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Atlas Of Histology Of The Juvenile Rat

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Atlas of Histology of the Juvenile Rat

Atlas of Histology of the Juvenile Rat Book
Author : George A Parker,Catherine A. Picut
Publisher : Academic Press
Release : 2016-05-04
ISBN : 0128026960
Language : En, Es, Fr & De

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Book Description :

Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals. While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42. Written and edited by highly experienced, board-certified toxicologic pathologists Includes more than 700 high-resolution microscopic images from organs that are typically examined in safety assessment toxicology studies Detailed figure legends and chapter narratives present the salient features of each organ at each time interval Figures are available for further study via Elsevier’s Virtual Microscope, which allows viewing of microscopic images at higher magnification Valuable resource for toxicologic pathologists who are confronted with interpretation of lesions in juvenile rats in situations where age-matched concurrent controls are not available for comparison, e.g., with unscheduled decedents Figures are available for further study on ScienceDirect with Virtual Microscope, which allows viewing of microscopic images at higher magnification

The Laboratory Rat

The Laboratory Rat Book
Author : Mark A. Suckow,F. Claire Hankenson,Ronald P. Wilson,Patricia L. Foley
Publisher : Academic Press
Release : 2019-11-10
ISBN : 0128143398
Language : En, Es, Fr & De

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Book Description :

The third edition of The Laboratory Rat features updated information on a variety of topics, including rats as research models for basic and translational research in areas such as genomics, alcoholism, diabetes, metabolic syndrome, obesity, neuroscience, spinal cord injury, traumatic brain injury, regenerative medicine, and infectious disease. New information related to the husbandry and veterinary care of rats is provided including topics related to nutrition, reproduction, anesthesia and surgery, infectious and noninfectious disease, and the care of surgical and other fragile models. It is a premier source of information on the laboratory rat, this book will be of interest to veterinary and medical students, senior graduate students, postdocs and researchers who utilize animals in biomedical research. New chapters on the care of surgical and fragile models and on the use of rats in research areas such as alcoholism, regenerative medicine, spinal cord injury, traumatic brain injury, and others are included. All chapters were written by scientific and veterinary experts. This book condenses information from many sources on topics related to the care and use of rats in research. It is the premier source of information on the laboratory rat.

Anatomy and Histology of the Laboratory Rat in Toxicology and Biomedical Research

Anatomy and Histology of the Laboratory Rat in Toxicology and Biomedical Research Book
Author : Robert L. Maynard,Noel Downes
Publisher : Academic Press
Release : 2019-02-08
ISBN : 0128118717
Language : En, Es, Fr & De

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Book Description :

Anatomy and Histology of the Laboratory Rat in Toxicology and Biomedical Research presents the detailed systematic anatomy of the rat, with a focus on toxicological needs. Most large works dealing with the laboratory rat provide a chapter on anatomy, but fall far short of the detailed account in this book which also focuses on the needs of toxicologists and others who use the rat as a laboratory animal. The book includes detailed guides on dissection methods and the location of specific tissues in specific organ systems. Crucially, the book includes classic illustrations from Miss H. G. Q. Rowett, along with new color photo-micrographs. Written by two of the top authors in their fields, this book can be used as a reference guide and teaching aid for students and researchers in toxicology. In addition, veterinary/medical students, researchers who utilize animals in biomedical research, and researchers in zoology, comparative anatomy, physiology and pharmacology will find this book to be a great resource. Illustrated with over 100 black and white and color images to assist understanding Contains detailed descriptions and explanations to accompany all images, thus helping with self-study Designed for toxicologic research for people from diverse backgrounds, including biochemistry, pharmacology, physiology, immunology and general biomedical sciences

Boorman s Pathology of the Rat

Boorman s Pathology of the Rat Book
Author : Andrew W. Suttie,Joel R. Leininger,Alys E. Bradley
Publisher : Academic Press
Release : 2017-12-18
ISBN : 0123914892
Language : En, Es, Fr & De

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Book Description :

Boorman’s Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations. Contains full, four color photographs from the NTP archive and database and coverage of all rat strains Provides an organ-by-organ and system-by-system approach that presents standard diagnostic criteria and basic content on histology and histological changes Includes comprehensive and detailed background incidence data Presents detailed descriptive content regarding changes in rat models during research

Toxicologic Pathology for Non Pathologists

Toxicologic Pathology for Non Pathologists Book
Author : Thomas J. Steinbach,Daniel J. Patrick,Mary Ellen Cosenza
Publisher : Springer Nature
Release : 2019-10-31
ISBN : 1493997777
Language : En, Es, Fr & De

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Book Description :

This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances. Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.

Comparative Anatomy and Histology

Comparative Anatomy and Histology Book
Author : Piper M. Treuting,Suzanne M. Dintzis,Kathleen S. Montine
Publisher : Academic Press
Release : 2017-08-29
ISBN : 0128029196
Language : En, Es, Fr & De

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Book Description :

The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models of human disease. Offers the only comprehensive source for comparing mouse, rat, and human anatomy and histology through over 1500 full-color images, in one reference work Enables human and veterinary pathologists to examine tissue samples with greater accuracy and confidence Teaches biomedical researchers to examine the histologic changes in their model rodents Experts from both human and veterinary fields take readers through each organ system in a side-by-side comparative approach to anatomy and histology - human Netter anatomy images along with Netter-style rodent images

Haschek and Rousseaux s Handbook of Toxicologic Pathology

Haschek and Rousseaux s Handbook of Toxicologic Pathology Book
Author : Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig,Brad Bolon
Publisher : Academic Press
Release : 2021-10-20
ISBN : 0128218290
Language : En, Es, Fr & De

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Book Description :

Haschek and Rousseaux's Handbook of Toxicologic Pathology: Volume 1: Principles and Practice of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Volume 1 of the Fourth Edition covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Completely revised with a number of new chapters, Volume 1 of the Handbook of Toxicologic Pathology is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Provides new chapters on digital pathology, juvenile pathology, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Clinical Laboratory Animal Medicine

Clinical Laboratory Animal Medicine Book
Author : Lesley A. Colby,Megan H. Nowland,Lucy H. Kennedy
Publisher : John Wiley & Sons
Release : 2019-10-11
ISBN : 1119489598
Language : En, Es, Fr & De

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Book Description :

The revised fifth edition of Clinical Laboratory Animal Medicine: An Introduction is an accessible guide to basic information for conducting animal research safely and responsibly. It includes a review of the unique anatomic and physiologic characteristics of laboratory animals, husbandry practices, and veterinary care of many animals frequently used in research, including rodents, rabbits, ferrets, zebrafish, nonhuman primates, and agricultural animals. The updated fifth edition adds two new chapters on zebrafish and large animals, new information on transgenic models and genetic editing, and expanded coverage of environmental enrichment and pain management. The book presents helpful tip boxes, images, and review questions to aid in comprehension and learning, and a companion website provides editable review questions and answers, instructional PowerPoints, and additional images not found in the book. This important text: • Provides a complete introduction to laboratory animal husbandry, diseases, and treatments • Offers a user-friendly format with helpful content that highlights important concepts • Contains new knowledge relating to technical methodologies, diseases, drug dosages, laws and regulations, and organizations • Covers information on regulations, facilities, equipment, housing, and research variables as well as veterinary care • Includes new chapters on zebrafish and cattle, sheep, goats, and pigs Written for veterinary technicians, veterinary students, practicing veterinarians, and research scientists, the fifth edition of Clinical Laboratory Animal Medicine continues to offer an essential guide to the ethical treatment and anatomic and physiological characteristics of research animals.

Comprehensive Toxicology

Comprehensive Toxicology Book
Author : Anonim
Publisher : Elsevier
Release : 2017-12-01
ISBN : 0081006128
Language : En, Es, Fr & De

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Book Description :

Comprehensive Toxicology, Third Edition, discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts

Reproductive and Developmental Toxicology

Reproductive and Developmental Toxicology Book
Author : Ramesh C. Gupta
Publisher : Academic Press
Release : 2022-03-31
ISBN : 0323915604
Language : En, Es, Fr & De

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Book Description :

Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis Includes new chapters on developments in systems toxicology and predictive modeling of male developmental toxicity, adverse outcome pathways in reproductive and developmental toxicology, ovarian and endometrial toxicity, developmental neurotoxicity of air pollution, and more

Immunopathology in Toxicology and Drug Development

Immunopathology in Toxicology and Drug Development Book
Author : George A. Parker
Publisher : Springer
Release : 2017-03-28
ISBN : 3319473778
Language : En, Es, Fr & De

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Book Description :

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

Toxicologic Pathology

Toxicologic Pathology Book
Author : Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath,Page Bouchard
Publisher : CRC Press
Release : 2018-08-31
ISBN : 0429997450
Language : En, Es, Fr & De

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Book Description :

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk. Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions. The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.

Medical and Surgical Management of Ocular Surface Disease in Exotic Animals An Issue of Veterinary Clinics of North America Exotic Animal Practice Ebook

Medical and Surgical Management of Ocular Surface Disease in Exotic Animals  An Issue of Veterinary Clinics of North America  Exotic Animal Practice  Ebook Book
Author : Sarah L. Czerwinski
Publisher : Elsevier Health Sciences
Release : 2018-11-21
ISBN : 0323655084
Language : En, Es, Fr & De

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Book Description :

This issue of Veterinary Clinics: Exotic Animal Practice, Guest Edited by Dr. Sarah Czerwinski, is devoted to the Medical and Surgical Management of Ocular Surface Disease in Exotic Animals. Dr. Czerwinski has assembled a list of articles that covers ocular surface disease in a wide range of animals, including: Rabbits; Rodents (Guinea pigs, mice, rats, and chinchillas); Ferrets; Marine mammals; Birds; New world camelids; Fish; Amphibians; and Reptiles (crocodilians, lizards, chelonians, and snakes).

Pathology of Genetically Engineered and Other Mutant Mice

Pathology of Genetically Engineered and Other Mutant Mice Book
Author : John P. Sundberg,Peter Vogel,Jerrold M. Ward
Publisher : John Wiley & Sons
Release : 2022-01-26
ISBN : 1119624576
Language : En, Es, Fr & De

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Book Description :

An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

The Mouse Brain in Stereotaxic Coordinates

The Mouse Brain in Stereotaxic Coordinates Book
Author : George Paxinos,Keith B. J. Franklin
Publisher : Gulf Professional Publishing
Release : 2004
ISBN : 9780125476409
Language : En, Es, Fr & De

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Book Description :

The Mouse Brain in Stereotaxic Coordinates, Second Edition has been the acknowledged reference in this field since the publication of the first edition, and is now available in a Compact Edition. This will provide a more affordable option for students, as well as researchers needing an additional lab atlas. This version includes the coronal diagrams delineating the entire brain as well as the introductory text from the Deluxe edition. It is an essential reference for anyone studying the mouse brain or related species. * Includes 100 detailed diagrams of the coronal set delineating the entire mouse brain * Compact edition of the most comprehensive and accurate mouse brain atlas available * Contains minor updates and revisions from the full edition

The Laboratory Rat

The Laboratory Rat Book
Author : Henry J. Baker,J. Russell Lindsey,Steven H. Wesibroth
Publisher : Elsevier
Release : 2013-10-02
ISBN : 1483268616
Language : En, Es, Fr & De

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Book Description :

The Laboratory Rat, Volume I: Biology and Diseases focuses on the use of rats in specific areas of research, ranging from dental research to toxicology. The first part of this book retraces the biomedical history of early events and personalities involved in the establishment of rats as a leading laboratory animal. The taxonomy, genetics and inbred strains of rats are also elaborated. The next chapters illustrate the hematology, clinical biochemistry, and anatomical and physiological features of the laboratory rat. This text concludes with a description of infectious diseases that may be contracted from laboratory and/or wild rats. This volume is a good source for commercial and institutional organizations involved in producing rats for research use, specialists in laboratory animal, animal care and research technicians, as well as students in graduate and professional curricula.

Comparative Anatomy of the Mouse and the Rat

Comparative Anatomy of the Mouse and the Rat Book
Author : Gheorghe M. Constantinescu,Cynthia Besch-Williford, DVM Ph.D.
Publisher : CRC Press
Release : 2018-04-05
ISBN : 9781138624030
Language : En, Es, Fr & De

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Book Description :

Key features: Beautifully illustrated with detailed, full-colour images - very user-friendly for investigators, students, and technicians who work with animals Provides essential information for research and clinical purposes, describing some structures not usually shown in any other anatomy atlas In each set of illustrations, the same view is depicted in the mouse and the rat for easy comparison Text draws attention to the anatomical features which are important for supporting the care and use of these animals in research Endorsed by the American Association of Laboratory Animal Science (AALAS) Comparative Anatomy of the Mouse and Rat: a Color Atlas and Text provides detailed comparative anatomical information for those who work with mice and rats in animal research. Information is provided about the anatomical features and landmarks for conducting a physical examination, collecting biological samples, making injections of therapeutic and experimental materials, using imaging modalities, and performing surgeries.

The Laboratory Rat Second Edition

The Laboratory Rat  Second Edition Book
Author : Patrick Sharp,Jason S. Villano
Publisher : CRC Press
Release : 2012-12-11
ISBN : 1439829861
Language : En, Es, Fr & De

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Book Description :

Rats have long been recognized as a valuable biomedical research model, notably in the investigation of aging, toxicology, addiction, and common human diseases such as diabetes and hypertension. In many instances, individuals conducting such research studies are charged with important responsibilities, including animal facility management, animal husbandry, veterinary care, regulatory compliance, and various experimental methodologies. With the advent of genetic manipulations and biomedical research technological advances such as bioimaging, the versatility and usefulness of the rat as an animal model has soared. The Laboratory Rat, Second Edition captures the multiple advances in this important animal model’s husbandry, veterinary care, and experimental methodology. This edition features augmented, expanded, and novel information on biology, anesthesia, analgesia, and experimental techniques benefiting personnel working with rats—from the animal care staff to the researcher and everyone in between. The book is also extremely useful to institutional animal care and use program supporters and elements, including animal care and use committees, institutional officials, occupational health and safety professionals, veterinary technicians, and veterinarians.

Atlas of Head and Neck Pathology E Book

Atlas of Head and Neck Pathology E Book Book
Author : Bruce M. Wenig
Publisher : Elsevier Health Sciences
Release : 2015-06-09
ISBN : 1455733814
Language : En, Es, Fr & De

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Book Description :

Atlas of Head and Neck Pathology delivers authoritative, highly visual guidance for effectively and accurately diagnosing a wide range of head and neck problems. This comprehensive resource features extensive, high-quality images depicting the histologic, immunohistochemical, cytologic, and diagnostic imaging appearance of every type of head and neck pathology. With a consistent, practical organization and succinct, bulleted format, the Atlas continues to be the resource general pathologists and specialists count on for reliable, easy-to-find answers. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Reach accurate diagnostic conclusions easily with a consistent, user-friendly format that explores each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations. Glean all essential, current, need-to-know information with sweeping revisions that include additional images shown in the frozen section, more content on odontogenic lesions and neoplasms, and inclusion of newly described entities such as igG-associated salivary gland diseases, mammary analog secretory carcinoma, and more. Review expanded coverage of critical areas with additional chapters on oral cavity and oropharynx, nasopharynx, and neck. Apply the most current staging of cancers from College of American Pathologists (TNM) and American Joint Committee on Cancer (AJCC).

A Practical Guide to the Histology of the Mouse

A Practical Guide to the Histology of the Mouse Book
Author : Cheryl L. Scudamore
Publisher : John Wiley & Sons
Release : 2014-02-10
ISBN : 1119941202
Language : En, Es, Fr & De

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Book Description :

A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues. This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions. This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology. Written by experienced pathologists and specifically tailored to the needs of scientists and histologists Full colour throughout Provides advice on sampling tissues, necropsy and recording data Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation