art of different nanomaterials design, synthesis, fabrication and their potential biomedical applications. It will be particularly useful for reading and research purposes, especially for science and engineering students, academics, and industrial researchers.