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Approaches To The Purification Analysis And Characterization Of Antibody Based Therapeutics

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Approaches to the Purification Analysis and Characterization of Antibody Based Therapeutics

Approaches to the Purification  Analysis and Characterization of Antibody Based Therapeutics Book
Author : Allan Matte
Publisher : Elsevier
Release : 2020-09-07
ISBN : 0081030193
Language : En, Es, Fr & De

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Book Description :

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography

Development of Antibody Based Therapeutics

Development of Antibody Based Therapeutics Book
Author : Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Klakamp
Publisher : Springer Science & Business Media
Release : 2012-04-24
ISBN : 1441959556
Language : En, Es, Fr & De

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Book Description :

Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ‘unit dose’ and ‘unit effect’ with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of biosuperior antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics.

Monoclonal Antibodies

Monoclonal Antibodies Book
Author : Philip Shepherd,Christopher J. Dean
Publisher : Practical Approach (Paperback)
Release : 2000
ISBN : 9780199637225
Language : En, Es, Fr & De

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Book Description :

Monoclonal Antibodies: A Practical Approach covers the preparation, testing, derivation, and applications of monoclonal antibodies. New immunological techniques incorporating tried and tested methodologies are described, making the book of interest to established and inexperienced immunologists. Both the standard somatic hybridization technique and recombinant techniques, including the use of phage libraries, for the preparation of rodent and human monoclonal antibodies are described. Protocols for both the small and large scale production are detailed, as well as purification and labelling (with both radioisotopes and non-radioisotopes) methods. The applications of monoclonal antibodies in immunoblotting, enzyme linked immunoassays, immunofluorescence, and FACS analysis are all covered in detail. Finally protocols are given for the use of monoclonal antibodies in rheumatoid arthritis, tissue typing, detecting DNA modified during chemotherapy, and in the clinical analysis of transplantation samples for malignancy. This book will therefore be an invaluable laboratory companion to anyone using monoclonal antibodies in their research.

Science

Science Book
Author : John Michels
Publisher : Unknown
Release : 2001-09
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Science book written by John Michels, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fibrinolysis Thrombolysis and Blood Clotting a Bibliography

Fibrinolysis  Thrombolysis  and Blood Clotting  a Bibliography Book
Author : Anonim
Publisher : Unknown
Release : 1969
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Fibrinolysis Thrombolysis and Blood Clotting a Bibliography book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Index Medicus

Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Purification and Analysis of Recombinant Proteins

Purification and Analysis of Recombinant Proteins Book
Author : SEETHARAM
Publisher : CRC Press
Release : 1991-01-07
ISBN : 9780824782771
Language : En, Es, Fr & De

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Book Description :

Covering both new and traditional topics in the purification and analysis of recombinant proteins, this volume demonstrates how to overcome problems in protein research and presents practical methods used in protein work, explaining their theoretical bases. The collection also explores innovative co

Federation Proceedings

Federation Proceedings Book
Author : Federation of American Societies for Experimental Biology
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Vols. for 1942- include proceedings of the American Physiological Society.

Current Research on Pre clinical Aspects of Cancer Therapy

Current Research on Pre clinical Aspects of Cancer Therapy Book
Author : Smithsonian Science Information Exchange. Current Cancer Research Project Analysis Center
Publisher : Unknown
Release : 1975
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

1038 references to research projects being conducted in the United States and elsewhere. Entries arranged under 5 topics, e.g., Preclinical studies of anticancer drugs, Preclinical radiation therapy, and Preclinical immunotherapy. Entriesinclude title, researcher, address, contract number, summary, and supporting agency. Indexes by subjects, investigators, contractors, supporting agencies, and contractor numbers.

Scientific Report

Scientific Report Book
Author : Ohio State University. Comprehensive Cancer Center
Publisher : Unknown
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Scientific Report book written by Ohio State University. Comprehensive Cancer Center, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Genetic Engineering News

Genetic Engineering News Book
Author : Anonim
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Cumulated Index Medicus

Cumulated Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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1987 Abstracts

1987 Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download 1987 Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Bibliography of Agriculture

Bibliography of Agriculture Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Cambridge Scientific Biochemistry Abstracts

Cambridge Scientific Biochemistry Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Therapeutic Proteins

Therapeutic Proteins Book
Author : C. Mark Smales,David Cameron James
Publisher : Springer Science & Business Media
Release : 2005
ISBN : 1592599222
Language : En, Es, Fr & De

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Book Description :

This volume contains contributions from leaders in the field of therapeutic protein expression, purification, characterization, formulation and viral inactivation who cover all aspects of protein drug production downstream of the discovery stage. Protocols for the production of therapeutic proteins using a variety of sources are covered. including bacterial and yeast expression systems, insect and mammalian cells. Therapeutic Proteins: Methods and Protocols will prove an invaluable resourse to all those working in the field of therapeutic protein production.

State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparability

State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparability Book
Author : Anthony R. Mire-Sluis
Publisher : S Karger Ag
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

With the latest advances in analytical technologies, most biological products can now be extensively characterized in terms of their identity, heterogeneity and impurity profile. The currently available analytical methods (both physicochemical and biological) can characterize the primary, secondary and to some extent, the higher order structure of proteins. The sensitivity and selectivity of these methods allow for the identification and characterization not only of the desired protein component, but also many product-related substances and impurities as well as process-related impurities present in the drug preparations. Using an appropriate selection of analytical tools, it may be possible to demonstrate physicochemical and functional comparability between protein products manufactured before and after a manufacturing change or during product development. However, the extent of demonstrable comparability depends on the tests used, on the nature of the product and on the basic understanding of structure-function relationships. Assessment of immunogenicity is also a critical component of product characterization and is highly dependent on the types of assays used.

Methods of Immunological Analysis Methods of Immunological Analysis

Methods of Immunological Analysis  Methods of Immunological Analysis Book
Author : Rene Masseyeff,Winfried Albert,Norman A. Staines
Publisher : Wiley-Blackwell
Release : 1992-12-22
ISBN : 9783527279074
Language : En, Es, Fr & De

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Book Description :

Everyone conducting analyses using immunological methods should read METHODS OF IMMUNOLOGICAL ANALYSIS. Now available! Three detailed volumes supplying a complete practice-oriented introduction to immunoanalysis. A set in themselves, they provide an extraordinarily comprehensive and up-to-date depiction of these methods. Both specialists and non-specialists will appreciate the broad scope of this set: It covers a wide area of the life sciences, chemistry and medicine, adjusted to the extensive applicability of immunoanalytical techniques. We at VCH feel that there is a definite need for this indispensable new series. Immunoanalysis is widely practised by analysts whose interests or training are not primarily in immunology. They clearly need the guidance that a good reference work provides. Furthermore, the range of immunochemical methods itself is so broad and its techniques so varied that even specialist immunologists and immunochemists find it difficult to assess different possible analytical approaches. They, too, need the support of an extensive reference work. Save 20% by subscribing to the series by 30 June 1993!

Government Reports Announcements Index

Government Reports Announcements   Index Book
Author : Anonim
Publisher : Unknown
Release : 1989-10
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Cancer Research

Cancer Research Book
Author : Anonim
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cancer Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.