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Basic Science Methods For Clinical Researchers

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Basic Science Methods for Clinical Researchers

Basic Science Methods for Clinical Researchers Book
Author : Morteza Jalali,Francesca Yvonne Louise Saldanha,Mehdi Jalali
Publisher : Academic Press
Release : 2017-03-31
ISBN : 012803078X
Language : En, Es, Fr & De

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Book Description :

Basic Science Methods for Clinical Researchers addresses the specific challenges faced by clinicians without a conventional science background. The aim of the book is to introduce the reader to core experimental methods commonly used to answer questions in basic science research and to outline their relative strengths and limitations in generating conclusive data. This book will be a vital companion for clinicians undertaking laboratory-based science. It will support clinicians in the pursuit of their academic interests and in making an original contribution to their chosen field. In doing so, it will facilitate the development of tomorrow’s clinician scientists and future leaders in discovery science. Serves as a helpful guide for clinical researchers who lack a conventional science background Organized around research themes pertaining to key biological molecules, from genes, to proteins, cells, and model organisms Features protocols, techniques for troubleshooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data Appendices provide resources for practical research methodology, including legal frameworks for using stem cells and animals in the laboratory, ethical considerations, and good laboratory practice (GLP)

Basic Science Techniques in Clinical Practice

Basic Science Techniques in Clinical Practice Book
Author : Hitendra R.H. Patel,Manit Arya,Iqbal Shergill
Publisher : Springer Science & Business Media
Release : 2008-08-25
ISBN : 1846287405
Language : En, Es, Fr & De

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Book Description :

A complete guide to implementing research projects for anyone in the medical professions. This book covers all the main areas, allowing anyone to set up and complete research projects. The techniques outlined here can easily be adapted to clinical projects. Written by international authors to provide a flavor from many institutions, the book’s appeal is cross-sectional, both at hospital and primary care levels worldwide. Providing cutting-edge information in an accessible manner, and containing diagrams and easy-to-follow step-by-step guides, this is the first guide of its kind. It contains a complete section on setting up and funding research projects.

Clinical Research Methods for Surgeons

Clinical Research Methods for Surgeons Book
Author : David F. Penson
Publisher : Springer Science & Business Media
Release : 2007-11-06
ISBN : 1597452300
Language : En, Es, Fr & De

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Book Description :

With his keen analytical mind and penchant for organization, Charles Darwin would have made an excellent clinical investigator. Unfortunately for surgery, his early exposure at Edinburgh to the brutality of operations in 1825 convinced him to reject his father’s plan for his career and pursue his interest in nature. His subsequent observations of how environmental pressures shaped the development of new species provided the essential mechanism to explain evolution and the disappearance of those species that failed to adapt. Today, surgeons face the same reality as new technology, progressive regulation by government and payers, medico-legal risks, and public demands for proof of performance force changes in behavior that our predecessors never imagined. We know that surgeons have always prided themselves on accurate documentation of their results, including their complications and deaths, but observational studies involving a single surgeon or institution have given way to demands for controlled interventional trials despite the inherent difficulty of studying surgical patients by randomized, blinded techniques. That is why this book is so timely and important. In a logical and comprehensive approach, the authors have assembled a group of experienced clinical scientists who can demonstrate the rich variety of techniques in epidemiology and statistics for reviewing existing publications, structuring a clinical study, and analyzing the resulting data.

Social Science Methods in Health Research

Social Science Methods in Health Research Book
Author : Abraham Rudnick,Cheryl Forchuk
Publisher : SAGE Publications Pvt. Limited
Release : 2017-04-13
ISBN : 9789386062017
Language : En, Es, Fr & De

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Book Description :

The six-volume Social Science Methods in Health Research set comprehensively addresses research methods used in social science for the health sector. The six volumes are illustrative and indicative of the range of social science methods in health research. It is ordered in large part according to the scope of the research questions covering the micro-, meso-, and mega-levels of health research. The first three volumes, Foundations, Basic Science and Clinical Research focuses mainly on micro- and meso-level studies. Volume 1 centres on the foundations of social science research, including history, ethics, and more. Volume 2 addresses the use of social science methods in basic biomedical studies involving humans and other animals, while Volume 3, the last volume provides insight into the importance of using social science methods in clinical research. Volumes 4-6, cover Organizations, Systems and Public Health Research, and address research methods that can be used to study health related issues in broad contexts, mainly at the mega-level. Volume 4 addresses methodological issues particular to studying health care organizations and how those organizations can be studied using methods from the social sciences including case studies, leadership research, and more. Volume 5 explores how social science methods can be used to study health care systems (across and beyond health care organizations), including policy studies, systems research, and more. Volume 6, the final volume focuses on social science methods in public health research, including population research, social determinants studies, and more.

Research Methodology in the Medical and Biological Sciences

Research Methodology in the Medical and Biological Sciences Book
Author : Petter Laake,Haakon Breien Benestad,Bjorn Reino Olsen
Publisher : Academic Press
Release : 2007-11-05
ISBN : 9780080552897
Language : En, Es, Fr & De

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Book Description :

Providing easy-to-access information, this unique sourcebook covers the wide range of topics that a researcher must be familiar with in order to become a successful experimental scientist. Perfect for aspiring as well as practicing professionals in the medical and biological sciences it discusses a broad range of topics that are common, yet not traditionally considered part of formal curricula. The information presented also facilitates communication across conventional disciplinary boundaries, in line with the increasingly multidisciplinary nature of modern research projects. Perfect for students with various professional backgrounds providing a broad scientific perspective Easily accessible, concise material makes learning about diverse methods achievable in today's fast-paced world

A Handbook of Research Methods for Clinical and Health Psychology

A Handbook of Research Methods for Clinical and Health Psychology Book
Author : Jeremy Miles,Paul Gilbert
Publisher : Oxford University Press on Demand
Release : 2005
ISBN : 9780198527565
Language : En, Es, Fr & De

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Book Description :

Though psychology as a discipline has grown enormously in popularity in recent years, compulsory courses in research methods and statistics are seldom embarked upon with any great enthusiasm within the undergraduate and postgraduate communities. Many postgraduate and PhD students start their research ill-equipped to design effective experiments and to properly analyse their results. This lack of knowledge also limits their ability to critically assess and evaluate research done by others. This book is a practical guide to carrying out research in health psychology and clinical psychology. It bridges the gap between undergraduate and postgraduate study. As well as describing the various techniques and methods available to students, it provides them with a proper understanding of what a specific technique does - going beyond the introductory descriptions typical of most undergraduate methods books. The book describes both quantitative and qualititative approaches to data collection, providing valuable advice on methods ranging from psychometric testing to discourse analysis. For both undergraduate and postgraduate students, the book will be essential in making them aware of the full range of techniques available, helping them to design scientifically rigorous experiments, and effectively analyse their results.

Methods of Clinical Epidemiology

Methods of Clinical Epidemiology Book
Author : Suhail A. R. Doi,Gail M. Williams
Publisher : Springer Science & Business Media
Release : 2013-06-01
ISBN : 3642371310
Language : En, Es, Fr & De

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Book Description :

“Methods of Clinical Epidemiology” serves as a text on methods useful to clinical researchers. It provides a clear introduction to the common research methodology specific to clinical research for both students and researchers. This book sets out to fill the gap left by texts that concentrate on public health epidemiology and focuses on what is not covered well in such texts. The four sections cover methods that have not previously been brought together in one text and serves as a second level textbook of clinical epidemiology methodology. This book will be of use to postgraduate students in clinical epidemiology as well as clinical researchers at the start of their careers.

Clinical Epidemiology

Clinical Epidemiology Book
Author : D. E. Grobbee,Arno W. Hoes
Publisher : Jones & Bartlett Learning
Release : 2009
ISBN : 0763753157
Language : En, Es, Fr & De

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Book Description :

In the current era of evidence-based medicine, clinical epidemiology is increasingly being recognized as an important tool in the critical appraisal of available evidence and the design of new studies. This book is a comprehensive resource that introduces the reader to the basics of clinical epidemiology. It explores the principles and methods that can be used to obtain quantitative evidence on the effects on interventions and on the diagnosis, etiology, and prognosis of disease.

Principles of Research Methodology

Principles of Research Methodology Book
Author : Phyllis G. Supino,Jeffrey S. Borer
Publisher : Springer Science & Business Media
Release : 2012-06-22
ISBN : 1461433606
Language : En, Es, Fr & De

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Book Description :

Principles of Research Methodology: A Guide for Clinical Investigators is the definitive, comprehensive guide to understanding and performing clinical research. Designed for medical students, physicians, basic scientists involved in translational research, and other health professionals, this indispensable reference also addresses the unique challenges and demands of clinical research and offers clear guidance in becoming a more successful member of a medical research team and critical reader of the medical research literature. The book covers the entire research process, beginning with the conception of the research problem to publication of findings. Principles of Research Methodology: A Guide for Clinical Investigators comprehensively and concisely presents concepts in a manner that is relevant and engaging to read. The text combines theory and practical application to familiarize the reader with the logic of research design and hypothesis construction, the importance of research planning, the ethical basis of human subjects research, the basics of writing a clinical research protocol and scientific paper, the logic and techniques of data generation and management, and the fundamentals and implications of various sampling techniques and alternative statistical methodologies. Organized in thirteen easy to read chapters, the text emphasizes the importance of clearly-defined research questions and well-constructed hypothesis (reinforced throughout the various chapters) for informing methods and in guiding data interpretation. Written by prominent medical scientists and methodologists who have extensive personal experience in biomedical investigation and in teaching key aspects of research methodology to medical students, physicians and other health professionals, the authors expertly integrate theory with examples and employ language that is clear and useful for a general medical audience. A major contribution to the methodology literature, Principles of Research Methodology: A Guide for Clinical Investigators is an authoritative resource for all individuals who perform research, plan to perform it, or wish to understand it better.

Designing Clinical Research

Designing Clinical Research Book
Author : Stephen B. Hulley,Steven R. Cummings,Warren S. Browner,Deborah G. Grady,Thomas B. Newman
Publisher : Lippincott Williams & Wilkins
Release : 2011-11-30
ISBN : 1451165854
Language : En, Es, Fr & De

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Book Description :

Designing Clinical Research sets the standard for providing a practical guide to planning, tabulating, formulating, and implementing clinical research, with an easy-to-read, uncomplicated presentation. This edition incorporates current research methodology—including molecular and genetic clinical research—and offers an updated syllabus for conducting a clinical research workshop. Emphasis is on common sense as the main ingredient of good science. The book explains how to choose well-focused research questions and details the steps through all the elements of study design, data collection, quality assurance, and basic grant-writing. All chapters have been thoroughly revised, updated, and made more user-friendly.

Essential Concepts in Clinical Research

Essential Concepts in Clinical Research Book
Author : Kenneth Schulz,David A. Grimes
Publisher : Elsevier Health Sciences
Release : 2018-07-19
ISBN : 0702073938
Language : En, Es, Fr & De

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Book Description :

This practical guide speaks to two audiences: those who read and those who conduct research. Clinicians are medical detectives by training. For each patient, they assemble clinical clues to establish causes of signs and symptoms. The task involves both clinical acumen and knowledge of medical research. This book helps guide clinicians through this detective work, by enabling them to make sense of research and to review medical literature critically. It will also be invaluable to researchers who conduct clinical research, particularly randomized controlled trials. Building on previously published, peer-reviewed articles from The Lancet, this handbook is essential for busy clinicians and active researchers interested in research methods. Written by leaders in the field of clinical research who have published extensively with authorship of hundreds of articles in medical journals. The authorship includes one of the three authors of the CONSORT guidelines for the reporting of randomized controlled trials. The book presents the essential concepts to a wide array of topics including randomized control trials, descriptive studies, cohort studies, case-control studies, bias, and screening tests. The book utilises a readable and humorous prose style, lightening what can be a difficult area for clinical readers. Derived from decades of teaching clinical research in seminar settings the book will empower clinicians to make sense of, and critically appraise, current medical research and will enable researchers to enrich the quality of their work. The updated new edition includes six new chapters: Surrogate endpoints Limitations of observational epidemiology Participant recruitment Practicalities of double-blinding Randomized trials in the context of a prospective meta-analysis Reporting studies in medical journals: CONSORT

Health Research Methodology

Health Research Methodology Book
Author : Anonim
Publisher : World Health Organization
Release : 2001
ISBN : 929061157X
Language : En, Es, Fr & De

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Book Description :

To accommodate requests from readers to incorporate recent developments on research methodology and experiences of past training courses the manual has been revised and reissued. A practical training manual covering the basic concepts and principles of s

Research Methods for Clinical Therapists E Book

Research Methods for Clinical Therapists E Book Book
Author : Carolyn M. Hicks
Publisher : Elsevier Health Sciences
Release : 2009-08-07
ISBN : 0702041882
Language : En, Es, Fr & De

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Book Description :

Struggling to do a project or dissertation, evaluate published research or conduct your own research? Help is at hand with this 5th edition of Research Methods for Clinical Therapists, which explains, in a clear and simple manner, how to evaluate existing research and how to conduct your own research. Aimed at undergraduate and postgraduate students, as well as the practising health care professional, the focus of the text is the design and analysis of experimental studies. These are vital to the effectiveness studies that are central to the work of the healthcare professional. Specific examples from different areas of healthcare are used to explain the core research concepts and relate them to clinical situations. Statistical theory and jargon are kept to a minimum. 'Key concept' boxes to explain technical research terms Activities and exercises (with answers provided in an appendix) to reinforce learning Sample critique of a published research article Comprehensive coverage of the key components of a robust research study Explanation of basic mathematical concepts Extended section on calculating sample sizes Guidelines on the preparation of posters Calculation of Inter-rater reliability measures, including Cohen’s Kappa, ICC (interclass correlation) and Bland-Altman graphs of inter-rater agreement Introduction to Receiver Operating Characteristics, for use in screening and diagnostic testing against gold-standards The Thurstone Paired Comparison Technique, valuable in capturing the user voice on a variety of service planning, design and development issues Undertaking Systematic Reviews Relevant further reading for each chapter to support readers in their work.

Surgery

Surgery Book
Author : Jeffrey Norton,Philip S. Barie,Ralph R. Bollinger,Alfred E. Chang,Stephen Lowry,Sean J. Mulvihill,Harvey I. Pass,Robert W. Thompson
Publisher : Springer Science & Business Media
Release : 2000-08-17
ISBN : 9780387984476
Language : En, Es, Fr & De

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Book Description :

Surgery provides a clinically oriented, evidence-based, encyclopedic reference of general surgery for all surgical residents, general surgeons, and medical students. Divided into eight sections, key issues in the care of the surgical patient are concisely presented and synthesized. This is also the first book of its kind to provide complete coverage on all aspects of cancer in surgery. The book is augmented by nearly 1,000 illustrations clearly depicting surgical technique and a CD-ROM with hot-links of all references to MEDLINE.

Essentials of Clinical Research

Essentials of Clinical Research Book
Author : Stephen P. Glasser
Publisher : Springer
Release : 2014-06-02
ISBN : 3319054708
Language : En, Es, Fr & De

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Book Description :

In its extensively revised and updated Second Edition, this book provides a solid foundation for readers interested in clinical research. Discussion encompasses genetic, pharmacoepidemiologic and implementation research. All chapters have been updated with new information and many new tables have been added to elucidate key points. The book now offers discussion on how to handle missing data when analyzing results, and coverage of Adaptive Designs and Effectiveness Designs and new sections on Comparative Effectiveness Research and Pragmatic Trials. Chapter 6 includes new material on Phase 0 Trials, expanded coverage of Futility Trials, a discussion of Medical Device approval, Off Label Drug use and the role of the FDA in regulating advertising. Additional new information includes the role of pill color and shape in association with the placebo effect and an examination of issues surrounding minority recruitment. The final chapter offers a new section on manuscript preparation along with a discussion of various guidelines being adopted by journals: CONSORT, STROBE, PRISMA, MOOSE and others; and coverage of Conflicts of Interest, Authorship, Coercive Citation, and Disclosures in Industry-Related Associations. Building on the strengths of its predecessor in its comprehensive approach and authoritative advice, the new edition offers more of what has made this book a popular, trusted resource for students and working researchers alike.

Methods of Learning and Techniques of Teaching

Methods of Learning and Techniques of Teaching Book
Author : Association for the Study of Medical Education
Publisher : Unknown
Release : 1969
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Methods of Learning and Techniques of Teaching book written by Association for the Study of Medical Education, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Translational and Experimental Clinical Research

Translational and Experimental Clinical Research Book
Author : Daniel P. Schuster,William J. Powers (MD.)
Publisher : Lippincott Williams & Wilkins
Release : 2005
ISBN : 9780781755658
Language : En, Es, Fr & De

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Book Description :

This volume is a comprehensive textbook for investigators entering the rapidly growing field of translational and experimental clinical research. The book offers detailed guidelines for designing and conducting a study and analyzing and reporting results and discusses key ethical and regulatory issues. Chapters address specific types of studies such as clinical experiments in small numbers of patients, pharmacokinetics and pharmacodynamics, and gene therapy and pharmacogenomic studies. A major section describes modern techniques of translational clinical research, including gene expression, identifying mutations and polymorphisms, cloning, transcriptional profiling, proteomics, cell and tissue imaging, tissue banking, evaluating substrate metabolism, and in vivo imaging.

Critical Thinking in Clinical Research

Critical Thinking in Clinical Research Book
Author : Felipe Fregni,Ben M. W. Illigens
Publisher : Oxford University Press
Release : 2018
ISBN : 0199324492
Language : En, Es, Fr & De

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Book Description :

Critical Thinking in Clinical Research explains the fundamentals of clinical research in a case-based approach. The core concept is to combine a clear and concise transfer of information and knowledge with an engagement of the reader to develop a mastery of learning and critical thinking skills. The book addresses the main concepts of clinical research, basics of biostatistics, advanced topics in applied biostatistics, and practical aspects of clinical research, with emphasis on clinical relevance across all medical specialties.

Clinical Research in Communication Disorders

Clinical Research in Communication Disorders Book
Author : M. N. Hegde,Anthony P. Salvatore
Publisher : Plural Publishing
Release : 2019-03-06
ISBN : 1635502004
Language : En, Es, Fr & De

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Book Description :

This thoroughly updated fourth edition of Clinical Research in Communication Disorders: Principles and Strategies remains an instrumental resource for courses on research methods and design in communication disorders. The book is separated into three key sections: science and the scientific methods, clinical research designs, and doing, reporting, and evaluating research. Together, these sections provide thorough coverage of both the single-subject and group design strategies along with issues of measurement; philosophy of science; ethics of research; and planning, conducting, and reporting research. Instructors and students in communication sciences and disorders will appreciate the text's comprehensive coverage of scientific methods, group and single-subject research designs, report writing, and ethics of research in a single source. New to the Fourth EditionNew coauthor, Anthony P. Salvatore, PhDA new chapter on statistical analysis of research data, including several statistical techniques for single-subject research data, meta-analysis of both group and single-subject studiesUpdated criteria for visual analysis of single-subject research dataNew sections on translational research, qualitative research, and mixed methods researchDescriptions of additional research designs not included in the previous edition (e.g., the regression discontinuity design)Updated information on research ethics and review of fraudulent biomedical researchWeb-based sources that monitor research fraud and recalled studiesUpdated and expanded references throughoutKey FeaturesChapter outlines open each chapter and provide a summary of the key topicsChapter summaries recap key points in an easy-to-read bulleted formatEnd-of-chapter study guides allow readers to test their knowledgeBolded key terms throughoutDisclaimer: Please note that ancillary content (such as documents, audio, and video, etc.) may not be included as published in the original print version of this book.

Fundamentals of Clinical Trials

Fundamentals of Clinical Trials Book
Author : Lawrence M. Friedman,Curt Furberg,David L. DeMets
Publisher : Springer Science & Business Media
Release : 1998
ISBN : 9780387985862
Language : En, Es, Fr & De

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Book Description :

This classic reference, now updated with the newest applications and results, addresses the fundamentals of such trials based on sound scientific methodology, statistical principles, and years of accumulated experience by the three authors.