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Basic Science Methods For Clinical Researchers

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Basic Science Methods for Clinical Researchers

Basic Science Methods for Clinical Researchers Book
Author : Morteza Jalali,Francesca Saldanha,Mehdi Jalali
Publisher : Academic Press
Release : 2017-04
ISBN : 9780128030776
Language : En, Es, Fr & De

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Book Description :

Basic Science Methods for Clinical Researchers addresses the specific challenges faced by clinicians without a conventional science background. The aim of the book is to introduce the reader to core experimental methods commonly used to answer questions in basic science research and to outline their relative strengths and limitations in generating conclusive data. This book will be a vital companion for clinicians undertaking laboratory-based science. It will support clinicians in the pursuit of their academic interests and in making an original contribution to their chosen field. In doing so, it will facilitate the development of tomorrow's clinician scientists and future leaders in discovery science. Serves as a helpful guide for clinical researchers who lack a conventional science background Organized around research themes pertaining to key biological molecules, from genes, to proteins, cells, and model organisms Features protocols, techniques for troubleshooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data Appendices provide resources for practical research methodology, including legal frameworks for using stem cells and animals in the laboratory, ethical considerations, and good laboratory practice (GLP)

Basic Science Methods for Clinical Researchers

Basic Science Methods for Clinical Researchers Book
Author : Morteza Jalali,Francesca Yvonne Louise Saldanha,Mehdi Jalali
Publisher : Academic Press
Release : 2017-03-31
ISBN : 012803078X
Language : En, Es, Fr & De

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Book Description :

Basic Science Methods for Clinical Researchers addresses the specific challenges faced by clinicians without a conventional science background. The aim of the book is to introduce the reader to core experimental methods commonly used to answer questions in basic science research and to outline their relative strengths and limitations in generating conclusive data. This book will be a vital companion for clinicians undertaking laboratory-based science. It will support clinicians in the pursuit of their academic interests and in making an original contribution to their chosen field. In doing so, it will facilitate the development of tomorrow’s clinician scientists and future leaders in discovery science. Serves as a helpful guide for clinical researchers who lack a conventional science background Organized around research themes pertaining to key biological molecules, from genes, to proteins, cells, and model organisms Features protocols, techniques for troubleshooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data Appendices provide resources for practical research methodology, including legal frameworks for using stem cells and animals in the laboratory, ethical considerations, and good laboratory practice (GLP)

Principles and Practice of Clinical Research

Principles and Practice of Clinical Research Book
Author : John I. Gallin,Frederick P Ognibene,Laura Lee Johnson
Publisher : Academic Press
Release : 2017-11-17
ISBN : 0128499044
Language : En, Es, Fr & De

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Book Description :

Principles and Practice of Clinical Research, Fourth Edition has been thoroughly revised to provide a comprehensive look at both the fundamental principles and expanding practice of clinical research. New to this edition of this highly regarded reference, authors have focused on examples that broadly reflect clinical research on a global scale while including a discussion of international regulations, studies, and implications. In addition to key topics such as bioethics, clinical outcome data, cultural diversity, protocol guidelines, and “omic platforms, this edition contains new chapters devoted to electronic health records and information resources for clinical researchers, as well as the many opportunities associated with big data. Covering a vast number of topics and practical advice for both novice and advanced clinical investigators, this book is a highly relevant and essential resource for all those involved in conducting research. Features input from experts in the field dedicated to translating scientific research from bench to bedside and back Provides expanded coverage of global clinical research Contains hands-on, practical suggestions, illustrations, and examples throughout Includes new chapters on the international regulation of drugs and biologics, the emergence of the important role of comparative effectiveness research and how to identify clinical risks and manage patient safety in a clinical research setting

Research Methods in Clinical Psychology

Research Methods in Clinical Psychology Book
Author : Chris Barker,Nancy Pistrang,Robert Elliott
Publisher : John Wiley & Sons
Release : 2015-09-25
ISBN : 1118773179
Language : En, Es, Fr & De

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Book Description :

Fully updated to reflect the latest developments, the third editionof Research Methods In Clinical Psychology offers acomprehensive introduction to the various methods, approaches, andstrategies for conducting research in the clinical psychologyfield. Represents the most accessible, user-friendly introduction toconducting and evaluating research for clinical psychologists andrelated professionals Ideal for students and practitioners who wish to conduct theirown research or gain a better understanding of publishedresearch Addresses important issues such as philosophical underpinningsof various methodologies, along with socio-political issues thatarise in clinical and community settings Step-by-step guidance through all phases of a clinicalpsychology research project—from initial concept andgroundwork, through to measurement, design, analysis, andinterpretation Updates to this edition include new or expanded coverage ofsuch topics as systematic review and literature searchingmethods, modern psychometric methods, guidance on choosing betweendifferent qualitative approaches, and conducting psychologicalresearch via the Internet

Clinical Research Methods for Surgeons

Clinical Research Methods for Surgeons Book
Author : David F. Penson
Publisher : Springer Science & Business Media
Release : 2007-11-06
ISBN : 1597452300
Language : En, Es, Fr & De

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Book Description :

With his keen analytical mind and penchant for organization, Charles Darwin would have made an excellent clinical investigator. Unfortunately for surgery, his early exposure at Edinburgh to the brutality of operations in 1825 convinced him to reject his father’s plan for his career and pursue his interest in nature. His subsequent observations of how environmental pressures shaped the development of new species provided the essential mechanism to explain evolution and the disappearance of those species that failed to adapt. Today, surgeons face the same reality as new technology, progressive regulation by government and payers, medico-legal risks, and public demands for proof of performance force changes in behavior that our predecessors never imagined. We know that surgeons have always prided themselves on accurate documentation of their results, including their complications and deaths, but observational studies involving a single surgeon or institution have given way to demands for controlled interventional trials despite the inherent difficulty of studying surgical patients by randomized, blinded techniques. That is why this book is so timely and important. In a logical and comprehensive approach, the authors have assembled a group of experienced clinical scientists who can demonstrate the rich variety of techniques in epidemiology and statistics for reviewing existing publications, structuring a clinical study, and analyzing the resulting data.

Designing Clinical Research

Designing Clinical Research Book
Author : Stephen B. Hulley,Steven R. Cummings,Warren S. Browner,Deborah G. Grady,Thomas B. Newman
Publisher : Lippincott Williams & Wilkins
Release : 2011-11-30
ISBN : 1451165854
Language : En, Es, Fr & De

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Book Description :

Designing Clinical Research sets the standard for providing a practical guide to planning, tabulating, formulating, and implementing clinical research, with an easy-to-read, uncomplicated presentation. This edition incorporates current research methodology—including molecular and genetic clinical research—and offers an updated syllabus for conducting a clinical research workshop. Emphasis is on common sense as the main ingredient of good science. The book explains how to choose well-focused research questions and details the steps through all the elements of study design, data collection, quality assurance, and basic grant-writing. All chapters have been thoroughly revised, updated, and made more user-friendly.

Basic Science Techniques in Clinical Practice

Basic Science Techniques in Clinical Practice Book
Author : Hitendra R.H. Patel,Manit Arya,Iqbal Shergill
Publisher : Springer Science & Business Media
Release : 2008-08-25
ISBN : 1846287405
Language : En, Es, Fr & De

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Book Description :

A complete guide to implementing research projects for anyone in the medical professions. This book covers all the main areas, allowing anyone to set up and complete research projects. The techniques outlined here can easily be adapted to clinical projects. Written by international authors to provide a flavor from many institutions, the book’s appeal is cross-sectional, both at hospital and primary care levels worldwide. Providing cutting-edge information in an accessible manner, and containing diagrams and easy-to-follow step-by-step guides, this is the first guide of its kind. It contains a complete section on setting up and funding research projects.

Clinical Research Methods in Speech Language Pathology and Audiology Third Edition

Clinical Research Methods in Speech Language Pathology and Audiology  Third Edition Book
Author : David L. Irwin,Norman J. Lass,Mary Pannbacker,Mary Ellen Tekieli Koay ,Jennifer S. Whited
Publisher : Plural Publishing
Release : 2019-01-17
ISBN : 1635501024
Language : En, Es, Fr & De

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Book Description :

Now in its third edition, Clinical Research Methods in Speech-Language Pathology and Audiology is a valuable and comprehensive resource for understanding and conducting clinical research in communication sciences and disorders. Graduate students and practicing clinicians will benefit from the text's detailed coverage of various research topics. Specifically, readers will learn the strengths and weaknesses of different research methodologies, apply the results of research to clinical practice and decision-making, and understand the importance of research ethics. Clinical Research Methods is the only text to take into account qualitative research and evidence-based practice, and to provide a detailed discussion of research ethics. Key Features Chapters begin with an outline of covered topics and learning objectivesEnd-of-chapter discussion questions apply concepts and incorporate real-life research situationsNumerous tables and charts display critical models and research procedures New to the Third Edition New co-authors, Mary Ellen Koay, PhD, CCC-SLP, FASHA, and Jennifer S. Whited, PhD, CCC-SLP, bring new and extensive research experiences to the team of authorsExpanded discussion of qualitative research methodsAdditional and updated examples of mixed method designs published in speech-language pathologyUpdated list of databases and sources for research in communication sciences and disordersUpdated references throughout, including many ASHA and AAA Codes of EthicsDisclaimer: Please note that ancillary content (such as documents, audio, and video, etc.) may not be included as published in the original print version of this book.

Clinical Research in Complementary Therapies E Book

Clinical Research in Complementary Therapies E Book Book
Author : George Thomas Lewith,Wayne B. Jonas,Harald Walach
Publisher : Elsevier Health Sciences
Release : 2010-11-23
ISBN : 0702049166
Language : En, Es, Fr & De

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Book Description :

The use of complementary therapies is exploding, increasing the pressure to establish a rigorous science to support its practice. Clinical Research in Complementary Therapies: Principles, Problems and Solutions provides students with the tools they need to research complementary and integrative medicine (CIM) and so fill this gap. Essential for both undergraduate and postgraduate students, this second edition is significantly updated and enhanced. Part 1 deals with research strategies and methods, explaining the major types of clinical research in CIM and how these inter-relate. New chapters are included on whole systems research, qualitative research and questionnaire development. Not all therapies can be treated the same way nor channeled through the signal process of randomized controlled trials. Therefore, detailed description of mixed methods approaches including observational, qualitative, cost-benefit and comparative effectiveness research are described. Part 2 deals with specific complementary therapies and how they are invested by experts in each field. The book analyses the key questions asked and the controversies debated in complementary medicine research and offers clear and innovative guidance for answering these questions. FEATURES • Provides an overarching synthesis of methods in CIM and how they are to be used collectively including the role of comparative effectiveness research • Suggests both general and specific factors which need to be considered in assessing or planning complementary therapy research • Pinpoints aspects of research which are different in orthodox research and complementary therapy research • Reviews the types of research carried out in specific complementary therapies and analyses issues which arise • Includes information on measuring the economic cost and benefits of complementary medicine, clinical audit and the role of placebos use • Builds upon recent research results, looks at the lessons these provide for all complementary therapies and suggests key issues to address in future research. • Provides an overarching synthesis of methods in CIM and how they are to be used collectively including the role of comparative effectiveness research • Suggests both general and specific factors which need to be considered in assessing or planning complementary therapy research • Pinpoints aspects of research which are different in orthodox research and complementary therapy research • Reviews the types of research carried out in specific complementary therapies and analyses issues which arise • Includes information on measuring the economic cost and benefits of complementary medicine, clinical audit and the role of placebos use • Builds upon recent research results, looks at the lessons these provide for all complementary therapies and suggests key issues to address in future research.

Basic Methods Handbook for Clinical Orthopaedic Research

Basic Methods Handbook for Clinical Orthopaedic Research Book
Author : Volker Musahl,Jón Karlsson,Michael T. Hirschmann,Olufemi R. Ayeni,Robert G. Marx,Jason L. Koh,Norimasa Nakamura
Publisher : Springer
Release : 2019-02-01
ISBN : 3662582546
Language : En, Es, Fr & De

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Book Description :

This book is designed to meet the needs of both novice and senior researchers in Orthopaedics by providing the essential, clinically relevant knowledge on research methodology that is sometimes overlooked during training. Readers will find a wealth of easy-to-understand information on all relevant aspects, from protocol design, the fundamentals of statistics, and the use of computer-based tools through to the performance of clinical studies with different levels of evidence, multicenter studies, systematic reviews, meta-analyses, and economic health care studies. A key feature is a series of typical case examples that will facilitate use of the volume as a handbook for most common research approaches and study types. Younger researchers will also appreciate the guidance on preparation of abstracts, poster and paper presentations, grant applications, and publications. The authors are internationally renowned orthopaedic surgeons with extensive research experience and the book is published in collaboration with ISAKOS.

Clinical Research in Communication Disorders

Clinical Research in Communication Disorders Book
Author : M. N. Hegde,Anthony P. Salvatore
Publisher : Plural Publishing
Release : 2019-03-06
ISBN : 1635502004
Language : En, Es, Fr & De

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Book Description :

This thoroughly updated fourth edition of Clinical Research in Communication Disorders: Principles and Strategies remains an instrumental resource for courses on research methods and design in communication disorders. The book is separated into three key sections: science and the scientific methods, clinical research designs, and doing, reporting, and evaluating research. Together, these sections provide thorough coverage of both the single-subject and group design strategies along with issues of measurement; philosophy of science; ethics of research; and planning, conducting, and reporting research. Instructors and students in communication sciences and disorders will appreciate the text's comprehensive coverage of scientific methods, group and single-subject research designs, report writing, and ethics of research in a single source. New to the Fourth EditionNew coauthor, Anthony P. Salvatore, PhDA new chapter on statistical analysis of research data, including several statistical techniques for single-subject research data, meta-analysis of both group and single-subject studiesUpdated criteria for visual analysis of single-subject research dataNew sections on translational research, qualitative research, and mixed methods researchDescriptions of additional research designs not included in the previous edition (e.g., the regression discontinuity design)Updated information on research ethics and review of fraudulent biomedical researchWeb-based sources that monitor research fraud and recalled studiesUpdated and expanded references throughoutKey FeaturesChapter outlines open each chapter and provide a summary of the key topicsChapter summaries recap key points in an easy-to-read bulleted formatEnd-of-chapter study guides allow readers to test their knowledgeBolded key terms throughoutDisclaimer: Please note that ancillary content (such as documents, audio, and video, etc.) may not be included as published in the original print version of this book.

The Sourcebook for Clinical Research

The Sourcebook for Clinical Research Book
Author : Natasha Martien,Jeff Nelligan
Publisher : Academic Press
Release : 2018-08-01
ISBN : 0128162430
Language : En, Es, Fr & De

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Book Description :

A single trial is complex, with numerous regulations, administrative processes, medical procedures, deadlines and specific protocol instructions to follow. And yet, there has existed no single-volume, comprehensive clinical research reference manual for investigators, medical institutions, and national and international research personnel to keep on the shelf as a ready reference to navigate through trial complexities and ensure compliance with U.S. Federal Regulations and ICH GCP until The Sourcebook for Clinical Research. An actionable, step-by-step guide through beginning to advanced topics in clinical research with forms, templates and checklists to download from a companion website (https://www.elsevier.com/books-and-journals/book-companion/9780128162422), so that study teams will be compliant and will find all the necessary tools within this book. Moreover, The Sourcebook for Clinical Research contains clear information and guidance on the newest changes in the industry to keep seasoned investigators and staff current and compliant, in addition to providing detailed information regarding the most complex topics. This book serves as a quick, actionable, off-the-shelf resource to keep by your side at the medical clinic. Makes vital trial conduct information easy to understand and instructs on how to practically apply current Federal regulations and Good Clinical Practice (ICH GCP) Offers extensive guidance that is crucial for guaranteeing compliance to clinical research regulations during each step of the clinical research process Provides up-to-date and extensive coverage of beginning to advanced topics, and, step-by-step actions to take during exceptional circumstances, including compassionate use, emergency use, human subjects protections for vulnerable populations, and federal audits Furnishes a detailed clinical research Glossary, and a comprehensive Appendix containing ready-to-use forms, templates, and checklists for clinical trial personnel to download and begin using immediately. Written for the fast-paced clinic environment with action steps and forms in the book to respond to a research subject’s needs urgently and compliantly

Skin Cancer Basic Science Clinical Research and Treatment

Skin Cancer  Basic Science  Clinical Research and Treatment Book
Author : Claus Garbe,Stefan Schmitz,Constantin E. Orfanos
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642787711
Language : En, Es, Fr & De

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Book Description :

In the past two decades, considerable interest in skin cancer has developed in the public and scientific communities. There may have been several reasons for this: - The rise in the global incidence of cutaneous cancers - New molecular biology techniques resulting in a better understanding of pathogenesis and improved diagnostic procedures - The advent of new pathological entities, e. g. , the endemic form of Kaposi's sarcoma - A constantly increasing range of therapeutic modalities, providing even more efficacious treatment and manage ment of skin cancers As N. E. Fusenig describes in the first chapter of this volume, basic research is only beginning to unravel the complex mechanism involved in cellular dedifferentiation and tumor progression. Progress is dearly needed, especially in dermato oncology, where the rise in the incidence of epithelial tumors has inflated the overall skin cancer incidence. The incidence of tumors of the skin exceeds that of all other neoplasias in humans, with recreational sun exposure being a suspected primary cause. Several studies on the effects of UV radiation have been included at the beginning of this volume. Even the role of long wavelength UV (UVA) has become a focus of research activities. The main concern is that the low carcinogenicity of UVA, in comparison to UVB, may be outweighed and exceeded in its effects by increased UV A exposure, e. g.

Principles and Practice of Clinical Research

Principles and Practice of Clinical Research Book
Author : John I. Gallin,Frederick P Ognibene
Publisher : Elsevier
Release : 2011-04-28
ISBN : 9780080489568
Language : En, Es, Fr & De

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Book Description :

The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers. *Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical Research *Addresses the vast opportunities for translation of basic science observations to the bedside through clinical research *Delves into data management and addresses how to collect data and use it for discovery *Contains valuable, up-to-date information on how to obtain funding from the federal government

Clinical Research

Clinical Research Book
Author : Manfred Stommel,Celia Wills
Publisher : Lippincott Williams & Wilkins
Release : 2004
ISBN : 9780781735186
Language : En, Es, Fr & De

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Book Description :

This unique textbook integrates statistical concepts into evidence-based clinical practice and patient management. Research concepts and techniques are drawn from epidemiology, bio-statistics, and psychometrics, as well as educational and social science research. Clinical examples throughout the text illustrate practical and scientifically sound applications of the concepts. Data tables and research vignettes highlight statistical distributions involving probability. Methods to locate and utilize web-based information relevant to clinical research are discussed, and web URLs are provided. Further learning is encouraged by the inclusion of suggested activities, recommended readings, references, and a comprehensive glossary of research terms. Additional resources are available at a Connection Website, connection.LWW.com/go/stommel.

Handbook of Clinical Psychology Competencies

Handbook of Clinical Psychology Competencies Book
Author : Jay C Thomas
Publisher : Springer Science & Business Media
Release : 2009-11-25
ISBN : 0387097562
Language : En, Es, Fr & De

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Book Description :

This three-volume handbook describes the core competency areas in providing psychological services relevant to practitioners as well as clinical researchers. It covers assessment and conceptualization of cases, the application of evidence-based methods, supervision, consultation, cross-cultural factors, and ethics.

Critical Thinking in Clinical Research

Critical Thinking in Clinical Research Book
Author : Felipe Fregni,Ben M. W. Illigens
Publisher : Oxford University Press
Release : 2018
ISBN : 0199324492
Language : En, Es, Fr & De

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Book Description :

Critical Thinking in Clinical Research explains the fundamentals of clinical research in a case-based approach. The core concept is to combine a clear and concise transfer of information and knowledge with an engagement of the reader to develop a mastery of learning and critical thinking skills. The book addresses the main concepts of clinical research, basics of biostatistics, advanced topics in applied biostatistics, and practical aspects of clinical research, with emphasis on clinical relevance across all medical specialties.

Research Training in the Biomedical Behavioral and Clinical Research Sciences

Research Training in the Biomedical  Behavioral  and Clinical Research Sciences Book
Author : National Research Council,Policy and Global Affairs,Board on Higher Education and Workforce,Committee to Study the National Needs for Biomedical, Behavioral, and Clinical Research Personnel
Publisher : National Academies Press
Release : 2011-02-28
ISBN : 0309209935
Language : En, Es, Fr & De

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Book Description :

Comprehensive research and a highly-trained workforce are essential for the improvement of health and health care both nationally and internationally. During the past 40 years the National Research Services Award (NRSA) Program has played a large role in training the workforce responsible for dramatic advances in the understanding of various diseases and new insights that have led to more effective and targeted therapies. In spite of this program, the difficulty obtaining jobs after the postdoc period has discouraged many domestic students from pursuing graduate postdoc training. In the United States, more than 50 percent of the postdoc workforce is made up of individuals who obtained their Ph.D.s from other countries. Indeed, one can make a strong argument that the influx of highly trained and creative foreigners has contributed greatly to U.S. science over the past 70 years. Research Training in the Biomedical, Behavioral, and Clinical Research Sciences discusses a number of important issues, including: the job prospects for postdocs completing their training; questions about the continued supply of international postdocs in an increasingly competitive world; the need for equal, excellent training for all graduate students who receive NIH funding; and the need to increase the diversity of trainees. The book recommends improvements in minority recruiting, more rigorous and extensive training in the responsible conduct of research and ethics, increased emphasis on career development, more attention to outcomes, and the requirement for incorporating more quantitative thinking in the biomedical curriculum.

Advancing the Nation s Health Needs

Advancing the Nation s Health Needs Book
Author : National Research Council,Policy and Global Affairs,Board on Higher Education and Workforce,Committee for Monitoring the Nation's Changing Needs for Biomedical, Behavioral, and Clinical Personnel
Publisher : National Academies Press
Release : 2005-08-13
ISBN : 0309094275
Language : En, Es, Fr & De

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Book Description :

This report is the twelfth assessment of the National Institutes of Health National Research Service Awards program. The research training needs of the country in basic biomedical, clinical, and behavioral and social sciences are considered. Also included are the training needs of oral health, nursing, and health services research. The report has been broadly constructed to take into account the rapidly evolving national and international health care needs. The past and present are analyzed, and predictions with regard to future needs are presented.

The Practical Guide to Clinical Research and Publication

The Practical Guide to Clinical Research and Publication Book
Author : Uzung Yoon
Publisher : Academic Press
Release : 2021-08-03
ISBN : 0128245182
Language : En, Es, Fr & De

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Book Description :

The Practical Guide to Clinical Research and Publication provides a comprehensive overview of the key foundations of epidemiology, statistics and epidemiological studies. This book presents the most important terms and knowledge in the field from a medical point-of-view. Sections contain numerous, clinically-oriented examples and drawings to facilitate understanding and clarify the relation to clinic and practice. The book contains many graphics and key points for easier understanding and is written using bullet points for ease of use and comprehension. It is ideal for physicians and clinical researchers who want to use it as guidance for clinical research or teaching. Contains numerous, clinically-oriented examples and drawings Provides an explanation of epidemiology and statistics to aid understanding of clinical research Written by a physician with extensive knowledge in research