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Bacterial Infections Of The Central Nervous System

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Bacterial Infections of the Central Nervous System

Bacterial Infections of the Central Nervous System Book
Author : Karen L. Roos,Allan R. Tunkel
Publisher : Elsevier
Release : 2010-01-23
ISBN : 0444534830
Language : En, Es, Fr & De

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Book Description :

Bacterial Infections of the Central Nervous System aims to provide information useful to physicians taking care of patients with bacterial infections in the central nervous system (CNS), which can lead to morbidity and mortality. The increased number of patients suffering from this infection has led to the development of vaccines and antibiotics. Comprised of four chapters, the book explains the general approach to patients with bacterial CNS infection. It also discusses various CNS infection concepts and terms. These include the characteristic neuroimaging appearance of specific bacterial infections, the limitations of neuroimaging, the cerebrospinal fluid analysis, the pathogenesis and pathophysiology of bacterial CNS infections, the developments of specific adjunctive strategies, and the principles of antimicrobial therapy. It also includes discussions on various diseases that target the CNS, such as meningitis, focal CNS infections, neurological complications of endocarditis, suppurative venous sinus thrombosis, infections in the neurosurgical patient, and CNS diseases caused by selected infectious agents and toxins. This book will serve as a guide for clinical physicians who have patients suffering from bacterial CNS infection. * Valuable insights into the pathophysiological mechanism of bacterial CNS infections * A multidisciplinary reach that provides critical information for neurologists, neurosurgeons, and specialists in infectious disease * Considerable information and emphasis on new diagnostic techniques and laboratory testing

Infectious Diseases of the Central Nervous System

Infectious Diseases of the Central Nervous System Book
Author : R.A. Thompson,John R. Green
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401163324
Language : En, Es, Fr & De

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Book Description :

The contents of this volume are based upon the proceedings of a Sympo sium entitled "Infectious Diseases of the Central Nervous System" held in Phoenix, Arizona, and sponsored by the Barrow Neurological Institute and Foundation during its Ninth Annual Symposium. The purpose of the Symposium was to bring together knowledgeable experts in this field to review information that is available and to enhance our knowledge of new developments in the field of infectious diseases in the central nervous system. Because the subject could not be covered in its entirety by this volume, we have placed particular emphasis on recent developments and new information. The volume includes a remarkably fresh and interesting discussion of viral diseases as they affect the nervous system, including conventional and unconventional virus agents, and in addition, discussions of path ophysiology and epidemiology and postinfectious diseases of the nervous system. A similar approach is taken to the treatment of bacterial infection. Discussions of pathophysiology are intertwined with discussions of diag nostic techniques, prevention techniques and treatment of bacterial in fections. Additional surgical problems are discussed regarding prevention and management of peri operative infection and brain abscess. Special consid eration was given to coccidioidomycosis which is prevalent in the western states; also, there is a discussion of parasitic infections. This volume will be of interest to neurologists and neurosurgeons and any physician dealing with infectious disease. RICHARD A. THOMPSON, M.D. JOHN R. GREEN, M.D.

Bacterial Infections of the Central Nervous System

Bacterial Infections of the Central Nervous System Book
Author : Karen L. Roos,Allan R. Tunkel
Publisher : Unknown
Release : 2016-06
ISBN : 9780444638229
Language : En, Es, Fr & De

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Book Description :

Download Bacterial Infections of the Central Nervous System book written by Karen L. Roos,Allan R. Tunkel, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Common Bacterial Infection in Infancy and Childhood

Common Bacterial Infection in Infancy and Childhood Book
Author : P. S. Low
Publisher : Unknown
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Common Bacterial Infection in Infancy and Childhood book written by P. S. Low, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Infections of the Central Nervous System

Infections of the Central Nervous System Book
Author : W. Michael Scheld,Richard J. Whitley,Christina M. Marra
Publisher : Lippincott Williams & Wilkins
Release : 2004
ISBN : 9780781743273
Language : En, Es, Fr & De

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Book Description :

The "gold standard" clinical reference on central nervous system infections is now in its thoroughly revised, updated Third Edition. More than 70 leading experts provide comprehensive, current information on all infections—both neural-specific and systemic—that involve the central nervous system. This edition includes new information on botulinum toxin as a biological weapon and a therapeutic agent, neurologic effects of viruses causing hemorrhagic fevers, and infections that have recently become more prevalent or been found in new geographic locations. The updated coverage of therapeutics includes AIDS/HIV medications and other antiviral drugs, new antifungal medications, and vaccinations against Lyme disease and bacterial meningitis.

Central Nervous System Bacterial Infections New Insights for the Healthcare Professional 2012 Edition

Central Nervous System Bacterial Infections  New Insights for the Healthcare Professional  2012 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-12-10
ISBN : 1464989095
Language : En, Es, Fr & De

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Book Description :

Central Nervous System Bacterial Infections: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Central Nervous System Bacterial Infections in a compact format. The editors have built Central Nervous System Bacterial Infections: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Central Nervous System Bacterial Infections in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Central Nervous System Bacterial Infections: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Central Nervous System Bacterial Infections Advances in Research and Treatment 2011 Edition

Central Nervous System Bacterial Infections  Advances in Research and Treatment  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-02-14
ISBN : 1464968950
Language : En, Es, Fr & De

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Book Description :

Central Nervous System Bacterial Infections: Advances in Research and Treatment: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Central Nervous System Bacterial Infections in a concise format. The editors have built Central Nervous System Bacterial Infections: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Central Nervous System Bacterial Infections in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Central Nervous System Bacterial Infections: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Central Nervous System Bacterial Infections Advances in Research and Treatment 2012 Edition

Central Nervous System Bacterial Infections   Advances in Research and Treatment  2012 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-12-26
ISBN : 1481616234
Language : En, Es, Fr & De

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Book Description :

Central Nervous System Bacterial Infections—Advances in Research and Treatment: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Central Nervous System Bacterial Infect in a concise format. The editors have built Central Nervous System Bacterial Infections—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Central Nervous System Bacterial Infect in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Central Nervous System Bacterial Infections—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Clinical Approach and Management of Bacterial Infections of the Central Nervous System Related to Hydrocephalus

Clinical Approach and Management of Bacterial Infections of the Central Nervous System Related to Hydrocephalus Book
Author : Iván Pelegrín Senent
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

INTRODUCTION: Community-acquired bacterial meningitis is a relevant entity related to a high morbidity and mortality, despite of the adjuvant and antibiotic treatments available. Morbidity and mortality are caused by neurological complications, being hydrocephalus one of the less investigated one and related to Listeria monocytogenes meningoencephalitis episodes, which increase have been reported in the last decade. Moreover, the devices used for treatment of hydrocephalus have a high risk of infection. These infections have a high personal and economic costs, and their prevention and treatment management can be optimised. HYPOTHESIS: Studying certain aspects of community-acquired bacterial and device-related infections of the central nervous system might improve management and outcome of these patients. OBJECTIVES: 1. To describe the impact on outcome with hydrocephalus complicating community acquired bacterial meningitis patients. 2. To evaluate prognostic factors related to sequelae and mortality in L. monocytogenes meningoencephalitis. 3. To assess efficacy of different treatment strategies on a cohort of patients with ventriculoperitoneal shunt infections. 4. To evaluate, in vitro, a new antibiotic-impregnated external ventricular drainage catheter to prevent Acinetobacter baumannii infections. METHODS: Observational clinical study of a cohort of community-acquired bacterial meningitis and ventriculoperitoneal shunt infection patients during more than 35 years in a university reference hospital. Experimental study of efficacy of an antibiotic-impregnated external ventricular catheter tested by a dynamic in vitro model. RESULTS: Among 790 community-acquired bacterial meningitis patients, 22 (3%) presented complicating hydrocephalus. 7/22 (32%) episodes were caused by L. monocytogenes and Streptococcus pneumoniae. Mortality of patients with complicating hydrocephalus was 50%. Age, time to illness and L. monocytogenes aetiology were risk factors related to development of hydrocephalus. L. monocytogenes episodes increased in the last decade (from 0.73 episodes/1000 admissions to 1.02/1000 admissions per year). Mortality was 24% and neurological sequelae 18%. Seizures were present in 14% and hydrocephalus in 16% of patients. The addition of gentamicin to ampicillin, use of adjuvant dexamethasone and antiepileptic prophylaxis with phenytoin did not influence outcome. Risk factors related to a worse outcome were the presence of hydrocephalus and the inappropriate empirical antibiotic treatment. Among 86 episodes of ventriculoperitoneal shunt infections: 6 received only antibiotic therapy; 24 were managed with a shunt removal without replacement; 37 were managed with a shunt replacement in 2 steps; and 19 with a shunt replacement in one step. The most effective strategy was shunt replacement in 2 steps (89% cure). 6/9 (67%) external ventricular drainage catheters impregnated with trimethoprim, rifampin and triclosan were free of colonisation at least for 3 weeks after several inoculations with 104 A. baumannii in an in vitro model. CONCLUSIONS: The development of hydrocephalus complicating an episode of community acquired bacterial meningitis causes a worse rate of mortality and sequelae. The outcome of L. monocytogenes patients could be improved if the empirical antibiotic treatment is accurate and if a precise suspicion and management of potential hydrocephalus occurs. Shunt removal, particularly in 2 steps when the patient is not shunt-dependant, is the best strategy in the treatment of a ventriculoperitoneal shunt infection, without increasing morbidity. A new external ventricular drainage catheter impregnated with triclosan, rifampin and trimethoprim might prevent multirresistant A. baumannii ventriculitis -- TDX.

Central Nervous System Bacterial Infections New Insights for the Healthcare Professional 2011 Edition

Central Nervous System Bacterial Infections  New Insights for the Healthcare Professional  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464914834
Language : En, Es, Fr & De

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Book Description :

Central Nervous System Bacterial Infections: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Central Nervous System Bacterial Infections in a compact format. The editors have built Central Nervous System Bacterial Infections: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Central Nervous System Bacterial Infections in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Central Nervous System Bacterial Infections: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Bacterial Infections of the Central Nervous System

Bacterial Infections of the Central Nervous System Book
Author : Karen L. Roos,Allan R. Tunkel
Publisher : Elsevier
Release : 2010-03-17
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Bacterial Infections of the Central Nervous System aims to provide information useful to physicians taking care of patients with bacterial infections in the central nervous system (CNS), which can lead to morbidity and mortality. The increased number of patients suffering from this infection has led to the development of vaccines and antibiotics. Comprised of four chapters, the book explains the general approach to patients with bacterial CNS infection. It also discusses various CNS infection concepts and terms. These include the characteristic neuroimaging appearance of specific bacterial infections, the limitations of neuroimaging, the cerebrospinal fluid analysis, the pathogenesis and pathophysiology of bacterial CNS infections, the developments of specific adjunctive strategies, and the principles of antimicrobial therapy. It also includes discussions on various diseases that target the CNS, such as meningitis, focal CNS infections, neurological complications of endocarditis, suppurative venous sinus thrombosis, infections in the neurosurgical patient, and CNS diseases caused by selected infectious agents and toxins. This book will serve as a guide for clinical physicians who have patients suffering from bacterial CNS infection. Valuable insights into the pathophysiological mechanism of bacterial CNS infections A multidisciplinary reach that provides critical information for neurologists, neurosurgeons, and specialists in infectious disease Considerable information and emphasis on new diagnostic techniques and laboratory testing

Central Nervous System Bacterial Infections Advances in Research and Treatment 2012 Edition

Central Nervous System Bacterial Infections   Advances in Research and Treatment  2012 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-12-26
ISBN : 1481616226
Language : En, Es, Fr & De

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Book Description :

Central Nervous System Bacterial Infections—Advances in Research and Treatment: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Central Nervous System Bacterial Infect in a concise format. The editors have built Central Nervous System Bacterial Infections—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Central Nervous System Bacterial Infect in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Central Nervous System Bacterial Infections—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Infections of the Central Nervous System

Infections of the Central Nervous System Book
Author : Fabrice Chretien,Kum Thong Wong,Leroy R. Sharer
Publisher : John Wiley & Sons
Release : 2020-03-30
ISBN : 1119467764
Language : En, Es, Fr & De

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Book Description :

Highly commended at the British Medical Association (BMA) Awards 2019, this new volume from the International Society of Neuropathology series addresses infections of the nervous system, written by expert editors. An expansive and inclusive contents list including rare disorders presented in easily referable chapters, containing; definitions, microbiological characteristics, epidemiology, clinical features, lab tests, pathology, genetics and treatment.

Infections of the Central Nervous System

Infections of the Central Nervous System Book
Author : W. Michael Scheld,Richard J. Whitley,Christina M. Marra
Publisher : Lippincott Williams & Wilkins
Release : 2014-04-21
ISBN : 146988366X
Language : En, Es, Fr & De

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Book Description :

Tap into the gold standard on central nervous system infections: Infections of the Central Nervous System, 4e is now fully revised and updated to accommodate the wealth of new CNS information discovered over the past decade. More than 90 leading experts contribute chapters, providing comprehensive, up-to-date information. With a broad scope and thorough detail, the text addresses pathogenesis, clinical manifestations, diagnosis, and therapy of various CNS infections and related conditions. Features: Every chapter has been extensively revised and updated, nearly half with new author teams NEW chapter on acute encephalitis NEW clinical information on treatment of tuberculosis, non-tubercular mycobacterial infections, brain abscess, and Lyme disease NEW color design and color images Numerous diagrams, figures, tables, illustrations and photographs demonstrate the content Evidence-based references

CNS Infections

CNS Infections Book
Author : Juan Carlos García-Moncó
Publisher : Springer
Release : 2018-01-17
ISBN : 3319702963
Language : En, Es, Fr & De

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Book Description :

This updated and expanded second edition covers selected infections of the central nervous system of considerable current interest. Aspects that are less well documented, such as spinal cord infections, central nervous system infections in patients with cancer, tropical infections, healthcare-associated ventriculitis or meningitis, and immunological problems in the international traveler are also discussed, as these are all problems relevant to daily practice. It is a multi-authored book written by experts in the field of neurological infection. A new section on infectious neuropathies is included. CNS Infections: A Clinical Approach is of value to the busy clinician; the neurological international community as well as all primary care doctors, internal medicine specialists and residents who take care of patients with suspected neurological infections.

T Cell mediated Immunoregulation by Parasitic and Bacterial Infections in the CNS During Autoimmunity and TB Infection

T Cell mediated Immunoregulation by Parasitic and Bacterial Infections in the CNS During Autoimmunity and TB Infection Book
Author : Gianna Hernández
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Homeostasis within the human body involves complex interactions between our native cells and a host of microbial communities that help our development and shape our immune system. We will explore some of the beneficial interactions from these relationships, as well as highlight the severe pathogenesis that can occur when immunity is compromised through the use of two central nervous system (CNS) disease models. CNSTB (CNS tuberculosis) is a rare, highly devastating manifestation of extra-pulmonary tuberculosis. This study uses a small animal model of CNSTB that permits us to investigate the immune responses following CNS Mycobacterium tuberculosis (Mtb) infection. We use intracerebral infection of mice with a strain of fluorescent Mtb which allows us to follow the fate of Mtb in vivo in the brain. We show a robust infiltration of immune cells into the brain and an IFN-[gamma] dominated T cell response. Prominent immune cell infiltration into the choroid plexus parenchyma supports that this is a major pathway for immune cell infiltration into the CNS in Mtb infection. The hygiene hypothesis posits that insufficient exposure to microorganisms due to modern sanitation can predispose susceptible individuals to immune dysregulation. The HINT2 clinical trial examines the immune response stimulated by Trichuris suis ova (TSO) when used as a treatment for Multiple Sclerosis (MS). During TSO treatment, the average number of new brain MRI active Gd+ lesions in the HINT patients was reduced. Changes in immune cell populations were monitored by cytofluorimetry of peripheral blood mononuclear cells. TSO administration led to a decrease in the percentage of activated effector T cells during treatment. This was accompanied by a reduction in the presence of T follicular helper cells in circulation, an increase in IL-4-expressing T cells, and greater numbers of regulatory T cells detectable in colonic biopsies in TSO treated patients.

Central Nervous System Infections An Issue of Neuroimaging Clinics

Central Nervous System Infections  An Issue of Neuroimaging Clinics Book
Author : Guarang Shah
Publisher : Elsevier Health Sciences
Release : 2012-11-14
ISBN : 1455747025
Language : En, Es, Fr & De

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Book Description :

CT, contrast CT, MRI, functional MRI, SPECT, CTA, and x-ray as tools to identify pathogens and diagnose intracranial infections are presented. Topics include: Epidemiology of Central Nervous System Infections; Imaging of Cranial Meningitis and Ventriculitis; Encephalitis, Cerebritis and Brain Abscess; Imaging of Central Nervous System Tuberculosis; Imaging of Rickettsial, Spirochetal, and Parasitic Infections; Imaging of Neurocysticercosis; Fungal Infections of the Central Nervous System; Central Nervous System Infections in the Pediatric Population; Imaging of Infectious Diseases of Spine; Neuropathological Findings in Intracranial Infections; Neurosurgical Approach to Infectious Disease of the Brain; Head and Neck Infections.

Childhood Pyogenic Meningitis

Childhood Pyogenic Meningitis Book
Author : Hasan Ejaz,Ikram-Ul Haq,Sundus Amin
Publisher : LAP Lambert Academic Publishing
Release : 2013
ISBN : 9783659338427
Language : En, Es, Fr & De

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Book Description :

Meningitis is inflammation of the meninges, the membranes covering the brain and spinal cord. The microbiologic causes of meningitis include bacteria, viruses, fungi, and parasites. They cause infection of the meninges that enters through the bloodstream from other parts of the body. Pyogenic meningitis is an acute bacterial infection of the central nervous system which is associated with remarkable mortalitY. The meninges have no host defenses to fight off invading bacteria. Meningeal inflammation of the brain or spinal cord can also be of non-infectious origin. One of the most important things to determine when meningitis is suspected is whether it is bacterial or viral. If a bacterial pathogen is the culprit, it is essential to identify the specific causative agent so that the appropriate antibiotics can be prescribed immediately. If left untreated, bacterial meningitis can lead to severe complications such as brain damage, hearing loss, epilepsy, and even death. The germs that cause bacterial meningitis are very common and live naturally in the back of the nose and throat. At any given time, 10% of the population is carrier of the disease but never actually become ill.

Neurological Complications of Infectious Diseases

Neurological Complications of Infectious Diseases Book
Author : Rodrigo Hasbun, MD MPH,Karen C. Bloch, MD MPH,Adarsh Bhimraj, MD
Publisher : Humana
Release : 2021-02-05
ISBN : 9783030560836
Language : En, Es, Fr & De

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Book Description :

This book offers a comprehensive review of the most common infectious diseases that affect the nervous system. Written by international experts, it provides a guide to clinicians for accurately diagnosing and treating these challenging syndromes. Organized into six sections, the book presents didactic, up-to-date information on the following topics relating to central nervous system (CNS) infections: diagnosis and evaluation of the patient, bacterial, viral, fungal and mycobacterial infections, disorders of the spinal cord, and a myriad of miscellaneous infections. Chapters specifically reflect and look to resolve the common obstacles clinicians face in the field, such as having unknown etiologies on the majority of CNS infections, insensitive and slow microbiological techniques, an increasing number of immunosuppressed individuals with atypical presentations and pathogens, and a lack of standardized diagnostic algorithms. A complex yet accessible addition to the Current Clinical Neurology Series, Neurological Complications of Infectious Diseases invaluably examines a wide range of infections that have neurological complications and sequelae.

Infections of the Nervous System

Infections of the Nervous System Book
Author : David Schlossberg
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461396980
Language : En, Es, Fr & De

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Book Description :

Dr. David Schlossberg presents his fifth volume in the series Clinical Topics in Infectious Disease, Infections of the Nervous System. This edited monograph brings together the leading authorities in infectious disease, neurology, and radiology to review the diagnosis and treatment of all major neurological infections. Topics covered include meningitis; acute CNS inflammation; infections of CNS shunts; brain and spinal epidural abscesses; the cerebellum and CNS infection; post-infection complications and syndromes; acute viral encephalitis; neurodegenerative peripheral nerve diseases; myelitis; CNS tuberculosis; cryptococcal, fungal, and parasitic infections; neurosyphilis, AIDS; Lyme disease; diagnostic imaging of CNS infection and inflammation; and evaluation of spinal fluid.