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Biomaterials In Immune Engineering

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Immunomodulatory Biomaterials

Immunomodulatory Biomaterials Book
Author : Stephen F. Badylak,Jennifer Elisseeff
Publisher : Elsevier
Release : 2021-07-30
ISBN : 0128214406
Language : En, Es, Fr & De

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Book Description :

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert” immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Biomaterials and Immune Response

Biomaterials and Immune Response Book
Author : Nihal Engin Vrana
Publisher : CRC Press
Release : 2018-07-20
ISBN : 1351377558
Language : En, Es, Fr & De

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Book Description :

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Biomaterials in Regenerative Medicine and the Immune System

Biomaterials in Regenerative Medicine and the Immune System Book
Author : Laura Santambrogio
Publisher : Springer
Release : 2015-09-04
ISBN : 3319180452
Language : En, Es, Fr & De

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Book Description :

The generation of tridimensional tissues, assembled from scaffolding materials populated with biologically functional cells, is the great challenge and hope of tissue bioengineering and regenerative medicine. The generation of biomaterials capable of harnessing the immune system has been particularly successful. This book provides a comprehensive view of how immune cells can be manipulated to suppresses inflammation, deliver vaccines, fight cancer cells, promote tissue regeneration or inhibit blood clotting and bacterial infections by functionally engineered biomaterials. However, long-lived polymers, such as those employed in orthopedic surgery or vascular stents, can often induce an immune reaction to their basic components. As a result, this book is also an important step towards coming to understand how to manipulate biomaterials to optimize their beneficial effects and downplay detrimental immune responses.

Encyclopedia of Biomaterials and Biomedical Engineering

Encyclopedia of Biomaterials and Biomedical Engineering Book
Author : Gary E. Wnek,Gary L. Bowlin
Publisher : CRC Press
Release : 2008-05-28
ISBN : 1498761437
Language : En, Es, Fr & De

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Book Description :

Written by more than 400 subject experts representing diverse academic and applied domains, this multidisciplinary resource surveys the vanguard of biomaterials and biomedical engineering technologies utilizing biomaterials that lead to quality-of-life improvements. Building on traditional engineering principles, it serves to bridge advances in mat

Engineering of Biomaterials for Drug Delivery Systems

Engineering of Biomaterials for Drug Delivery Systems Book
Author : Anilkumar Parambath
Publisher : Woodhead Publishing
Release : 2018-02-01
ISBN : 0081017510
Language : En, Es, Fr & De

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Book Description :

Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field. Provides a self-contained work for the field of biomaterials for drug delivery Summarizes the current knowledge on PEGylation and strategies for bypassing it Presents research on an important, though under-represented issue in biomaterials Written by a world-class team of research scientists, engineers and clinicians

Engineering Neural Tissue from Stem Cells

Engineering Neural Tissue from Stem Cells Book
Author : Stephanie Willerth
Publisher : Academic Press
Release : 2017-07-05
ISBN : 0128113863
Language : En, Es, Fr & De

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Book Description :

Engineering Neural Tissue from Stem Cells covers the basic knowledge needed to understand the nervous system and how existing cells can be used to create neural tissue. This book presents a broad range of topics related to the design requirements for engineering neural tissue from stem cells. It begins with the anatomy and function of the central and peripheral nervous system, also covering stem cells, their relation to the nervous system and their function in recovery after injury or disease. In addition, the book explores the role of the extracellular matrix and vasculature/immune system and biomaterials, including their suitability for neural tissue engineering applications. Provides readers entering the field with a strong basis of neural tissue engineering processes and real-world applications Discusses the most current clinical trials and their importance of treating nervous system disorders Reviews the structure and immune response of the nervous system, including the brain, spinal cord and their present cells Offers a necessary overview of the natural and synthetic biomaterials used to engineer neural tissue

Host Response to Biomaterials

Host Response to Biomaterials Book
Author : Stephen F Badylak
Publisher : Academic Press
Release : 2015-05-08
ISBN : 0128005009
Language : En, Es, Fr & De

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Book Description :

Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine. Explains the various categories of biomaterials and their significance for clinical applications Contains a range of extensive coverage, including, but not limited to, orthopedic, surgery, dental, general surgery, neurosurgery, lower urinary tract, and regenerative medicine Includes regulations regarding combination devices

Definitions of Biomaterials for the Twenty First Century

Definitions of Biomaterials for the Twenty First Century Book
Author : Xingdong Zhang,David Williams
Publisher : Elsevier
Release : 2019-06-20
ISBN : 012818292X
Language : En, Es, Fr & De

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Book Description :

Definitions of Biomaterials for the Twenty-First Century is a review of key, critical biomaterial terms and definitions endorsed by the International Union of Societies for Biomaterials Science and Engineering. The topics and definitions discussed include those in general biomaterials and applications, biocompatibility, implantable and interventional devices, drug delivery systems, regenerative medicine and emerging biomaterials. The book reviews the discussion of these terms by leaders in the global biomaterials community and summarizes the agreed upon definitions. Provides readers with the official definitions of critical biomaterials terms endorsed by the International Union of Societies for Biomaterials Science and Engineering Includes the combined contributions from more than 50 global leaders in the biomaterials community Updates terms based on the latest advances in clinical and scientific understanding and expanded scope of biomaterials science

Frontiers of Engineering

Frontiers of Engineering Book
Author : National Academy of Engineering
Publisher : National Academies Press
Release : 2019-02-28
ISBN : 0309487501
Language : En, Es, Fr & De

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Book Description :

This volume presents papers on the topics covered at the National Academy of Engineering's 2018 US Frontiers of Engineering Symposium. Every year the symposium brings together 100 outstanding young leaders in engineering to share their cutting-edge research and innovations in selected areas. The 2018 symposium was held September 5-7 and hosted by MIT Lincoln Laboratory in Lexington, Massachusetts. The intent of this book is to convey the excitement of this unique meeting and to highlight innovative developments in engineering research and technical work.

Bio inspired Materials for Biomedical Engineering

Bio inspired Materials for Biomedical Engineering Book
Author : Anthony B. Brennan,Chelsea M. Kirschner
Publisher : John Wiley & Sons
Release : 2014-03-19
ISBN : 1118843436
Language : En, Es, Fr & De

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Book Description :

This book covers the latest bio-inspired materials synthesistechniques and biomedical applications that are advancing the fieldof tissue engineering. Bio-inspired concepts for biomedicalengineering are at the forefront of tissue engineering andregenerative medicine. Scientists, engineers and physicians areworking together to replicate the sophisticated hierarchicalorganization and adaptability found in nature and selected byevolution to recapitulate the cellular microenvironment. Thisbook demonstrates the dramatic clinical breakthroughs that havebeen made in engineering all four of the major tissue types andmodulating the immune system. Part I (Engineering Bio-inspired Material Microenvironments)covers Bio-inspired Presentation of Chemical Cues, Bio-inspiredPresentation of Physical Cues, and Bio-inspired Integration ofNatural Materials. Part II (Bio-inspired Tissue Engineering) addresses tissueengineering in epithelial tissue, muscle tissue, connective tissue,and the immune system.

Immunomodulatory Biomaterials

Immunomodulatory Biomaterials Book
Author : Stephen F. Badylak,Jennifer Elisseeff
Publisher : Woodhead Publishing
Release : 2021-07-30
ISBN : 0128214562
Language : En, Es, Fr & De

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Book Description :

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Adverse Reactions to Biomaterials State of the Art in Biomaterial Risk Assessment Immunomodulation and In Vitro Models for Biomaterial Testing

Adverse Reactions to Biomaterials  State of the Art in Biomaterial Risk Assessment  Immunomodulation and In Vitro Models for Biomaterial Testing Book
Author : Nihal Engin Vrana,Amir M. Ghaemmaghami,Pinar Zorlutuna
Publisher : Frontiers Media SA
Release : 2019-05-15
ISBN : 2889458229
Language : En, Es, Fr & De

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Book Description :

