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Biomarkers In Toxicology

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Biomarkers in Toxicology

Biomarkers in Toxicology Book
Author : Ramesh C. Gupta
Publisher : Academic Press
Release : 2019-02-13
ISBN : 0128146567
Language : En, Es, Fr & De

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Book Description :

Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields. Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers Includes completely revised chapters, along with additional chapters on the newest developments in the field Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more

Genomic and Epigenomic Biomarkers of Toxicology and Disease

Genomic and Epigenomic Biomarkers of Toxicology and Disease Book
Author : Saura C. Sahu
Publisher : Wiley-Blackwell
Release : 2022-12-15
ISBN : 9781119807674
Language : En, Es, Fr & De

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Book Description :

Download Genomic and Epigenomic Biomarkers of Toxicology and Disease book written by Saura C. Sahu, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Environmental Toxicology and Risk Assessment

Environmental Toxicology and Risk Assessment Book
Author : Diane S. Henshel
Publisher : ASTM International
Release : 1996
ISBN : 9780803120310
Language : En, Es, Fr & De

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Book Description :

Papers presented at symposium as in title, held 3-5 April 1995, Denver, Colo.

Technical Aspects of Toxicological Immunohistochemistry

Technical Aspects of Toxicological Immunohistochemistry Book
Author : Syed A. Aziz,Rekha Mehta
Publisher : Humana Press
Release : 2015-12-23
ISBN : 1493915169
Language : En, Es, Fr & De

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Book Description :

This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues. Eleven comprehensive chapters provide pathologists and researchers in various sub-disciplines of toxicology with a comprehensive review of the methods and approaches for immunohistochemical staining in various target tissues. It explores the tissue-antigen and antibody-specific problems that may be encountered during the staining procedures and provide potential avenues for resolving various methodological issues. Special attention is paid to the latest enhancement procedures for antigen retrieval and visualization as well as image analysis and antigen quantification. Written by leading researchers in toxicology and pathology, this book is a significant resource for toxicologists and pathologists working with rodents, monkeys and aquatic animal tissues.

Computational Toxicology

Computational Toxicology Book
Author : Hong Fang,Huixiao Hong,Zhichao Liu,Roger Perkins,Reagan Kelly,John Beresney,Weida Tong,Bruce A. Fowler
Publisher : Elsevier Inc. Chapters
Release : 2013-06-04
ISBN : 0128060522
Language : En, Es, Fr & De

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Book Description :

Current advances in genomics, proteomics, and metabolomics are widely anticipated to translate in the future to a constellation of benefits in human health. However, few biomarkers for risk assessment using “omics” technologies have been reported in the last decade. Nevertheless, the potential application for omics technologies is tremendous. The use of biomarker-based monitoring approaches as a tool for environmental risk assessment is often critically limited by a lack of integrated bioinformatics approaches, statistical analyses, and predictive models. In this chapter we discuss the key steps for omics biomarker discovery and also present the use of the decision forest (DF) classification method as an example with specific application to microarray gene expression data, proteomics, and SNP genotypic data. An integrated bioinformatics approach with the correct choice of samples, omics technologies, and statistical techniques will allow the development of powerful new biomarkers for safety assessment.

Drug Discovery Toxicology

Drug Discovery Toxicology Book
Author : Yvonne Will,J. Eric McDuffie,Andrew J. Olaharski,Brandon D. Jeffy
Publisher : John Wiley & Sons
Release : 2016-04-18
ISBN : 1119053331
Language : En, Es, Fr & De

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Book Description :

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Biomarkers in Ecotoxicology

Biomarkers in Ecotoxicology Book
Author : Susan M. Cormier,Society of Environmental Toxicology and Chemistry,Symposium on Biomarkers in Ecotoxicology
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomarkers in Ecotoxicology book written by Susan M. Cormier,Society of Environmental Toxicology and Chemistry,Symposium on Biomarkers in Ecotoxicology, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Toxicity Biomarkers

Toxicity Biomarkers Book
Author : S. Srivastava
Publisher : IOS Press
Release : 2005
ISBN : 9781586035259
Language : En, Es, Fr & De

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Book Description :

