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Autophagy

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Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging

Autophagy  Cancer  Other Pathologies  Inflammation  Immunity  Infection  and Aging Book
Author : M. A. Hayat
Publisher : Academic Press
Release : 2016-12-28
ISBN : 0128094273
Language : En, Es, Fr & De

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Book Description :

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Autophagy Biology and Diseases

Autophagy  Biology and Diseases Book
Author : Zhiping Xie
Publisher : Springer Nature
Release : 2021-07-14
ISBN : 9811628300
Language : En, Es, Fr & De

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Book Description :

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 3 focuses on the technical aspects of autophagy research. It is comprised of two parts. The first part discusses the basic process of autophagy, including its overall classification and individual stages in the life cycle of autophagosomes. The second part discusses the tools, strategies, and model systems in current autophagy research, including cell and animal models, detection and manipulation methods, as well as screening, genomic, proteomic and bioinformatic approaches. The book is written and edited by a team of active scientists. It is intended as a practical reference resource for interested researchers to get started on autophagy studies.

Autophagy in Health and Disease

Autophagy in Health and Disease Book
Author : Beverly Rothermel,Abhinav Diwan
Publisher : Elsevier
Release : 2021-09-22
ISBN : 012822004X
Language : En, Es, Fr & De

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Book Description :

Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is an international effort by investigators from 15 different countries whose many contributions are comprised in 28 chapters organized into six sections. The first section (Chapters 1-7) covers foundational concepts, including history, trajectory of the research field, mechanisms of autophagy, and autophagy regulation. The second section (Chapters 8-11) details developmental aspects, including stem cells, embryogenesis, hematopoiesis, and paligenosis. The subsequent sections are devoted to the role of autophagy in specific organ systems involved in metabolic control and diabetes (Chapters 12-15), the cardiovascular system (Chapters 16-18), and the nervous system (Chapters 19-20). The final section (Chapters 21-28) addresses autophagy in other organ systems vital to human health and longevity. Also included are chapters on microautophagy, chaperone-mediated autophagy, and the potential for autophagy as a therapeutic target. Autophagy in Health and Disease is invaluable to anyone new to the field as well as established investigators looking for a broader understanding of autophagy from outside their specific field of study. Provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathology Offers extended coverage of the mechanisms that mediate autophagy Covers the role of autophagy in stem cells and induced pluripotent stem cells, as well as the regenerative process of paligenosis Highlights important questions that remain to be addressed

Autophagy in Health and Disease

Autophagy in Health and Disease Book
Author : Roberta A. Gottlieb
Publisher : Academic Press
Release : 2012-10-16
ISBN : 0123851017
Language : En, Es, Fr & De

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Book Description :

Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes

Autophagy in Health and Disease

Autophagy in Health and Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2020-06-30
ISBN : 0128220228
Language : En, Es, Fr & De

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Book Description :

Autophagy in Health and Disease, Volume 175, presents the latest insights from renowned experts in the field who discuss the key role of autophagic responses in the preservation of cellular and organismal homeostasis and how defects in the molecular apparatus for autophagy drive or accompany disease. Specific chapters in this new release include Crosstalk between autophagy and cell death signaling: mechanisms and therapeutic relevance, C. elegans to model autophagy-related human disorders, Autophagy in Kidney Disease: advances and therapeutic potential, Autophagy in Chronic Lung Disease, Autophagy in motoneuronal disorders, Strategies employed by viruses to manipulate autophagy, and much more. Provides an outstanding panel of recognized experts in the field who discuss the latest in autophagy Includes critical discussions of autophagy in the context of each major human disorder Models autophagy-related human pathologies in lower eukaryotes

Studies of the Molecular Components of Autophagy and the Sorting Mechanism of the Multivesicular Body Pathway in Saccharomyces Cerevisiae

Studies of the Molecular Components of Autophagy and the Sorting Mechanism of the Multivesicular Body Pathway in Saccharomyces Cerevisiae Book
Author : Ju Huang
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Studies of the Molecular Components of Autophagy and the Sorting Mechanism of the Multivesicular Body Pathway in Saccharomyces Cerevisiae book written by Ju Huang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Autophagy

Autophagy Book
Author : Daniel Klionsky
Publisher : CRC Press
Release : 2003-12-15
ISBN : 1498713270
Language : En, Es, Fr & De

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Book Description :

