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Biomaterials For 3d Tumor Modeling

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Biomaterials for 3D Tumor Modeling

Biomaterials for 3D Tumor Modeling Book
Author : Subhas C. Kundu,Rui L. Reis
Publisher : Elsevier
Release : 2020-09-03
ISBN : 0128181281
Language : En, Es, Fr & De

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Book Description :

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Biomaterials for 3D Tumor Modeling

Biomaterials for 3D Tumor Modeling Book
Author : Subhas C. Kundu,Rui L Reis
Publisher : Elsevier
Release : 2020-08-22
ISBN : 012818129X
Language : En, Es, Fr & De

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Book Description :

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Tumor Organoids

Tumor Organoids Book
Author : Shay Soker,Aleksander Skardal
Publisher : Humana Press
Release : 2017-10-20
ISBN : 3319605119
Language : En, Es, Fr & De

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Book Description :

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Cell derived Matrices Part A

Cell derived Matrices Part A Book
Author : Anonim
Publisher : Academic Press
Release : 2020-03-26
ISBN : 0128201738
Language : En, Es, Fr & De

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Book Description :

Cell-Derived Matrices, Part A, Volume 156, provides a detailed description and step-by-step methods surrounding the use of three-dimensional cell-derived matrices for tissue engineering applications. Biochemical, biophysical and cell biological approaches are presented, along with sample results. Specific chapters cover Anisotropic cell-derived matrices with controlled 3D architecture, Generation of functional fluorescently-labelled cell-derived matrices by means of genetically-modified fibroblasts, Bi-layered cell-derived matrices, Engineering clinically-relevant cell-derived matrices using primary fibroblasts, Decellularized matrices for bioprinting applications, and much more. Contains contributions from leading experts in the field from across the globe Covers a wide array of topics on the use of cell-derived matrices for tissue engineering and regenerative medicine applications Includes relevant, analysis-based topics, such as quantification of the mechanical properties, decellularization protocols, and innovative matrix engineering methods

Biomaterials and Microfluidics Based Tissue Engineered 3D Models

Biomaterials  and Microfluidics Based Tissue Engineered 3D Models Book
Author : J. Miguel Oliveira,Rui L. Reis
Publisher : Springer Nature
Release : 2020-04-13
ISBN : 3030365883
Language : En, Es, Fr & De

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Book Description :

This contributed volume reviews the latest advances on relevant 3D tissue engineered in vitro models of disease making use of biomaterials and microfluidics. The main focus of this book is on advanced biomaterials and microfluidics technologies that have been used in in vitro mimetic 3D models of human diseases and show great promise in revolutionizing personalized medicine. Readers will discover important topics involving biomaterials and microfluidics design, advanced processing techniques, and development and validation of organ- and body-on-a-chip models for bone, liver, and cancer research. An in depth discussion of microfabrication methods for microfluidics development is also provided. This work is edited by two truly multidisciplinary scientists and includes important contributions from well-known experts in their fields. The work is written for both early stage and experienced researchers, and well-established scientists enrolled in the fields of biomaterials, microfluidics, and tissue engineering, and is especially suited to those who wish to become acquainted with the principles and latest developments of in vitro models of diseases, such as professionals working in pharma, medicine, and engineering.

Biologically responsive Hybrid Biomaterials

Biologically responsive Hybrid Biomaterials Book
Author : Esmaiel Jabbari,Ali Khademhosseini
Publisher : World Scientific
Release : 2010
ISBN : 981429568X
Language : En, Es, Fr & De

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Book Description :

Conjugation of synthetic materials with cell-responsive biologically-active molecules, in addition to providing structural support and release of biomolecules in the regenerating region, can provide the signaling factors required to initiate the cascade of cell migration, adhesion, differentiation, maturation, growth factor modulation, maintenance of matrix integrity, and tissue morphogenesis. Nanoparticles conjugated with ligands that preferentially interact with cell surface receptors in the tumor environment have the potential to drastically improve bioavailability, selectivity and residence time of the chemotherapeutic agent in the tumor microenvironment, while limiting their peripheral toxicity. Multivalent presentation of tumor-associated antigens on a targeted delivery system containing T and B cell epitopes can result in strong, long-lasting, self-adjuvant immunity against cancer and other diseases in vaccination. These examples demonstrate that cell-responsive conjugate biomaterials have profoundly impacted the medical field. This book is divided into three sections. In the first section, synthesis and characterization, conformation, structure-activity, self-assembly, and host response of conjugate hybrid biomaterials are covered. The second section is dedicated to the applications of conjugate biomaterials in drug delivery and vaccination while the last section is devoted to tissue engineering applications including cell adhesion, control of the stem cell niche, cartilage regeneration, neural and vascular tissue engineering, and dynamic cell culture systems for functionalized biomaterials. There is no doubt that biologically-responsive conjugate biomaterials play a key role in the design of biologics and medical devices, and this pioneering reference book provides a comprehensive review on synthesis, characterization, structure-activity, 3D assembly/fabrication, host response and the emerging applications of conjugate hybrid biomaterials.

Microfluidics and Biosensors in Cancer Research

Microfluidics and Biosensors in Cancer Research Book
Author : David Caballero,Subhas C. Kundu,Rui L. Reis
Publisher : Springer Nature
Release : 2022-06-27
ISBN : 3031040392
Language : En, Es, Fr & De

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Book Description :

This book offers a comprehensive overview of the development and application of microfluidics and biosensors in cancer research, in particular, their applications in cancer modeling and theranostics. Over the last decades, considerable effort has been made to develop new technologies to improve the diagnosis and treatment of cancer. Microfluidics has proven to be a powerful tool for manipulating biological fluids with high precision and efficiency and has already been adopted by the pharmaceutical and biotechnology industries. With recent technological advances, particularly biosensors, microfluidic devices have increased their usefulness and importance in oncology and cancer research. The aim of this book is to bring together in a single volume all the knowledge and expertise required for the development and application of microfluidic systems and biosensors in cancer modeling and theranostics. It begins with a detailed introduction to the fundamental aspects of tumor biology, cancer biomarkers, biosensors and microfluidics. With this knowledge in mind, the following sections highlight important advances in developing and applying biosensors and microfluidic devices in cancer research at universities and in the industry. Strategies for identifying and evaluating potent disease biomarkers and developing biosensors and microfluidic devices for their detection are discussed in detail. Finally, the transfer of these technologies into the clinical environment for the diagnosis and treatment of cancer patients will be highlighted. By combining the recent advances made in the development and application of microfluidics and biosensors in cancer research in academia and clinics, this book will be useful literature for readers from a variety of backgrounds. It offers new visions of how this technology can influence daily life in hospitals and companies, improving research methodologies and the prognosis of cancer patients.

Silk Biomaterials for Tissue Engineering and Regenerative Medicine

Silk Biomaterials for Tissue Engineering and Regenerative Medicine Book
Author : Subhas Kundu
Publisher : Elsevier
Release : 2014-03-24
ISBN : 0857097067
Language : En, Es, Fr & De

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Book Description :

Silk is increasingly being used as a biomaterial for tissue engineering applications, as well as sutures, due to its unique mechanical and chemical properties. Silk Biomaterials for Tissue Engineering and Regenerative Medicine discusses the properties of silk that make it useful for medical purposes and its applications in this area. Part one introduces silk biomaterials, discussing their fundamentals and how they are processed, and considering different types of silk biomaterials. Part two focuses on the properties and behavior of silk biomaterials and the implications of this for their applications in biomedicine. These chapters focus on topics including biodegradation, bio-response to silk sericin, and capillary growth behavior in porous silk films. Finally, part three discusses the applications of silk biomaterials for tissue engineering, regenerative medicine, and biomedicine, with chapters on the use of silk biomaterials for vertebral, dental, dermal, and cardiac tissue engineering. Silk Biomaterials for Tissue Engineering and Regenerative Medicine is an important resource for materials and tissue engineering scientists, R&D departments in industry and academia, and academics with an interest in the fields of biomaterials and tissue engineering. Discusses the properties and applications of silk for medical purposes Considers pharmaceutical and cosmeceutical applications

Recent 3D Tumor Models for Testing Immune Mediated Therapies

Recent 3D Tumor Models for Testing Immune Mediated Therapies Book
Author : Silvia Scaglione,Roberta Castriconi,Jacques Zimmer
Publisher : Frontiers Media SA
Release : 2022-01-10
ISBN : 2889740153
Language : En, Es, Fr & De

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Book Description :

Download Recent 3D Tumor Models for Testing Immune Mediated Therapies book written by Silvia Scaglione,Roberta Castriconi,Jacques Zimmer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomaterials for Cancer Therapeutics

Biomaterials for Cancer Therapeutics Book
Author : Kinam Park
Publisher : Elsevier
Release : 2013-11-23
ISBN : 0857096761
Language : En, Es, Fr & De

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Book Description :

Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction. This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials. A complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer Discusses the fundamentals of biomaterials for cancer therapeutics Discusses synthetic vaccines, proteins and polymers for cancer therapeutics

3D printable Gel inks for Tissue Engineering

3D printable Gel inks for Tissue Engineering Book
Author : Anuj Kumar,Stefan Ioan Voicu,Vijay Kumar Thakur
Publisher : Springer Nature
Release : 2021-09-11
ISBN : 9811646678
Language : En, Es, Fr & De

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Book Description :

This book provides the necessary fundamentals and background for researchers and research professionals working in the field of 3D bioprinting in tissue engineering. In 3D bioprinting, design and development of the biomaterial-inks/bio-inks is a major challenge in providing 3D microenvironments specific to anatomical and architectural demands of native tissues. The focal point of this book is to provide the basic chemistry of biomaterials, updates on current processing, developments, and challenges, and recent advancements in tissue-specific 3D printing/bioprinting. This book is will serve as a go-to reference on bioprinting and is ideal for students, researchers and professionals, working academia, government, the medical industry, and healthcare.

Engineering 3D Tissue Test Systems

Engineering 3D Tissue Test Systems Book
Author : Karen J.L. Burg,Didier Dréau,Timothy Burg
Publisher : CRC Press
Release : 2017-07-28
ISBN : 1351644548
Language : En, Es, Fr & De

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Book Description :

Engineering 3D Tissue Test Systems provides an introduction to, and unique coverage of, a rapidly evolving area in biomaterials engineering. It reveals the current and future research responses, the current and future diagnostic applications, and provides a comprehensive overview to foster innovation. It offers insight into the importance of 3D systems and their use as benchtop models, spanning applications from basic scientific research to clinical diagnostics. Methods and limitations of building 3D tissue structures are evaluated, with attention given to the cellular, polymeric, and fabrication instrumentation components. The book covers the important aspects of polymeric tissue test systems, highlighting the needs and constraints of the industry, and includes a chapter on regulatory and pricing issues.

Bioinspired Biomaterials

Bioinspired Biomaterials Book
Author : Heung Jae Chun,Rui L. Reis,Antonella Motta,Gilson Khang
Publisher : Springer Nature
Release : 2020-06-29
ISBN : 9811532583
Language : En, Es, Fr & De

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Book Description :

This book is the first of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. Topics addressed in this volume, which is devoted to bioinspired biomaterials, range from novel biomaterials for regenerative medicine through to emerging enabling technologies with applications in, for example, drug delivery, maternal–fetal medicine, peripheral nerve repair and regeneration, and brain tumor therapy. New bioinspired hydrogels receive detailed attention in the book, and a further focus is the use of bioinspired biomaterials in the regulation of stem cell fate. Here the coverage includes the role of scaffolds in cartilage regeneration, the bioapplication of inorganic nanomaterials in tissue engineering, and guidance of cell migration to improve tissue regeneration. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.