Since the dawn of civilization, humans have feared the unknown risks associated with the use of new natural herbs or other natural medications to cure their pain, aches and illnesses. In the ancient Indian Ayurvedic Medicine which is over 4000 years old, the 'Visha (poison) Tantra (wisdom)' was developed as a discipline of medicine encompassing Toxicology and Preventive Medicines. Visha Tantra included the study of various toxic herbs and animals and their antidotes as well as the biomarkers of toxic effects. In the Visha Tantra and the practice of Ayurvedic medicine, there have been objective descriptions of the changes in colour and amount of urine, changes in the colour of nails, skin, and eyes, breathing patterns, gastrointestinal disturbances, and precautionary measures to prevent adverse effects as biomarkers of toxicity associated with the use of herbal medicines and certain foods. The adverse effects are the inevitable outcome of the environmental and industrial chemicals and pharmaceuticals; however, efforts are ongoing to prevent unexpected life-threatening toxicities and / or irreversible organ damage. The search for non-invasive biomarkers that can be objectively linked to adverse effects associated with man-made synthetic chemicals including pharmaceuticals and environmental pollutants is becoming an important priority for academics, federal agencies, pharmaceutical and industrial companies. This publication is devoted to toxicity biomarkers of target organs of toxicity and molecular epidemiology. It provides a comprehensive review of a wide spectrum of biomarkers, including molecular epidemiology biomarkers of aflatoxin and hepatitis B virus induced hepatocarcinogenesis, cytokines as the biomarkers of hepatocellular injury, drug-induced vascular injury, nephrotoxicity and reproductive toxicity biomarkers.

Toxicologic Biomarkers

Toxicologic Biomarkers Book
Author : Anthony P. DeCaprio
Publisher : CRC Press
Release : 2006-04-18
ISBN : 1000611825
Language : En, Es, Fr & De

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Book Description :

Responding to the explosion of advances in the use of biomarkers to efficiently, rapidly, and economically evaluate the health effects of chemical entities, this authoritative reference provides a detailed overview of the theory, development, and practical application of biomarkers in the toxicological, environmental, forensic, and pharmaceutical s

Environmental Toxicology and Risk Assessment

Environmental Toxicology and Risk Assessment Book
Author : Diane Susan Henshel
Publisher : ASTM International
Release : 1999
ISBN : 9780803126183
Language : En, Es, Fr & De

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Book Description :

Download Environmental Toxicology and Risk Assessment book written by Diane Susan Henshel, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular Biological Markers for Toxicology and Risk Assessment

Molecular Biological Markers for Toxicology and Risk Assessment Book
Author : Bruce A. Fowler
Publisher : Academic Press
Release : 2016-06-10
ISBN : 0128019018
Language : En, Es, Fr & De

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Book Description :

Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice. Introduces the use of molecular biomarkers to detect toxic effects of chemicals as early as possible Provides an accessible overview of this emerging, interdisciplinary field, to best inform decision making in chemical and pharmaceutical safety Includes a section on risk communication of these complex concepts, essential for effective risk assessment Provides new insights into the initial mechanisms of chemical-induced toxicity and carcinogenicity

Animal Biomarkers as Pollution Indicators

Animal Biomarkers as Pollution Indicators Book
Author : David B. Peakall
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401123462
Language : En, Es, Fr & De

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Book Description :

Ecotoxicology is a relatively new scientific discipline. Indeed, it might be argued that it is only during the last 5-10 years that it has come to merit being regarded as a true science, rather than a collection of procedures for protecting the environment through management and monitoring of pollutant discharges into the environment. The term 'ecotoxicology' was first coined in the late sixties by Prof. Truhaut, a toxicologist who had the vision to recognize the importance of investigating the fate and effects of chemicals in ecosystems. At that time, ecotoxicology was considered a sub-discipline of medical toxicology. Subsequently, several attempts have been made to portray ecotoxicology in a more realistic light. Notably, both F. Moriarty (1988) and F. Ramade (1987) emphasized in their books the broad basis of ecotoxicology, encompassing chemical and radiation effects on all components of ecosystems. In doing so, they and others have shifted concern from direct chemical toxicity to man, to the far more subtle effects that pollutant chemicals exert on natural biota. Such effects potentially threaten the existence of all life on Earth. Although I have identified the sixties as the era when ecotoxicology was first conceived as a coherent subject area, it is important to acknowledge that studies that would now be regarded as ecotoxicological are much older. Wherever people's ingenuity has led them to change the face of nature significantly, it has not escaped them that a number of biological con sequences, often unfavourable, ensue.

Biomarkers of Environmental Toxicants

Biomarkers of Environmental Toxicants Book
Author : Kun Lu,Robert J Turesky
Publisher : Mdpi AG
Release : 2020-10-02
ISBN : 9783039367368
Language : En, Es, Fr & De

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Book Description :

Biomarkers of environmental toxicants are measures of exposures, some of which can serve to assess disease risk and inter-individual susceptibilities. Metabolites, protein and DNA adducts also serve to elucidate the mechanisms of the bioactivation and detoxication of reactive toxicant intermediates. Some environmental chemicals act as modulators of gene and protein activity, and induce the dysbiosis of the microbiome, which impacts the metabolome and overall health. In this Special Issue on "Biomarkers of Environmental Toxicants", review articles and original research studies are featured, covering the latest bioanalytical, biochemical and mass spectrometry-based technologies, to monitor exposures through targeted and non-targeted methods, and mechanistic studies that examine the biological effects of environmental toxicants in cells and humans. Diverse topics, such as exposome, microbiome, DNA/protein adducts and t-RNA modifications, as well as important environment toxicants, including heavy metals, benzene, phthalates, aldehydes, glycidol, tobacco smoke and aristolochic acids, are covered. Novel analytical methods, such as protein adductomics, DNA adduct analysis in formalin-fixed paraffin-embedded tissues, site-specific mutagenesis assay and accelerator mass spectrometry, are also included. This collection provides a valuable update of the most recent biochemical and analytical tools that employ biomarkers in toxicology research, biomarker discovery, and exposure and risk assessment in population-based studies.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

A Comprehensive Guide to Toxicology in Nonclinical Drug Development Book
Author : Ali S. Faqi
Publisher : Academic Press
Release : 2016-11-03
ISBN : 0128036214
Language : En, Es, Fr & De

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Book Description :

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology

Eco Toxicology

Eco Toxicology Book
Author : J. T. Zelikoff,J. M. Lynch,J. Shepers
Publisher : Unknown
Release : 1979
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Eco Toxicology book written by J. T. Zelikoff,J. M. Lynch,J. Shepers, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Tobacco Smoke Exposure Biomarkers

Tobacco Smoke Exposure Biomarkers Book
Author : Qingyuan Hu,Hongwei Hou
Publisher : CRC Press
Release : 2015-04-01
ISBN : 1498705618
Language : En, Es, Fr & De

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Book Description :

Written by experts in the analytical chemistry of tobacco smoke, Tobacco Smoke Exposure Biomarkers summarizes the toxicology, metabolic pathway, and biomarkers of nicotine, TSNAs, PAHs, VOCs, AAs, Catechol and Hydroquinone, HCN, CO and NOx, and heavy metals, and the use of this biomarker in exposure assessment and/or cigarette smoke exposure environmental epidemiology. A convenient one-stop guide, the book brings together information on some exposure biomarkers and nicotine addiction in humans with regulatory implications and strategies. The authors also include discussions of how smoke exposure biomarkers may be used to shape regulation and health policy. Ethics guidelines, details of method development, and the validated relative bioanalytical method provided in the appendixes rounds out the coverage. The book gives you tools to further research biomarkers for tobacco carcinogens and to face emerging health challenges such as delivery of nicotine via electronic cigarettes.

Biomarkers in Environmental Toxicology

Biomarkers in Environmental Toxicology Book
Author : Anonim
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomarkers in Environmental Toxicology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomarkers of Chemical Exposure

Biomarkers of Chemical Exposure Book
Author : International Federation of Clinical Chemistry
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomarkers of Chemical Exposure book written by International Federation of Clinical Chemistry, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomarkers of Environmental Contamination

Biomarkers of Environmental Contamination Book
Author : 0 McCarthy
Publisher : CRC Press
Release : 2018-01-18
ISBN : 1351087169
Language : En, Es, Fr & De

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Book Description :

How can biological markers help assess and predict human health risks? Find out the answers to this question and others in this timely new book examining the use of biological markers in animals and plants for evaluating the ecological and health effects of environmental contamination. The book explains the concept of environmental sentinels, presents example of field studies and discusses the utility of biomarkers within a risk analysis paradigm. Anyone who needs to know how to assess and predict environmental contamination should consider this book essential reading.

Introduction to Toxicology

Introduction to Toxicology Book
Author : John Timbrell
Publisher : CRC Press
Release : 2019-10-30
ISBN : 1000026981
Language : En, Es, Fr & De

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Book Description :

Since the publication of the first edition of Introduction to Toxicology , toxicology has become a more mature science, the number of undergraduate and postgraduate courses has increased and thus the need for a regularly updated introductory text has become more pressing. This third edition caters for this need in a clear and easy-to-read style, featuring: * Up-to-the-minute information * Relevant toxicological examples that reinforce principles * End-of-chapter essay questions * New and redrawn illustrations * Glossary of terms * Extensively revised bibliography The fundamental principles of absorption, distribution, metabolism and excretion are described in the introductory chapters, as are the types of exposure and response. In subsequent chapters these are clarified with the use of carefully chosen examples. Among the topics considered are the potential adverse effects of drugs, pesticides, food additives and industrial chemicals.