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Asymmetric Metal Catalysis In Enantioselective Domino Reactions

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Asymmetric Metal Catalysis in Enantioselective Domino Reactions

Asymmetric Metal Catalysis in Enantioselective Domino Reactions Book
Author : Helene Pellissier
Publisher : John Wiley & Sons
Release : 2019-08-02
ISBN : 3527822518
Language : En, Es, Fr & De

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Book Description :

Introduces an innovative and outstanding tool for the easy synthesis of complex chiral structures in a single step Covering all of the literature since the beginning of 2006, this must-have book for chemists collects the major progress in the field of enantioselective one-, two-, and multicomponent domino reactions promoted by chiral metal catalysts. It clearly illustrates how enantioselective metal-catalyzed processes constitute outstanding tools for the development of a wide variety of fascinating one-pot asymmetric domino reactions, thereby allowing many complex products to be easily generated from simple materials in one step. The book also strictly follows the definition of domino reactions by Tietze as single-, two-, as well as multicomponent transformations. Asymmetric Metal Catalysis in Enantioselective Domino Reactions is divided into twelve chapters, dealing with enantioselective copper-, palladium-, rhodium-, scandium-, silver-, nickel-, gold-, magnesium-, cobalt-, zinc-, yttrium and ytterbium-, and other metal-catalyzed domino reactions. Most of the chapters are divided into two parts dealing successively with one- and two-component domino reactions, and three-component processes. Each part is subdivided according to the nature of domino reactions. Each chapter of the book includes selected applications of synthetic methodologies to prepare natural and biologically active products. -Presents the novel combination of asymmetric metal catalysis with the concept of fascinating domino reactions, which allows high molecular complexity with a remarkable level of enantioselectivity -Showcases an incredible tool synthesizing complex and diverse chiral structures in a single reaction step -Includes applications in total synthesis of natural products and biologically active compounds -Written by a renowned international specialist in the field -Stimulates the design of novel asymmetric domino reactions and their use in the synthesis of natural products, pharmaceuticals, agrochemicals, and materials Asymmetric Metal Catalysis in Enantioselective Domino Reactions will be of high interest to synthetic, organic, medicinal, and catalytic chemists in academia and R&D departments.

Asymmetric Metal Catalysis in Enantioselective Domino Reactions

Asymmetric Metal Catalysis in Enantioselective Domino Reactions Book
Author : Hélène Pellissier
Publisher : Unknown
Release : 2019
ISBN : 9783527822539
Language : En, Es, Fr & De

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Book Description :

Introduces an innovative and outstanding tool for the easy synthesis of complex chiral structures in a single step Covering all of the literature since the beginning of 2006, this must-have book for chemists collects the major progress in the field of enantioselective one-, two-, and multicomponent domino reactions promoted by chiral metal catalysts. It clearly illustrates how enantioselective metal-catalyzed processes constitute outstanding tools for the development of a wide variety of fascinating one-pot asymmetric domino reactions, thereby allowing many complex products to be easily generated from simple materials in one step. The book also strictly follows the definition of domino reactions by Tietze as single-, two-, as well as multicomponent transformations. Asymmetric Metal Catalysis in Enantioselective Domino Reactions is divided into twelve chapters, dealing with enantioselective copper-, palladium-, rhodium-, scandium-, silver-, nickel-, gold-, magnesium-, cobalt-, zinc-, yttrium and ytterbium-, and other metal-catalyzed domino reactions. Most of the chapters are divided into two parts dealing successively with one- and two-component domino reactions, and three-component processes. Each part is subdivided according to the nature of domino reactions. Each chapter of the book includes selected applications of synthetic methodologies to prepare natural and biologically active products.-Presents the novel combination of asymmetric metal catalysis with the concept of fascinating domino reactions, which allows high molecular complexity with a remarkable level of enantioselectivity -Showcases an incredible tool synthesizing complex and diverse chiral structures in a single reaction step -Includes applications in total synthesis of natural products and biologically active compounds -Written by a renowned international specialist in the field -Stimulates the design of novel asymmetric domino reactions and their use in the synthesis of natural products, pharmaceuticals, agrochemicals, and materials Asymmetric Metal Catalysis in Enantioselective Domino Reactions will be of high interest to synthetic, organic, medicinal, and catalytic chemists in academia and R & D departments.

Asymmetric Domino Reactions

Asymmetric Domino Reactions Book
Author : Hélène Pellissier
Publisher : Royal Society of Chemistry
Release : 2013-03-13
ISBN : 1849736510
Language : En, Es, Fr & De

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Book Description :

This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings in solvent, time, energy, and costs. Unsurprisingly, the high levels of efficiency and enantioselectivity generally reached in these reactions have been exploited for the production of a wide number of complex chiral molecules with dense stereochemistry and functionality, which are motifs present in biologically active compounds and natural products. The book is divided into three principal sections, dealing successively with asymmetric domino reactions based on the use of chiral auxiliaries, asymmetric domino reactions based on the use of chiral metal catalysts, and asymmetric domino reactions based on the use of chiral organocatalysts, covering the literature since the beginning of 2006try{F5_flush(document);}catch(e){}

Asymmetric Metal Catalysis in Enantioselective Domino Reactions

Asymmetric Metal Catalysis in Enantioselective Domino Reactions Book
Author : Helene Pellissier
Publisher : John Wiley & Sons
Release : 2019-10-07
ISBN : 3527346198
Language : En, Es, Fr & De

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Book Description :

Introduces an innovative and outstanding tool for the easy synthesis of complex chiral structures in a single step Covering all of the literature since the beginning of 2006, this must-have book for chemists collects the major progress in the field of enantioselective one-, two-, and multicomponent domino reactions promoted by chiral metal catalysts. It clearly illustrates how enantioselective metal-catalyzed processes constitute outstanding tools for the development of a wide variety of fascinating one-pot asymmetric domino reactions, thereby allowing many complex products to be easily generated from simple materials in one step. The book also strictly follows the definition of domino reactions by Tietze as single-, two-, as well as multicomponent transformations. Asymmetric Metal Catalysis in Enantioselective Domino Reactions is divided into twelve chapters, dealing with enantioselective copper-, palladium-, rhodium-, scandium-, silver-, nickel-, gold-, magnesium-, cobalt-, zinc-, yttrium and ytterbium-, and other metal-catalyzed domino reactions. Most of the chapters are divided into two parts dealing successively with one- and two-component domino reactions, and three-component processes. Each part is subdivided according to the nature of domino reactions. Each chapter of the book includes selected applications of synthetic methodologies to prepare natural and biologically active products. -Presents the novel combination of asymmetric metal catalysis with the concept of fascinating domino reactions, which allows high molecular complexity with a remarkable level of enantioselectivity -Showcases an incredible tool synthesizing complex and diverse chiral structures in a single reaction step -Includes applications in total synthesis of natural products and biologically active compounds -Written by a renowned international specialist in the field -Stimulates the design of novel asymmetric domino reactions and their use in the synthesis of natural products, pharmaceuticals, agrochemicals, and materials Asymmetric Metal Catalysis in Enantioselective Domino Reactions will be of high interest to synthetic, organic, medicinal, and catalytic chemists in academia and R&D departments.

Enantioselective Multicatalysed Tandem Reactions

Enantioselective Multicatalysed Tandem Reactions Book
Author : Helene Pellissier
Publisher : Royal Society of Chemistry
Release : 2014-08-19
ISBN : 1782621350
Language : En, Es, Fr & De

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Book Description :

Chiral molecules are needed for the production of many pharmaceuticals and materials, and catalytic asymmetric synthesis provides a method for the preparation of such chiral products. For the synthesis of complex molecules, such as natural products and biologically active compounds, more than one catalytic reaction may be necessary and tandem catalysis refers to the combination of catalytic reactions into one synthesis. By combing catalysts it enables a more efficient, economical and selective one pot approach for complex molecule synthesis which could not be achieved through single specific catalytic systems. The challenge is finding the right catalyst which is compatible with other catalysts but also tolerates reagents, solvent and intermediates generated during the course of the reaction. Enantioselective Multicatalysed Tandem Reactions provides an overview of recent developments in the area. The first part of the book covers asymmetric tandem reactions catalysed by multiple catalysts from the same discipline (organocatalysts, two metal and multienzyme-catalysed reactions). The second part looks at tandem reactions catalysed by multiple catalysts from different disciplines including reactions catalysed by a combination of metals and organocatalysts, reactions catalysed by a combination of metals and enzymes, and finally reactions catalysed by a combination of organocatalysts and enzymes. The book will appeal to researchers and professionals in academic and industrial laboratories interested in catalysis, biocatalysis and organic synthesis of chiral compounds.

Enantioselective Cobalt catalysed Transformations

Enantioselective Cobalt catalysed Transformations Book
Author : Hélène Pellissier
Publisher : Royal Society of Chemistry
Release : 2018-08-15
ISBN : 1788015096
Language : En, Es, Fr & De

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Book Description :

With a foreword from leading organic chemist Professor Paul Wender, this book collects the major developments reported in the past thirty years in the field of enantioselective reactions promoted by chiral cobalt catalysts, illustrating the power of these green catalysts to provide all types of organic reactions from the basic to completely novel methodologies. The search for new methodologies to prepare optically pure products is one of the most active areas of research in organic synthesis. Of the methods available for preparing chiral compounds, catalytic asymmetric synthesis has attracted the most attention. In particular, asymmetric transition-metal catalysis is a powerful tool for performing reactions in a highly enantioselective fashion. Efforts to develop new asymmetric transformations have previously focused on the use of rare metals such as titanium, palladium, iridium and gold. However, the ever-growing need for environmentally friendly catalytic processes has prompted chemists to focus on the more abundant and less toxic first-row transition metals, such as cobalt, to develop new catalytic systems. The ability of cobalt catalysts to adopt unexpected reaction pathways has led to an impressive number of enantioselective cobalt-promoted transformations being developed over the past three decades. These have included the synthesis of many different types of products, often under relatively mild conditions and with remarkable enantioselectivities. This book is a useful reference resource for chemists, both academic and industrial, working in organic synthesis and interested in greener or more economical catalytic alternatives.

Synthesis of Heterocycles via Metal Catalyzed Reactions that Generate One or More Carbon Heteroatom Bonds

Synthesis of Heterocycles via Metal Catalyzed Reactions that Generate One or More Carbon Heteroatom Bonds Book
Author : John P. Wolfe
Publisher : Springer
Release : 2013-09-11
ISBN : 3642388809
Language : En, Es, Fr & De

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Book Description :

Synthesis of Saturated Heterocycles via Metal-Catalyzed Alkene Carboamination or Carboalkoxylation Reactions, by John P. Wolfe Synthesis of Saturated Heterocycles via Metal-Catalyzed Alkene Diamination, Aminoalkoxylation, or Dialkoxylation Reactions, by Sherry R. Chemler Synthesis of Heterocycles via Metal-Catalyzed Wacker-Type Oxidative Cyclization Reactions of Alkoxy- or Amino-Alkenes, by Wanbin Zhang Synthesis of Saturated Heterocycles via Metal-Catalyzed Hydroamination or Hydroalkoxylation Reactions, by Lisa D. Julian Synthesis of Saturated Heterocycles via Metal-Catalyzed Allylic Alkylation Reactions, by Aaron Aponick Synthesis of Heterocycles via Metal-Catalyzed Cascade/Domino Reactions that Generate a C–N or C–O Bond, by Mark Lautens Synthesis of Saturated Heterocycles via Metal-Catalyzed Formal Cycloaddition Reactions that Generate a C–N or C–O Bond, by Jerome Waser

Catalytic Asymmetric Conjugate Reactions

Catalytic Asymmetric Conjugate Reactions Book
Author : Armando Cordova
Publisher : John Wiley & Sons
Release : 2010-12-01
ISBN : 9783527632091
Language : En, Es, Fr & De

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Book Description :

This unique and long-awaited handbook on this important topic in the hot field of stereoselective organic synthesis covers several types of nucleophiles. Top international authors deal with modern forms of achieving stereoselective conjugate additions based on the use of chiral auxiliaries or asymmetric catalysis, such as P-N ligands, organocatalysis, domino reactions, Lewis acid and base catalysis. There is also a discussion of the employment of enantioselective conjugate addition transformations in total synthesis of important molecules. With its reliable and previously unpublished experimental procedures, this is a true source of high quality information.

Enantioselective Cobalt catalysed Transformations

Enantioselective Cobalt catalysed Transformations Book
Author : Hélène Pellissier
Publisher : Royal Society of Chemistry
Release : 2018-08-15
ISBN : 1788015150
Language : En, Es, Fr & De

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Book Description :

With a foreword from leading organic chemist Professor Paul Wender, this book collects the major developments reported in the past thirty years in the field of enantioselective reactions promoted by chiral cobalt catalysts, illustrating the power of these green catalysts to provide all types of organic reactions from the basic to completely novel methodologies. The search for new methodologies to prepare optically pure products is one of the most active areas of research in organic synthesis. Of the methods available for preparing chiral compounds, catalytic asymmetric synthesis has attracted the most attention. In particular, asymmetric transition-metal catalysis is a powerful tool for performing reactions in a highly enantioselective fashion. Efforts to develop new asymmetric transformations have previously focused on the use of rare metals such as titanium, palladium, iridium and gold. However, the ever-growing need for environmentally friendly catalytic processes has prompted chemists to focus on the more abundant and less toxic first-row transition metals, such as cobalt, to develop new catalytic systems. The ability of cobalt catalysts to adopt unexpected reaction pathways has led to an impressive number of enantioselective cobalt-promoted transformations being developed over the past three decades. These have included the synthesis of many different types of products, often under relatively mild conditions and with remarkable enantioselectivities. This book is a useful reference resource for chemists, both academic and industrial, working in organic synthesis and interested in greener or more economical catalytic alternatives.

Vanadium Catalysis

Vanadium Catalysis Book
Author : Manas Sutradhar,Armando J L Pombeiro,José Armando L da Silva
Publisher : Royal Society of Chemistry
Release : 2020-11-11
ISBN : 1839160896
Language : En, Es, Fr & De

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Book Description :

Vanadium is one of the more abundant elements in the Earth’s crust and exhibits a wide range of oxidation states in its compounds making it potentially a more sustainable and more economical choice as a catalyst than the noble metals. A wide variety of reactions have been found to be catalysed by homogeneous, supported and heterogeneous vanadium complexes and the number of applications is growing fast. Bringing together the research on the catalytic uses of this element into one essential resource, including theoretical perspectives on proposed mechanisms for vanadium catalysis and an overview of its relevance in biological processes, this book is a useful reference for industrial and academic chemists alike.

Multicomponent Reactions

Multicomponent Reactions Book
Author : Jieping Zhu,Hugues Bienaymé
Publisher : John Wiley & Sons
Release : 2006-03-06
ISBN : 3527604243
Language : En, Es, Fr & De

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Book Description :

In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic chemists, andthose working in organometallics both in academia and industry.

Enantioselective Nickel catalysed Transformations

Enantioselective Nickel catalysed Transformations Book
Author : Helene Pellissier
Publisher : Royal Society of Chemistry
Release : 2016-03-21
ISBN : 1782626700
Language : En, Es, Fr & De

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Book Description :

Due to the lower costs of nickel catalysts and the high abundance of nickel complexes, enantioselective nickel-mediated transformations have received a continuous and growing attention in recent years. This book demonstrates the diversity of chemistry catalysed by chiral nickel catalysts. Discussing several different enantioselective transformations, this book presents the impressive range of uses that have been found for novel and already known nickel chiral catalysts, from basic organic transformations to completely novel methodologies including fascinating one-pot domino and multicomponent reactions. This much-needed book is ideal for researchers and industrialists in organic chemistry, synthesis and medicinal chemistry.

Organometallic Chemistry and Catalysis

Organometallic Chemistry and Catalysis Book
Author : Didier Astruc
Publisher : Springer Science & Business Media
Release : 2007-08-02
ISBN : 3540461280
Language : En, Es, Fr & De

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Book Description :

This volume covers both basic and advanced aspects of organometallic chemistry of all metals and catalysis. In order to present a comprehensive view of the subject, it provides broad coverage of organometallic chemistry itself. The catalysis section includes the challenging activation and fictionalization of the main classes of hydrocarbons and the industrially crucial heterogeneous catalysis. Summaries and exercises are provides at the end of each chapter, and the answers to these exercises can be found at the back of the book. Beginners in inorganic, organic and organometallic chemistry, as well as advanced scholars and chemists from academia and industry will find much value in this title.

Catalytic Methods in Asymmetric Synthesis

Catalytic Methods in Asymmetric Synthesis Book
Author : Michelangelo Gruttadauria,Francesco Giacalone
Publisher : John Wiley & Sons
Release : 2011-07-05
ISBN : 9781118087985
Language : En, Es, Fr & De

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Book Description :

This book covers advances in the methods of catalytic asymmetric synthesis and their applications. Coverage moves from new materials and technologies to homogeneous metal-free catalysts and homogeneous metal catalysts. The applications of several methodologies for the synthesis of biologically active molecules are discussed. Part I addresses recent advances in new materials and technologies such as supported catalysts, supports, self-supported catalysts, chiral ionic liquids, supercritical fluids, flow reactors and microwaves related to asymmetric catalysis. Part II covers advances and milestones in organocatalytic, enzymatic and metal-based mediated asymmetric synthesis, including applications for the synthesis of biologically active molecules. Written by leading international experts, this book consists of 16 chapters with 2000 References and illustrations of 560 schemes and figures.

Progress in Heterocyclic Chemistry

Progress in Heterocyclic Chemistry Book
Author : Gordon W. Gribble,John A. Joule
Publisher : Newnes
Release : 2012-12-31
ISBN : 0080968082
Language : En, Es, Fr & De

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Book Description :

"Progress in Heterocyclic Chemistry" (PHC) an ongoing reference work on heterocyclic chemistry is published with the active involvement of The International Society of Heterocyclic Chemistry (ISHC) whose aim is to promote heterocyclic chemistry, in particular by serving as the primary sponsoring agency for the ISHC-Congress, a large biannual meeting attracting up to a thousand participants. Recognized as the premiere review of heterocyclic chemistry Contributions from leading researchers in the field Systematic survey of the important 2011 heterocyclic chemistry literature

Perspectives in Organopalladium Chemistry for the 21st Century

Perspectives in Organopalladium Chemistry for the 21st Century Book
Author : J. Tsuji
Publisher : Elsevier Science Limited
Release : 1999-11-23
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Perspectives in Organopalladium Chemistry for the 21st Century is a monograph on modern organopalladium chemistry, with an emphasis on the use of palladium in organic synthesis. The collection of articles is reprinted from a special issue of the Journal of Organometallic Chemistry. The field of organopalladium chemistry is evolving rapidly, building on a growing catalogue of reactions that employ palladium-containing catalysts. This book should hold particular interest for those who apply palladium reagents and catalysts to organic synthesis; in fact, palladium is considered by many to be the most useful transition element employed for organic syntheses. This selection of articles by leading scientists, published as "Perspectives in Organopalladium Chemistry for the 21st Century", provides an impressive overview of the field that every chemist who works with organometallic palladium catalysts should read.

Metal Catalyzed Cross Coupling Reactions and More

Metal Catalyzed Cross Coupling Reactions and More Book
Author : Armin de Meijere,Stefan Bräse,Martin Oestreich
Publisher : John Wiley & Sons
Release : 2013-12-04
ISBN : 3527655603
Language : En, Es, Fr & De

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Book Description :

This three volume book is the follow-up handbook to the bestselling volume "Metal-Catalyzed Cross-Coupling Reactions", the definitive reference in the field. In line with the enormous developments in this area, this is not a new edition, but rather a new book in three volumes with over 50% more content. This new content includes C-H activation, shifting the focus away from typical cross-coupling reactions, while those topics and chapters found in de Meijere/Diederich's book have been updated and expanded. With its highly experienced editor team and the list of authors reading like an international Who's-Who in the field, this work will be of great interest to every synthetic chemist working in academia and industry.

Metal Nanoparticles for Catalysis

Metal Nanoparticles for Catalysis Book
Author : Franklin Tao
Publisher : Royal Society of Chemistry
Release : 2014-06-12
ISBN : 1782621032
Language : En, Es, Fr & De

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Book Description :

Catalysis is a central topic in chemical transformation and energy conversion. Thanks to the spectacular achievements of colloidal chemistry and the synthesis of nanomaterials over the last two decades, there have also been significant advances in nanoparticle catalysis. Catalysis on different metal nanostructures with well-defined structures and composition has been extensively studied. Metal nanocrystals synthesized with colloidal chemistry exhibit different catalytic performances in contrast to metal nanoparticles prepared with impregnation or deposition precipitation. Additionally, theoretical approaches in predicting catalysis performance and understanding catalytic mechanism on these metal nanocatalysts have made significant progress. Metal Nanoparticles for Catalysis is a comprehensive text on catalysis on Nanoparticles, looking at both their synthesis and applications. Chapter topics include nanoreactor catalysis; Pd nanoparticles in C-C coupling reactions; metal salt-based gold nanocatalysts; theoretical insights into metal nanocatalysts; and nanoparticle mediated clock reaction. This book bridges the gap between nanomaterials synthesis and characterization, and catalysis. As such, this text will be a valuable resource for postgraduate students and researchers in these exciting fields.

Asymmetric Synthesis Of 3 3 disubstituted Oxindoles

Asymmetric Synthesis Of 3  3 disubstituted Oxindoles Book
Author : Dalpozzo Renato,Pellissier Helene,Chimni Swapandeep Singh,Rios Torres Ramon
Publisher : World Scientific
Release : 2019-09-11
ISBN : 1786347318
Language : En, Es, Fr & De

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Book Description :

Indole derivatives are the most common heterocycle compounds present in nature, for this reason, they have been referred to as 'privileged structures'. In fact, many approved drugs — and natural products — belong to this family. Among indole derivatives, oxindoles have a structural complexity, which have stimulated generations of synthetic chemists to design strategies for assembling these structures, and their enantioselective synthesis is still growing.This book proposes to describe the known enantioselective syntheses of oxindole derivatives. It is divided in six chapters each referring to a specific class of asymmetric oxindole derivatives. After the introduction, Chapter 2 describes all-carbon spirooxindoles; Chapter 3, open chain 3,3-dialkyloxindoles; Chapter 4, 3-substituted-3-aminooxindoles; Chapter 5, 3-substituted-3-hydroxyoxindoles; Chapter 6, 3-hetero-3-substituted oxindoles. It will be a useful tool for synthetic chemists, who assemble total synthesis of natural products, as well as for drug discovery chemists either in academic or in industry R&S laboratories.

Asymmetric Phosphine mediated Condensation Reactions

Asymmetric Phosphine mediated Condensation Reactions Book
Author : Nolan Taylor McDougal
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract: Asymmetric synthesis, the ability to control the three-dimensional structure of a molecule, has revolutionized the advance of new and efficient catalysts within organic chemistry. The development of organic molecules of low molecular weight acting as catalysts, without the use of any metals, has burgeoned. The variety of chiral hydrogen-bond donors that have been developed and applied to asymmetric synthesis indicates the high synthetic value of these as organocatalysts. A review which demonstrates the power of asymmetric Brønsted acid-catalyzed reactions within synthetic organic chemistry is presented. Through investigations of the metal alkoxide-promoted Morita-Baylis-Hillman reaction, an asymmetric Brønsted acid-catalyzed reaction was discovered. The reaction was developed into a highly enantioselective procedure for the addition of 2-cyclohexen-1-one to aldehydes promoted by triethylphosphine and a catalytic amount of a BINOL-derived Brønsted acid. The desired allylic alcohol products are provided in good yields and in up to 96% enantiomeric excess for a variety of aldehydes. This asymmetric Brønsted acid-catalyzed Morita-Baylis-Hillman reaction is a unique addition to the area of organocatalysis in that an organic promoter and chiral, hydrogen-bond-donating organic catalyst are necessary for the reaction to proceed. Phosphines were found to mediate the highly diastereoselective synthesis of bicyclo[3.2.1]octenones from 1,4-dien-3-ones. The highly functionalized products were formed in good yields under the optimized conditions for various aromatic ketones, which condense in the presence of diethylphenylphosphine, and aliphatic ketones, which require the use of tributyphosphine. Mechanistic studies support a domino formal [4 + 2] cycloaddition-Wittig reaction mechanism. Cyclopentenone products can be synthesized via a similar domino Michael-Wittig reaction mechanism from isopropenyl phenyl ketone.