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Biomarkers Of Kidney Disease

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Biomarkers of Kidney Disease

Biomarkers of Kidney Disease Book
Author : Charles L. Edelstein
Publisher : Academic Press
Release : 2010-10-27
ISBN : 9780123756732
Language : En, Es, Fr & De

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Book Description :

A biomarker is a molecule that is measured as a marker of normal biological processes, disease processes or the response to a diagnostic or therapeutic intervention. Kidney diseases like acute kidney injury, chronic kidney disease, diabetic nephropathy, glomerular disease, renal cancer and preeclampsia still have a high morbidity. Measurement of biomarkers in the blood or urine that detect patients at risk of kidney diseases or that detect kidney diseases in the earliest stage may ultimately result in preventative or earlier or more effective treatments for kidney diseases. Biomarkers of Kidney Disease reviews the basic and clinical research on biomarkers of the common kidney diseases including acute kidney injury, chronic kidney disease, renal cancer, diabetic nephropathy, glomerular disease and preeclampsia. The characteristics of an ideal biomarker of kidney diseases and statistical analysis of biomarker studies is detailed. The latest techniques for biomarker detection like metabolomics and proteomics is covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation and preeclampsia. Presents a comprehensive, translational source for all aspects of renal biomarkers in one reference work Experts in renal disease biomarkers (from all areas of academic and medical research) take readers from the bench research (cellular and molecular mechanism) to new therapeutic approaches

Biomarkers in Renal Disease

Biomarkers in Renal Disease Book
Author : Mitchell H. Rosner
Publisher : Nova Publishers
Release : 2008
ISBN : 9781604561135
Language : En, Es, Fr & De

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Book Description :

Advances in long-term improvement and outcomes of patients with kidney disease will require the use of novel biomarkers to identify patients at high risk for kidney disease and to diagnose kidney disease early for effective treatment. A biomarker is a substance found in the blood, body fluids or tissues that provides a measure of normal biological or pathological processes or response to pharmacological compounds or drugs. There are a wide variety of biomarkers including but not limited to mRNA, proteins and peptides, and lipid molecules. In AKI, important pathophysiological processes such as inflammation, apoptotic and necrotic cell death and, tubule regeneration may be reflected in blood or urine. An array of candidate markers along with clinical information in long-term clinical studies with appropriate analytical methodologies will likely provide prognostic information. Despite well-known limitations, currently the most widely used biomarkers for the early diagnosis of CKD and AKI are proteinuria, serum creatinine and blood urea nitrogen. Most clinicians are aware that serum creatinine and blood urea nitrogen are poor biomarkers due to inherent characteristics of these molecules and handling by the kidney. Creatinine is secreted and urea nitrogen is reabsorbed by the renal tubules. Many endogenous substances interfere in the assay for creatinine. Serum creatinine and urea appear late after acute kidney injury and the serum levels in part depend on the generation (large or small body mass). Acute kidney injury is a non steady state condition thus serum creatinine and urea nitrogen will lag behind kidney injury. For these reasons new biomarkers are imperative. With knowledge of these limitations in use of current biomarkers and the lack of progress in reducing the mortality and morbidity from kidney disease, there has been a great surge of interest in identifying novel biomarkers with a particular emphasis on the early diagnosis of kidney disease. A variety of methods have been employed including transcriptomics, proteomics, gene arrays and lipidomics. Currently, candidate biomarkers have been found in different disorders and have been tested in humans and many candidate biomarkers have yet to be identified. Most studies to date are preliminary and require validation in large multicentre studies followed by commercial assay development validation and testing. This new book outlines the rapid advances made in the field of biomarker development for kidney disease in which a variety of novel molecules have been identified and studied in humans.

Biomarkers of Renal Diseases

Biomarkers of Renal Diseases Book
Author : Joaquín García-Estañ,Felix Vargas
Publisher : MDPI
Release : 2021-01-19
ISBN : 3039439111
Language : En, Es, Fr & De

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Book Description :

This book provides important and updated information on current research devoted to urinary biomarkers. Urinary biomarkers are characteristics that can be objectively measured and evaluated as indicators of normal biological or pathogenic processes of pharmacological responses to therapeutic intervention.

