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Biomarkers Of Neuroinflammation

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Biomarkers of Neuroinflammation

Biomarkers of Neuroinflammation Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2018-03-16
ISBN : 0309463653
Language : En, Es, Fr & De

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Book Description :

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.

Biomarkers of Neuroinflammation

Biomarkers of Neuroinflammation Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2018-02-16
ISBN : 0309463688
Language : En, Es, Fr & De

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Book Description :

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.

Neurodegenerative Diseases Biomarkers

Neurodegenerative Diseases Biomarkers Book
Author : Philip V. Peplow,Bridget Martinez,Thomas A. Gennarelli
Publisher : Humana
Release : 2021-10-21
ISBN : 9781071617113
Language : En, Es, Fr & De

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Book Description :

This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.

Novel Biomarkers in Alzheimer rsquo s Disease

Novel Biomarkers in Alzheimer rsquo s Disease Book
Author : Chiara Villa
Publisher : MDPI
Release : 2021-02-05
ISBN : 3039439030
Language : En, Es, Fr & De

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Book Description :

Alzheimer’s disease (AD) represents the most common form of dementia in the elderly population worldwide. AD is characterized by progressive neurodegeneration that leads to a gradual deterioration of memory and other cognitive functions. Given the global prevalence and impact of AD, there is a critical need to establish biomarkers that can be used to detect AD in individuals before the onset of clinical signs and provide mitigating therapeutics. The aim of this Special Issue is to discuss the current knowledge as well as future perspectives on the role of biomarkers in the screening, diagnosis, treatment and follow-up of AD.

Neuroinflammation

Neuroinflammation Book
Author : Alireza Minagar
Publisher : Elsevier
Release : 2010-12-17
ISBN : 9780123849144
Language : En, Es, Fr & De

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Book Description :

Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities

Biomarkers for Traumatic Brain Injury

Biomarkers for Traumatic Brain Injury Book
Author : Svetlana Dambinova,Ronald L. Hayes,Kevin K. W. Wang
Publisher : Royal Society of Chemistry
Release : 2012
ISBN : 1849733899
Language : En, Es, Fr & De

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Book Description :

Examines current and prospective biomarkers for assessment of traumatic brain injury using a multidisciplinary approach involving biochemistry, molecular biology and clinical chemistry.

Biomarkers of Brain Injury and Neurological Disorders

Biomarkers of Brain Injury and Neurological Disorders Book
Author : Kevin K. W. Wang,Zhiqun Zhang,Firas H. Kobeissy
Publisher : CRC Press
Release : 2014-10-28
ISBN : 1482239825
Language : En, Es, Fr & De

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Book Description :

This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.

Investigating Imaging Biomarkers of Neuroinflammation and Neurodegeneration in Rodent Models of Alzheimer s Disease

Investigating Imaging Biomarkers of Neuroinflammation and Neurodegeneration in Rodent Models of Alzheimer s Disease Book
Author : Aisling Chaney
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Investigating Imaging Biomarkers of Neuroinflammation and Neurodegeneration in Rodent Models of Alzheimer s Disease book written by Aisling Chaney, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neurochemical Aspects of Alzheimer s Disease

Neurochemical Aspects of Alzheimer s Disease Book
Author : Akhlaq A. Farooqui
Publisher : Academic Press
Release : 2017-05-25
ISBN : 0128099380
Language : En, Es, Fr & De

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Book Description :

Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders. Provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for Alzheimer's disease Written for researchers, clinicians, and advanced graduate students in neurology, neuroscience, neurochemistry, and neuropharmacology Acts as the first book to provide a comprehensive description of the signal transduction processes associated with pathogenesis of Alzheimer's disease

Role of Biomarkers in Medicine

Role of Biomarkers in Medicine Book
Author : Mu Wang,Frank Witzmann
Publisher : BoD – Books on Demand
Release : 2016-08-17
ISBN : 9535125052
Language : En, Es, Fr & De

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Book Description :

The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.

Validation and Development of Iron as an Imaging based Biomarker of Neuroinflammation in Alzheimer s Disease

Validation and Development of Iron as an Imaging based Biomarker of Neuroinflammation in Alzheimer s Disease Book
Author : Phillip Scott DiGiacomo
Publisher : Unknown
Release : 2021
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Despite decades of research, Alzheimer's disease (AD) remains poorly understood and without effective treatment or prevention. The presence of amyloid beta and tau pathology together is thought to result in neurodegeneration, or the loss of synapses and neurons, but the mechanism by which the two interact to produce this neurodegeneration is unknown. Recent data suggest an interplay between inflammation and iron dysregulation in the pathogenesis of AD that may be a key component of AD pathology. Most of this work, however, has lacked the simultaneous analysis of iron, inflammation, and hallmark AD pathology, necessary to elucidate the mechanistic link between iron and neurodegeneration in AD. To address this gap and deliver iron as a biomarker for AD, we have developed a novel, multimodal ex vivo imaging pipeline, integrating novel correlative MR-histology tools with advanced microscopy, including electron microscopy and x-ray microscopy techniques, to interrogate iron deposition and oxidation state in human brain tissue in situ. We have additionally implemented a novel prospective motion correction system for high-field MRI to enable ultra-high-resolution human brain imaging and facilitate the translation of our ex vivo findings to the patient setting. While the initial application of these tools has been to validate iron as a biomarker of neuroinflammation in AD, we have developed a broadly applicable set of imaging tools with the potential to molecularly validate and translate MRI-based biomarkers across tissue types and diseases.

Oxidative Stress and Antioxidant Protection

Oxidative Stress and Antioxidant Protection Book
Author : Donald Armstrong,Robert D. Stratton
Publisher : John Wiley & Sons
Release : 2016-01-14
ISBN : 111883240X
Language : En, Es, Fr & De

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Book Description :

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

Mechanisms of Neuroinflammation

Mechanisms of Neuroinflammation Book
Author : Gonzalo Emiliano Aranda Abreu
Publisher : BoD – Books on Demand
Release : 2017-08-23
ISBN : 9535134515
Language : En, Es, Fr & De

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Book Description :

"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Biology of C Reactive Protein in Health and Disease

Biology of C Reactive Protein in Health and Disease Book
Author : Waliza Ansar,Shyamasree Ghosh
Publisher : Springer
Release : 2016-03-23
ISBN : 8132226801
Language : En, Es, Fr & De

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Book Description :

This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution. Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail. The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.

Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders

Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders Book
Author : Paul C. Guest
Publisher : Springer
Release : 2019-02-12
ISBN : 3030055426
Language : En, Es, Fr & De

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Book Description :

This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.

Cavernous Malformations

Cavernous Malformations Book
Author : Issam A. Awad,Daniel L. Barrow
Publisher : Thieme
Release : 1993
ISBN : 9781879284074
Language : En, Es, Fr & De

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Book Description :

The massive convergence of information about cavernous malformations has been synthesized in this volume by experts in the field of pathology, neuroradiology and neurosurgery. Cavernous Malformations represents state-of-the-art knowledge about this lesion and the spectrum of opinion about its nature, clinical behavior and management strategies. Highlights of Cavernous Malformations: Definition and pathologic features Epidemiology Diagnostic imaging Epilepsy Hemorrhage Conservative management Surgical intervention Microsurgical treatments Spinal cavernous malformations Pediatrics Radiotherapy (Distributed by Thieme for the American Association of Neurological Surgeons)

Improving the Utility and Translation of Animal Models for Nervous System Disorders

Improving the Utility and Translation of Animal Models for Nervous System Disorders Book
Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2013-04-25
ISBN : 0309266335
Language : En, Es, Fr & De

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Book Description :

Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

Neuroinflammation in Stroke

Neuroinflammation in Stroke Book
Author : Ulrich Dirnagl,Bernd Elger
Publisher : Springer Science & Business Media
Release : 2013-04-17
ISBN : 3662054264
Language : En, Es, Fr & De

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Book Description :

The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.

Advancing Gene Targeted Therapies for Central Nervous System Disorders

Advancing Gene Targeted Therapies for Central Nervous System Disorders Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2019-10-31
ISBN : 0309495873
Language : En, Es, Fr & De

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Book Description :

On April 23 and 24, 2019 the Forum on Neuroscience and Nervous System Disorders convened a workshop titled "Advancing Gene-Targeted Therapies for Central Nervous System Disorders" in Washington, DC. This public workshop brought together experts and key stakeholders from academia, government, industry, philanthropic foundations, and disease/patient-focused nonprofit organizations to explore approaches for advancing the development of gene-targeted therapies for central nervous system (CNS) disorders, and implications of developing these therapies. Participants explored lessons learned from both successful and unsuccessful clinical development programs; new knowledge about the genetic underpinnings of brain disorders; the current status and future potential of gene-targeted therapies for CNS disorders; challenges and potential solutions for translating preclinical findings to approved therapies; and patient and caregiver perspectives. They also discussed what will be needed to develop these therapies for common disorders such as Alzheimer's and Parkinson's disease, as well as neuropsychiatric and neurodevelopmental disorders such as schizophrenia and autism. The workshop included approaches that target both DNA and RNA, as well as gene products using viral vectors, antisense oligonucleotides, and RNA interference. This publication summarizes the presentations and discussion of the workshop.

Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Blood Brain Barrier

Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Blood     Brain Barrier Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2018-05-29
ISBN : 0309473101
Language : En, Es, Fr & De

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Book Description :

Despite substantial advances in developing treatments for the serious illnesses that affect people worldwide, there remains a tremendous unmet need in the treatment of complex neurologic diseases, including neuropsychiatric and neurodegenerative disorders. Chief among the challenges that have hindered the development of therapeutics for central nervous system (CNS) disorders is the bloodâ€"brain barrier (BBB). The Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop to explore the challenges associated with the BBB that have thus far stymied development of CNS drugs, examine new technologies that could address these challenges, and highlight potential opportunities for moving the field forward. This publication summarizes the presentations and discussions from the workshop.