Download Autophagy And Cardiometabolic Diseases Full eBooks in PDF, EPUB, and kindle. Autophagy And Cardiometabolic Diseases is one my favorite book and give us some inspiration, very enjoy to read. you could read this book anywhere anytime directly from your device.
Book Description :
Download Autophagy and Protein Quality Control in Cardiometabolic Diseases book written by Jun Ren, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.
Book Description :
Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations
Book Description :
Unbalanced energy intake over expenditure causes obesity, and the prevalence and incidences of obesity have increased over last decades. People with obesity have a cluster of metabolic co-morbidities called metabolic syndrome which substantially increase the risk of diabetes and cardiovascular diseases. The pathophysiological mechanisms underlying metabolic syndrome are multifaceted and one contributing factor is altered adipokines profiles. Adiponectin is the most abundant adipokine in the circulation and a low serum adiponectin level is implicated in multiple diseases. Adiponectin acts on various tissues by improving energy metabolism and conferring protective effects. Majority of studies suggest adiponectins beneficial effects are mediated through AMPK signaling. AMPK is a master regulator of energy metabolism and activated upon low energy status. AMPK activates multiple cellular process to generate energy including autophagy. Autophagy is a conserved catabolic process which confers an adaptive force against stresses by mobilizing energy sources and preventing toxin accumulation. The studies presented here investigating molecular mechanism underlying adiponectins pleotropic effects, particularly focusing on its relation to autophagy. In the first study, the effects of iron overload on autophagy in skeletal muscle were observed. Iron toxicity is associated with reduced circulating adiponectin level and increased the diabetes mellitus incidences. Chronic iron overload altered the autophagy regulatory signaling mTOR, which impaired autophagy lysosome reformation, a novel late stage autophagy process crucial for insulin sensitivity. In the second and third studies, the changes in cardiac autophagy following pressure overload or myocardial infarction were monitored in mice lacking adiponectin. Adiponectin deficient mice exhibited exaggerated cardiac remodeling with evidence of autophagy impairments. With an advanced live-animal imaging system, a lower autophagy activity was observed in adiponectin knockout mice hearts after stresses. Cell culture experiments further validated that adiponectin directly stimulated autophagy flux and protected cardiomyocytes from cell death. Taken together, the studies described here highlight that adiponectin is an important regulator of autophagy in skeletal muscle and hearts, and adiponectin signaling is a potential therapeutic target to modulate autophagy rates.
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Download New Drug Targets for Proteotoxicity in Cardiometabolic Diseases book written by Jun Ren,Xin Wang,Ying Mei Zhang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.
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This book establishes a bridge between exercise-mediated functional status of autophagy and non-communicable chronic diseases for elucidating and clarifying the corresponding signal pathways and underlying mechanisms. The book consists of 13 chapters focusing on the in-depth discussion on signal pathways for regulating the functional status of autophagy for the prevention, treatment and rehabilitation of chronic diseases, the optimization of exercise intervention strategies for common and frequently-occurring chronic diseases, and the development of exercise mimetic pills for the persons with disability for exercise performance, or the persons without willing to exercise. This book is interesting and will be useful to a wide readership in the various fields of exercise science, exercise fitness, sports medicine, preventive medicine, and functional foods.
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The accumulation of dysfunctional proteins and organelles is a defining feature of metabolic disease in nearly every tissue. A key pathway addressing this challenge is the autophagy-lysosome system which serves to identify, sequester, and degrade cellular components. Here, I first report on harnessing TFEB, a transcription factor master regulator of genes involved in autophagy-lysosome biogenesis, lipid metabolism, and mitochondrial metabolism to drive this pathway in adipocytes. We found that TFEB overexpression protects mice from diet induced obesity and adverse metabolic sequelae including insulin resistance and hepatic steatosis. TFEB modestly induces expression of autophagy and lysosomal genes, but this targeting seemed insufficient to explain the observed metabolic phenotypes. Instead, we found that TFEB robustly induced expression of mitochondrial and lipid metabolic genes, resulting in enhanced thermogenesis. We identified the transcriptional coactivator PGC-1[alpha] as a key target of TFEB in adipocytes and demonstrated that TFEB-induced effects were largely PGC-1[alpha] dependent. These studies position TFEB as a potent regulator of adipocyte physiology with implications for targeting this pathway therapeutically.Second, I functionally characterized genetic variants in the Lysosomal Acid Lipase (LIPA) genetic risk locus for coronary artery disease. LIPA is the sole lysosomal cholesterol esterase crucial for lipid metabolism in the atherosclerotic plaque, and rare loss-of-function variants lead to severe cholesterol accumulation and early death. As a whole, we found the risk variants were associated with a gain-of-function in human monocyte enzyme activity and expression attributable to intronic variants in the locus. We also identified a single exonic variant in the risk locus resulting in the amino acid substitution T16P which could plausibly disrupt enzyme trafficking amounting to a net loss of function. Studied in isolation, however, the exonic variant did not functionally impair enzyme expression, secretion, stability, or trafficking to the lysosome. These results establish the LIPA risk locus for coronary artery disease as resulting from a gain-of-function and set the stage for future studies mechanistically exploring mechanisms of pathogenesis.
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Harness the health benefits of intermittent fasting--a comprehensive guide with meal plans and more Intermittent fasting (IF) is an evidence-based eating program that's existed in multiple forms for nearly 2,500 years, with roots in evolution and religion. That said, there are many ways to approach it and apply it to your life. This book is filled with essential information, how-to advice, FAQs, meal plans, and recipes to help you adopt and maintain an intermittent fasting lifestyle for weight loss and improved health. In this book, you will discover: - What is intermittent fasting; - How to use it to your advantage; - Why you're failing to lose weight despite doing the best you can to eat healthily; - What are the true healing capacities of your own body, and how to eat to unlock the body's hidden potentials; - How to trigger fast and permanent weight loss; - How conventional dieting causes insulin resistance, and what you can do to start burning fat instead of your muscles to lose weight; - How to fast easily and effectively while being full and satisfied; - How to lose weight without calorie restriction; - How to eat trigger Autophagy, the powerful process of self-healing, and - How to recover from cardiometabolic diseases using the right foods; - And so much more! Here's everything you need to apply intermittent fasting to your life so you can look and feel your best. Let's get started!
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This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine
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During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.
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Have you been trying to slim down unsuccessfully? Have you starved for days and weeks, only to regain all of the weight with crash dieting? If this is true, "Intermittent Fasting to Unlock Hidden Potentials" is the right book for you! In this book, you will learn: What is intermittent fasting; How to use it to your advantage; Why you're failing to lose weight despite doing the best you can to eat healthily; What are the true healing capacities of your own body, and how to eat to unlock the body's hidden potentials; How to trigger fast and permanent weight loss; How conventional dieting causes insulin resistance, and what you can do to start burning fat instead of your muscles to lose weight; How to fast easily and effectively while being full and satisfied; How to lose weight without calorie restriction; How to eat trigger Autophagy, the powerful process of self-healing, and How to recover from cardiometabolic diseases using the right foods; " Intermittent Fasting to Unlock Hidden Potentials" uses a scientific approach to present you with explanations for the most common causes of weight gain and health problems related to diet, such as: Obesity as a result of insulin resistance; Cardiometabolic disorders as a result of a maladjusted, habitual diet; Insulin resistance and its effects on metabolism and weight gain. Furthermore, "Intermittent Fasting to Unlock Hidden Potentials" will give you a thorough explanation of fasting, its origins and history, and the physiological reactions that happen as a result of it. In this book, you will learn about numerous scientifically verified benefits of fasting. You will learn how intermittent fasting can help you: Lose weight permanently with a simple, sustainable, and satisfying diet plan; Cure insulin resistance and turn your body into a fat-burning machine; Schedule your meals and exercises to grow muscle mass and burn the fatty tissue; Change your diet to support cardiovascular health and improve well-being; Identify how your diet affects your health and find the right strategies to support your health with natural foods; Learn how to use diet to strengthen your immune system, brainpower, and muscle power; and How to enhance the benefits of fasting by going on the Keto diet. Don't miss out on the opportunity to start burning fat in a matter of days and learn how to trigger some of the most powerful physiological processes of self-healing. Hurry and grab your copy of "Intermittent Fasting to Unlock Hidden Potentials" right now
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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
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Download Programmed Cell Death and Cardiovascular Disease book written by Zhi Qi,Rongxue Wu,Xiongwen Chen,Zhiqiang Lin, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.
Book Description :
This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine.
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Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is an international effort by investigators from 15 different countries whose many contributions are comprised in 28 chapters organized into six sections. The first section (Chapters 1-7) covers foundational concepts, including history, trajectory of the research field, mechanisms of autophagy, and autophagy regulation. The second section (Chapters 8-11) details developmental aspects, including stem cells, embryogenesis, hematopoiesis, and paligenosis. The subsequent sections are devoted to the role of autophagy in specific organ systems involved in metabolic control and diabetes (Chapters 12-15), the cardiovascular system (Chapters 16-18), and the nervous system (Chapters 19-20). The final section (Chapters 21-28) addresses autophagy in other organ systems vital to human health and longevity. Also included are chapters on microautophagy, chaperone-mediated autophagy, and the potential for autophagy as a therapeutic target. Autophagy in Health and Disease is invaluable to anyone new to the field as well as established investigators looking for a broader understanding of autophagy from outside their specific field of study. Provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathology Offers extended coverage of the mechanisms that mediate autophagy Covers the role of autophagy in stem cells and induced pluripotent stem cells, as well as the regenerative process of paligenosis Highlights important questions that remain to be addressed
Book Description :
Obesity, defined as accumulation of excessive body fat, has grown dramatically and imposes a devastating, pandemic health threat. If uncorrected, obesity may confer an increased susceptibility to the onset and development of insulin resistance, hypertension, type 2 diabetes, and the cadre of metabolic syndrome. More importantly, evidence from our group and other laboratories has demonstrated that obesity contributes to the development of cardiac anomalies. Although multiple signaling pathways have been identified as responsible for cardiac dysfunction in obese individuals, the precise mechanism still remains elusive. The autophagy–lysosome pathway, which regulates the degradation of large intracellular organelles and protein aggregates, is essential for the maintenance of cardiomyocytes under physiological and pathological conditions. Recent studies have suggested that the autophagy pathway plays a pivotal role in the development of cardiac anomalies induced by obesity. In the present chapter, we focus on how autophagy is involved in the regulation of cardiac function in obesity and metabolic syndrome.
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This book introduces charnolophagy (CP) as energy-driven, lysosomal-dependent mitochondrial inclusion-specific pleomorphic Charnoly body (CB) autophagy (ATG) involving free radical-induced Ca2+ dyshomeostasis, ΔΨ collapse, and ATP depletion in congenital diseases, pressure ulcers, metabolic diseases, hepatic diseases, diabetes, obesity, inflammatory diseases, musculoskeletal diseases, sarcopenia, cachexia, respiratory diseases, gastrointestinal diseases, hyperlipidemia, skin and hair diseases, pulmonary diseases, cardiovascular diseases, renal diseases, sepsis-induced multi-organ failure, reproductive diseases, inflammatory diseases, ophthalmic diseases, neurodegenerative diseases, drug addiction, aging, microbial (including COVID-19) infections, and belligerent malignancies implicated in early morbidity and mortality and disease-specific spatiotemporal, targeted, safe, and effective evidence-based personalized theranostic charnolopharmacotherapeutics to cure them. Basic DRESS and GELS principles, nanoparticles to cure chronic multidrug-resistant (MDR) diseases, antioxidants as free radical scavengers, CB antagonists, CP regulators, and CS stabilizers to curb CB molecular pathogenesis (CBMP) are described for better quality of life and longevity. Specific guidelines for environmental protection and preservation of zoological and botanical species at the verge of extinction, Triple "I" Hypothesis for mitochondrial quality control, and transcriptional regulation of CSexR and CSendoR to cure chronic diseases are presented. Novel CP index is introduced to evaluate MDR malignancies and other chronic diseases. WHO, CDC, FDA, NIH, policy planners, cosmetologists, trichologists, players, athletes, dancers, wrestlers, equestrians, young women, aging population, toxicologists, environmental protectionists, pharmaceutical industry, biomedical scientists, researchers, medical students, physicians, nurses, paramedical professionals, and global audience will be interested in this interesting book to prevent pandemics and raise healthcare awareness.
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Cardiovascular Diseases: Advances in Research and Treatment: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cardiovascular Diseases. The editors have built Cardiovascular Diseases: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cardiovascular Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cardiovascular Diseases: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Description :
This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.
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Download Metabolic Regulation in the Development of Cardiovascular Diseases book written by Xiaoqiang Tang,Md. Shenuarin Bhuiyan,InKyeom Kim, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.
Book Description :
One of the most intriguing and compelling issues to impact contemporary biology to date is the concept that cell death is genetically regulated. Observations by Kerr and Wyllie, made more than 30 years ago on the basis of distinct morphological criteria, markedly distinguished apoptosis from classical cell death by necrosis. Apoptosis is a highly regulated, evolutionary conserved, genetic program of cell death essential for normal development and tissue homeostasis. The discovery of apoptosis as a regulated event and potentially amenable to therapeutic interventions has generated considerable excitement because it meant that disease entities resulting from either too much, or too little, apoptosis could be potentially cured with new therapies that target apoptosis. While there is little doubt that necrosis induced by massive cellular trauma is likely an unregulated event, several lines of investigation have challenged the dogma that necrotic cell death is merely unregulated. Emerging data has shifted the paradigm in our thinking about necrosis as a regulated event. Autophagy is another cellular process that has received considerable attention over the past two decades and its remarkable involvement in the processes of cell survival, death and tumorigenesis. Macro autophagy is a catabolic process that involves the selective and targeted removal of oxidized proteins, macromolecular structures and organelles through an elaborate cellular process involving a lysosome mediated pathway. Other forms of autophagy involving adapter proteins, commonly referred to as chaperone mediated autophagy, involves the selective removal of cellular cargo by the ubiquitin-proteasome pathway. The book will serve as a reference guide for basic and clinical scientists who are interested in understanding how these critical cellular processes impact the pathogenesis of human disease.