Adverse immune reactions to biomaterials are important bottlenecks for translation of novel biomaterials for clinical use. Moreover, recent advances in highthrough-put biomaterial discovery and synthetic biology, while providing exciting new veues, also significantly increases potential risks related to the in vivo reactions to these new materials. For example, the novel materials might have unintended biological activities due to their natural building blocks. In this perspective, biomaterial field needs i) better understanding of cell/biomaterial interactions at systems level; ii) development of new analysis and testing tools for advanced risk assessment iii) tools and technologies for modulating reactions to biomaterials and iv) advanced in vitro models for understanding and testing of reactions to biomaterials. In the following collection of articles you will find examples of such systems,together with comprehensive reviews of current developments in in vitro model systems. The collection also contains articles that elucidate the immune reaction to biomaterials in vitro and in vitro.

Biomaterials in Translational Medicine

Biomaterials in Translational Medicine Book
Author : Lei Yang,Sarit Bhaduri,Thomas J. Webster
Publisher : Academic Press
Release : 2018-11-30
ISBN : 012813478X
Language : En, Es, Fr & De

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Book Description :

Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine Includes the translational or commercialization status of these new biomaterials Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials

Materials for Biomedical Engineering

Materials for Biomedical Engineering Book
Author : Mohamed N. Rahaman,Roger F. Brown
Publisher : John Wiley & Sons
Release : 2021-11-23
ISBN : 1119551080
Language : En, Es, Fr & De

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Book Description :

MATERIALS FOR BIOMEDICAL ENGINEERING A comprehensive yet accessible introductory textbook designed for one-semester courses in biomaterials Biomaterials are used throughout the biomedical industry in a range of applications, from cardiovascular devices and medical and dental implants to regenerative medicine, tissue engineering, drug delivery, and cancer treatment. Materials for Biomedical Engineering: Fundamentals and Applications provides an up-to-date introduction to biomaterials, their interaction with cells and tissues, and their use in both conventional and emerging areas of biomedicine. Requiring no previous background in the subject, this student-friendly textbook covers the basic concepts and principles of materials science, the classes of materials used as biomaterials, the degradation of biomaterials in the biological environment, biocompatibility phenomena, and the major applications of biomaterials in medicine and dentistry. Throughout the text, easy-to-digest chapters address key topics such as the atomic structure, bonding, and properties of biomaterials, natural and synthetic polymers, immune responses to biomaterials, implant-associated infections, biomaterials in hard and soft tissue repair, tissue engineering and drug delivery, and more. Offers accessible chapters with clear explanatory text, tables and figures, and high-quality illustrations Describes how the fundamentals of biomaterials are applied in a variety of biomedical applications Features a thorough overview of the history, properties, and applications of biomaterials Includes numerous homework, review, and examination problems, full references, and further reading suggestions Materials for Biomedical Engineering: Fundamentals and Applications is an excellent textbook for advanced undergraduate and graduate students in biomedical materials science courses, and a valuable resource for medical and dental students as well as students with science and engineering backgrounds with interest in biomaterials.

Biosurfaces

Biosurfaces Book
Author : Kantesh Balani,Vivek Verma,Arvind Agarwal,Roger Narayan
Publisher : John Wiley & Sons
Release : 2015-01-23
ISBN : 111895064X
Language : En, Es, Fr & De

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Book Description :

Ideal as a graduate textbook, this title is aimed at helpingdesign effective biomaterials, taking into account the complexinteractions that occur at the interface when a synthetic materialis inserted into a living system. Surface reactivity,biochemistry, substrates, cleaning, preparation, and coatingsare presented, with numerous case studies and applicationsthroughout. Highlights include: Starts with concepts and works up to real-life applicationssuch as implantable devices, medical devices, prosthetics, and drugdelivery technology Addresses surface reactivity, requirements for surface coating,cleaning and preparation techniques, and characterization Discusses the biological response to coatings Addresses biomaterial-tissue interaction Incorporates nanomechanical properties and processingstrategies

The Immune Response to Implanted Materials and Devices

The Immune Response to Implanted Materials and Devices Book
Author : Bruna Corradetti
Publisher : Springer
Release : 2016-11-30
ISBN : 3319454331
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

