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Biomaterials and Immune Response

Biomaterials and Immune Response Book
Author : Nihal Engin Vrana
Publisher : CRC Press
Release : 2018-07-20
ISBN : 1351377566
Language : En, Es, Fr & De

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Book Description :

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Biomimetic Medical Materials

Biomimetic Medical Materials Book
Author : Insup Noh
Publisher : Springer
Release : 2018-11-23
ISBN : 9811304459
Language : En, Es, Fr & De

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Book Description :

This volume outlines the current status in the field of biomimetic medical materials and illustrates research into their applications in tissue engineering. The book is divided into six parts, focusing on nano biomaterials, stem cells, tissue engineering, 3D printing, immune responses and intellectual property. Each chapter has its own introduction and outlines current research trends in a variety of applications of biomimetic medical materials. The biomimetic medical materials that are covered include functional hydrogels, nanoparticles for drug delivery and medicine, the 3D bioprinting of biomaterials, sensor materials, stem cell interactions with biomaterials, immune responses to biomaterials, biodegradable hard scaffolds for tissue engineering, as well as other important topics, like intellectual property. Each chapter is written by a team of experts. This volume attempts to introduce the biomimetic properties of biomedical materials within the context of our current understanding of the nanotechnology of nanoparticles and fibres and the macroscopic aspects of 3D bioprinting.

Engineering Zwitterionic Biomaterials for Immune Modulation and Drug Delivery

Engineering Zwitterionic Biomaterials for Immune Modulation and Drug Delivery Book
Author : Bowen Li
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The development of biotherapeutics, which hold promising potential to treat diverse disease, is limited by their inadequate circulation half-lives and inherent immunogenicity. Conjugation of non-ionic poly (ethylene glycol) (PEG), known as PEGylation, has been widely employed as the gold standard to ameliorate the pharmacokinetic (PK) and immunological profiles of proteins. Unfortunately, PEG grafted onto immunogenic proteins has been shown to induce anti-PEG antibodies (Abs) that could cause loss of efficacy and even lethal adverse reactions. To confront the "PEG dilemma", zwitterionic materials with superhydrophilicity are emerging as promising alternatives for PEG. This dissertation summarizes recent studies from the design, synthesis and characterization of zwitterionic polymers to the in vitro and in vivo studies of poly(zwitterion)- protein nanomedicine. The influence of PEG and zwitterionic poly(carboxy betaine) (PCB) on immune systems is firstly discussed, revealing the low immunogenic risk of zwitterionic materials. Based on this design principle, new protein-delivery tactics are proposed to avoid the generation of undesirable immune responses, either by completely shielding proteins from immune recognition or by actively inducing antigen-specific immune tolerance. Furthermore, new classes of naturally-inspired inert or immunomodulatory zwitterionic materials are developed to further improve the efficacy and safety of protein therapeutics, enriching the arsenal of biomaterial tools for drug delivery.

Materials for Biomedical Engineering

Materials for Biomedical Engineering Book
Author : Mohamed N. Rahaman,Roger F. Brown
Publisher : John Wiley & Sons
Release : 2021-11-01
ISBN : 1119551099
Language : En, Es, Fr & De

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Book Description :

MATERIALS FOR BIOMEDICAL ENGINEERING A comprehensive yet accessible introductory textbook designed for one-semester courses in biomaterials Biomaterials are used throughout the biomedical industry in a range of applications, from cardiovascular devices and medical and dental implants to regenerative medicine, tissue engineering, drug delivery, and cancer treatment. Materials for Biomedical Engineering: Fundamentals and Applications provides an up-to-date introduction to biomaterials, their interaction with cells and tissues, and their use in both conventional and emerging areas of biomedicine. Requiring no previous background in the subject, this student-friendly textbook covers the basic concepts and principles of materials science, the classes of materials used as biomaterials, the degradation of biomaterials in the biological environment, biocompatibility phenomena, and the major applications of biomaterials in medicine and dentistry. Throughout the text, easy-to-digest chapters address key topics such as the atomic structure, bonding, and properties of biomaterials, natural and synthetic polymers, immune responses to biomaterials, implant-associated infections, biomaterials in hard and soft tissue repair, tissue engineering and drug delivery, and more. Offers accessible chapters with clear explanatory text, tables and figures, and high-quality illustrations Describes how the fundamentals of biomaterials are applied in a variety of biomedical applications Features a thorough overview of the history, properties, and applications of biomaterials Includes numerous homework, review, and examination problems, full references, and further reading suggestions Materials for Biomedical Engineering: Fundamentals and Applications is an excellent textbook for advanced undergraduate and graduate students in biomedical materials science courses, and a valuable resource for medical and dental students as well as students with science and engineering backgrounds with interest in biomaterials.

An Introduction to Tissue Biomaterial Interactions

An Introduction to Tissue Biomaterial Interactions Book
Author : Kay C. Dee,David A. Puleo,Rena Bizios
Publisher : John Wiley & Sons
Release : 2003-04-14
ISBN : 0471461121
Language : En, Es, Fr & De

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Book Description :

An Introduction to Tissue-Biomaterial Interactions acquaintsan undergraduate audience with the fundamental biological processesthat influence these sophisticated, cutting-edge procedures.Chapters one through three provide more detail about themolecular-level events that happen at the tissue-implant interface,while chapters four through ten explore selected material,biological, and physiological consequences of these events. Theimportance of the body’s wound-healing response is emphasizedthroughout. Specific topics covered include:Structure andproperties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples oftissue-biomaterial interactions The text also provides extensive coverage of the three pertinentinterfaces between the body and the biomaterial, between the bodyand the living cells, and between the cells and the biomaterialthat are critical in the development of tissue-engineered productsthat incorporate living cells within a biomaterial matrix. Idealfor a one-semester, biomedical engineering course, An Introductionto Tissue-Biomaterial Interactions provides a solid framework forunderstanding today’s and tomorrow’s implantablebiomedical devices.

Bio inspired Materials for Biomedical Engineering

Bio inspired Materials for Biomedical Engineering Book
Author : Anthony B. Brennan,Chelsea M. Kirschner
Publisher : John Wiley & Sons
Release : 2014-03-19
ISBN : 1118843436
Language : En, Es, Fr & De

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Book Description :

This book covers the latest bio-inspired materials synthesistechniques and biomedical applications that are advancing the fieldof tissue engineering. Bio-inspired concepts for biomedicalengineering are at the forefront of tissue engineering andregenerative medicine. Scientists, engineers and physicians areworking together to replicate the sophisticated hierarchicalorganization and adaptability found in nature and selected byevolution to recapitulate the cellular microenvironment. Thisbook demonstrates the dramatic clinical breakthroughs that havebeen made in engineering all four of the major tissue types andmodulating the immune system. Part I (Engineering Bio-inspired Material Microenvironments)covers Bio-inspired Presentation of Chemical Cues, Bio-inspiredPresentation of Physical Cues, and Bio-inspired Integration ofNatural Materials. Part II (Bio-inspired Tissue Engineering) addresses tissueengineering in epithelial tissue, muscle tissue, connective tissue,and the immune system.

Immunomodulatory Biomaterials

Immunomodulatory Biomaterials Book
Author : Stephen F. Badylak,Jennifer Elisseeff
Publisher : Woodhead Publishing
Release : 2021-07-30
ISBN : 0128214562
Language : En, Es, Fr & De

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Book Description :

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

The Immune Response to Implanted Materials and Devices

The Immune Response to Implanted Materials and Devices Book
Author : Bruna Corradetti
Publisher : Springer
Release : 2016-11-30
ISBN : 3319454331
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

Definitions of Biomaterials for the Twenty First Century

Definitions of Biomaterials for the Twenty First Century Book
Author : Xingdong Zhang,David Williams
Publisher : Elsevier
Release : 2019-06-20
ISBN : 012818292X
Language : En, Es, Fr & De

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Book Description :

Definitions of Biomaterials for the Twenty-First Century is a review of key, critical biomaterial terms and definitions endorsed by the International Union of Societies for Biomaterials Science and Engineering. The topics and definitions discussed include those in general biomaterials and applications, biocompatibility, implantable and interventional devices, drug delivery systems, regenerative medicine and emerging biomaterials. The book reviews the discussion of these terms by leaders in the global biomaterials community and summarizes the agreed upon definitions. Provides readers with the official definitions of critical biomaterials terms endorsed by the International Union of Societies for Biomaterials Science and Engineering Includes the combined contributions from more than 50 global leaders in the biomaterials community Updates terms based on the latest advances in clinical and scientific understanding and expanded scope of biomaterials science

Humoral and T Cell Immune Responses to Model Antigen Delivered with Biomaterials Used in Tissue Engineering

Humoral and T Cell Immune Responses to Model Antigen Delivered with Biomaterials Used in Tissue Engineering Book
Author : Melissa Marie Stein
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Humoral and T Cell Immune Responses to Model Antigen Delivered with Biomaterials Used in Tissue Engineering book written by Melissa Marie Stein, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomimicked Biomaterials

Biomimicked Biomaterials Book
Author : Heung Jae Chun,Rui L. Reis,Antonella Motta,Gilson Khang
Publisher : Springer Nature
Release : 2020-06-29
ISBN : 9811532621
Language : En, Es, Fr & De

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Book Description :

This book is the second of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. In this volume, which is devoted to biomimetic biomaterials, the opening section discusses bone regeneration by means of duck’s feet-derived collagen scaffold and the use of decellularized extracellular matrices. The role of various novel biomimetic hydrogels in regenerative medicine is then considered in detail. The third section focuses on the control of stem cell fate by biomimetic biomaterials, covering exosome-integrated biomaterials for bone regeneration, cellular responses to materials for biomedical engineering, and the regulation of stem cell functions by micropatterned structures. Finally, the use of nano-intelligent biocomposites in regenerative medicine is addressed, with discussion of, for example, recent advances in biphasic calcium phosphate bioceramics and blood-contacting polymeric biomaterials. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.

Engineering Neural Tissue from Stem Cells

Engineering Neural Tissue from Stem Cells Book
Author : Stephanie Willerth
Publisher : Academic Press
Release : 2017-07-05
ISBN : 0128113863
Language : En, Es, Fr & De

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Book Description :

Engineering Neural Tissue from Stem Cells covers the basic knowledge needed to understand the nervous system and how existing cells can be used to create neural tissue. This book presents a broad range of topics related to the design requirements for engineering neural tissue from stem cells. It begins with the anatomy and function of the central and peripheral nervous system, also covering stem cells, their relation to the nervous system and their function in recovery after injury or disease. In addition, the book explores the role of the extracellular matrix and vasculature/immune system and biomaterials, including their suitability for neural tissue engineering applications. Provides readers entering the field with a strong basis of neural tissue engineering processes and real-world applications Discusses the most current clinical trials and their importance of treating nervous system disorders Reviews the structure and immune response of the nervous system, including the brain, spinal cord and their present cells Offers a necessary overview of the natural and synthetic biomaterials used to engineer neural tissue

Foundations of Biomaterials Engineering

Foundations of Biomaterials Engineering Book
Author : Maria Cristina Tanzi,Silvia Farè,Gabriele Candiani
Publisher : Academic Press
Release : 2019-03-16
ISBN : 0128094591
Language : En, Es, Fr & De

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Book Description :

Foundations of Biomaterials Engineering provides readers with an introduction to biomaterials engineering. With a strong focus on the essentials of materials science, the book also examines the physiological mechanisms of defense and repair, tissue engineering and the basics of biotechnology. An introductory section covers materials, their properties, processing and engineering methods. The second section, dedicated to Biomaterials and Biocompatibility, deals with issues related to the use and application of the various classes of materials in the biomedical field, particularly within the human body, the mechanisms underlying the physiological processes of defense and repair, and the phenomenology of the interaction between the biological environment and biomaterials. The last part of the book addresses two areas of growing importance: Tissue Engineering and Biotechnology. This book is a valuable resource for researchers, students and all those looking for a comprehensive and concise introduction to biomaterials engineering. Offers a one-stop source for information on the essentials of biomaterials and engineering Useful as an introduction or advanced reference on recent advances in the biomaterials field Developed by experienced international authors, incorporating feedback and input from existing customers

Biomaterials Science

Biomaterials Science Book
Author : Buddy D. Ratner,Allan S. Hoffman,Frederick J. Schoen,Jack E. Lemons
Publisher : Academic Press
Release : 2012-12-31
ISBN : 008087780X
Language : En, Es, Fr & De

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Book Description :

The revised edition of this renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science. It provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. Over 29,000 copies sold, this is the most comprehensive coverage of principles and applications of all classes of biomaterials: "the only such text that currently covers this area comprehensively" - Materials Today Edited by four of the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and expanded, key new topics include of tissue engineering, drug delivery systems, and new clinical applications, with new teaching and learning material throughout, case studies and a downloadable image bank

Biomaterials for 3D Tumor Modeling

Biomaterials for 3D Tumor Modeling Book
Author : Subhas C. Kundu,Rui L Reis
Publisher : Elsevier
Release : 2020-08-22
ISBN : 012818129X
Language : En, Es, Fr & De

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Book Description :

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Biomaterials Science

Biomaterials Science Book
Author : Buddy D. Ratner,Allan S. Hoffman,Frederick J. Schoen,Jack E. Lemons
Publisher : Elsevier
Release : 2004-08-18
ISBN : 008047036X
Language : En, Es, Fr & De

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Book Description :

The second edition of this bestselling title provides the most up-to-date comprehensive review of all aspects of biomaterials science by providing a balanced, insightful approach to learning biomaterials. This reference integrates a historical perspective of materials engineering principles with biological interactions of biomaterials. Also provided within are regulatory and ethical issues in addition to future directions of the field, and a state-of-the-art update of medical and biotechnological applications. All aspects of biomaterials science are thoroughly addressed, from tissue engineering to cochlear prostheses and drug delivery systems. Over 80 contributors from academia, government and industry detail the principles of cell biology, immunology, and pathology. Focus within pertains to the clinical uses of biomaterials as components in implants, devices, and artificial organs. This reference also touches upon their uses in biotechnology as well as the characterization of the physical, chemical, biochemical and surface properties of these materials. Provides comprehensive coverage of principles and applications of all classes of biomaterials Integrates concepts of biomaterials science and biological interactions with clinical science and societal issues including law, regulation, and ethics Discusses successes and failures of biomaterials applications in clinical medicine and the future directions of the field Cover the broad spectrum of biomaterial compositions including polymers, metals, ceramics, glasses, carbons, natural materials, and composites Endorsed by the Society for Biomaterials

Mechanism of Biomaterial Adjuvant Effect

Mechanism of Biomaterial Adjuvant Effect Book
Author : Mutsumi Yoshida
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Development of combination products such as tissue engineered constructs which combine biomaterials with biologics has prompted the need to clarify the role of biomaterial in potentiating the immune response towards the biological component due to adjuvant effect. In tissue engineering applications, immune responses are to be minimized while vaccine strategies seek to enhance the protective immune response. Thesis project presented herein showed that adjuvant effect of poly(lactic-co-glycolic acid) (PLGA) is mediated in part by maturation of dendritic cells (DCs), immune cells that orchestrate adaptive immune response. Maturation of human peripheral blood monocyte-derived DCs in response to PLGA contact was demonstrated in vitro and in vivo by increased co-stimulatory and MHC molecule expression, mixed lymphocyte reaction, cytokine release, and delayed type hypersensitivity reaction. In contrast to PLGA, agarose did not induce DC maturation, in accordance with its low inflammatory effect. Roles of various receptors involved in DC maturation and recognition of biomaterials were assessed by in vitro receptor blocking studies. In particular, role of Toll-like receptors were further investigated using DCs derived from bone marrows of murine model of Toll-like receptor 4 deficiency (C3H/HeJ). While PLGA induced maturation of DCs from C57BL6 mice, maturation was not observed in DCs from C3H/HeJ strain or control strain, C3H/HeOuJ, perhaps due to particular haplotypes of these animals. Collectively, these results establish the differential adjuvant effects of agarose and PLGA on the level of DC maturation, and begin to elucidate the mechanisms of biomaterial adjuvant effect. In addition, assays developed herein provide methods to screen for biomaterials to be used in combination products, such that biomaterials with desired levels of adjuvanticity as measured by DC maturation effects may be selected for given application.

Handbook of Biomaterial Properties

Handbook of Biomaterial Properties Book
Author : William Murphy,Jonathan Black,Garth Hastings
Publisher : Springer
Release : 2016-06-11
ISBN : 1493933051
Language : En, Es, Fr & De

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Book Description :

This book provides tabular and text data relating to normal and diseased tissue materials and materials used in medical devices. Comprehensive and practical for students, researchers, engineers, and practicing physicians who use implants, this book considers the materials aspects of both implantable materials and natural tissues and fluids. Examples of materials and topics covered include titanium, elastomers, degradable biomaterials, composites, scaffold materials for tissue engineering, dental implants, sterilization effects on material properties, metallic alloys, and much more. Each chapter author considers the intrinsic and interactive properties of biomaterials, as well as their appropriate applications and historical contexts. Now in an updated second edition, this book also contains two new chapters on the cornea and on vocal folds, as well as updated insights, data, and citations for several chapters.

Biomaterials and Immune Response

Biomaterials and Immune Response Book
Author : Nihal Engin Vrana
Publisher : CRC Press
Release : 2018-07-20
ISBN : 1351377558
Language : En, Es, Fr & De

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Book Description :

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Biomaterials in Regenerative Medicine and the Immune System

Biomaterials in Regenerative Medicine and the Immune System Book
Author : Laura Santambrogio
Publisher : Springer
Release : 2015-09-04
ISBN : 3319180452
Language : En, Es, Fr & De

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Book Description :

The generation of tridimensional tissues, assembled from scaffolding materials populated with biologically functional cells, is the great challenge and hope of tissue bioengineering and regenerative medicine. The generation of biomaterials capable of harnessing the immune system has been particularly successful. This book provides a comprehensive view of how immune cells can be manipulated to suppresses inflammation, deliver vaccines, fight cancer cells, promote tissue regeneration or inhibit blood clotting and bacterial infections by functionally engineered biomaterials. However, long-lived polymers, such as those employed in orthopedic surgery or vascular stents, can often induce an immune reaction to their basic components. As a result, this book is also an important step towards coming to understand how to manipulate biomaterials to optimize their beneficial effects and downplay detrimental immune responses.