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Bioinformatics for Vaccinology

Bioinformatics for Vaccinology Book
Author : Darren R. Flower
Publisher : John Wiley & Sons
Release : 2008-10-13
ISBN : 0470699825
Language : En, Es, Fr & De

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Book Description :

“... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once...” Human Vaccines, 2010 "... This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..." –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.

The Impact of Bioinformatics on Vaccine Design and Development

The Impact of Bioinformatics on Vaccine Design and Development Book
Author : Ribas-Aparicio Rosa María
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Vaccines are the pharmaceutical products that offer the best cost-benefit ratio in the prevention or treatment of diseases. In that a vaccine is a pharmaceutical product, vaccine development and production are costly and it takes years for this to be accomplished. Several approaches have been applied to reduce the times and costs of vaccine development, mainly focusing on the selection of appropriate antigens or antigenic structures, carriers, and adjuvants. One of these approaches is the incorporation of bioinformatics methods and analyses into vaccine development. This chapter provides an overview of the application of bioinformatics strategies in vaccine design and development, supplying some successful examples of vaccines in which bioinformatics has furnished a cutting edge in their development. Reverse vaccinology, immunoinformatics, and structural vaccinology are described and addressed in the design and development of specific vaccines against infectious diseases caused by bacteria, viruses, and parasites. These include some emerging or re-emerging infectious diseases, as well as therapeutic vaccines to fight cancer, allergies, and substance abuse, which have been facilitated and improved by using bioinformatics tools or which are under development based on bioinformatics strategies.

Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines

Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines Book
Author : Darren R. Flower,Yvonne Perrie
Publisher : Springer Science & Business Media
Release : 2012-12-09
ISBN : 1461450705
Language : En, Es, Fr & De

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Book Description :

This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.

Molecular Vaccines

Molecular Vaccines Book
Author : Matthias Giese
Publisher : Springer Science & Business Media
Release : 2013-11-08
ISBN : 3319009788
Language : En, Es, Fr & De

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Book Description :

This title discusses all aspects of non-infectious and non-cancer– so called NINC – vaccines. Hypertension, diabetes and allergy vaccine development are referred to as well as the use of adjuvants and nanotechnology in vaccine development. The way of novel vaccines from bench to preclinical to clinical studies and launch to the market under EMEA (European Medicines Agency) and FDA (Food and Drug Administration) guidelines are described in-depth. The book is therefore of interest for researchers and clinicians engaged in vaccine development and molecular vaccine application.

Reverse Vaccinology

Reverse Vaccinology Book
Author : Pedro A Reche,Richard Moxon,Rino Rappuoli
Publisher : Frontiers Media SA
Release : 2020-01-15
ISBN : 2889633853
Language : En, Es, Fr & De

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Book Description :

Download Reverse Vaccinology book written by Pedro A Reche,Richard Moxon,Rino Rappuoli, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Textbook Of Bioinformatics A Information theoretic Perspectives Of Bioengineering And Biological Complexes

Textbook Of Bioinformatics  A  Information theoretic Perspectives Of Bioengineering And Biological Complexes Book
Author : Perambur S Neelakanta
Publisher : World Scientific
Release : 2020-08-24
ISBN : 9811212902
Language : En, Es, Fr & De

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Book Description :

This book on bioinformatics is designed as an introduction to the conventional details of genomics and proteomics as well as a practical comprehension text with an extended scope on the state-of-the-art bioinformatic details pertinent to next-generation sequencing, translational/clinical bioinformatics and vaccine-design related viral informatics.It includes four major sections: (i) An introduction to bioinformatics with a focus on the fundamentals of information-theory applied to biology/microbiology, with notes on bioinformatic resources, data bases, information networking and tools; (ii) a collection of annotations on the analytics of biomolecular sequences, with pertinent details presented on biomolecular informatics, pairwise and multiple sequences, viral sequence informatics, next-generation sequencing and translational/clinical bioinformatics; (iii) a novel section on cytogenetic and organelle bioinformatics explaining the entropy-theoretics of cellular structures and the underlying informatics of synteny correlations; and (iv) a comprehensive presentation on phylogeny and species informatics.The book is aimed at students, faculty and researchers in biology, health/medical sciences, veterinary/agricultural sciences, bioengineering, biotechnology and genetic engineering. It will be a useful companion for managerial personnel in the biotechnology and bioengineering industries as well as in health/medical science.

Introduction to Molecular Vaccinology

Introduction to Molecular Vaccinology Book
Author : Matthias Giese
Publisher : Springer
Release : 2016-03-11
ISBN : 331925832X
Language : En, Es, Fr & De

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Book Description :

This textbook provides an easy-to-understand introduction to the complex topic of vaccine research and development. It gives a comprehensive though clearly arranged insight to the most important aspects of molecular vaccinology, leading from the basics in immunology, to design of vaccines and mode of action of vaccines to the actual formulation, manufacturing and registration of vaccines. The volume is therefore a valuable text about modern vaccinology for graduate students and a basic introduction for newcomers in vaccine design and development.