Starting in the early 1970s, a type of programmed cell death called apoptosis began to receive attention. Over the next three decades, research in this area continued at an accelerated rate. In the early 1990s, a second type of programmed cell death, autophagy, came into focus. Autophagy has been studied in mammalian cells for many years. The recen

Metabolic Autophagy

Metabolic Autophagy Book
Author : Siim Land
Publisher : Metabolic Autophagy Diet
Release : 2019-02-09
ISBN : 9781790686391
Language : En, Es, Fr & De

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Book Description :

Intermittent Fasting for Longevity and Performance Your cells are constantly monitoring the nutrient status of the cells to determine whether or not to conserve energy or to promote growth. **One of the few known ways of increasing lifespan in almost all species is caloric restriction and energy deprivation.** This triggers many metabolic pathways and processes that make the organism more adaptable to environmental stressors and thus live longer. **The metabolism has two sub-categories or sub-processes called anabolism and catabolism. ** * Anabolism, meaning 'upward' in Greek, describes the synthesis of biological molecules to build up new physical matter in the body. * Catabolism, meaning 'downward' in Greek, describes the breaking down of biological molecules to release energy. This can apply to the breakdown of bodily tissue as well as the digestion of food that then gets assimilated into the body through anabolic processes. In addition to 'Metabolic', you can also find another word in the title - 'Autophagy', which translates from Ancient Greek into 'self-devouring' or 'eating of self'. This is central to the main practice of this book. By maintaining a balance between anabolism and catabolism, you can effectively extend your lifespan. The process of autophagy entails your healthy cells devouring the old, worn-out, weak ones and converting them back into energy. It's literally your body eating itself and using that to maintain homeostasis. There are many longevity-boosting benefits to this as illustrated in virtually all other species. This book is a collection of guidelines about the principles of the anabolic-catabolic cycles in regards to nutrition and exercise. It's definitely not a panacea - a solution or remedy for all conditions and circumstances. Instead, it's a very specific protocol that's not supposed to apply for all situations. **Metabolic Autophagy will teach you:** * What increases lifespan in humans and other species * Why there's so much disease and obesity in society * How to promote health and longevity with intermittent fasting * What is Autophagy and how it works * How to age slower and be vigorous throughout your life * Which foods make you live longer and build muscle * How the nutrient regulators of mTOR, AMPK, sirtuins, FOXO proteins, hormesis and others affect longevity * What are circadian rhythms and how they affect your health * Metabolic Autophagy Foods list and their anabolic-catabolic score * Supplements that support muscle growth and longevity * Many extras and bonuses in regards to food and exerciseSiim Land is a best-selling author, anthropologist, entrepreneur, high-performance coach and a biohacker who writes about optimizing health and human performance.This book incorporates daily lifestyle and dietary practices that help to cross the chasm between longevity and high performance.

Autophagy Biology and Diseases

Autophagy  Biology and Diseases Book
Author : Weidong Le
Publisher : Springer Nature
Release : 2020-07-15
ISBN : 9811542724
Language : En, Es, Fr & De

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Book Description :

This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine

Autophagy in Peripheral Neuropathy

Autophagy in Peripheral Neuropathy Book
Author : Ayman Osman
Publisher : Linköping University Electronic Press
Release : 2017-10-23
ISBN : 9176854728
Language : En, Es, Fr & De

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Book Description :

Peripheral neuropathy includes a wide range of diseases affecting millions around the world, and many of these diseases have unknown etiology. Peripheral neuropathy in diabetes represents a large proportion of peripheral neuropathies. Nerve damage can also be caused by trauma. Peripheral neuropathies are a significant clinical problem and efficient treatments are largely lacking. In the case of a transected nerve, different methods have been used to repair or reconstruct the nerve, including the use of nerve conduits, but functional recovery is usually poor. Autophagy, a cellular mechanism that recycles damaged proteins, is impaired in the brain in many neurodegenerative diseases affecting animals and humans. No research, however, has investigated the presence of autophagy in the human peripheral nervous system. In this study, I present the first structural evidence of autophagy in human peripheral nerves. I also show that the density of autophagy structures is higher in peripheral nerves of patients with chronic idiopathic axonal polyneuropathy (CIAP) and inflammatory neuropathy than in controls. The density of these structures increases with the severity of the neuropathy. In animal model, using Goto-Kakizaki (GK) rats with diabetes resembling human type 2 diabetes, activation of autophagy by local administration of rapamycin incorporated in collagen conduits that were used for reconnection of the transected sciatic nerve led to an increase in autophagy proteins LC3 and a decrease in p62 suggesting that the autophagic flux was activated. In addition, immunoreactivity of neurofilaments, which are parts of the cytoskeleton of axons, was increased indicating increased axonal regeneration. I also show that many proteins involved in axonal regeneration and cell survival were up-regulated by rapamycin in the injured sciatic nerve of GK rats four weeks after injury. Taken together, these findings provide new knowledge about the involvement of autophagy in neuropathy and after peripheral nerve injury and reconstruction using collagen conduits.

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging

Autophagy  Cancer  Other Pathologies  Inflammation  Immunity  Infection  and Aging Book
Author : M. A. Hayat
Publisher : Academic Press
Release : 2014-12-31
ISBN : 0128010533
Language : En, Es, Fr & De

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Book Description :

Volume 6 provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Attention is given to a number of mechanistic advances in the understanding of regulation, particularly the importance of nutrient availability; microRNAs; and cross-talk with other protein degradation pathways. Intracellular pathogen repurposing of autophagy for pathogenic benefit is also provided, with coverage of Herpesvirus protein modulation of autophagy; the varicella-zoster virus and the maintenance of homeostasis; and the relationship between autophagy and the hepatitis b virus. The significance of autophagy in host defense is elucidated, providing a specific focus on facilitation of antigen presentation; participation in thymic development; and the sharing of regulatory nodes with innate immunity. Selective autophagy for the degradation of mitochondria and endocytosed gap junctions are also explored. This book is an asset to newcomers as a concise overview of the regulation of autophagy, its role in host defense and immunity, and selective autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series

Autophagy and Cardiometabolic Diseases

Autophagy and Cardiometabolic Diseases Book
Author : Jun Ren,James R. Sowers,Yingmei Zhang
Publisher : Academic Press
Release : 2018-04-12
ISBN : 0128054425
Language : En, Es, Fr & De

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Book Description :

Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations

Autophagy in Tissue Injury and Homeostasis

Autophagy in Tissue Injury and Homeostasis Book
Author : Pei-Hui Lin
Publisher : MDPI
Release : 2020-12-15
ISBN : 303943781X
Language : En, Es, Fr & De

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Book Description :

Autophagy (“auto-digestion”), a lysosome-dependent process, degrades and turns over damaged or senescent organelles and proteins. Autophagy is a highly regulated process that impacts several vital cellular responses, including inflammation, cell death, energy metabolism, and homeostasis of organelles (mitochondria and others). Although the role of autophagy in the maintenance of tissue homeostasis is well documented, its role during tissue injury and regeneration is still emerging. In this Special Issue on “Autophagy in Tissue Injury and Homeostasis”, we focus on the roles of autophagy in systemic, specific tissue (organs/cells) injury or organ failure associated with sepsis, inflammation, metabolic disorder, toxic chemicals, ischemia-reperfusion injury, hypoxic oxidative stress, tissue fibrosis, trauma, and nutrient starvation. The knowledge gained from the identification and characterization of new molecular mechanisms will shed light on biomedical applications for tissue protection through the modulation of autophagy.

Autophagy A Double Edged Sword

Autophagy   A Double Edged Sword Book
Author : Yannick Bailly
Publisher : BoD – Books on Demand
Release : 2013-04-17
ISBN : 9535110624
Language : En, Es, Fr & De

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Book Description :

The chapters in this book review the latest advances in the molecular mechanisms of autophagy, highlighting some of the most challenging research topics. The focus is mainly on how this basic cell defense mechanism comes into play in various pathologies, including liver diseases, myopathies, infectious diseases, cancers and neurodegenerative diseases. In these diseases, the contradictory autophagy roles of cell survival versus cell death emphasize the necessity of taking into account this double-edged nature in future development of already promising, autophagy- modulating, therapies.

Autophagy in Immune Response Impact on Cancer Immunotherapy

Autophagy in Immune Response  Impact on Cancer Immunotherapy Book
Author : Salem Chouaib
Publisher : Academic Press
Release : 2020-05-25
ISBN : 0128196092
Language : En, Es, Fr & De

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Book Description :

Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies. Presents updated knowledge on autophagy at the basic level and its potential use in cancer treatment Offers the first book to cover autophagy at the interface of cell biology, immunology and tumor biology Provides a wealth of information on the topic in a coherent and comprehensive collection of contributions by world renowned scientists and investigators

Autophagy from Big Data to Physiological Significance

Autophagy  from Big Data to Physiological Significance Book
Author : Ioannis Nezis,Sovan Sarkar,Maria Ines Vaccaro
Publisher : Frontiers Media SA
Release : 2020-02-10
ISBN : 2889634825
Language : En, Es, Fr & De

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Book Description :

Download Autophagy from Big Data to Physiological Significance book written by Ioannis Nezis,Sovan Sarkar,Maria Ines Vaccaro, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

New Roles of Autophagy Pathways in Cancer

New Roles of Autophagy Pathways in Cancer Book
Author : Daniel Hector Grasso,Eugenia Morselli,Waleska Kerllen Martins,Claudio Marcelo Fader
Publisher : Frontiers Media SA
Release : 2021-09-10
ISBN : 2889712818
Language : En, Es, Fr & De

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Book Description :

Download New Roles of Autophagy Pathways in Cancer book written by Daniel Hector Grasso,Eugenia Morselli,Waleska Kerllen Martins,Claudio Marcelo Fader, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Autophagy in plants and algae

Autophagy in plants and algae Book
Author : Diane C Bassham,Jose L Crespo
Publisher : Frontiers Media SA
Release : 2015-05-15
ISBN : 2889194779
Language : En, Es, Fr & De

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Book Description :

Autophagy (also known as macroautophagy) is an evolutionarily conserved process by which cytoplasmic components are nonselectively enclosed within a double-membrane vesicle known as the autophagosome and delivered to the vacuole for degradation of toxic components and recycling of needed nutrients. This catabolic process is required for the adequate adaptation and response of the cell, and correspondingly the whole organism, to different types of stress including nutrient starvation or oxidative damage. Autophagy has been extensively investigated in yeasts and mammals but the identification of autophagy-related (ATG) genes in plant and algal genomes together with the characterization of autophagy-deficient mutants in plants have revealed that this process is structurally and functionally conserved in photosynthetic eukaryotes. Recent studies have demonstrated that autophagy is active at a basal level under normal growth in plants and is upregulated during senescence and in response to nutrient limitation, oxidative stress, salt and drought conditions and pathogen attack. Autophagy was initially considered as a non-selective pathway, but numerous observations mainly obtained in yeasts revealed that autophagy can also selectively eliminate specific proteins, protein complexes and organelles. Interestingly, several types of selective autophagy appear to be also conserved in plants, and the degradation of protein aggregates through specific adaptors or the delivery of chloroplast material to the vacuole via autophagy has been reported. This research topic aims to gather recent progress on different aspects of autophagy in plants and algae. We welcome all types of articles including original research, methods, opinions and reviews that provide new insights about the autophagy process and its regulation.

Interplay between Autophagy and Metabolic Syndrome Causes Consequences and Therapeutic Challenges

Interplay between Autophagy and Metabolic Syndrome  Causes  Consequences and Therapeutic Challenges Book
Author : Joilson O. Martins,William T. Festuccia,Karen Yvonne Stokes,Stephen Fernandes Rodrigues
Publisher : Frontiers Media SA
Release : 2021-12-01
ISBN : 288971747X
Language : En, Es, Fr & De

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Book Description :

Download Interplay between Autophagy and Metabolic Syndrome Causes Consequences and Therapeutic Challenges book written by Joilson O. Martins,William T. Festuccia,Karen Yvonne Stokes,Stephen Fernandes Rodrigues, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Autophagy and Related Transcription Factors in Liver and Gut Diseases

Autophagy and Related Transcription Factors in Liver and Gut Diseases Book
Author : Nabil Eid,Paul Thomes,Manoj B. Menon,Tao Zeng,Nuno Raimundo,Jose C. Fernandez-Checa,Lin Wang
Publisher : Frontiers Media SA
Release : 2020-03-02
ISBN : 2889635465
Language : En, Es, Fr & De

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Book Description :

Download Autophagy and Related Transcription Factors in Liver and Gut Diseases book written by Nabil Eid,Paul Thomes,Manoj B. Menon,Tao Zeng,Nuno Raimundo,Jose C. Fernandez-Checa,Lin Wang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.