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Download Die Entstehung der Schizophrenie book written by Manfred Bleuler,Jules Angst, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.
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The first comprehensive, multi-specialty text on ultrasound guidance in interventional procedures, this book uses the authors extensive clinical experience to provide a full overview of modern interventional ultrasound. For all practitioners, whether new to the procedures or already using them, Interventional Ultrasound offers expert advice and solutions to commonly encountered questions and problems. Special Features: Provides a complete approach to interventional ultrasound, beginning with essential basics on materials, equipment, setup requirements, informed consent issues, microbiologic aspects, and hygiene Covers specific, ultrasound-guided diagnostic and therapeutic interventions in the abdomen, thorax, urogenital tract, musculoskeletal system, thyroid and other sites, including indications, selection of materials and biopsy devices, preparation and detailed, hands-on techniques as well as management of complications Describes key recent advances, such as the use of ultrasound contrast agents in interventional procedures, adapting ultrasound transducers for endoscopic use in biopsies of the thorax and gastrointestinal tract, performing percutaneous biopsy aspiration and drainage with ultrasound, employing sonography in advanced ablative techniques and more Explores such cutting edge topics as symptom-oriented palliative care interventions, applications in critical care medicine and interventions in children Highlights, for the first time, the vital role of assisting personnel in interventional ultrasound procedures Offering easy-to-follow instructions and nearly 600 high-quality illustrations, Interventional Ultrasound takes a practical, cookbook approach ideal for daily use in the hospital or clinic. It is an indispensable reference for interventional radiologists, gastroenterologists, internists, surgeons and other specialists who need to stay up-to-date on the newest technology and applications in this rapidly advancing field.
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The last decade or so has seen remarkable advances in our knowledge of cough. This applies especially to its basic mechanisms: the types of airway sensors, the phar- cological receptors on their membranes, the brainstem organization of the ‘cough centre’, and the involvement of the cerebral cortex in the sensations and the vol- tary control of cough. With the exception of the last of these, nearly all the studies have been on experimental animals rather than humans, for obvious reasons. One group of experimental studies has particular relevance to human patients, and that is the demonstration of the sensitization of cough pathways both in the periphery and in the brainstem. Similar sensitizations have been shown for patients with chronic cough or who have been exposed to pollutants, and it is reasonable to suppose that this is the basis of their cough and that the underlying mechanisms are generally similar in humans and other species. Important advances are also being made in clinical cough research. For the three main causes of clinical cough, asthma, post-nasal drip syndrome, and gast- oesophageal re?ux disease, we are beginning to understand the pathological processes involved. There remains a diagnostically obdurate group of idiopathic chronic coughers, but even for them approaches are being devised to clarify und- lying mechanisms and to establish diagnoses. Perhaps surprisingly, the ?eld in which there has been the least spectacular - vance is the therapy of cough.
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This book is a practical resource for clinicians who manage patients with chronic cough, which represents a major challenge in the clinic due to multiple diagnostic and therapeutic considerations. Essential assessments for cough and treatable traits are described, covering the upper and lower airways and the gastrointestinal tract, and appropriate treatments are identified according to the different findings and diagnoses. Based on recent mechanistic and clinical advances, the authors also discuss novel diagnostic and therapeutic options, including pharmacological and non-pharmacological approaches to control cough. Particular considerations of importance when dealing with chronic cough in children and the elderly are addressed separately. The book will be an invaluable guide and reference for all practitioners who require up-to-date information on how best to assess, diagnose, and treat patients with chronic cough.
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Immunological Surveillance
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Download The Politics of Cancer book written by Samuel S. Epstein, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.
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Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.
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This book focuses on instrumentation of chemi- and bioluminescence and discusses the nature of chemiluminescence as the exothermic oxidation of a substrate organic compound to give an energy-rich product that is luminescent. It describes the applications of chemiluminescence.
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Obtain all the core knowledge in pain management you need from one of the most trusted resources in the field. The new edition of Practical Management of Pain gives you completely updated, multidisciplinary overview of every aspect of pain medicine, including evaluation, diagnosis of pain syndromes, rationales for management, treatment modalities, and much more. In print and online, it is all the expert guidance necessary to offer your patients the best possible relief. "In summary, this is the best explanation of what lies behind MRI that I have read, taking what can be a dry subject and making it readily understandable and really interesting. I would recommend it to anyone starting their MRI training and anyone trying to teach MRI to others." Reviewed by RAD Magazine, June 2015 Understand and apply the latest developments in pain medicine with brand-new chapters covering disability assessment, central post-stroke pain, chronic widespread pain, and burn pain. Effectively ease your patients' pain with today's best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents (such as topical analgesics). Access up-to-the-minute knowledge on all aspects of pain management, from general principles to specific management techniques, with contributions from renowned experts in the field. Read the full text and view all the images online at expertconsult.com. Understand and apply the latest developments in pain management with brand-new chapters covering disability assessment, central post-stroke pain, widespread chronic pain, and burn pain. Effectively ease your patients' pain with today's best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents (such as topical analgesics).
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Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up. Highlights include: Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agencies Authors from different major pharmaceutical and biotechnology companies Describes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market
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This completely revised successor to the Handbook of Microscopy supplies in-depth coverage of all imaging technologies from the optical to the electron and scanning techniques. Adopting a twofold approach, the book firstly presents the various technologies as such, before going on to cover the materials class by class, analyzing how the different imaging methods can be successfully applied. It covers the latest developments in techniques, such as in-situ TEM, 3D imaging in TEM and SEM, as well as a broad range of material types, including metals, alloys, ceramics, polymers, semiconductors, minerals, quasicrystals, amorphous solids, among others. The volumes are divided between methods and applications, making this both a reliable reference and handbook for chemists, physicists, biologists, materials scientists and engineers, as well as graduate students and their lecturers.
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Download Clinical Management of Chronic Obstructive Pulmonary Disease book written by William MacNee,Richard L. ZuWallack,Joseph Keenan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.
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Pathology of Infectious Diseases, by Gary W. Procop, MD, A Volume in the Foundations in Diagnostic Pathology Series, packs all of today's most essential information on infectious disease pathology into a compact, high-yield format! Well-organized and segmented by type of infectious organism, the book's pragmatic approach complemented by abundant full-color, high-quality photomicrographs and clinical photos, and at-a-glance tables makes it easy to access the information you need to quickly and accurately detect and identify pathogenic organisms. Chapters on immunohistochemical and molecular techniques as well as artifacts and pitfalls guide you to accurate detection and identifications. Quickly find the information you need thanks to a well-organized, user-friendly format with templated headings, detailed illustrations, at-a-glance tables, and segmentation by type of infectious organism—viral, bacterial, fungal, and parasitic. Avoid common problems that can lead to an incorrect diagnosis. A special section on artifacts and pitfalls shows you what to look for. Get superb visual guidance from an abundance of full-color, high-quality photomicrographs and clinical photos. Employ the latest diagnostic advancements including immunohistochemical and molecular techniques. Learn from one of the very best. Dr. Gary W. Procop, one of the most outstanding young clinical pathologists in medical microbiology in American medicine, shares his vision about how new technologies may be used to rapidly identify pathogenic organisms and detect resistance to treatment regimens. Recognized for distinguished research contributions to the discipline of clinical microbiology, he was the recipient of the 2007 American Society for Microbiology (ASM) BD Award for Research in Clinical Microbiology and elected to the American Academy of Microbiology in recognition of his scientific achievements. Implement proven diagnostic approaches such as real-time PCR assays and pepticnucleic acid probes with guidance from the pioneer of these techniques!
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This book addresses the main challenges affecting modern logistics and supply chains and is organized according to five main themes: supply chain strategy and management, information and communication technology (ICT) for logistics and related business models, vertical and horizontal collaboration, intelligent hubs (e.g. ports and cities) and policy for sustainable logistics. The key findings presented are based on both extensive research and on business cases. The book examines logistics from a comprehensive viewpoint embracing the entire supply chain. The overarching advanced logistics and supply chain concept at the heart of this book endeavors to contribute to a sustainable intelligent transport system by making it more efficient, cost-effective, safe, reliable and competitive. Specifically, the book focuses on the need for a variety of supply chain, logistics and transport options, on the potential offered by technological developments, infrastructural and organizational aspects, information flows, the financial and legal domain, harmonization and the complexity of implementation. In closing, the book presents new approaches to the coordination of sound business and governance models.
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Beginning in 1970, the International Bile Acid Meeting has taken place every two years and each time new progress in our understanding of the complex role of bile acids in many metabolic processes of the liver and the intestine has been revealed by a selected group of leading scientists from all over the world. Although originally mainly physiological data on bile acid synthesis and transport were emphasized, and later on also the therapeutic benefit of bile acids in gallstone disease and cholestasis was discovered, we have come now to the molecular biology and genetic era with major discoveries in transport defects and related diseases. This book is the proceedings of Falk Symposium No. 120, held in The Hague, The Netherlands, on October 12-13, 2000 - the 16th International Bile Acid Meeting. One of the main discoveries recently has been the identification of nuclear receptors for bile acids, which gives them a much broader perspective than previously anticipated. It even suggests that bile acids can regulate their biosynthesis and enterohepatic circulation transcriptionally. It will therefore not be surprising that this topic, together with the molecular regulation of cholesterol 7alpha-hydroxylase and cholesterol homeostasis, has a dominant place in these proceedings. Another important topic is the progress in our molecular understanding of hepatic (both at the basolateral and canalicular sites), cholangiocytic and intestinal bile acid transport processes. Further insights into genetic defects causing cholestasis or intestinal malabsorption in animal models and in human diseases are also discussed by a number of well-known authors. Finally the last section deals with new findings on the role of bile acid therapy in cholestatic syndromes or chemoprevention and with the potential benefit of bile acid inhibitors. All contributors provide an update on the most recent developments in their field.
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Download Vitamin D Deficiency and Covid 19 book written by Dr David C Anderson,Dr David S Grimes, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.
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Over 40 renowned scientists from all around the world discuss the work and influence of Werner Heisenberg. The papers result from the symposium held by the Alexander von Humboldt-Stiftung on the occasion of the 100th anniversary of Heisenberg's birth, one of the most important physicists of the 20th century and cofounder of modern-day quantum mechanics. Taking atomic and laser physics as their starting point, the scientists illustrate the impact of Heisenberg's theories on astroparticle physics, high-energy physics and string theory right up to processing quantum information.
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The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of drug metabolism in vivo: variability of psychotropic drugs, antiepileptic drugs, the dopamine precursor levodopa, cardiovascular active drugs and anti HIV drugs. Seven chapters address the interindividual variability of the main drug metabolizing enzymes: CYP-450s, acetyltransferases, glucuronosyl transferase, methyl transferases, sulfotransferases and glutathione transferases in human liver and extrahepatic tissues. A separate chapter discusses the prediction of drug interaction. Comprehensive in coverage, and with contributions from the leading international experts, this book is essential reading for researchers from both academia and the pharmaceutical industry. Advanced undergraduates and postgraduates in pharmacology, clinical pharmacology, toxicology, biochemistry and epidemiology who are interested in drug metabolism will also find this an indispensable resource.
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New essays reappraising the history of the book, manuscripts, and texts.
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Microbial physiology, biochemistry and genetics allowed the formulation of concepts that turned out to be important in the study of higher organisms. In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book. Another section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation. The next fifteen chapters deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12. The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle.