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Oxford Textbook of Axial Spondyloarthritis

Oxford Textbook of Axial Spondyloarthritis Book
Author : Robert Inman,Joachim Sieper
Publisher : Oxford University Press
Release : 2016-10-01
ISBN : 0198734441
Language : En, Es, Fr & De

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Book Description :

Axial Spondyloarthritis is a timely addition to the Oxford Textbooks in Rheumatology series, providing a comprehensive reference to this rapidly evolving field. The conceptual framework of the disease has now evolved beyond ankylosing spondylitis to encompass a broader concept of axial inflammation. Earlier recognition has opened the door to earlier intervention, and the understanding of the biologic basis of axial SpA has seen significant advances in recent years. The first textbook to cover axial spondyloarthritis in this level of detail from a global perspective, this volume offers a practical and complete resource compiled by a multidisciplinary and multinational team of experts. Beginning with a historical perspective on the disease, the textbook provides a comprehensive background in the epidemiology, diagnosis, and classification of axial spondyloarthritis. Immune mechanisms and genetics are covered, along with imaging and a detailed section on the range of treatments options currently available. A section on extra-articular manifestations provides a comprehensive knowledge base for the clinician treating patients with spondyloarthritis, and chapters on the economics of the disease, physical functioning, and patient registries complete the broad coverage of the topic. Practical, easy to use, yet detailed with respect to pathophysiology, diagnostics, and management, this textbook provides a comprehensive reference for rheumatologists, general practitioners, internists, and paediatricians managing patients with axial spondyloarthritis.

Axial Spondyloarthritis

Axial Spondyloarthritis Book
Author : Stefan Siebert,Raj Sengupta,Alexander Tsoukas
Publisher : Oxford University Press
Release : 2016-09-22
ISBN : 0198755295
Language : En, Es, Fr & De

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Book Description :

Axial spondyloarthritis is the commonest inflammatory arthritis affecting the spine. Typically first presenting to a variety of primary and secondary care professionals, the high global disease burden of this condition has created a need for increased awareness of this condition across a rangeof rheumatology specialties.A pocketbook aimed at the non-specialist reader Axial Spondyloarthritis is the essential guide to this common condition. Focusing on the practical implications of developments in classification, diagnosis and treatment, this easily accessible text fully covers the broader spectrum of the disease.Concise and fully illustrated, this addition to the Oxford Rheumatology Library covers the history and pathophysiology of axial spondylitis, alongside detailed sections on treatments, complications and manifestations of the condition. With each section supported by a handy key points section, AxialSpondyloarthritis is a useful and constructive resource for any practitioner or trainee encountering this condition.

Axial Spondyloarthritis

Axial Spondyloarthritis Book
Author : Philip Mease,Muhammad Asim Khan
Publisher : Elsevier Health Sciences
Release : 2019-02-16
ISBN : 0323568017
Language : En, Es, Fr & De

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Book Description :

Focusing on the key essentials you need to know, Axial Spondyloarthritis provides a quick, expert overview of axSpA from a clinical perspective. This concise resource by Drs. Philip Mease and Muhammad Khan presents practical recommendations and guidelines for the diagnosis, management, and treatment of spondyloarthritis impacting the axial skeleton alongside an overview of epidemiology, special populations, and patient education. Discusses key information on genetic factors and disease biomarkers. Presents an overview of clinical features, classification criteria, and imaging to aid in diagnosis. Covers management and treatment guidelines, including non-pharmacologic management and the use of biologics. Consolidates essential information on this timely topic into a single, convenient resource.

Clinician s Manual on Axial Spondyloarthritis

Clinician   s Manual on Axial Spondyloarthritis Book
Author : Joachim Sieper,Jürgen Braun
Publisher : Springer
Release : 2014-05-28
ISBN : 1907673857
Language : En, Es, Fr & De

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Book Description :

A thorough guide for readers to quickly gain an update on standard diagnosis and treatment methods for axial spondyloarthritis. Approximately 80 illustrations and images are used throughout the text to exemplify the disease and diagnostic and treatment algorithms. Easily accessible text and tables review the current treatment recommendations and emerging treatment options based on recent clinical trials.

Imaging Atlas of Axial Spondyloarthritis

Imaging Atlas of Axial Spondyloarthritis Book
Author : J O'Neill,Walter Maksymowych
Publisher : Unknown
Release : 2020-01-10
ISBN : 9780228817574
Language : En, Es, Fr & De

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Book Description :

A practical comprehensive visual guide to the complex imaging appearance of axial spondyloarthritis in clinical practice. This atlas is a collaboration between diagnostic imaging and rheumatology, providing an extensive array of images that illustrate the diverse pathology that occurs in the SIJ and spine in patients with axial SpA. While the primary focus is on MRI there are also examples of plain radiographic and CT findings to highlight the comparative advantages and disadvantages of different imaging modalities. Additional images also illustrate the potential pitfalls of MRI and the wide imaging and clinical differential diagnosis that can be confused with axSpA. - User friendly with clear and concise descriptions of pathology with over 220 images. - Over 100 images of normal imaging anatomy. - Excellent visual guide for the radiologist and rheumatologist - State of the art imaging. - All cases are derived from rheumatology referral and offer excellent insight into everyday practice. - Supported by reference drawing, summary tables. - Includes a clinical case challenge with multiple MRI cases for review. - Provides an in-depth review of a new MRI reporting system for axial SpA in clinical practice

Recognizing Axial Spondyloarthritis

Recognizing Axial Spondyloarthritis Book
Author : Janneke de Winter
Publisher : Unknown
Release : 2018
ISBN : 9789463324250
Language : En, Es, Fr & De

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Book Description :

Download Recognizing Axial Spondyloarthritis book written by Janneke de Winter, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Spondyloarthritis The Changing Landscape Today An Issue of Rheumatic Disease Clinics of North America E Book

Spondyloarthritis  The Changing Landscape Today  An Issue of Rheumatic Disease Clinics of North America  E Book Book
Author : Xenofon Baraliakos,Michael H. Weisman
Publisher : Elsevier Health Sciences
Release : 2020-06-02
ISBN : 0323733786
Language : En, Es, Fr & De

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Book Description :

This issue of Rheumatic Disease Clinics, guest edited by Drs. Xenofon Baraliakos and Michael H. Weisman, Spondyloarthritis: The Changing Landscape Today, takes a very comprehensive look at all of the essential topics surrounding spondyloarthritis. This issue is one of four selected each year by Dr. Weisman, who is also our series consulting editor. This very comprehensive issue will include the following topics (among others): Molecular biology approaches to understanding SpA; Microbiome and its role in SpA; Classification criteria in axSpA; Administrative data and coding for axSpA; Approach to the patient with IBD and AxSpA; Axial PsA vs. Axial SpA with Psoriasis; Emerging imaging techniques in SpA; The future of imaging in axSpA; Treatment Recommendations vs. Treat to Target in axSpA; The future of axSpA treatmentAxSpA in the era of Precision Medicine; Quality of Life as an outcome in studies of axSpA; Gender differences in SpA; The patient’s perspective on the burden of disease in axSpA; and Juvenile SpA.

Axial Spondyloarthritis

Axial Spondyloarthritis Book
Author : Anonim
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Ankylosing Spondylitis Axial Spondyloarthritis

Ankylosing Spondylitis   Axial Spondyloarthritis Book
Author : Muhammad Asim Khan
Publisher : Unknown
Release : 2016-11-11
ISBN : 9781943236084
Language : En, Es, Fr & De

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Book Description :

Download Ankylosing Spondylitis Axial Spondyloarthritis book written by Muhammad Asim Khan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomarkers in Axial Spondyloarthritis

Biomarkers in Axial Spondyloarthritis Book
Author : Anonim
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract : Purpose of review: To assess the literature for biomarker validation studies that address key unmet needs related to the evaluation and management of patients with axial spondyloarthritis (SpA). This review focused on biomarkers facilitating early diagnosis and reflecting disease activity, structural damage on radiography, and clinical response to major therapies. Recent findings: Early diagnosis may be facilitated by measurement of antibodies to the human leukocyte antigen class II-associated invariant chain peptide (anti-CD74) but sensitivity declines with increasing duration of disease. No disease activity biomarkers have demonstrated consistent superiority over standard C-reactive protein (CRP), and future validation should employ multivariate analysis aimed at demonstrating the added value of any associated biomarkers beyond available clinical parameters of disease activity and the use of magnetic resonance imaging inflammation as the primary endpoint. Several biomarkers reflecting inflammation (CRP and calprotectin), angiogenesis (vasoactive endothelial growth factor), and connective tissue turnover (C2 M, C3 M, and citrullinated metalloproteinase degraded fragment of vimentin ) have recently been shown to reflect radiographic progression in multivariate studies adjusted for baseline severity. Future studies should be prospective and demonstrate that predictive capacity adds to the information provided by known predictors such as CRP and baseline modified Stoke AS Spine Score. Calprotectin is a promising predictor of response to major therapies for axial SpA. Summary: Several promising biomarkers addressing major unmet clinical needs require further validation in prospective studies.

The Clinical Utility of Human Leucocyte Antigen B27 in Axial Spondyloarthritis

The Clinical Utility of Human Leucocyte Antigen B27 in Axial Spondyloarthritis Book
Author : Anonim
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract The association between HLA-B27 and AS was first established in the early 1970s. Since then, our understanding of this disease has changed, such that we now recognize AS to be the extreme of the clinical phenotype within a disease spectrum known as axial SpA (axSpA). Recent advances in therapeutic options have driven the need for earlier diagnosis and many screening strategies have been proposed to facilitate this. In parallel, our understanding of axSpA genetics, and especially the contribution of HLA-B27, has expanded. In this article we will present and discuss the evidence supporting the use of HLA-B27 in clinical practice. We will briefly summarize the evolution of the concept of axSpA, the prevalence of HLA-B27 and axSpA and the potential role of HLA-B27 in the aetiopathogenesis of axSpA and focus on the utility of HLA-B27 in everyday clinical practice.

The Burden of Early Axial Spondyloarthritis

The Burden of Early Axial Spondyloarthritis Book
Author : Anonim
Publisher : Unknown
Release : 2020
ISBN : 9789464021271
Language : En, Es, Fr & De

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Book Description :

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Emerging Drugs for the Treatment of Axial Spondyloarthritis

Emerging Drugs for the Treatment of Axial Spondyloarthritis Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Imaging Findings Suggestive of Axial Spondyloarthritis in Diffuse Idiopathic Skeletal Hyperostosis

Imaging Findings Suggestive of Axial Spondyloarthritis in Diffuse Idiopathic Skeletal Hyperostosis Book
Author : Anonim
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract : Objective: To describe the magnetic resonance imaging (MRI) findings in diffuse idiopathic skeletal hyperostosis (DISH) patients and to assess the proportion of DISH patients whose MRI findings would fulfill the Assessment of Spondyloarthritis International Society (ASAS) criteria for a positive MRI of axial spondyloarthritis (SpA). Methods: This study involved all DISH patients who had a spine or sacroiliac (SI) joint MRI performed between January 2009 and December 2014. Sociodemographic and clinical data were collected. Available radiographs and MRI were analyzed and blindly scored by an experienced reader, using the Spondyloarthritis Research Consortium of Canada (SPARCC) scores for both spine and SI joint MRI. Results: A total of 53 symptomatic DISH patients was included in the analysis. The mean ± SD SPARCC score of the spine was 18.3 ± 23.4. Thirty‐five patients (67.3%) had at least 1 fatty corner. Thirty patients (57.7%) met the ASAS definition of a spine MRI suggestive of axial SpA, but only 6 patients (15.8%) with an available SI joint MRI had sacroiliitis according to ASAS criteria. Only 1 patient (3.3%) had ≥3 erosions on the SI joint. Conclusion: Inflammatory lesions of the spine are common on the MRI of symptomatic DISH patients, and more than half fulfilled the ASAS criteria for a spine MRI suggestive of axial SpA. However, only a few patients met the ASAS definition of active sacroiliitis, suggesting that MRI of the SI joint but not of the spine might allow the differential diagnosis of DISH versus axial SpA in the elderly.

Early Recognition of Axial Spondyloarthritis

Early Recognition of Axial Spondyloarthritis Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 9789493014459
Language : En, Es, Fr & De

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Book Description :

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Risk for Adverse Pregnancy Outcome in Axial Spondyloarthritis and Rheumatoid Arthritis

Risk for Adverse Pregnancy Outcome in Axial Spondyloarthritis and Rheumatoid Arthritis Book
Author : Stephanie Livia van den Brandt
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Risk for Adverse Pregnancy Outcome in Axial Spondyloarthritis and Rheumatoid Arthritis book written by Stephanie Livia van den Brandt, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Axial Spondyloarthritis and Disease Progression

Axial Spondyloarthritis and Disease Progression Book
Author : Anonim
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Immunohistological Analysis of Active Sacroiliitis in Patients with Axial Spondyloarthritis

Immunohistological Analysis of Active Sacroiliitis in Patients with Axial Spondyloarthritis Book
Author : Anonim
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract : Abstract: The sacroiliac joints (SIJs) are one of the most common sites involved in axial spondyloarthritis (axSpA), and there are few studies on the histopathology of the SIJ in this group of patients. Mononuclear cell infiltrates in the bone marrow and fibrous tissue resembling a pannus formation were the pathological features of early sacroiliitis in our previous study. We undertook a further immunohistological evaluation of these features in patients with axSpA. Biopsy specimens from the SIJ of 6 patients with established ankylosing spondylitis (AS) and 13 patients with nonradiographic axial spondyloarthritis (nr-axSpA) were analyzed. An immunohistological method was performed to examine the macrophages (CD163), T cells (CD3), and B cells (CD20). Mononuclear cell infiltrates in the bone marrow were observed in only 6 patients with nr-axSpA. Fibrous tissue was observed in all patients with established AS and 9 patients with nr-axSpA. Macrophage, T cell, and B cell infiltrates could be detected in both the bone marrow and fibrous tissue. All bone marrow specimens from 6 nr-axSpA patients exhibited CD163+ macrophage infiltrates; of these, 5 exhibited CD20+ B cell infiltrates and 3 exhibited CD3+ T cell infiltrates. Among the fibrous tissue specimens, all exhibited macrophage infiltrates, 9 exhibited B cell infiltrates, and 4 exhibited T cell infiltrates. In addition to macrophages and T cells, B cells are also involved in active sacroiliitis in patients with axSpA.

Spondyloarthropathies An Issue of Rheumatic Disease Clinics E Book

Spondyloarthropathies  An Issue of Rheumatic Disease Clinics   E Book Book
Author : Juergen Braun,Joachim Sieper
Publisher : Elsevier Health Sciences
Release : 2012-11-14
ISBN : 1455750603
Language : En, Es, Fr & De

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Book Description :

Edited by Drs. Juergen Braun and Joachim Sieper, this issue of Rheumatic Disease Clinics comprehensively reviews the state of the art of spondyloarthritis (SpA) diagnosis, prognosis, pathogenesis and genetic insights, and treatment. The worldwide burden of SpA now exceeds that of rheumatoid arthritis. General topics covered include inflammatory back pain, pathophysiology, imaging techniques, and therapeutic strategies.