Biomarkers in Disease Methods Discoveries and Applications

Biomarkers in Disease  Methods  Discoveries and Applications Book
Author : Vinood B. Patel
Publisher : Unknown
Release : 2021-09-18
ISBN : 9789400777002
Language : En, Es, Fr & De

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Book Description :

Download Biomarkers in Disease Methods Discoveries and Applications book written by Vinood B. Patel, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomarkers in Kidney Disease

Biomarkers in Kidney Disease Book
Author : Vinood B. Patel
Publisher : Springer
Release : 2016-03-11
ISBN : 9789400776982
Language : En, Es, Fr & De

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Book Description :

In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.

Biomarkers of Common Childhood Renal Diseases

Biomarkers of Common Childhood Renal Diseases Book
Author : Samuel N. Uwaezuoke
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Novel biomarkers are now used in the diagnostic and prognostic evaluation of common kidney diseases in children. The increased scientific interest in these biomarkers is partly due to the remarkable progress in their discovery techniques, and their validation in clinical subjects. However, the wide variation in their sensitivity and specificity is still a major concern. In the identification of biomarkers of kidney injury, an ideal biomarker should be produced after organ injury in concentrations which directly correlates with the degree of injury; should be easily measured in body fluids; and should serve as a potential tool to monitor therapeutic response which is predicated upon a post-injury decrease in its concentration. This book chapter aims to highlight and discuss the novel biomarkers used in the diagnostic and prognostic evaluation of common acute diseases of the kidney in children, such as urinary tract infection (UTI) and acute kidney injury (AKI), as well as chronic kidney disease (CKD) secondary to idiopathic nephrotic syndrome (INS) and diabetic nephropathy (DN).

Urine Proteomics in Kidney Disease Biomarker Discovery

Urine Proteomics in Kidney Disease Biomarker Discovery Book
Author : Youhe Gao
Publisher : Springer
Release : 2014-10-29
ISBN : 9401795231
Language : En, Es, Fr & De

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Book Description :

This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce the most significant changes in urine. This book tries to show researchers and graduate students, who are in or entering the field, "all things considered" rather than "the current affair".

The Identification of Novel Urine Biomarkers of Chronic Kidney Disease that Offer Better Prediction of Progression Than Conventional Clinical Methods

The Identification of Novel Urine Biomarkers of Chronic Kidney Disease that Offer Better Prediction of Progression Than Conventional Clinical Methods Book
Author : Zainal Abedin
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Identification of Novel Urine Biomarkers of Chronic Kidney Disease that Offer Better Prediction of Progression Than Conventional Clinical Methods book written by Zainal Abedin, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Diabetic Kidney Disease

Diabetic Kidney Disease Book
Author : Takashi Wada,Kengo Furuichi,Naoki Kashihara
Publisher : Springer Nature
Release : 2020-12-21
ISBN : 9811593019
Language : En, Es, Fr & De

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Book Description :

This book presents the latest information on the clinical-pathological features of diabetic kidney disease. The data included is based on a cohort study of biopsy-proven diabetic nephropathy patients and nephrosclerosis patients, who were observed over a long term, and on the long-term registry for diabetic nephropathy (diabetic kidney disease) in Japan. It provides a clinical-pathological axis in clinical settings, including differential pathological/clinical diagnoses of CKD in diabetic patients (e.g. the presence of “classic” diabetic nephropathy and/or nephrosclerosis and/or other primary kidney diseases). The abundant biopsy specimens with long-term medical records provide a detailed pathological and clinical description. The book also includes urine-sample data for developing and validating possible candidates for novel biomarkers for diabetic kidney disease.Many countries, including Japan, have ageing populations, in which nephrosclerosis contributes to the progression of kidney lesions in patients with diabetic kidney disease. As such, a comparison of a diabetic nephropathy cohort with nephrosclerosis is indispensable to offer better treatments.This comprehensive and informative book is an indispensible reference resource for all physicians and researchers in the field of nephrology and diabetes.

ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes

ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes Book
Author : J.A. Kellum,P.A. McCullough,R.L. Mehta,P.T. Murray,C. Ronco
Publisher : Karger Medical and Scientific Publishers
Release : 2013-05-14
ISBN : 3318024066
Language : En, Es, Fr & De

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Book Description :

Associated with both acute kidney injury (AKI) and cardio-renal syndromes (CRS), new biomarkers represent both a popular area of investigation and a new opportunity for advancement of therapy. This book contains the resolutions of the most recent ADQI conferences on biomarkers in AKI (Dublin) and on cardio-renal syndromes (Venice). The first part answers specific questions about new biomarkers and their use and utility in AKI: What are the most suitable candidate molecules and physiologic measures, how solid and evidence based is the discovery phase? How can we incorporate the new biomarkers in the AKI conceptual model describing the evolution from susceptibility to insult, decreased GFR and organ death? Even if we have a positive biomarker pattern and we can identify patients at risk or patients with early or even subclinical AKI, how is this information affecting our clinical behavior and practice? The second part is dedicated to the appraisal of the current knowledge about the pathophysiological mechanisms involved in different forms of CRS: it contains contributions on the state-of-the-art knowledge and practice of CRS, particularly focusing on the pathophysiology of the five subtypes. Acute and chronic mechanisms of damage are explored in depth, with particular attention to the primacy of organ involvement and the subsequent pathways of organ crosstalk.Presenting the most recent research in the field of biomarkers, AKI and CRS, this publication is an important educational tool for advanced investigators and clinical experts, but also for students and fellows.

Controversies in Acute Kidney Injury

Controversies in Acute Kidney Injury Book
Author : John A. Kellum,C. Ronco,J. L. Vincent
Publisher : Karger Medical and Scientific Publishers
Release : 2011
ISBN : 3805598106
Language : En, Es, Fr & De

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Book Description :

A timely update Acute kidney injury (AKI) is a serious and as yet incompletely understood disorder in which sudden impairment of kidney function occurs secondary to one or more of a variety of underlying conditions. This disorder is very common in (elderly) ICU patients and is associated with very high mortality. Many of those who survive suffer from permanent kidney failure and other long-term morbidities, which may include cardiovascular disease and immune dysfunction. Epidemiologic evidence suggests that AKI is not a single disease, but a syndrome comprised of multiple, often coexisting, etiologies. Being usually part of multiorgan failure syndrome, it calls for multiple organ support therapy. The publication at hand contains sections on prerenal azotemia syndromes, dying of' or with' AKI, pathophysiology of sepsis- induced acute kidney injury, developments in prevention / treatment / rehabilitation, and renal support. Reporting the latest recommendations from experts, it provides valuable information for those that are interested in understanding the disorder and its treatment options.

Investigation of Chronic Kidney Disease Related Biomarkers in Association with Clinical Characteristics and Outcomes in a Large Prospective CKD Cohort

Investigation of Chronic Kidney Disease Related Biomarkers in Association with Clinical Characteristics and Outcomes in a Large Prospective CKD Cohort Book
Author : Helen Alderson
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Investigation of Chronic Kidney Disease Related Biomarkers in Association with Clinical Characteristics and Outcomes in a Large Prospective CKD Cohort book written by Helen Alderson, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Kidney Biomarkers

Kidney Biomarkers Book
Author : Seema S. Ahuja,Brian Castillo
Publisher : Academic Press
Release : 2020-07-31
ISBN : 0128159235
Language : En, Es, Fr & De

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Book Description :

Since laboratory testing and biomarkers are an integral part in the diagnosis and treatment of kidney disease, Kidney Biomarkers: Clinical Aspects and Laboratory Determination covers currently used biomarkers as well as markers that are in development. Laboratories are increasingly more involved in the follow-up confirmatory laboratory testing and this unique volume showcases the collaboration needed to solve diagnostic clinical puzzles between the laboratory and clinician. This volume provides guidance on laboratory test selection and results interpretation in patients. Sources of inaccurate results in the measurement of kidney biomarkers are discussed along with possibility of eliminating such interferences. Each chapter is organized with a uniform easy-to-follow format with insightful case examples highlighting the collaboration between clinical laboratorians and clinicians. Categorizes biomarkers into diagnostic markers, disease follow-up markers, and prognostic biomarkers Include case examples to show the collaboration between the clinical laboratorian and clinician Discusses the application of kidney biomarkers in clinical practice along with addressing laboratory aspects of kidney biomarker determination

Advances in Nephropathy

Advances in Nephropathy Book
Author : Thomas Rath
Publisher : BoD – Books on Demand
Release : 2018-10-24
ISBN : 1789842352
Language : En, Es, Fr & De

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Book Description :

Chronic kidney disease (CKD) is a world-wide known disease affecting up to 4% of the population with increasing figures in developing countries. Life expectancy of patients affected by CKD is shortened compared to the overall population and only a minority of patients reach end stage renal disease (ESRD) with the need for dialysis or renal transplantation; death overtakes dialysis. In nine chapters, this book focuses on different aspects related to the pathophysiology and clinical aspects of CKD, providing interesting insights into new and old biomarkers, allowing us to increase diagnostic and prognostic meaningfulness. In addition, chapters deal with new developments in glomerulopathies, but also aspects of the "tubulocentric" shift will be beneficial for the open-minded reader. Nevertheless, new insights into chronic kidney disease (CKD) and acute kidney injury (AKI) are provided.

Chronic Kidney Disease An Issue of Veterinary Clinics of North America Small Animal Practice E Book

Chronic Kidney Disease  An Issue of Veterinary Clinics of North America  Small Animal Practice  E Book Book
Author : David J. Polzin,Larry D. Cowgill
Publisher : Elsevier Health Sciences
Release : 2016-09-10
ISBN : 0323477178
Language : En, Es, Fr & De

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Book Description :

This issue of Veterinary Clinics of North America: Small Animal Practice focuses on Chronic Kidney Disease. Article topics include: New Biomarkers for Detecting Kidney Disease; Is Progressive CKD a Slow AKI?; Current Understanding of the Pathogenesis of Progressive CKD in Cats; Controversies; Update on Managing Feeding and Hydration in Dogs and Cats with CKD; Update on Phosphorous and Calcitriol Therapy; Update on Medical Management of Clinical Manifestations of CKD; and more!

The Identification of MiRNA Biomarkers of Chronic Kidney Disease and Development of Minimally invasive Methods of Molecular Detection

The Identification of MiRNA Biomarkers of Chronic Kidney Disease and Development of Minimally invasive Methods of Molecular Detection Book
Author : Cristina Beltrami
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Identification of MiRNA Biomarkers of Chronic Kidney Disease and Development of Minimally invasive Methods of Molecular Detection book written by Cristina Beltrami, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Acute Kidney Injury Basic Research and Clinical Practice

Acute Kidney Injury   Basic Research and Clinical Practice Book
Author : X. Ding,M.H. Rosner,C. Ronco
Publisher : Karger Medical and Scientific Publishers
Release : 2018-01-23
ISBN : 3318063118
Language : En, Es, Fr & De

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Book Description :

Acute Kidney Injury (AKI) is a complex syndrome that is prevalent among hospitalized patients. In recent years, occurrence of AKI events has risen due to a growing susceptibility of fragile and elderly subjects and an increase in the use of complex procedures such as cardiovascular surgery and imaging techniques. Exposure to potentially nephrotoxic drugs, such as new chemotherapeutic agents, is also proving to be a cause of AKI. This book summarizes recent advances in various settings. A reappraisal of current definitions and staging classifications for AKI in the literature is followed by a description of new criteria for identifying patients at risk and characterizing early kidney damage by using biomarkers. Other important topics include the sequelae of AKI and AKI in special populations such as children, the elderly, and those with cancer. The effects of AKI and its consequences on healthcare expenditures are also addressed from several perspectives. AKI management requires the cooperation of different specialists to optimize outcomes. This book is thus a perfect tool not only for nephrologists, but for every specialist involved in the complicated endeavor of improving patient care.

Biomarkers in Chronic Kidney Disease The Linkage Between Inflammation Ventricular Dysfunction and Overhydration

Biomarkers in Chronic Kidney Disease   The Linkage Between Inflammation  Ventricular Dysfunction and Overhydration Book
Author : Olimpia Ortega
Publisher : Unknown
Release : 2011
ISBN : 9789533073774
Language : En, Es, Fr & De

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Book Description :

Download Biomarkers in Chronic Kidney Disease The Linkage Between Inflammation Ventricular Dysfunction and Overhydration book written by Olimpia Ortega, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomarkers of Kidney Disease

Biomarkers of Kidney Disease Book
Author : Charles L. Edelstein
Publisher : Academic Press
Release : 2016-11-08
ISBN : 0128030356
Language : En, Es, Fr & De

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Book Description :

Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation, and preeclampsia. New chapters include biomarkers of cardiovascular disease in patients with CKD, biomarkers of Polycystic Kidney Disease, and biomarkers and the role of nanomedicine. Explores both the practical and conceptual steps performed in the discovery of biomarkers in kidney disease Presents a comprehensive account of newer biomarker discover strategies, such as metabolomics and proteomics, all illustrated by clear examples Offers clear translational presentations by the top basic and clinical researchers in each specific renal disease, including AKI, transplantation, cancer, CKD, PKD, diabetic nephropathy, preeclampsia, and glomerular disease