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Atlas Of Early Zebrafish Brain Development

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Atlas of Early Zebrafish Brain Development

Atlas of Early Zebrafish Brain Development Book
Author : Dr. Thomas Mueller,Mario Wullimann
Publisher : Academic Press
Release : 2015-11-18
ISBN : 0124172865
Language : En, Es, Fr & De

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Book Description :

Atlas of Early Zebrafish Brain Development: A Tool for Molecular Neurogenetics, Second Edition, remains the only neuroanatomical expression atlas of important genetic and immunohistochemical markers of this vertebrate model system. It represents a key reference and interpretation matrix for analyzing expression domains of genes involved in Zebrafish brain development and neurogenesis, and serves as a continuing milestone in this research area. This updated volume provides in-situ hybridized and immunostained preparations of complete series of brain sections, revealing markers of the fundamental stages in the life history of neuronal cells in very high quality preparations and photographic plates. Specific additions to this edition include documentation on the distribution of neurons expressing GABA, dopamine and serotonin, material on the basal ganglia, hypothalamus, and the caudal, segmented part of the diencephalon, new theories on the early organization of the telencephalon and thalamus, and integration of a comparative perspective on the mid- and hindbrain. Documentation on the distribution of neurons expressing GABA, dopamine and serotonin Material on the basal ganglia, hypothalamus, and the caudal, segmented part of the diencephalon New theories about the early organization of the telencephalon and thalamus Integration of a comparative perspective on the mid- and hindbrain

Atlas of Early Zebrafish Brain Development

Atlas of Early Zebrafish Brain Development Book
Author : Thomas Mueller,Mario F. Wullimann
Publisher : Gulf Professional Publishing
Release : 2005-08-08
ISBN : 9780444517388
Language : En, Es, Fr & De

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Book Description :

The Atlas of Early Zebrafish Brain Development is the first neuroanatomical expression atlas of important genetic and immunohistochemical markers of a vertebrate model system. In-situ hybridized and immunostained preparations of complete series of brain sections reveal markers of the fundamental stages in the life history of neuronal cells (proliferation/determination, migration and neuronal differentiation) in very high quality preparations and photographic plates. Early brain organization is vividly demonstrated and local variations in brain development are shown in a holistic view. This book represents a key reference and interpretation matrix to analyze expression domains of genes involved in Zebrafish brain development and neurogenesis and thus represents a milestone in this research area. There is simply no alternative source for combined neuroanatomical and gene expression data in the Zebrafish at this level of detail. The book introduces the reader to the field and shows principles of vertebrate brain development and neurogenesis. It will also be of great value to investigators of other model organisms such as frog, chick and mouse.

Atlas of Zebrafish Development

Atlas of Zebrafish Development Book
Author : Robert Bryson-Richardson,Silke Berger,Peter Currie
Publisher : Academic Press
Release : 2012
ISBN : 0123740169
Language : En, Es, Fr & De

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Book Description :

Zebrafish are widely considered an excellent model system for vertebrate development. The embryo is transparent, thereby enabling visualization and use of labelling and transgenic approaches. Moreover, because of the ease of inducing new mutations in zebrafish and similarity with the human genome, this organism may be used effectively for disease studies. For example, mutant zebrafish are being utilized for testing drugs that will combat a range of human diseases, from Alzheimer's and cancer to kidney failure and congenital heart disease. For the first time, this atlas provides the research community with a complete reference for zebrafish anatomy spanning the early embryo all the way to adulthood. The authors employ the technique of optical projection tomography (OPT), and offer a series of sections in multiple planes from each sample. The contents are organized by developmental stages, with over 200 images that contain annotations describing anatomical structures relevant to development. In addition, chapters feature explanatory text that highlights major developments in the zebrafish during each stage. * Provides the first comprehensive anatomical resource that covers all regions of zebrafish anatomy from the larval period to adulthood. * The over 200 images include explanatory notes * Each chapter contains a concise description of key anatomical features that factor in zebrafish development * Despite many years of use as a model system, until now there has never been a guide to zebrafish at the larval stage. * The book's website contains a database of over 10k sections from different regions as well as 3D images that are interactive.

Neuroanatomy of the Zebrafish Brain

Neuroanatomy of the Zebrafish Brain Book
Author : Mario F. Wulliman,Barbara Rupp,Heinrich Reichert
Publisher : Birkhäuser
Release : 1997-03-14
ISBN : 9783034898522
Language : En, Es, Fr & De

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Book Description :

gene-expression patterns in the zebrafish correspond well The zebrafish belongs to the teleostean family of with the neuromeric model of Puelles and Rubenstein cyprinids (minnows), which includes other neurobiologi­ (1993) is very encouraging for further research in this cally well investigated species such as goldfish (Carassius model system, which holds the promise of revealing fun­ auratus) and carp (e. g. Cyprinus carpio). damental neurogenetic patterns and mechanisms in ver­ In a recent taxonomic revision (Barman, 1991), all spe­ tebrates. cies of the genus Brachydanio were reassigned to the genus Danio. Thus, the current species designation of the zebrafish is Danio (formerly Brachydanio) rerio (Hamil­ ton-Buchanan, 1822). As a cyprinid, the zebrafish belongs Generation of zebrafish mutants via saturation mutagenesis to the large group of ostariophysan teleosts (6000 species, The goal of saturation mutagenesis is to identify most - if Lauder and Liem, 1983). Most ostariophysans are charac­ not all- genes affecting early animal development and to terized by a sophisticated apparatus - the Weberian ossi­ understand their hierarchical, regulative role during de­ des - to transmit sound from the swim bladder to the velopment (for reviews, see: Mullins and Ntisslein-Vol­ inner ear. The ostariophysans belong to the most derived hard, 1993; Solnica-Krezel et aI. , 1994). This approach has group of teleosts, the euteleosts (17000 species), which recently been applied to the zebrafish system, and the re­ have three more basic teleostean outgroups, the oste­ sults are impressive.

Neuroanatomy of the Zebrafish Brain

Neuroanatomy of the Zebrafish Brain Book
Author : Mario F. Wulliman,Barbara Rupp,Heinrich Reichert
Publisher : Birkhäuser
Release : 2012-12-06
ISBN : 3034889798
Language : En, Es, Fr & De

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Book Description :

Download Neuroanatomy of the Zebrafish Brain book written by Mario F. Wulliman,Barbara Rupp,Heinrich Reichert, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Behavioral and Neural Genetics of Zebrafish

Behavioral and Neural Genetics of Zebrafish Book
Author : Robert T. Gerlai
Publisher : Academic Press
Release : 2020-04-03
ISBN : 012817529X
Language : En, Es, Fr & De

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Book Description :

Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics

Development and Engineering of Dopamine Neurons

Development and Engineering of Dopamine Neurons Book
Author : Jeroen Pasterkamp,Marten P. Smidt,J. Peter H. Burbach
Publisher : Springer Science & Business Media
Release : 2009-12-16
ISBN : 1441903224
Language : En, Es, Fr & De

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Book Description :

Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.

The world according to zebrafish How neural circuits generate behaviour

The world according to zebrafish  How neural circuits generate behaviour Book
Author : Gonzalo G. De Polavieja,German Sumbre
Publisher : Frontiers E-books
Release : 2014-11-07
ISBN : 2889193284
Language : En, Es, Fr & De

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Book Description :

Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.

Evolution of Nervous Systems

Evolution of Nervous Systems Book
Author : Anonim
Publisher : Academic Press
Release : 2016-11-23
ISBN : 0128040963
Language : En, Es, Fr & De

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Book Description :

Evolution of Nervous Systems, Second Edition is a unique, major reference which offers the gold standard for those interested both in evolution and nervous systems. All biology only makes sense when seen in the light of evolution, and this is especially true for the nervous system. All animals have nervous systems that mediate their behaviors, many of them species specific, yet these nervous systems all evolved from the simple nervous system of a common ancestor. To understand these nervous systems, we need to know how they vary and how this variation emerged in evolution. In the first edition of this important reference work, over 100 distinguished neuroscientists assembled the current state-of-the-art knowledge on how nervous systems have evolved throughout the animal kingdom. This second edition remains rich in detail and broad in scope, outlining the changes in brain and nervous system organization that occurred from the first invertebrates and vertebrates, to present day fishes, reptiles, birds, mammals, and especially primates, including humans. The book also includes wholly new content, fully updating the chapters in the previous edition and offering brand new content on current developments in the field. Each of the volumes has been carefully restructured to offer expanded coverage of non-mammalian taxa, mammals, primates, and the human nervous system. The basic principles of brain evolution are discussed, as are mechanisms of change. The reader can select from chapters on highly specific topics or those that provide an overview of current thinking and approaches, making this an indispensable work for students and researchers alike. Presents a broad range of topics, ranging from genetic control of development in invertebrates, to human cognition, offering a one-stop resource for the evolution of nervous systems throughout the animal kingdom Incorporates the expertise of over 100 outstanding investigators who provide their conclusions in the context of the latest experimental results Presents areas of disagreement and consensus views that provide a holistic view of the subjects under discussion

An Adult Zebrafish Brain Atlas to Investigate Shh Mediated Cell cell Signaling in Neurogenic Zones

An Adult Zebrafish Brain Atlas to Investigate Shh Mediated Cell cell Signaling in Neurogenic Zones Book
Author : Alyssa P. Lutservitz
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Adult neurogenesis occurs in proliferative zones of the brain that contain neural progenitor cell populations capable of differentiating into specific cell types. However, we remain limited in our understanding of the signals that regulate neural progenitor cell proliferation and differentiation in adults. Recently zebrafish (Danio rerio) have emerged as an excellent model for studying the molecular mechanisms behind adult neurogenesis, because sixteen proliferative zones remain active in the adult brains. Thousands of fluorescent transgenic reporter lines have been generated in zebrafish that reveal gene expression patterns of cell-cell signaling systems, some of which may regulate neurogenesis in these brain regions. Using a new tissue clearing technique and whole brain imaging with fluorescent light sheet microscopy (FLSM) we have generated the first 3-Dimensional atlas of gene expression in an intact adult zebrafish brain. So far we have created a reference brain image and have aligned the expression patterns from three transgenic lines. This work is a preliminary step in the generation of a new, open access brain atlas called the Zebrafish Adult Brain Browser (ZABB). While generating this atlas we focused on documenting the adult brain regions responsive to Sonic Hedgehog (Shh), a cell-cell signaling system known to regulate neurogenesis during embryonic development. We used two Shh-reporter lines to create another atlas comparing reporter transgene expression in whole brain and sectioned tissue to the expression of the Hedgehog (Hh) target gene ptch2 using in situ hybridization. We show that the reporter lines reveal different Hh responsive domains, but together identify fourteen Hh responsive regions in the brain, nine of which are known proliferative zones. Thus, it appears that subsets of both proliferating neural progenitors and non-proliferative cells remain Hh responsive in adult brains. Our data suggests that Hh signaling contributes to the regulation of neural progenitor cells in nine of the sixteen proliferative zones. Uncovering the molecular mechanisms behind adult neurogenesis and forming a greater understanding of adult neural stem cell regulation has the potential to influence the treatment of many neurodegenerative diseases and cancers.

The Superior Colliculus Tectum Cell Types Circuits Computations Behaviors

The Superior Colliculus Tectum  Cell Types  Circuits  Computations  Behaviors Book
Author : Karl Farrow,Tadashi Isa,Harald Luksch,Keisuke Yonehara,
Publisher : Frontiers Media SA
Release : 2019-08-16
ISBN : 2889459713
Language : En, Es, Fr & De

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Book Description :

Download The Superior Colliculus Tectum Cell Types Circuits Computations Behaviors book written by Karl Farrow,Tadashi Isa,Harald Luksch,Keisuke Yonehara,, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Zic Gene Regulation and Function in Zebrafish Brain Development

Zic Gene Regulation and Function in Zebrafish Brain Development Book
Author : Molly K. Nyholm
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Zic Gene Regulation and Function in Zebrafish Brain Development book written by Molly K. Nyholm, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Adaptive Function and Brain Evolution

Adaptive Function and Brain Evolution Book
Author : Agustín González,Fernando Martinez-Garcia,Luis Puelles,Hans J Ten Donkelaar
Publisher : Frontiers E-books
Release : 2014-10-27
ISBN : 2889193063
Language : En, Es, Fr & De

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Book Description :

The brain of each animal shows specific traits that reflect its phylogenetic history and its particular lifestyle. Therefore, comparing brains is not just a mere intellectual exercise, but it helps understanding how the brain allows adaptive behavioural strategies to face an ever-changing world and how this complex organ has evolved during phylogeny, giving rise to complex mental processes in humans and other animals. These questions attracted scientists since the times of Santiago Ramon y Cajal one of the founders of comparative neurobiology. In the last decade, this discipline has undergone a true revolution due to the analysis of expression patterns of morphogenetic genes in embryos of different animals. The papers of this e-book are good examples of modern comparative neurobiology, which mainly focuses on the following four Grand Questions: a) How are different brains built during ontogeny? b) What is the anatomical organization of mature brains and how can they be compared? c) How do brains work to accomplish their function of ensuring survival and, ultimately, reproductive success? d) How have brains evolved during phylogeny? The title of this e-book, Adaptive Function and Brain Evolution, stresses the importance of comparative studies to understand brain function and, the reverse, of considering brain function to properly understand brain evolution. These issues should be taken into account when using animals in the research of mental function and dysfunction, and are fundamental to understand the origins of the human mind.

Flow Sensing in Air and Water

Flow Sensing in Air and Water Book
Author : Horst Bleckmann,Joachim Mogdans,Sheryl L. Coombs
Publisher : Springer Science & Business Media
Release : 2014-01-22
ISBN : 364241446X
Language : En, Es, Fr & De

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Book Description :

In this book, leading scientists in the fields of sensory biology, neuroscience, physics and engineering explore the basic operational principles and behavioral uses of flow sensing in animals and how they might be applied to engineering applications such as autonomous control of underwater or aerial vehicles. Although humans possess no flow-sensing abilities, countless aquatic (e.g. fish, cephalopods and seals), terrestrial (e.g. crickets and spiders) and aerial (e.g. bats) animals have flow sensing abilities that underlie remarkable behavioral feats. These include the ability to follow silent hydrodynamic trails long after the trailblazer has left the scene, to form hydrodynamic images of their environment in total darkness, and to swim or fly efficiently and effortlessly in the face of destabilizing currents and winds.

The rights and wrongs of zebrafish Behavioral phenotyping of zebrafish

The rights and wrongs of zebrafish  Behavioral phenotyping of zebrafish Book
Author : Allan V. Kalueff
Publisher : Springer
Release : 2017-02-06
ISBN : 3319337742
Language : En, Es, Fr & De

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Book Description :

Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans (~75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally). Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book “The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling” explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes. The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.

New Insights Into Adult Neurogenesis and Neurodegeneration Challenges for Brain Repair

New Insights Into Adult Neurogenesis and Neurodegeneration  Challenges for Brain Repair Book
Author : Jose Angel Morales-Garcia,Naoko Kaneko,Vicente Herranz-Pérez
Publisher : Frontiers Media SA
Release : 2022-04-04
ISBN : 2889749088
Language : En, Es, Fr & De

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Book Description :

Download New Insights Into Adult Neurogenesis and Neurodegeneration Challenges for Brain Repair book written by Jose Angel Morales-Garcia,Naoko Kaneko,Vicente Herranz-Pérez, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Intrinsic and Extrinsic Contributions to the Development of the Zebrafish Olfactory Epithelium

Intrinsic and Extrinsic Contributions to the Development of the Zebrafish Olfactory Epithelium Book
Author : Maegan Veronica Rivard Harden
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

I have used the zebrafish, Danio rerio to study the following stages of olfactory sensory system development: the cell movements underlying olfactory placode (OP) formation, environmentally induced gene expression changes in the differentiating OP and modulation of gene expression changes in sensory neuron development.

Building Brains

Building Brains Book
Author : David Price,Andrew P. Jarman,John O. Mason,Peter C. Kind
Publisher : John Wiley & Sons
Release : 2011-04-04
ISBN : 0470979887
Language : En, Es, Fr & De

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Book Description :

Download Building Brains book written by David Price,Andrew P. Jarman,John O. Mason,Peter C. Kind, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Neuronal Ceroid Lipofuscinoses Batten Disease

The Neuronal Ceroid Lipofuscinoses  Batten Disease  Book
Author : Sara Mole,Ruth Williams,Hans Goebel
Publisher : OUP Oxford
Release : 2011-03-10
ISBN : 019101558X
Language : En, Es, Fr & De

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Book Description :

The neuronal ceroid lipofuscinoses are an extremely rare group of inherited neurodegenerative diseases that primarily affect children. Core symptoms of these conditions typically include epilepsy, cognitive decline and visual failure. These diseases are so rare that professionals who come into contact with them need a consultative reference work that enables them to become expert, or identify who to contact for more details. Fully updated and revised, this second edition continues to be the definitive volume on this devastating group of disorders. Written by an international collection of authorities in the field, it provides invaluable advice on their diagnosis, patient care, and new treatments that are available. This new edition of the definitive reference text on the neuronal ceroid lipofuscinoses will prove useful for clinicians, family physicians, research scientists, diagnostic laboratories, families affected by the disease as well as by workers in industry planning translational research.

Biology of the NMDA Receptor

Biology of the NMDA Receptor Book
Author : Antonius M. VanDongen
Publisher : CRC Press
Release : 2008-10-29
ISBN : 9781420044157
Language : En, Es, Fr & De

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Book Description :

The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world’s leading authorities on NMDA receptors, Biology of the NMDA Receptor brings together virtually all the players in this important field.