Cellulose Chemistry and Properties Fibers Nanocelluloses and Advanced Materials

Cellulose Chemistry and Properties  Fibers  Nanocelluloses and Advanced Materials Book
Author : Orlando J. Rojas
Publisher : Springer
Release : 2016-02-25
ISBN : 3319260154
Language : En, Es, Fr & De

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Book Description :

Vincent Bulone et al.: Cellulose sources and new understanding of synthesis in plants Thomas Heinze et al.:Cellulose structure and properties Thomas Rosenau, Antje Potthast, Ute Henniges et al.: Recent developments in cellulose aging (degradation / yellowing / chromophore formation) Sunkyu Park et al.:Cellulose crystallinity Lina Zhang et al.:Gelation and dissolution behavior of cellulose Yoshiyuki Nishio et al.:Cellulose and derivatives in liquid crystals Alessandro Gandini, Naceur Belgacem et al.:The surface and in-depth modification of cellulose fibers Emily D. Cranston et al.:Interfacial properties of cellulose Herbert Sixta, Michael Hummel et al.Cellulose Fibers Regenerated from Cellulose Solutions in Ionic Liquids Qi Zhou et al.:Cellulose-based biocomposites Orlando Rojas et al.:Films of cellulose nanocrystals and nanofibrils Pedro Fardim et al.:Functional cellulose particles Wadood Hamad et al.:Cellulose Composites

An Introduction to Tissue Biomaterial Interactions

An Introduction to Tissue Biomaterial Interactions Book
Author : Kay C. Dee,David A. Puleo,Rena Bizios
Publisher : John Wiley & Sons
Release : 2003-04-14
ISBN : 0471461121
Language : En, Es, Fr & De

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Book Description :

An Introduction to Tissue-Biomaterial Interactions acquaintsan undergraduate audience with the fundamental biological processesthat influence these sophisticated, cutting-edge procedures.Chapters one through three provide more detail about themolecular-level events that happen at the tissue-implant interface,while chapters four through ten explore selected material,biological, and physiological consequences of these events. Theimportance of the body’s wound-healing response is emphasizedthroughout. Specific topics covered include:Structure andproperties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples oftissue-biomaterial interactions The text also provides extensive coverage of the three pertinentinterfaces between the body and the biomaterial, between the bodyand the living cells, and between the cells and the biomaterialthat are critical in the development of tissue-engineered productsthat incorporate living cells within a biomaterial matrix. Idealfor a one-semester, biomedical engineering course, An Introductionto Tissue-Biomaterial Interactions provides a solid framework forunderstanding today’s and tomorrow’s implantablebiomedical devices.

Biomimetic Medical Materials

Biomimetic Medical Materials Book
Author : Insup Noh
Publisher : Springer
Release : 2018-11-23
ISBN : 9811304459
Language : En, Es, Fr & De

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Book Description :

This volume outlines the current status in the field of biomimetic medical materials and illustrates research into their applications in tissue engineering. The book is divided into six parts, focusing on nano biomaterials, stem cells, tissue engineering, 3D printing, immune responses and intellectual property. Each chapter has its own introduction and outlines current research trends in a variety of applications of biomimetic medical materials. The biomimetic medical materials that are covered include functional hydrogels, nanoparticles for drug delivery and medicine, the 3D bioprinting of biomaterials, sensor materials, stem cell interactions with biomaterials, immune responses to biomaterials, biodegradable hard scaffolds for tissue engineering, as well as other important topics, like intellectual property. Each chapter is written by a team of experts. This volume attempts to introduce the biomimetic properties of biomedical materials within the context of our current understanding of the nanotechnology of nanoparticles and fibres and the macroscopic aspects of 3D bioprinting.

Regenerative Medicine Applications in Organ Transplantation

Regenerative Medicine Applications in Organ Transplantation Book
Author : Giuseppe Orlando
Publisher : Academic Press
Release : 2013-10-13
ISBN : 9780123985231
Language : En, Es, Fr & De

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Book Description :

Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant community Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions