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Biomaterials For 3d Tumor Modeling

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Biomaterials for 3D Tumor Modeling

Biomaterials for 3D Tumor Modeling Book
Author : Subhas Kundu,Rui L. Reis
Publisher : Elsevier
Release : 2020-08-22
ISBN : 012818129X
Language : En, Es, Fr & De

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Book Description :

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Biomaterials and Microfluidics Based Tissue Engineered 3D Models

Biomaterials  and Microfluidics Based Tissue Engineered 3D Models Book
Author : J. Miguel Oliveira,Rui L. Reis
Publisher : Springer Nature
Release : 2020-04-13
ISBN : 3030365883
Language : En, Es, Fr & De

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Book Description :

This contributed volume reviews the latest advances on relevant 3D tissue engineered in vitro models of disease making use of biomaterials and microfluidics. The main focus of this book is on advanced biomaterials and microfluidics technologies that have been used in in vitro mimetic 3D models of human diseases and show great promise in revolutionizing personalized medicine. Readers will discover important topics involving biomaterials and microfluidics design, advanced processing techniques, and development and validation of organ- and body-on-a-chip models for bone, liver, and cancer research. An in depth discussion of microfabrication methods for microfluidics development is also provided. This work is edited by two truly multidisciplinary scientists and includes important contributions from well-known experts in their fields. The work is written for both early stage and experienced researchers, and well-established scientists enrolled in the fields of biomaterials, microfluidics, and tissue engineering, and is especially suited to those who wish to become acquainted with the principles and latest developments of in vitro models of diseases, such as professionals working in pharma, medicine, and engineering.

Biomaterials for Cancer Therapeutics

Biomaterials for Cancer Therapeutics Book
Author : Kinam Park
Publisher : Woodhead Publishing
Release : 2020-03-05
ISBN : 0081029845
Language : En, Es, Fr & De

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Book Description :

Biomaterials for Cancer Therapeutics: Evolution and Innovation, Second Edition, discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Part Two discusses synthetic vaccines, proteins and polymers for cancer therapeutics. Part Three focuses on theranosis and drug delivery systems, while the final set of chapters look at biomaterial therapies and cancer cell interaction. Cancer affects people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is being developed to target, treat and prevent cancer. Hence, this book is a welcomed resource to the discussion. Provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, treatment and prevention of cancer Discusses how the properties of specific biomaterials make them important in cancer treatment Covers synthetic vaccines, proteins and polymers for cancer therapeutics

Biomaterials Science

Biomaterials Science Book
Author : William R Wagner,Shelly E. Sakiyama-Elbert,Guigen Zhang,Michael J. Yaszemski
Publisher : Academic Press
Release : 2020-05-23
ISBN : 0128161388
Language : En, Es, Fr & De

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Book Description :

The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials’ community. The most comprehensive coverage of principles and applications of all classes of biomaterials Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. Online chapter exercises available for each chapter

Advances in Biomaterials for Biomedical Applications

Advances in Biomaterials for Biomedical Applications Book
Author : Anuj Tripathi,Jose Savio Melo
Publisher : Springer
Release : 2017-01-24
ISBN : 9811033285
Language : En, Es, Fr & De

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Book Description :

This book highlights recent advances in the field of biomaterials design and the state of the art in biomaterials applications for biomedicine. Addressing key aspects of biomaterials, the book explores technological advances at multi-scale levels (macro, micro, and nano), which are used in applications related to cell and tissue regeneration. The book also discusses the future scope of bio-integrated systems. The contents are supplemented by illustrated examples, and schematics of molecular and cellular interactions with biomaterials/scaffolds are included to promote a better understanding of the complex biological mechanisms involved in material-to-biomolecule interactions. The book also covers factors that govern cell growth, differentiation, and regeneration in connection with the treatment and recovery of native biological systems. Tissue engineering, drug screening and delivery, and electrolyte complexes for biomedical applications are also covered in detail. This book offers a comprehensive reference guide for multi-disciplinary communities working in the area of biomaterials, and will benefit researchers and graduate students alike.

Cell Derived Matrices Part B

Cell Derived Matrices Part B Book
Author : N.A
Publisher : Academic Press
Release : 2020-04-23
ISBN : 0128201754
Language : En, Es, Fr & De

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Book Description :

Cell-Derived Matrices Part B, Volume 157 provides a detailed description and step-by-step methods surrounding the use of three-dimensional cell-derived matrices for tissue engineering applications. Chapters in this new release include Glaucomatous cell-derived matrices, Cardiac tissue explants decellularization, Decellularization of skin matrices for wound healing applications, Guiding axonal growth by aligned cell-derived matrices for spinal cord injury regeneration, Human Mesenchymal Stem Cell–Derived Matrices for Enhanced Osteoregeneration, Amniotic decellularized matrices, Three-Dimensional (3-D) Tissue Reconstruction without Scaffold, Tubular cell-derived matrices for TERM applications, and more. Contains contributions from leading experts in the field from across the globe Covers a wide array of topics surrounding the use of cell-derived matrices for tissue engineering and regenerative medicine applications Includes relevant, analysis-based topics, such as the quantification of mechanical properties, decellularization protocols, and innovative matrix engineering methods

Cell derived Matrices Part A

Cell derived Matrices Part A Book
Author : N.A
Publisher : Academic Press
Release : 2020-03-26
ISBN : 0128201738
Language : En, Es, Fr & De

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Book Description :

Cell-Derived Matrices, Part A, Volume 156, provides a detailed description and step-by-step methods surrounding the use of three-dimensional cell-derived matrices for tissue engineering applications. Biochemical, biophysical and cell biological approaches are presented, along with sample results. Specific chapters cover Anisotropic cell-derived matrices with controlled 3D architecture, Generation of functional fluorescently-labelled cell-derived matrices by means of genetically-modified fibroblasts, Bi-layered cell-derived matrices, Engineering clinically-relevant cell-derived matrices using primary fibroblasts, Decellularized matrices for bioprinting applications, and much more. Contains contributions from leading experts in the field from across the globe Covers a wide array of topics on the use of cell-derived matrices for tissue engineering and regenerative medicine applications Includes relevant, analysis-based topics, such as quantification of the mechanical properties, decellularization protocols, and innovative matrix engineering methods

Tumor Organoids

Tumor Organoids Book
Author : Shay Soker,Aleksander Skardal
Publisher : Humana Press
Release : 2017-10-20
ISBN : 3319605119
Language : En, Es, Fr & De

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Book Description :

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

3D microtissue models to target tumor dormancy and invasion processes

3D microtissue models to target tumor dormancy and invasion processes Book
Author : Carsten Wenzel
Publisher : GRIN Verlag
Release : 2016-07-04
ISBN : 366825172X
Language : En, Es, Fr & De

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Book Description :

Doctoral Thesis / Dissertation from the year 2014 in the subject Medicine - Biomedical Engineering, grade: 1,0, Technical University of Berlin (Biotechnologie), language: English, abstract: Despite all efforts to discover novel therapeutic options to treat cancer the disease remains devastating causing more than 14 million deaths in 2012 - and the trend is rising. Some parts of the preclinical drug discovery process rely on cell culture models to reproduce the pathophysiological features of cancer in in vitro experiments. These cellular models are then used in screening campaigns that aim to identify substances such as small molecules, peptides, or interfering RNA that alter the phenotype of a cancer cell in a desired manner. One of the main properties of cancer cells is their uncontrolled cell division. Accordingly, the cell cycle is a major target for chemotherapy, but resistance to chemotherapy frequently causes treatment failure in patients with advanced and inoperable cancer. As the distance from supplying blood vessels increases, oxygen and nutrient concentrations decrease and cancer cells react by halting cell cycle progression and entering a dormant state. As cytostatic drugs mainly target proliferating cells, cancer cell dormancy is considered a major resistance mechanism to this class of anti-cancer drugs. Therefore, substances that target cancer cells in poorly vascularized tumor regions have the potential to enhance cytostatic-based chemotherapy in solid tumors. Multicellular tumor spheroids (MCTS) allow for three-dimensional growth conditions, thus reproducing several parameters of the tumor microenvironment, including oxygen and nutrient gradients as well as the development of dormant tumor regions. Here, the evaluation of a 3D cell culture high-content screening system led to the identification of nine substances from two commercially available drug libraries that specifically target cells in inner MCTS core regions. Subsequently, the mode of action of the identified compounds could be identified as respiratory chain inhibitors. Ultimately, benefits in combinational treatment with commonly used cytostatics in MCTS were proven. The data suggest a rationale to find and evaluate new substances that target the altered metabolism of tumor cells in dormant tumor regions to enhance cytostaticbased therapies. In a second approach the combination of different cell types in a 3D cell co-culture model was evaluated, which allows monitoring of invasion processes in different malignancies. Among them idiopathic pulmonary fibrosis (IPF) currently affects 50.000 people per year with high mortality rates. [...]

Biofabrication and 3D Tissue Modeling

Biofabrication and 3D Tissue Modeling Book
Author : Dong-Woo Cho
Publisher : Royal Society of Chemistry
Release : 2019-01-02
ISBN : 1788011988
Language : En, Es, Fr & De

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Book Description :

3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, it provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.

Evaluation of a Biomaterial based Three dimensional Model of Breast Cancer Metastasis

Evaluation of a Biomaterial based Three dimensional Model of Breast Cancer Metastasis Book
Author : Jenna Evelyn Al-Saleh
Publisher :
Release : 2019
ISBN :
Language : En, Es, Fr & De

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Book Description :

Breast cancer metastasis (BCM) remains one of the leading causes of death in women with cancer. Research over the last several decades has indicated that the microenvironment plays a critical role in the activation of the metastatic cascade. Inflammatory cytokines secreted by adipocytes in the tumor microenvironment, such as leptin, can play key roles in metastasis and are of interest as predictive diagnostic indicators. In this work, three-dimensional (3D) chitosan-collagen scaffolds were created and evaluated to characterize their mechanical properties. Studies were performed to assess cell viability and metastatic protein expression to determine the scaffold efficacy for mimicking BCM. Leptin was then incorporated into the 3D models to study the effects of leptin on BCM. Expression of metastasis-related cytokines was measured towards building a proof-of-concept statistical model for predicting BCM based on varying levels of biomarkers, such as leptin.

Biomaterials for Brain Therapy and Repair

Biomaterials for Brain Therapy and Repair Book
Author : Sara Pedron,Brendan A.C. Harley
Publisher : Frontiers Media SA
Release : 2019-02-06
ISBN : 2889457478
Language : En, Es, Fr & De

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Book Description :

Prevalence of brain related diseases is expected to increase significantly in the next decades. Therefore, there is a vital need to develop effective, personalized models of human brain that can provide information about brain development, and the unique neurobiology of brain disorders. The use of biomaterials can play a strategic role for the future understanding and treatment of complex CNS diseases. Three-dimensional brain cultures have shown promise in disease modelling, cell transplantation and modulation of tissue repair.

Comprehensive Biomaterials

Comprehensive Biomaterials Book
Author : Paul Ducheyne,Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
Publisher : Elsevier
Release : 2015-08-28
ISBN : 0080552943
Language : En, Es, Fr & De

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Book Description :

Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development

Multi Parametric Live Cell Microscopy of 3D Tissue Models

Multi Parametric Live Cell Microscopy of 3D Tissue Models Book
Author : Ruslan I. Dmitriev
Publisher : Springer
Release : 2017-10-26
ISBN : 3319673580
Language : En, Es, Fr & De

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Book Description :

This book provides an essential overview of existing state-of-the-art quantitative imaging methodologies and protocols (intensity-based ratiometric and FLIM/ PLIM). A variety of applications are covered, including multi-parametric quantitative imaging in intestinal organoid culture, autofluorescence imaging in cancer and stem cell biology, Ca2+ imaging in neural ex vivo tissue models, as well as multi-parametric imaging of pH and viscosity in cancer biology. The current state-of-the-art of 3D tissue models and their compatibility with live cell imaging is also covered. This is an ideal book for specialists working in tissue engineering and designing novel biomaterial.

Cell Culture Technology

Cell Culture Technology Book
Author : Cornelia Kasper,Verena Charwat,Antonina Lavrentieva
Publisher : Springer
Release : 2018-10-10
ISBN : 3319748548
Language : En, Es, Fr & De

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Book Description :

This textbook provides an overview on current cell culture techniques, conditions, and applications specifically focusing on human cell culture. This book is based on lectures, seminars and practical courses in stem cells, tissue engineering, regenerative medicine and 3D cell culture held at the University of Natural Resources and Life Sciences Vienna BOKU and the Gottfried Wilhelm Leibniz University Hannover, complemented by contributions from international experts, and therefore delivers in a compact and clear way important theoretical, as well as practical knowledge to advanced graduate students on cell culture techniques and the current status of research. The book is written for Master students and PhD candidates in biotechnology, tissue engineering and biomedicine working with mammalian, and specifically human cells. It will be of interest to doctoral colleges, Master- and PhD programs teaching courses in this area of research.

Bioinspired Materials Science and Engineering

Bioinspired Materials Science and Engineering Book
Author : Guang Yang,Lin Xiao,Lallepak Lamboni
Publisher : John Wiley & Sons
Release : 2018-08-21
ISBN : 111939032X
Language : En, Es, Fr & De

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Book Description :

An authoritative introduction to the science and engineering of bioinspired materials Bioinspired Materials Science and Engineering offers a comprehensive view of the science and engineering of bioinspired materials and includes a discussion of biofabrication approaches and applications of bioinspired materials as they are fed back to nature in the guise of biomaterials. The authors also review some biological compounds and shows how they can be useful in the engineering of bioinspired materials. With contributions from noted experts in the field, this comprehensive resource considers biofabrication, biomacromolecules, and biomaterials. The authors illustrate the bioinspiration process from materials design and conception to application of bioinspired materials. In addition, the text presents the multidisciplinary aspect of the concept, and contains a typical example of how knowledge is acquired from nature, and how in turn this information contributes to biological sciences, with an accent on biomedical applications. This important resource: Offers an introduction to the science and engineering principles for the development of bioinspired materials Includes a summary of recent developments on biotemplated formation of inorganic materials using natural templates Illustrates the fabrication of 3D-tumor invasion models and their potential application in drug assessments Explores electroactive hydrogels based on natural polymers Contains information on turning mechanical properties of protein hydrogels for biomedical applications Written for chemists, biologists, physicists, and engineers, Bioinspired Materials Science and Engineering contains an indispensible resource for an understanding of bioinspired materials science and engineering.

Deformable Models

Deformable Models Book
Author : Aly Farag
Publisher : Springer Science & Business Media
Release : 2007-08-10
ISBN : 0387683437
Language : En, Es, Fr & De

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Book Description :

This book covers the complete spectrum of deformable models, its evolution as an imagery field and its use in many biomedical engineering and clinical application disciplines. The book focuses on the core image processing techniques, theory and biomaterials useful to research and industry. Contributors are all pioneers in the field.

Polymer Nanocomposites and Biomaterials from Chemical Cross linking to 3d Printing

Polymer Nanocomposites and Biomaterials  from Chemical Cross linking to 3d Printing Book
Author : Huseini Patanwala
Publisher :
Release : 2017
ISBN :
Language : En, Es, Fr & De

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Book Description :

Part 1: Aerogel is an open-celled, microporous, solid foam composed of a network of interconnected structures formed by replacing the solvent in wet gel with air. Integrating the intrinsic mechanical and electrical properties of carbon nanotubes (CNTs) with those of an aerogel provides a new class of material with unique multifunctional properties which may find applications not limited to fuel cells, super capacitors and batteries. I attempt at improving the mechanical integrity by first functionalizing the CNTs with carboxylic (-COOH) groups and subsequently cross-linking the CNTs using diisocyanate to form polyurea-CNT (PUA-CNT) composite aerogels. Mechanical properties of the final PUA-CNT aerogels are presented. Part 2: 3D printing is an additive manufacturing technique capable of creating highly complex and customized structures that are otherwise difficult or impossible to produce using conventional methods such as injection molding. Fused Deposition Modeling (FDM) based on micro-extrusion of thermoplastics is one of the most commonly used methods for 3D printing. The second part of this thesis reports incorporation of carbon nanotubes (CNTs) into PLA with a goal to improve the mechanical properties of the 3D-printed composites. The orientation distribution of CNTs within the printed extrudates has been characterized using X-ray Diffraction (XRD) and scanning electron microscopy (SEM). The effects of process conditions on CNT orientation and the subsequent mechanical properties of fabricated test coupons have been explored. Part 3: Breast cancer is caused by the development of malignant cells in the breast forming a lump or mass called tumor. The malignant cells originate in the lining of the milk glands or ducts of the breast (ductal epithelium) and grow into the surrounding breast tissue. As per the American Cancer Society, in 2015, 1 out of 7 women diagnosed with breast cancer died due to complications arising from the disease. I lay down the foundations for precise and reproducible FDM based 3D bioprinting to help understand the interactions of breast cancer cells with its microenvironment which upon further mathematical modeling may lead to better strategies to treat the disease. Rheology is used as a tool to identify printing parameters of Matrigel®; an extracellular matrix.