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Biased Signaling In Physiology Pharmacology And Therapeutics

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Biased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology  Pharmacology and Therapeutics Book
Author : Brian J Arey
Publisher : Elsevier
Release : 2014-06-05
ISBN : 0124115071
Language : En, Es, Fr & De

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Book Description :

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

Pharmacology of G Protein Coupled Receptors

Pharmacology of G Protein Coupled Receptors Book
Author : Anonim
Publisher : Academic Press
Release : 2011-09-08
ISBN : 0123859530
Language : En, Es, Fr & De

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Book Description :

G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones. In addition, emerging drug targets such as receptor families for fatty acids, carboxylic acids, lipid mediators, etc. are included. Final chapters cover novel mechanisms of signal regulation through PDZ domains and RGS proteins. This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists

Arrestins Pharmacology and Therapeutic Potential

Arrestins   Pharmacology and Therapeutic Potential Book
Author : Vsevolod V. Gurevich
Publisher : Springer Science & Business Media
Release : 2013-11-29
ISBN : 3642411991
Language : En, Es, Fr & De

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Book Description :

This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.

The Physiology and Pharmacology of Leucine rich Repeat GPCRs

The Physiology and Pharmacology of Leucine rich Repeat GPCRs Book
Author : Brian J. Arey,James A. Dias
Publisher : Frontiers Media SA
Release : 2016-08-05
ISBN : 2889199584
Language : En, Es, Fr & De

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Book Description :

G protein-coupled receptors (GPCRs) represent a large and physiologically important class of cell surface receptors. There are approximately 750 known GPCRs present in the human genome that can be subdivided into general classes based upon sequence homology within their transmembrane domains. Therapeutically, GPCRs represent a fertile source for the development of therapies as they are a significant percentage of our current pharmacopeia. Among the three subclasses of GPCRs, the Class A (rhodopsin-like) receptors are by far the most prevalent and extensively studied. However, within the Class A receptors, sub-families of receptors can be distinguished based upon common sequence motifs within the transmembrane domains as well as extracellular and intracellular domains. One such family of Class A receptors is characterized by multiple leucine- rich repeats within their amino- terminal domains (the Leucine-rich Repeat family (LRR)). This family of GPCRs are best represented by the glycoprotein hormone receptors (LHR, FSHR and TSHR) which have been studied extensively but also includes receptors for the peptide hormone relaxin (RXFP1 and RXFP2 (RXFP2 also binds insulin-like peptide 3)) and three other receptors (LGR4, LGR5 and LGR6). LGR4-6 were, until recently, considered orphan receptors. However, emerging data have revealed that these proteins are the receptors for a family of growth factors called R-spondins. Over the last 20 years much has been learned about LRR receptors, including the development of synthetic agonists and antagonists, new insights into signaling (including signaling bias) and the physiological role these receptors play in regulating the function of many tissues. This topic will focus on what is known concerning the regulation of these receptors, their signaling pathways, functional consequences of activation and pharmacology.

GPCRs

GPCRs Book
Author : Beata Jastrzebska,Paul S.-H. Park
Publisher : Academic Press
Release : 2019-09-11
ISBN : 0128167289
Language : En, Es, Fr & De

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Book Description :

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer’s disease, Parkinson’s disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth. Addresses our current understanding and novel advances in the GPCR field, directing readers towards recent finding of key significance for translational medicine Combines a thorough discussion of structure and function of GPCRs with disease association and drug discovery Features chapter contributions from international experts in GPCR structure, signaling, physiology and pharmacology

GPCRs

GPCRs Book
Author : Beata Jastrzebska,Paul S. H. Park
Publisher : Academic Press
Release : 2019-10
ISBN : 9780128162286
Language : En, Es, Fr & De

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Book Description :

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer's disease, Parkinson's disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth. Addresses our current understanding and novel advances in the GPCR field, directing readers towards recent finding of key significance for translational medicine Combines a thorough discussion of structure and function of GPCRs with disease association and drug discovery Features chapter contributions from international experts in GPCR structure, signaling, physiology and pharmacology

Neural Regulation of Metabolism

Neural Regulation of Metabolism Book
Author : Qi Wu,Ruimao Zheng
Publisher : Springer
Release : 2018-11-02
ISBN : 9811312869
Language : En, Es, Fr & De

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Book Description :

This book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically. The book first introduces the latest studies on the neural and cellular mechanisms of hypothalamic neurons, hypothalamic glial cells, neural circuitries, cellular signaling pathways, and synaptic plasticity in the control of appetite, body weight, feeding-related behaviors and metabolic disorders. It then summarizes the humoral mechanisms by which critical adipocyte-derived hormones and lipoprotein lipase regulate lipid and glucose metabolism, and examines the role of the hypothalamus-sympathetic nerve, a critical nerve pathway from CNS to peripheral nervous system (PNS), in the regulation of metabolism in multiple tissues/organs. Furthermore, the book discusses the functions of adipose tissue in energy metabolism. Lastly, it explores dietary interventions to treat neural diseases and some of the emerging technologies used to study the neural regulation of metabolism. Presenting cutting-edge developments in the neural regulation of metabolism, the book is a valuable reference resource for graduate students and researchers in the field of neuroscience and metabolism.

Cumulated Index Medicus

Cumulated Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cumulated Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pharmacology

Pharmacology Book
Author : H. P. Rang
Publisher : Unknown
Release : 2001
ISBN : 9780443065743
Language : En, Es, Fr & De

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Book Description :

Adapted for the U.S., this New Edition of PHARMACOLOGY, a popular UK text, describes what drugs do and emphasizes the mechanisms by which they act. The U.S. edition is revised and updated to reflect the substantial differences in drug names, FDA approvals, terminology, and guidelines for use. It also boasts new and revised chapters to ensure that students are up to date on the very latest information. Each chapter begins with a summary of information essential to the chapter and key points are highlighted within the text to alert students to crucial concepts. Spanish version also available, ISBN: 84-8174-492-1

5th Annual Congress of the British Society for Immunology

5th Annual Congress of the British Society for Immunology Book
Author : British Society for Immunology. Congress
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download 5th Annual Congress of the British Society for Immunology book written by British Society for Immunology. Congress, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

American Book Publishing Record

American Book Publishing Record Book
Author : Anonim
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download American Book Publishing Record book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Dissertation Abstracts International

Dissertation Abstracts International Book
Author : Anonim
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Dissertation Abstracts International book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Psychopharmacology Abstracts

Psychopharmacology Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1981
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Psychopharmacology Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

G Protein Coupled Receptors

G Protein Coupled Receptors Book
Author : Anonim
Publisher : Academic Press
Release : 2013-01-28
ISBN : 012407944X
Language : En, Es, Fr & De

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Book Description :

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers G protein coupled receptors Contains chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation

Basic Clinical Pharmacology Thirteenth Edition SMARTBOOKTM

Basic   Clinical Pharmacology  Thirteenth Edition  SMARTBOOKTM Book
Author : Bertram G. Katzung,Anthony J. Trevor
Publisher : McGraw Hill Professional
Release : 2014-12-22
ISBN : 0071826416
Language : En, Es, Fr & De

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Book Description :

Gain a full understanding of the basic science andclinical use of drugs with the most up-to-date andcomprehensive pharmacology text in the health sciences A Doody's Core Title for 2017! 400 ILLUSTRATIONS--MANY IN FULL COLOR Organized to reflect the course sequence in many pharmacology courses and in integrated curricula, Basic & Clinical Pharmacology covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. Selection of the subject matter and order of its presentation are based on the authors' many years of experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students. Coverage that spans every aspect of medical pharmacology: Encompasses every aspect of medical pharmacology including botanicals and over-the-counter drugs New chapter on pharmacogenomics with important examples Emphasis is placed on discussion of druggroups and prototypes Clinically relevant, the book includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects Full-color presentation with more than 400 illustrations Case studies introduce clinical problems in most chapters Summary tables and diagrams encapsulate important information Includes many new drugs A Generic Name/Trade Name Table appears at the end of most chapters for easy reference when writing a chart order or prescription

Issues in Pharmacology Pharmacy Drug Research and Drug Innovation 2011 Edition

Issues in Pharmacology  Pharmacy  Drug Research  and Drug Innovation  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464963444
Language : En, Es, Fr & De

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Book Description :

Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Philosophical Transactions of the Royal Society of London

Philosophical Transactions of the Royal Society of London Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Philosophical Transactions of the Royal Society of London book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A Textbook of Pharmaceutical Medicine

A Textbook of Pharmaceutical Medicine Book
Author : Ronald David Mann,Michael David Rawlins,Richard Maitland Auty
Publisher : Parthenon Publishing
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This textbook comprises a collection of over 50 articles on aspects of pharmaceutical medicine, ranging over new drug development, pre-clinical research and post-marketing surveillance. Controversies over suspicious data and medicines for the Third World are also covered.

Molecular Neuropharmacology A Foundation for Clinical Neuroscience Fourth Edition

Molecular Neuropharmacology  A Foundation for Clinical Neuroscience  Fourth Edition Book
Author : Eric J. Nestler,Steven E. Hyman,Robert C. Malenka
Publisher : McGraw Hill Professional
Release : 2020-09-05
ISBN : 1260456919
Language : En, Es, Fr & De

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Book Description :

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The definitive guide to treating neurologic and psychiatric disorders with drugs and other approaches Fully updated with the latest research and drugs, Nestler, Hyman, & Malenka’s Molecular Neuropharmacology, Fourth Edition, is the leading guide to molecular neuroscience. Providing an in-depth look at the neuropharmacological fundamentals of the nervous system, it delivers the knowledge and insight you need to master the pathophysiology of neurologic and psychiatric disorders. Complete with tables, diagrams, and figures clearly illustrating the intricacies of neurochemistry and molecular neuroscience, this peerless guide reviews the effects of drug action (organized by drug category) to enhance your understanding of major disease mechanisms, and it explains the pathophysiology and neuropharmacology of all major neurologic and psychiatric disorders. Concise overviews of the effects of drugs and other treatment approaches are presented in a way that boosts your understanding and retention of critical concepts. Nestler, Hyman, & Malenka’s Molecular Neuropharmacology provides a deep dive into: General principles of neurophar¬macology Nervous system function Drugs that act on neuronal and glial function Major neurotrans¬mitter systems in the brain and spinal cord Atypical neurotransmitters, including peptides, growth factors, and cytokines Major brain and spinal cord systems at the molecular, cellular, and circuit levels in health and disease