Vaccines

Vaccines Book
Author : Farhat Afrin,Hassan Hemeg,Hani Ozbak
Publisher : BoD – Books on Demand
Release : 2017-09-06
ISBN : 9535134752
Language : En, Es, Fr & De

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Book Description :

Microbes that elude host's defenses and have developed resistance to the existing antibiotic arsenal continuously invade the human body. Cure for such diseases is inevitable as it may result in high morbidity and mortality, if not properly treated. Vaccination represents the most cost-effective way for disease prevention. Vaccines activate sentinels of the immune system including macrophages and T, B, and dendritic cells to release a battery of effector molecules and cytokines and ward off infection. For long-lasting protection, the memory cells also need to be evoked. This book encompasses biotechnological vaccines in clinical use, cocooning, disease resurgence postvaccination and other vaccine adverse effects, prospects of therapeutic versus prophylactic vaccines, and design of effective vaccines using bioinformatic tools and engineering molecular pattern interactions.

Bioinformatics Sequences Structures Phylogeny

Bioinformatics  Sequences  Structures  Phylogeny Book
Author : Asheesh Shanker
Publisher : Springer
Release : 2018-10-13
ISBN : 9811315620
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of the concepts and approaches used for sequence, structure, and phylogenetic analysis. Starting with an introduction to the subject and intellectual property protection for bioinformatics, it guides readers through the latest sequencing technologies, sequence analysis, genomic variations, metagenomics, epigenomics, molecular evolution and phylogenetics, structural bioinformatics, protein folding, structure analysis and validation, drug discovery, reverse vaccinology, machine learning, application of R programming in biological data analysis, and the use of Linux in handling large data files.

Disarmament Forum

Disarmament Forum Book
Author : Anonim
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Disarmament Forum book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Physico chemical Procedures for the Characterization of Vaccines

Physico chemical Procedures for the Characterization of Vaccines Book
Author : Fred Brown,Michael J. Corbel,Elwyn Griffiths,International Association for Biologicals
Publisher : S Karger Ag
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume brings together recent developments in the field of physico-chemical procedures and provides a perspective of the contribution that this methodology can make to facilitate the production and quality control of bacterial and viral vaccines. A growing number of vaccines today is based on well-defined materials, including vaccines based on purified protein antigens of natural origin or produced by rDNA technology, polysaccharides, semi-synthetic poly- or oligosaccharide-protein conjugates and novel nucleic acid constructs. Although in principle much better defined than 'traditional' vaccines, these new products raise new challenges of their own. The realization that biological assays often show limitations in characterizing these vaccines together with mounting social and political pressures to move away from test methods using live animals have shifted interest to methods providing a precise and objective means of characterization at the molecular level as an effective alternative. The growing sophistication of many procedures for physico-chemical analysis has made their application to biological materials a workable reality. This volume contains contributions describing the application of all the principal methods currently in use for evaluating carbohydrate, lipopolysaccharide, lipid, protein, glycoprotein, and lipoprotein components of vaccines, whether produced by conventional methods or recombinant technology. It is clear from the information presented that this approach is gaining momentum and that we are seeing only the beginning of its impact in the field of vaccines and vaccinology.

Vaccines for Humans

Vaccines for Humans Book
Author : European Commission. Directorate-General for Health and Consumer Protection
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Recoge : Basic vaccinology - Diseases specific vaccine research - Clinical research and capacity building.

Bioinformatics for Immunomics

Bioinformatics for Immunomics Book
Author : Darren D.R. Flower,Matthew Davies,Shoba Ranganathan
Publisher : Springer
Release : 2009-10-03
ISBN : 9781441905406
Language : En, Es, Fr & De

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Book Description :

Like many words, the term “immunomics” equates to different ideas contingent on context. For a brief span, immunomics meant the study of the Immunome, of which there were, in turn, several different definitions. A now largely defunct meaning rendered the Immunome as the set of antigenic peptides or immunogenic proteins within a single microorganism – be that virus, bacteria, fungus, or parasite – or microbial population, or antigenic or allergenic proteins and peptides derived from the environment as a whole, containing also proteins from eukaryotic sources. However, times have changed and the meaning of immunomics has also changed. Other newer definitions of the Immunome have come to focus on the plethora of immunological receptors and accessory molecules that comprise the host immune arsenal. Today, Immunomics or immunogenomics is now most often used as a synonym for high-throughput genome-based immunology. This is the study of aspects of the immune system using high-throughput techniques within a conc- tual landscape borne of both clinical and biophysical thinking.

Encyclopedia of Genetics Genomics Proteomics and Bioinformatics 8 Volume Set

Encyclopedia of Genetics  Genomics  Proteomics and Bioinformatics  8 Volume Set Book
Author : Michael J. Dunn,Lynn B. Jorde,Peter F. R. Little,Shankar Subramaniam
Publisher : Wiley
Release : 2005-11-11
ISBN : 9780470849743
Language : En, Es, Fr & De

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Book Description :

Available in print and online, this unique reference brings together all four fields of genetics, genomics, proteomics, and bioinformatics to meet your dynamic research requirements. It brings together the latest concepts in these vibrant areas and ensures a truly multidisciplinary approach. Topics include genetic variation and evolution, epigenetics, the human genome, expression profiling, proteome families, structural proteomics, gene finding/gene structure, protein function and annotation, and more. The work incorporates a vast amount of topical information, profiles cutting-edge techniques, and presents the very latest findings from an international team of over five hundred contributors. With articles for both students and more experienced scientists, this is a key reference source for everyone. Contains more than 450 articles covering all aspects of genomics, proteomics, bioinformatics and related technologies Includes a glossary containing over 550 clear and concise definitions "I am pleased to recommend it heartily as a essential reference tool…should remain the definitive work…for many years to come." THE CHEMICAL EDUCATOR “Jorde…and co-editors have done a remarkable job in coordinating this information, distilling it into a package that is both easy to navigate and over-flowing in discovery." ELECTRIC REVIEW

Abstracts of the General Meeting of the American Society for Microbiology

Abstracts of the     General Meeting of the American Society for Microbiology Book
Author : American Society for Microbiology. General Meeting
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Abstracts of the General Meeting of the American Society for Microbiology book written by American Society for Microbiology. General Meeting, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Dissertation Abstracts International

Dissertation Abstracts International Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Dissertation Abstracts International book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Immunoinformatics

Immunoinformatics Book
Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Release : 2004-03-05
ISBN : 0470090758
Language : En, Es, Fr & De

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Book Description :

The astounding diversity of the immune system and the complexity of its regulatory pathways makes immunology a combinatorial science. Computational analysis has therefore become an essential element of immunology research and this has led to the creation of the emerging field of immunoinformatics. This book is the first to feature thorough coverage of this new field. Immunoinformatics facilitates the understanding of immune function by modelling the interactions among immunological components. Biological research provides ever deeper insights into the complexity of living organisms while computer science provides an effective means to store and analyse large volumes of complex data. Combining the two fields increases the efficiency of biological research and offers the potential for major advances in the study of biological systems. This book encompasses key developments in immunoinformatics, including immunological databases, sequence analysis, structure modelling, mathematical modelling of the immune system, simulation of laboratory experiments, statistical support for immunological experimentation and immunogenomics. The difficulties in effective application of bioinformatic tools in immunology arise at both ends of the spectrum: most immunologists have only a limited comprehension of sophisticated data analysis and applicability and limitations, while the average computer scientist lacks knowledge of the depth and complexity of biological data. The purpose of this book, therefore, is to present contributions from a multidisciplinary team of biologists and computer scientists to explore the issues related to better understanding of immune function and, in particular, to help apply new computer science methods to immunological research. Related Novartis Foundation symposia: 247 In Silico Simulation of Biological Processes Chair: Denis Noble 252 Generation and effector functions of regulatory lymphocytes Chair: Jean-François Bach

New Scientist

New Scientist Book
Author : Anonim
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download New Scientist book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Innovative Therapeutic and Immunomodulatory Strategies for Protozoan Infections

Innovative Therapeutic and Immunomodulatory Strategies for Protozoan Infections Book
Author : Jorge Enrique Gomez-Marin,Kamal El Bissati
Publisher : Frontiers Media SA
Release : 2019-11-04
ISBN : 2889631273
Language : En, Es, Fr & De

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Book Description :

Human protozoan infections are an important target for development of new vaccines and drugs. No completely efficacious vaccines for human protozoan infections are available and in the case of malaria resistance to the most efficacious antimalarials has become a global challenge. In ocular toxoplasmosis complete eradication of the body is not possible, exposing patients to new reactivations. The need of treatment or vaccines for and of less toxic drugs for Leishmania are urgent tasks for protozoologists research community. New research strategies have appeared that enlarged the possibilities for treatment and vaccine development. Reverse vaccinology, bioinformatic search of second use drug candidates and ex vivo analysis have afforded new fields for development.

Directory of Research Grants 2005

Directory of Research Grants 2005 Book
Author : Jeremy T. Miner,Lynn E. Miner,Greenwood-Heinemann Publishing
Publisher : Oryx Press
Release : 2004
ISBN : 9781573565981
Language : En, Es, Fr & De

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Book Description :

A treasure chest of information on more than 5,100 current programs from 1,880 sponsors. Find grants for basic research, equipment acquisition, building construction/renovation, fellowships, and 23 other program types.