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Artemisinin Based And Other Antimalarials

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Artemisinin Based and Other Antimalarials

Artemisinin Based and Other Antimalarials Book
Author : Guoqiao Li,Ying Li,Zelin Li,Meiyi Zeng
Publisher : Academic Press
Release : 2017-11-28
ISBN : 0128132116
Language : En, Es, Fr & De

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Book Description :

Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology. Presents details of all stages of drug development, including in vitro experiment, animal exploratory studies, animal tests for toxicity, safety and efficacy followed by stages I, II, III and IV, safety and efficacy in human volunteers and patients with malaria Provides many physical-chemical laboratory procedures, such as NMR, MS, HPLC and X-ray diffraction used in drug development Includes practical methodology of clinical trials from many research centers and countries to demonstrate the importance of this discovery

Treatment and Prevention of Malaria

Treatment and Prevention of Malaria Book
Author : Henry M. Staines,Sanjeev Krishna
Publisher : Springer Science & Business Media
Release : 2012-01-06
ISBN : 3034604793
Language : En, Es, Fr & De

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Book Description :

Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.

Antimalarial Agents

Antimalarial Agents Book
Author : Graham L. Patrick
Publisher : Elsevier
Release : 2020-06-16
ISBN : 0081012101
Language : En, Es, Fr & De

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Book Description :

Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work toward antimalarial solutions, providing practical guidance on past and current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world's population. Advances over several decades have seen vast improvements in the eff ectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a historical overview of malaria and antimalarial research, this book goes on to describe the biological aspects of malaria, highlighting the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite's genome, established drug targets, and potential drug targets for the future. This sets the scene for the following chapters which provide a detailed study of the medicinal chemistry of antimalarial agents, with a focus on the design of antimalarial drugs. Drawing on the knowledge of its experienced authors, and coupling historic research with current fi ndings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development, and administration of antimalarial drugs, including student academic researchers, medicinal chemists, malaria researchers, and pharmaceutical scientists. Consolidates both past and current developments in the discovery and design of antimalarial drugs Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected

Examining USAID s Anti malaria Policies

Examining USAID s Anti malaria Policies Book
Author : Heather Adamson,United States. Congress. Senate. Committee on Homeland Security and Governmental Affairs. Subcommittee on Federal Financial Management, Government Information, and International Security
Publisher : Amicus
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Amicus Readers at level 1 include: a picture glossary, a table of contents, index, websites, and literacy notes located in the back of each book. Additionally, content words are introduced within the text supported by a variety of photo labels. In particular, this title describes a shopping trip to the grocery store, including various departments such as the bakery and deli. Includes visual literacy activity.

Pharmacokinetics and Pharmacodynamics of Antimalarial Drugs Used in Combination Therapy

Pharmacokinetics and Pharmacodynamics of Antimalarial Drugs Used in Combination Therapy Book
Author : Qigui Li,Mark R. Hickman
Publisher : Bentham Science Publishers
Release : 2015-06-04
ISBN : 1681080540
Language : En, Es, Fr & De

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Book Description :

Malaria takes a great toll on human health and well-being, particularly in tropical regions including Sub-Saharan Africa, Southeast Asia, Oceania and parts of the Americas. In recent years, some Plasmodium strains have become increasingly resistant to all classes of conventional antimalarial drugs currently in use. Researchers have, therefore, stepped up efforts to revise atimalarial drug policies, develop new drugs, and implement new strategies to combat this disease. In order to prevent widespread resistance, antimalarial combination therapies (ACTs) have been deployed and a World Antimalarial Resistance Network has been established as a means of anitimalarial drug resistance surveillance. Artemisinin-based combination therapies have proven to be useful as a replacement for standard regimens. Currently, these ACTs successfully cure patients suffering from uncomplicated malaria with superior efficacy and lower toxicity, but there remains a huge challenge (high mortality rate) associated with treatment of severe malaria. Studies of drug disposition and drug efficacy (PK/PD evaluations) are essential to understanding why drugs work as antimalarials as they illustrate issues with drug resistance, drug safety and drug toxicity that are critical to finding the appropriate drug dose for patients. This eBook illustrates how currently available combination antimalarial drugs can be optimized for effective malaria treatment. Chapters in this book explain methods to select combination drugs based on PK/PD evaluations followed by methods o reduce drug toxicity based on these evaluations. The book also summarizes efforts that are being made by the research community to improve ACT. It is, therefore, a handy reference for medical professionals and pharmacologists working on antimalarial drugs.

Will a Global Subsidy of Artemisinin based Combination Treatment ACTs for Malaria Delay the Emergence of Resistance and Save Lives

Will a Global Subsidy of Artemisinin based Combination Treatment  ACTs  for Malaria Delay the Emergence of Resistance and Save Lives  Book
Author : Ramanan Laxminarayan,A. Mead Over,David L. Smith
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Artemisinin-based combination treatments (ACTs) are seen as an important tool in the global effort to roll back malaria. With rapidly increasing parasite resistance to chloroquine in many parts of the world, there is greater international recognition of the need for both a different antimalarial and a coordinated malaria treatment strategy to ensure that resistance does not needlessly cut short the useful therapeutic life of any successor drug to chloroquine. The effectiveness of antimalarial drugs is a global public good, of particular value in malarious regions that also are among the most economically impoverished parts of the world. Inappropriate drug use in neighboring countries reduces the incentive of any given country to deploy drug regimens that may be rapidly undermined by resistance originating outside their borders. Therefore, a case can be made for globally coordinated action to protect the effectiveness of these valuable drugs ... " -- Cover verso.

Guidelines for the Treatment of Malaria

Guidelines for the Treatment of Malaria Book
Author : World Health Organization
Publisher : World Health Organization
Release : 2010
ISBN : 9241547928
Language : En, Es, Fr & De

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Book Description :

"The purpose of this document is to provide comprehensible, global, evidence-based guidelines to help formulate policies and protocols for the treatment of malaria. Information is presented on the treatment of uncomplicated malaria, including disease in special groups (young children, pregnant women, people who are HIV positive, travellers from non-malaria endemic regions) and in complex emergency situations and severe malaria."--Publisher's description.

Cumulated Index Medicus

Cumulated Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cumulated Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Environmental Health Perspectives

Environmental Health Perspectives Book
Author : Anonim
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Environmental Health Perspectives book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Malawi Demographic and Health Survey 2010

Malawi Demographic and Health Survey  2010 Book
Author : Malawi. National Statistical Office,ICF Macro (Firm)
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Malawi Demographic and Health Survey 2010 book written by Malawi. National Statistical Office,ICF Macro (Firm), available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Antimalarial Chemotherapy

Antimalarial Chemotherapy Book
Author : Philip J. Rosenthal
Publisher : Springer Science & Business Media
Release : 2001-04-01
ISBN : 1592591116
Language : En, Es, Fr & De

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Book Description :

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Current Organic Chemistry

Current Organic Chemistry Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Provides in depth reviews on current progress in the fields of asymmetric synthesis, organometallic chemistry, bioorganic chemistry, heterocyclic chemistry, natural product chemistry, and analytical methods in organic chemistry. Each issue is edited by an appointed Executive Guest Editor

Antimalarial Drug II

Antimalarial Drug II Book
Author : Anonim
Publisher : Springer
Release : 1984-02-01
ISBN : 9783540126171
Language : En, Es, Fr & De

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Book Description :

The construction of this volume has been guided by two personal convictions. Experience in the field of experimental chemotherapy, both in the pharmaceutical industry and academia, has convinced us that recent quantum technological advances in biochemistry, molecular biology, and immunology will permit and, indeed, necessitate an increasingly greater use of rational drug development in the future than has been the custom up to now. In Part l, therefore, we asked our contributors to provide detailed reviews covering the biology of the malaria parasites and their relation with their hosts, the experimental procedures including culture techniques that are necessary to take a drug from primary screening to clinical trial, and an account of antimalarial drug resistance. Our second conviction is that many research workers are all too loath to learn from the lessons of the past. For this reason we asked the contributors to Part 2 of this volume to review very thoroughly the widely scattered but voluminous literature on those few chemical groups that have provided the antimalarial drugs in clinical use at the present time. Much can be learned from the history of their development and the problems that have arisen with them in man. Some indeed may still have much to offer if they can be deployed in better ways than they are at present. This question has been taken up by several authors.

Common Antimalarial Trees and Shrubs of East Africa

Common Antimalarial Trees and Shrubs of East Africa Book
Author : Anonim
Publisher : World Agroforestry Centre Eastern and Central Africa Program
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Common Antimalarial Trees and Shrubs of East Africa book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Commonwealth Health Ministers Book 2008

Commonwealth Health Ministers Book 2008 Book
Author : Commonwealth Secretariat
Publisher : Commonwealth Secretarial
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A central source of information regarding current health priorities focused around the Millennium Development Goals.The 2008 edition is focused on e-health. With contributions from many of the world's leading experts on e-health issues.

Guidelines for the Treatment of Malaria Third Edition

Guidelines for the Treatment of Malaria  Third Edition Book
Author : World Health Organization
Publisher : World Health Organization
Release : 2015-08-13
ISBN : 9241549122
Language : En, Es, Fr & De

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Book Description :

Malaria remains an important cause of illness and death in children and adults in countries in which it is endemic. Malaria control requires an integrated approach including prevention (primarily vector control) and prompt treatment with effective antimalarial agents. Malaria case management consisting of prompt diagnosis and effective treatment remains a vital component of malaria control and elimination strategies. Since the publication of the first edition of the Guidelines for the treatment of malaria in 2006 and the second edition in 2010 all countries in which P. falciparum malaria is endemic have progressively updated their treatment policy from use of ineffective monotherapy to the currently recommended artemisinin-based combination therapies (ACT). This has contributed substantially to current reductions in global morbidity and mortality from malaria. Unfortunately resistance to artemisinins has arisen recently in P. falciparum in South-East Asia which threatens these gains. This third edition of the WHO Guidelines for the treatment of malaria contains updated recommendations based on a firmer evidence base for most antimalarial drugs and in addition include recommendation on the use of drugs to prevent malaria in groups at high risk. The Guidelines provide a framework for designing specific detailed national treatment protocols taking into account local patterns of resistance to antimalarial drugs and health service capacity. It provides recommendations on treatment of uncomplicated and severe malaria in all age groups all endemic areas in special populations and several complex situations. In addition on the use of antimalarial drugs as preventive therapy in healthy people living in malaria-endemic areas who are high risk in order to reduce morbidity and mortality from malaria. The Guidelines are designed primarily for policy-makers in ministries of health who formulate country-specific treatment guidelines. Other groups that may find them useful include health professionals and public health and policy specialists that are partners in health or malaria control and the pharmaceutical industry. The treatment recommendations in the main document are brief; for those who wish to study the evidence base in more detail a series of annexes is provided with references to the appropriate sections of the main document.

Controlling Infectious Diseases

Controlling Infectious Diseases Book
Author : Mary Mederios Kent,Sandra Yin
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Controlling Infectious Diseases book written by Mary Mederios Kent,Sandra Yin, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Multiple Indicator Cluster Survey 2009

Multiple Indicator Cluster Survey  2009 Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Multiple Indicator Cluster Survey 2009 book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Malaria

Malaria Book
Author : Melissa Abramovitz
Publisher : Unknown
Release : 2005-07-15
ISBN : 9781590185926
Language : En, Es, Fr & De

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Book Description :

Discusses the symptoms and prognosis of people with malaria and how it is spread, including a history of how people have dealt with malaria in the past and what is being done to eradicate it in the future.

Angola Malaria Indicator Survey 2006 07

Angola Malaria Indicator Survey 2006 07 Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Angola Malaria Indicator Survey 2006 07 book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.