Enabling Biomaterials for New Biomedical Technologies and Clinical Therapies

Enabling Biomaterials for New Biomedical Technologies and Clinical Therapies Book
Author : Hasan Uludag,Abhay Pandit,Liisa Kuhn
Publisher : Frontiers Media SA
Release : 2020-07-14
ISBN : 2889638537
Language : En, Es, Fr & De

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Book Description :

Download Enabling Biomaterials for New Biomedical Technologies and Clinical Therapies book written by Hasan Uludag,Abhay Pandit,Liisa Kuhn, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nanobiotechnology

Nanobiotechnology Book
Author : Alok Dhawan,Sanjay Singh,Ashutosh Kumar,Rishi Shanker
Publisher : CRC Press
Release : 2018-03-26
ISBN : 1351031562
Language : En, Es, Fr & De

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Book Description :

This book combines the contributions from the experts of material science, molecular biology, toxicology bio-organic and bio-inorganic chemistry, toxicologists and environmental and food technology etc. to fathom the full scope of current and future of developments in the area of Nanobiotechnology. This book can also be used as text book for graduate students as an essential reference material, and as an reading material for general readers having a curiosity in Nanobiotechnology.

Microfluidic Cell Culture Systems

Microfluidic Cell Culture Systems Book
Author : Christopher Bettinger,Jeffrey T Borenstein,Sarah L Tao
Publisher : William Andrew
Release : 2012-12-31
ISBN : 143773460X
Language : En, Es, Fr & De

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Book Description :

The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology. This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles of microfluidic device design and operation and their application to cell culture techniques. The resulting book is crammed with strategies and techniques that can be immediately deployed in the lab. Equally, the insights into cell culture applications will provide those involved in traditional microfluidics and BioMEMS with an understanding of the specific demands and opportunities presented by biological applications. The goal is to guide new and interested researchers and technology developers to the important areas and state-of-the-practice strategies that will enhance the efficiency and value of their technologies, devices and biomedical products. Provides insights into the design and development of microfluidic systems with a specific focus on cell culture applications Focuses on strategies and techniques for the design and fabrication of microfluidic systems and devices for cell culture Provides balanced coverage of microsystems engineering and bioengineering

Rational Design and Characterization of Innovative Multifunctional Biomimetic Materials

Rational Design and Characterization of Innovative Multifunctional Biomimetic Materials Book
Author : Lia Rimondini,Lorenzo Moroni,Andrea Cochis
Publisher : Frontiers Media SA
Release : 2021-04-13
ISBN : 2889666875
Language : En, Es, Fr & De

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Book Description :

Download Rational Design and Characterization of Innovative Multifunctional Biomimetic Materials book written by Lia Rimondini,Lorenzo Moroni,Andrea Cochis, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

3D Bioprinting in Medicine

3D Bioprinting in Medicine Book
Author : Murat Guvendiren
Publisher : Springer
Release : 2019-08-02
ISBN : 3030239063
Language : En, Es, Fr & De

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Book Description :

This book provides current and emerging developments in bioprinting with respect to bioprinting technologies, bioinks, applications, and regulatory pathways. Topics covered include 3D bioprinting technologies, materials such as bioinks and bioink design, applications of bioprinting complex tissues, tissue and disease models, vasculature, and musculoskeletal tissue. The final chapter is devoted to clinical applications of bioprinting, including the safety, ethical, and regulatory aspects. This book serves as a go-to reference on bioprinting and is ideal for students, researchers and professionals, including those in academia, government, the medical industry, and healthcare.

Comprehensive Biomaterials II

Comprehensive Biomaterials II Book
Author : Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
Publisher : Elsevier
Release : 2017-05-18
ISBN : 0081006926
Language : En, Es, Fr & De

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Book Description :

Comprehensive Biomaterials II, Second Edition brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications

Biomechanics in Oncology

Biomechanics in Oncology Book
Author : Cheng Dong,Nastaran Zahir,Konstantinos Konstantopoulos
Publisher : Springer
Release : 2018-10-27
ISBN : 3319952943
Language : En, Es, Fr & De

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Book Description :

This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. This book also: Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy Includes insight into NCIs’ role in supporting biomechanics in oncology research Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer