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Biomaterials In Immune Engineering

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Engineering Zwitterionic Biomaterials for Immune Modulation and Drug Delivery

Engineering Zwitterionic Biomaterials for Immune Modulation and Drug Delivery Book
Author : Bowen Li
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The development of biotherapeutics, which hold promising potential to treat diverse disease, is limited by their inadequate circulation half-lives and inherent immunogenicity. Conjugation of non-ionic poly (ethylene glycol) (PEG), known as PEGylation, has been widely employed as the gold standard to ameliorate the pharmacokinetic (PK) and immunological profiles of proteins. Unfortunately, PEG grafted onto immunogenic proteins has been shown to induce anti-PEG antibodies (Abs) that could cause loss of efficacy and even lethal adverse reactions. To confront the "PEG dilemma", zwitterionic materials with superhydrophilicity are emerging as promising alternatives for PEG. This dissertation summarizes recent studies from the design, synthesis and characterization of zwitterionic polymers to the in vitro and in vivo studies of poly(zwitterion)- protein nanomedicine. The influence of PEG and zwitterionic poly(carboxy betaine) (PCB) on immune systems is firstly discussed, revealing the low immunogenic risk of zwitterionic materials. Based on this design principle, new protein-delivery tactics are proposed to avoid the generation of undesirable immune responses, either by completely shielding proteins from immune recognition or by actively inducing antigen-specific immune tolerance. Furthermore, new classes of naturally-inspired inert or immunomodulatory zwitterionic materials are developed to further improve the efficacy and safety of protein therapeutics, enriching the arsenal of biomaterial tools for drug delivery.

Biomaterials and Immune Response

Biomaterials and Immune Response Book
Author : Nihal Engin Vrana
Publisher : CRC Press
Release : 2018-07-20
ISBN : 1351377558
Language : En, Es, Fr & De

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Book Description :

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Biomimicked Biomaterials

Biomimicked Biomaterials Book
Author : Heung Jae Chun,Rui L. Reis,Antonella Motta,Gilson Khang
Publisher : Springer Nature
Release : 2020-06-29
ISBN : 9811532621
Language : En, Es, Fr & De

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Book Description :

This book is the second of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. In this volume, which is devoted to biomimetic biomaterials, the opening section discusses bone regeneration by means of duck’s feet-derived collagen scaffold and the use of decellularized extracellular matrices. The role of various novel biomimetic hydrogels in regenerative medicine is then considered in detail. The third section focuses on the control of stem cell fate by biomimetic biomaterials, covering exosome-integrated biomaterials for bone regeneration, cellular responses to materials for biomedical engineering, and the regulation of stem cell functions by micropatterned structures. Finally, the use of nano-intelligent biocomposites in regenerative medicine is addressed, with discussion of, for example, recent advances in biphasic calcium phosphate bioceramics and blood-contacting polymeric biomaterials. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.

Definitions of Biomaterials for the Twenty First Century

Definitions of Biomaterials for the Twenty First Century Book
Author : Xingdong Zhang,David Williams
Publisher : Elsevier
Release : 2019-06-20
ISBN : 012818292X
Language : En, Es, Fr & De

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Book Description :

Definitions of Biomaterials for the Twenty-First Century is a review of key, critical biomaterial terms and definitions endorsed by the International Union of Societies for Biomaterials Science and Engineering. The topics and definitions discussed include those in general biomaterials and applications, biocompatibility, implantable and interventional devices, drug delivery systems, regenerative medicine and emerging biomaterials. The book reviews the discussion of these terms by leaders in the global biomaterials community and summarizes the agreed upon definitions. Provides readers with the official definitions of critical biomaterials terms endorsed by the International Union of Societies for Biomaterials Science and Engineering Includes the combined contributions from more than 50 global leaders in the biomaterials community Updates terms based on the latest advances in clinical and scientific understanding and expanded scope of biomaterials science

The Immune Response to Implanted Materials and Devices

The Immune Response to Implanted Materials and Devices Book
Author : Bruna Corradetti
Publisher : Springer
Release : 2016-11-30
ISBN : 3319454331
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

Biomimetic Medical Materials

Biomimetic Medical Materials Book
Author : Insup Noh
Publisher : Springer
Release : 2018-11-23
ISBN : 9811304459
Language : En, Es, Fr & De

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Book Description :

This volume outlines the current status in the field of biomimetic medical materials and illustrates research into their applications in tissue engineering. The book is divided into six parts, focusing on nano biomaterials, stem cells, tissue engineering, 3D printing, immune responses and intellectual property. Each chapter has its own introduction and outlines current research trends in a variety of applications of biomimetic medical materials. The biomimetic medical materials that are covered include functional hydrogels, nanoparticles for drug delivery and medicine, the 3D bioprinting of biomaterials, sensor materials, stem cell interactions with biomaterials, immune responses to biomaterials, biodegradable hard scaffolds for tissue engineering, as well as other important topics, like intellectual property. Each chapter is written by a team of experts. This volume attempts to introduce the biomimetic properties of biomedical materials within the context of our current understanding of the nanotechnology of nanoparticles and fibres and the macroscopic aspects of 3D bioprinting.

Bio inspired Materials for Biomedical Engineering

Bio inspired Materials for Biomedical Engineering Book
Author : Anthony B. Brennan,Chelsea M. Kirschner
Publisher : John Wiley & Sons
Release : 2014-03-19
ISBN : 1118843436
Language : En, Es, Fr & De

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Book Description :

This book covers the latest bio-inspired materials synthesistechniques and biomedical applications that are advancing the fieldof tissue engineering. Bio-inspired concepts for biomedicalengineering are at the forefront of tissue engineering andregenerative medicine. Scientists, engineers and physicians areworking together to replicate the sophisticated hierarchicalorganization and adaptability found in nature and selected byevolution to recapitulate the cellular microenvironment. Thisbook demonstrates the dramatic clinical breakthroughs that havebeen made in engineering all four of the major tissue types andmodulating the immune system. Part I (Engineering Bio-inspired Material Microenvironments)covers Bio-inspired Presentation of Chemical Cues, Bio-inspiredPresentation of Physical Cues, and Bio-inspired Integration ofNatural Materials. Part II (Bio-inspired Tissue Engineering) addresses tissueengineering in epithelial tissue, muscle tissue, connective tissue,and the immune system.

Foundations of Biomaterials Engineering

Foundations of Biomaterials Engineering Book
Author : Maria Cristina Tanzi,Silvia Farè,Gabriele Candiani
Publisher : Academic Press
Release : 2019-03-16
ISBN : 0128094591
Language : En, Es, Fr & De

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Book Description :

Foundations of Biomaterials Engineering provides readers with an introduction to biomaterials engineering. With a strong focus on the essentials of materials science, the book also examines the physiological mechanisms of defense and repair, tissue engineering and the basics of biotechnology. An introductory section covers materials, their properties, processing and engineering methods. The second section, dedicated to Biomaterials and Biocompatibility, deals with issues related to the use and application of the various classes of materials in the biomedical field, particularly within the human body, the mechanisms underlying the physiological processes of defense and repair, and the phenomenology of the interaction between the biological environment and biomaterials. The last part of the book addresses two areas of growing importance: Tissue Engineering and Biotechnology. This book is a valuable resource for researchers, students and all those looking for a comprehensive and concise introduction to biomaterials engineering. Offers a one-stop source for information on the essentials of biomaterials and engineering Useful as an introduction or advanced reference on recent advances in the biomaterials field Developed by experienced international authors, incorporating feedback and input from existing customers

An Introduction to Tissue Biomaterial Interactions

An Introduction to Tissue Biomaterial Interactions Book
Author : Kay C. Dee,David A. Puleo,Rena Bizios
Publisher : John Wiley & Sons
Release : 2003-04-14
ISBN : 0471461121
Language : En, Es, Fr & De

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Book Description :

An Introduction to Tissue-Biomaterial Interactions acquaintsan undergraduate audience with the fundamental biological processesthat influence these sophisticated, cutting-edge procedures.Chapters one through three provide more detail about themolecular-level events that happen at the tissue-implant interface,while chapters four through ten explore selected material,biological, and physiological consequences of these events. Theimportance of the body’s wound-healing response is emphasizedthroughout. Specific topics covered include:Structure andproperties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples oftissue-biomaterial interactions The text also provides extensive coverage of the three pertinentinterfaces between the body and the biomaterial, between the bodyand the living cells, and between the cells and the biomaterialthat are critical in the development of tissue-engineered productsthat incorporate living cells within a biomaterial matrix. Idealfor a one-semester, biomedical engineering course, An Introductionto Tissue-Biomaterial Interactions provides a solid framework forunderstanding today’s and tomorrow’s implantablebiomedical devices.

Humoral and T Cell Immune Responses to Model Antigen Delivered with Biomaterials Used in Tissue Engineering

Humoral and T Cell Immune Responses to Model Antigen Delivered with Biomaterials Used in Tissue Engineering Book
Author : Melissa Marie Stein
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Humoral and T Cell Immune Responses to Model Antigen Delivered with Biomaterials Used in Tissue Engineering book written by Melissa Marie Stein, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Host Response to Biomaterials

Host Response to Biomaterials Book
Author : Stephen F Badylak
Publisher : Academic Press
Release : 2015-05-08
ISBN : 0128005009
Language : En, Es, Fr & De

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Book Description :

Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine. Explains the various categories of biomaterials and their significance for clinical applications Contains a range of extensive coverage, including, but not limited to, orthopedic, surgery, dental, general surgery, neurosurgery, lower urinary tract, and regenerative medicine Includes regulations regarding combination devices

Biomaterials for Organ and Tissue Regeneration

Biomaterials for Organ and Tissue Regeneration Book
Author : Nihal Vrana,Helena Knopf-Marques,Julien Barthes
Publisher : Woodhead Publishing
Release : 2020-03-20
ISBN : 0081029071
Language : En, Es, Fr & De

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Book Description :

Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on enabling technologies, such as bioprinting, on chip organ systems and in silico simulations. Provides a systematic overview of the field, from fundamentals, to current challenges and opportunities Encompasses the classic paradigm of tissue engineering for creation of new functional tissue Discusses enabling technologies such as bioprinting, organ-on-chip systems and in silico simulations

Biomaterials and Immune Response

Biomaterials and Immune Response Book
Author : Nihal Engin Vrana
Publisher : CRC Press
Release : 2018-07-20
ISBN : 1351377566
Language : En, Es, Fr & De

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Book Description :

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Biomaterials for Tissue Engineering

Biomaterials for Tissue Engineering Book
Author : Mehdi Razavi
Publisher : Bentham Science Publishers
Release : 2017-10-03
ISBN : 1681085364
Language : En, Es, Fr & De

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Book Description :

This volume reviews the published knowledge about bioactive composites, protein scaffolds and hydrogels. Chapters also detail the production parameters and clarify the evaluation protocol for analysis or testing and scaffolding biomaterials. The volume concludes with a summary of applications of porous scaffold in medicine. Each chapter links basic scientific and engineering concepts to practical applications for the benefit of the reader. The text offers a wealth of information that will be of use to all students, bioengineers, materials scientists, chemists, physicians and surgeons concerned with the properties, performance, and the application of tissue engineering scaffolds in clinical settings.

Immunomodulatory Biomaterials

Immunomodulatory Biomaterials Book
Author : Stephen F. Badylak,Jennifer Elisseeff
Publisher : Woodhead Publishing
Release : 2021-08-01
ISBN : 0128214562
Language : En, Es, Fr & De

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Book Description :

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Encyclopedia of Biomaterials and Biomedical Engineering

Encyclopedia of Biomaterials and Biomedical Engineering Book
Author : Gary E. Wnek,Gary L. Bowlin
Publisher : CRC Press
Release : 2008-05-28
ISBN : 1498761437
Language : En, Es, Fr & De

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Book Description :

Written by more than 400 subject experts representing diverse academic and applied domains, this multidisciplinary resource surveys the vanguard of biomaterials and biomedical engineering technologies utilizing biomaterials that lead to quality-of-life improvements. Building on traditional engineering principles, it serves to bridge advances in mat

Introduction to Biomedical Engineering

Introduction to Biomedical Engineering Book
Author : John Enderle, Ph.D.,Joseph Bronzino,Susan M. Blanchard
Publisher : Academic Press
Release : 2005-04-20
ISBN : 0122386620
Language : En, Es, Fr & De

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Book Description :

Since publication in 1999, the first edition of Introduction to Biomedical Engineering has dominated the market of biomedical engineering texts. Under the direction of John Enderle, Susan Blanchard and Joe Bronzino, leaders in the field have contributed chapters on the most relevant subjects for biomedical engineering students. These chapters coincide with courses offered in all biomedical engineering programs so that it can be used at different levels for a variety of courses of this evolving field. Both Enderle and Blanchard are on the Accreditation Board for Engineering and Technology (ABET), the body that sets the standard for US-based engineering programs. These standards have been used as a guideline for examples and pedagogy. New to this edition: Computational Biology, Medical Imaging, Genomics and Bioinformatics. · 60% update from first edition to reflect the developing field of biomedical engineering. · Pioneer title in the Academic Press Series in Biomedical Engineering · Over 4,000 units of first edition sold · MatLab examples included in every chapter

Handbook of Biomaterials Biocompatibility

Handbook of Biomaterials Biocompatibility Book
Author : Masoud Mozafari
Publisher : Woodhead Publishing Limited
Release : 2020-06
ISBN : 9780081029671
Language : En, Es, Fr & De

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Book Description :

Handbook of Biomaterials Biocompatibility is a systematic reference on host response to different biomaterials, taking into account their physical, mechanical and chemical properties. The book reviews recent progress in the design and study of biomaterials biocompatibility, along with current understanding on how to control immune system response. Sections provide the fundamental theories and challenges of biomaterials biocompatibility, the role of different biomaterials physicochemical surface properties on cell responses, cell responses to different physicochemical properties of polymers, ceramics, metals, carbons and nanomaterials, and biomaterials in different tissues, such as the cardiac, nervous system, cartilage and bone. This resource will be suitable for those working in the fields of materials science, regenerative engineering, medicine, medical devices and nanotechnology. Reviews the fundamental theories and challenges of biomaterials biocompatibility, including an overview of the standards and regulations Provides an overview on the cellular and molecular mechanisms involved in host responses to biomaterials Systematically looks at cellular response and tissue response to a wide range of biomaterials, including polymers, metals, ceramics, alloys and nanomaterials

Biomaterials in Regenerative Medicine and the Immune System

Biomaterials in Regenerative Medicine and the Immune System Book
Author : Laura Santambrogio
Publisher : Springer
Release : 2015-09-04
ISBN : 3319180452
Language : En, Es, Fr & De

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Book Description :

The generation of tridimensional tissues, assembled from scaffolding materials populated with biologically functional cells, is the great challenge and hope of tissue bioengineering and regenerative medicine. The generation of biomaterials capable of harnessing the immune system has been particularly successful. This book provides a comprehensive view of how immune cells can be manipulated to suppresses inflammation, deliver vaccines, fight cancer cells, promote tissue regeneration or inhibit blood clotting and bacterial infections by functionally engineered biomaterials. However, long-lived polymers, such as those employed in orthopedic surgery or vascular stents, can often induce an immune reaction to their basic components. As a result, this book is also an important step towards coming to understand how to manipulate biomaterials to optimize their beneficial effects and downplay detrimental immune responses.

Biomaterials Science

Biomaterials Science Book
Author : Buddy D. Ratner,Allan S. Hoffman,Frederick J. Schoen,Jack E. Lemons
Publisher : Academic Press
Release : 2012-12-31
ISBN : 008087780X
Language : En, Es, Fr & De

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Book Description :

The revised edition of this renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science. It provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. Over 29,000 copies sold, this is the most comprehensive coverage of principles and applications of all classes of biomaterials: "the only such text that currently covers this area comprehensively" - Materials Today Edited by four of the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and expanded, key new topics include of tissue engineering, drug delivery systems, and new clinical applications, with new teaching and learning material throughout, case studies and a downloadable image bank