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Autophagy And Cardiometabolic Diseases

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Autophagy and Cardiometabolic Diseases

Autophagy and Cardiometabolic Diseases Book
Author : Jun Ren,James R. Sowers,Yingmei Zhang
Publisher : Academic Press
Release : 2018-04-12
ISBN : 0128054425
Language : En, Es, Fr & De

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Book Description :

Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations

Autophagy Biology and Diseases

Autophagy  Biology and Diseases Book
Author : Weidong Le
Publisher : Springer Nature
Release : 2020-07-15
ISBN : 9811542724
Language : En, Es, Fr & De

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Book Description :

This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine

Autophagy in Immune Response Impact on Cancer Immunotherapy

Autophagy in Immune Response  Impact on Cancer Immunotherapy Book
Author : Salem Chouaib
Publisher : Academic Press
Release : 2020-05
ISBN : 0128196092
Language : En, Es, Fr & De

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Book Description :

Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies.

Novel Concepts in Cardiac Energy Metabolism From Biology to Disease

Novel Concepts in Cardiac Energy Metabolism  From Biology to Disease Book
Author : Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran
Publisher : Frontiers Media SA
Release : 2019-08-08
ISBN : 2889459381
Language : En, Es, Fr & De

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Book Description :

Download Novel Concepts in Cardiac Energy Metabolism From Biology to Disease book written by Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cardiovascular Diseases Advances in Research and Treatment 2011 Edition

Cardiovascular Diseases  Advances in Research and Treatment  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464921016
Language : En, Es, Fr & De

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Book Description :

Cardiovascular Diseases: Advances in Research and Treatment: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cardiovascular Diseases. The editors have built Cardiovascular Diseases: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cardiovascular Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cardiovascular Diseases: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Handbook of Physiology The cardiovascular system

Handbook of Physiology  The cardiovascular system Book
Author : Anonim
Publisher : Unknown
Release : 1980
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Handbook of Physiology The cardiovascular system book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Medicinal Plants for Cardiovascular and Neurodegenerative Aging related Diseases From Bench to Bedside

Medicinal Plants for Cardiovascular and Neurodegenerative Aging related Diseases  From Bench to Bedside Book
Author : Yue Liu,Valentina Echeverria Moran,Youhua Xu
Publisher : Frontiers Media SA
Release : 2020-12-08
ISBN : 2889661601
Language : En, Es, Fr & De

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Book Description :

Download Medicinal Plants for Cardiovascular and Neurodegenerative Aging related Diseases From Bench to Bedside book written by Yue Liu,Valentina Echeverria Moran,Youhua Xu, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Aldehyde Dehydrogenases

Aldehyde Dehydrogenases Book
Author : Jun Ren,Yingmei Zhang,Junbo Ge
Publisher : Springer
Release : 2019-07-31
ISBN : 9811362602
Language : En, Es, Fr & De

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Book Description :

This volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes. It thoroughly reviews the roles of ALDH family in alcohol metabolism, as well as recent findings of their emerging roles in a variety of human pathologies such as cardiovascular diseases, diabetes, obesity, stroke, cancer, liver diseases and kidney diseases. Delicate contribution of ALDH enzymes in the therapeutics against chronic diseases is also discussed. It demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine. The book will appeal to scientists, physicians, graduate and professional students in the fields of ALDH enzymes, alcohol metabolism, cardiometabolic and other chronic diseases. Pharmaceutical and other companies developing new tools for cardiometabolic and chronic diseases treatment will also find this a valuable resource.

Resveratrol and Health Volume 1215

Resveratrol and Health  Volume 1215 Book
Author : Ole Vang,Dipak K. Das
Publisher : Wiley-Blackwell
Release : 2011-02-14
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume presents manuscripts stemming from the conference entitled "Resveratrol 2010: First International Conference of Resveratrol and Health," held September 13-16, 2010 in Copenhagen, Denmark"--Table of contents page.

Mitochondrial Dynamics in Cardiovascular Medicine

Mitochondrial Dynamics in Cardiovascular Medicine Book
Author : Gaetano Santulli
Publisher : Springer
Release : 2017-05-25
ISBN : 3319553305
Language : En, Es, Fr & De

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Book Description :

This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.

Mitochondrial Dysfunction and Cardiovascular Diseases

Mitochondrial Dysfunction and Cardiovascular Diseases Book
Author : Sebastiano Sciarretta,Richard N. Kitsis,Junichi Sadoshima
Publisher : Frontiers Media SA
Release : 2021-03-04
ISBN : 2889665569
Language : En, Es, Fr & De

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Book Description :

Download Mitochondrial Dysfunction and Cardiovascular Diseases book written by Sebastiano Sciarretta,Richard N. Kitsis,Junichi Sadoshima, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Reduced Autophagic Response by Oxidative Stress in Angiotensin II induced Hypertrophic H9C2 Cells Causes More Apoptotic Cell Death

The Reduced Autophagic Response by Oxidative Stress in Angiotensin II induced Hypertrophic H9C2 Cells Causes More Apoptotic Cell Death Book
Author : Anonim
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Autophagy is an important process in the pathogenesis of cardiovascular diseases, and angiotensin II (Ang II) plays a causative role in the induction of cardiomyocyte autophagy. The purpose of this study was to explore whether, under conditions of oxidative stress, levels and types of cell death were different in untreated and Ang II-treated cardiomyocytes (H9C2 cells). Treatment with 20 μM Ang II induced cardiac hypertrophy in H9C2 cells, with increased expression of the hypertrophic markers c-Fos, ß-myosin heavy chain, atrial natriuretic factor (ANF), and brain natriuretic factor (BNF). Under normal conditions, there was no difference in the levels of autophagic vacuoles and apoptotic bodies in untreated and Ang II-treated H9C2 cells. However, oxidative stress generated by 100 μM H2 O2 triggered autophagy in untreated control cells, but had a reduced effect in Ang II-induced hypertrophic cells, resulting in more cell death, and this was associated with a decrease in connexin 43 expression. Blocking this autophagic response with 3-methyladenine resulted in a significant increase in cell death and apoptosis of H9C2 cells but did not significantly affect the response of Ang II-treated cells. The autophagic response to 100 μM H2 O2 provides a survival advantage for cells and this is reduced by Ang II treatment.

Mitochondria and Their Role in Cardiovascular Disease

Mitochondria and Their Role in Cardiovascular Disease Book
Author : José Marín-García
Publisher : Springer Science & Business Media
Release : 2012-11-19
ISBN : 146144599X
Language : En, Es, Fr & De

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Book Description :

Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.

Integrative Cardiology

Integrative Cardiology Book
Author : Massimo Fioranelli
Publisher : Springer
Release : 2017-02-10
ISBN : 331940010X
Language : En, Es, Fr & De

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Book Description :

This book is a detailed guide to a new integrative approach to the prevention and treatment of various cardiac disorders and risk factors, including coronary artery disease, congestive heart failure, arrhythmias, dyslipidemia, and hypertension. This approach combines various strategies, including metabolic cardiology, low-dose medicine, exercise programs, stress management programs, evaluation for inherited risk factors, and various other healing modalities. Metabolic cardiology focuses on the prevention, management, and treatment of cardiovascular disease at the cellular level through biochemical interventions with nutritional supplements that can promote energy production in the heart. Low-dose medicine, on the other hand, interprets pathological phenomena as an imbalance in intercellular signaling that may be corrected through the administration of low physiological doses of messenger molecules. Therapies outside of mainstream medicine may also be deployed in integrative cardiology, for example acupuncture, herbal medicine, and homeopathy. Integrative Cardiology will be of interest to all practitioners wishing to learn about an approach that incorporates the incredible advances in medication and technology with a focus on nutrition, lifestyle, and mind–body influences.

Biochemical Physiological Molecular Aspects of Human Nutrition

Biochemical  Physiological    Molecular Aspects of Human Nutrition Book
Author : Martha H. Stipanuk
Publisher : Saunders
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Presents advanced nutrition in a comprehensive format ideal for graduate students in nutritional programs, organic chemistry, physiology, biochemistry and molecular biology. Focuses on the biology of human nutrition at the molecular, cellular, tissue and whole-body levels.

Indian Journal of Biochemistry Biophysics

Indian Journal of Biochemistry   Biophysics Book
Author : Anonim
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Indian Journal of Biochemistry Biophysics book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Circulation

Circulation Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Circulation book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A Rab5 Endosomal Pathway Mediates Parkin Dependent Mitochondrial Clearance

A Rab5 Endosomal Pathway Mediates Parkin Dependent Mitochondrial Clearance Book
Author : Babette Hammerling
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Mitochondria are critical for multiple cellular functions. However, damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal, and failure to do so contributes to neurodegenerative and cardiovascular diseases. Degradation of mitochondria is an important cellular quality control mechanism and is mediated by two distinct pathways: one involving Parkin-mediated autophagy and the other dependent on mitophagy receptors. Mitochondrial disposal via autophagy is dependent on damaged organelles being marked using several mechanisms including ubiquitylation by Parkin. Here I report a novel pathway for mitochondrial elimination that is dependent on functional Parkin but not on Drp1-mediated mitochondrial fission. This pathway is also distinct from Rab9- and Ulk1/2-mediated alternative autophagy. I show that mitochondria are sequestered by Rab5-positive early endosomes via the ESCRT machinery. These vesicles mature into late endosomes before delivery to lysosomes for degradation. Although this endosomal pathway is activated by stressors that also activate mitochondrial autophagy, endosomal-mediated mitochondrial clearance is initiated before autophagy. Moreover, in cells defective for autophagy, mitochondria are eliminated as promptly and completely through this endosomal pathway as in wild type cells. The autophagy protein Beclin1 regulates activation of Rab5 and endosomal-mediated degradation of mitochondria, suggesting crosstalk between these two pathways. Abrogation of Rab5 and the endosomal pathway results in the accumulation of damaged mitochondria and increases susceptibility to cell death in embryonic fibroblasts and cardiac myocytes. I also demonstrate that the mitophagy receptor BNIP3 can utilize the Rab5-endosomal pathway to clear mitochondria in cells, independent of Parkin. These data reveal a new mechanism for mitochondrial quality control mediated by Rab5 and early endosomes. Defects in this pathway could be involved in or contribute to a variety of disease states, and it may be possible to therapeutically target it in order to compensate for impaired autophagy that is a result of disease or aging.

Intermittent Fasting

Intermittent Fasting Book
Author : Melany Flores
Publisher : Unknown
Release : 2020-11-05
ISBN : 9781801141703
Language : En, Es, Fr & De

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Book Description :

Are you tired of trying diets that don't give visible results? Have you tried unsuccessfully to lose weight by following restricted dietary regimens? You're not alone! About half of Americans say that they are trying to lose weight, according to a report from the Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS). What's more, the report revealed that women are more likely trying to lose weight than males! Well, there's a solution for you! Intermittent fasting is the solution to these and many other problems, as you will find in this book. The benefits of this intermittent fasting diet include not only accelerated metabolism and subsequent weight loss but also increased resistance to disease. Intermittent fasting means that the body does not use sugars as the first source of energy, but fats, promoting a significant lowering of insulin, responsible for diseases, cardiovascular diseases, and cancer in particular. In addition, intermittent fasting promotes the production of growth hormone, thus slowing down the aging process, regulates the intestine, promotes the lowering of triglyceride levels and facilitates weight loss without a yo-yo effect. This book will teach you: What is intermittent fasting and how to do it correctly; The benefits of this particular diet; Various types of intermittent fasting, helping you to choose the one that best suits you; What foods to eat and what foods to avoid; The tricks to succeed with the intermittent fasting; Because intermittent fasting is the best diet compared to other diets; What lies behind the success of this diet. It will be explained in detail, in fact, the process of metabolic autophagy and how it can affect the well-being of your life;  Numerous advice, always supported by scientific bases, will guide you step by step to the correct execution of this great diet, helping you to achieve satisfactory results after just a few weeks! This text also contains targeted food plans for each type of INTERMITTENT FASTING, with more than 80 delicious and easy to prepare recipes!