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Antimalarial Agents

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Antimalarial Agents

Antimalarial Agents Book
Author : Graham L. Patrick
Publisher : Elsevier
Release : 2020-06-16
ISBN : 0081012101
Language : En, Es, Fr & De

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Book Description :

Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work toward antimalarial solutions, providing practical guidance on past and current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world's population. Advances over several decades have seen vast improvements in the eff ectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a historical overview of malaria and antimalarial research, this book goes on to describe the biological aspects of malaria, highlighting the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite's genome, established drug targets, and potential drug targets for the future. This sets the scene for the following chapters which provide a detailed study of the medicinal chemistry of antimalarial agents, with a focus on the design of antimalarial drugs. Drawing on the knowledge of its experienced authors, and coupling historic research with current fi ndings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development, and administration of antimalarial drugs, including student academic researchers, medicinal chemists, malaria researchers, and pharmaceutical scientists. Consolidates both past and current developments in the discovery and design of antimalarial drugs Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected

Antimalarial Agents

Antimalarial Agents Book
Author : Poul Thompson
Publisher : Elsevier
Release : 2012-12-02
ISBN : 032315168X
Language : En, Es, Fr & De

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Book Description :

Medicinal Chemistry, Volume 12: Antimalarial Agents: Chemistry and Pharmacology presents the essentials of both biology and chemistry pertinent to the chemotherapy of malaria. This book discusses the nature of the disease, the physiology and biochemistry of the plasmodia, and the mode of action of drugs. Organized into 19 chapters, this volume begins with an overview of the most intensive efforts to develop synthetic antimalarial drugs. This text then examines how drugs are evaluated as well as the specific chemotherapy in malaria. Other chapters consider the diversity of chemical structures exhibiting antimalarial activity with emphasis on structure–activity relationships and methods of synthesis. This book discusses as well the plasmodial effects by quinine in vivo. The final chapter deals with the miscellaneous structures known to have activity against some types of plasmodial infection in animals. This book is a valuable resource for chemists and biologists involved in the development of antimalarial drugs.

Survey of Antimalarial Agents

Survey of Antimalarial Agents Book
Author : George Robert Coatney
Publisher : Unknown
Release : 1953
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Survey of Antimalarial Agents book written by George Robert Coatney, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

STERIC HINDRANCE AND SYNERGISM IN THE DESIGN OF ANTIMALARIAL AGENTS

STERIC HINDRANCE AND SYNERGISM IN THE DESIGN OF ANTIMALARIAL AGENTS  Book
Author : DOUGLAS CLIFFORD MORRISON
Publisher : Unknown
Release : 1964
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download STERIC HINDRANCE AND SYNERGISM IN THE DESIGN OF ANTIMALARIAL AGENTS book written by DOUGLAS CLIFFORD MORRISON, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Treatment and Prevention of Malaria

Treatment and Prevention of Malaria Book
Author : Henry M. Staines,Sanjeev Krishna
Publisher : Springer Science & Business Media
Release : 2012-01-06
ISBN : 3034604793
Language : En, Es, Fr & De

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Book Description :

Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.

Essentials of Clinical Pharmacology in Nursing

Essentials of Clinical Pharmacology in Nursing Book
Author : Bradley R. Williams,Charold Lee Morris Baer
Publisher : Springhouse Publishing Company
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Concise presentation of basic pharmacologic information for the student. Units 1 and 2 address fundamentals of pharmacology and drag administration. Units 3- 16 group drags by therapeutic classification with each chapter covering pharmacokinetics, pharmacodynamics, pharmacotherapeutics, adverse drug reactions and nursing process steps in administering drugs. Additional chapters cover dosage measurements and calculations, administration routes and techniques, uncategorized drugs and more. Disk has questions and exercises for self-study.

Microbiology Abstracts

Microbiology Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Microbiology Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Lexi Comp s Drug Interactions Handbook

Lexi Comp s Drug Interactions Handbook Book
Author : Kenneth A. Bachmann
Publisher : Lexi-Comp Incorporated
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Lexi Comp s Drug Interactions Handbook book written by Kenneth A. Bachmann, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Clinical Pharmacology and Nursing

Clinical Pharmacology and Nursing Book
Author : Charold Lee Morris Baer,Bradley R. Williams
Publisher : Springhouse Publishing Company
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Includes software offering more than 1,300 multiple-choice questions and other activities complete with answers and rationales, nursing process step, client needs category, taxonomic level when applicable, chapter and unit tests, a comprehensive test, and a score report. Text has been updated to include all approved drugs. Contents include general pharmacology, the nursing process and pharmacotherapeutics, coverage of all drug classes, and data on hundreds of generic drugs. Charts, diagrams, and illustrations.

Medicinal Chemistry and Drug Discovery Chemotherapeutic agents

Medicinal Chemistry and Drug Discovery  Chemotherapeutic agents Book
Author : Alfred Burger
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Medicinal Chemistry and Drug Discovery Chemotherapeutic agents book written by Alfred Burger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pharmacology and the Nursing Process

Pharmacology and the Nursing Process Book
Author : Linda Lane Lilley
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Providing up-to-date, clinically relevant information on pharmacology and nursing, this text uses a body systems approach. It includes case studies featuring specific clinical situations, as well as critical thinking questions to promote clinical applicability of content.

Burger s Medicinal Chemistry and Drug Discovery Therapeutic agents

Burger s Medicinal Chemistry and Drug Discovery  Therapeutic agents Book
Author : Alfred Burger
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Burger s Medicinal Chemistry and Drug Discovery Therapeutic agents book written by Alfred Burger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chemistry Towards Disease and Poverty Eradication

Chemistry Towards Disease and Poverty Eradication Book
Author : Anonim
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Chemistry Towards Disease and Poverty Eradication book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Evaluation of Novel 4 aminoquinolines for Treatment of Drug resistant Malaria

Evaluation of Novel 4 aminoquinolines for Treatment of Drug resistant Malaria Book
Author : Peter B. Madrid
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Malaria is a devastating disease that kills over a million children every year. Resistance to many of the most potent and affordable drugs has led to a renewed need for new antimalarials therapeutics. The tools of combinatorial synthesis were used to create several libraries of quinoline compounds with diversity at various positions around the 4-aminoquinoline scaffold. The structure-activity relationships for both the quinoline ring and basic side chains were defined based on in vitro activity against multiple strains of Plasmodium falciparum. Substitutions around the quinoline ring did not lead to substantial gains in activity against the drug-resistant W2 parasite strain. Conversely, the addition of substituents to the terminal nitrogen in the basic side chain led to several compounds with potent activities against drug-resistant parasite strains. In particular, the addition of an aromatic group with a hydrogen-bond accepting functional group led to several compounds with IC50 values less than 10 nM against the drug-resistant W2 strain of P. falciparum. This series of potent compounds was found to have poor metabolic stability, but conversion of the tertiary amine side chain into an analogous secondary amine, led to a set of potent and metabolically stable lead compounds.

Comprehensive Dermatologic Drug Therapy

Comprehensive Dermatologic Drug Therapy Book
Author : Stephen E. Wolverton
Publisher : W B Saunders Company
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This unique reference is the only drug-based therapeutics book in dermatology published in more than a decade. It covers the full spectrum of drugs prescribed for cutaneous diseases, including numerous topical, intralesional, and systemic drugs. To ensure quick access to information, each chapter features 5-10 drug tables; pharmacology key concepts; mechanisms of action; indications and contraindications; adverse effects; monitoring guidelines; and drug interactions. The tables alone make this reference a practical, convenient, and unique resource for the busy practitioner. Covers all dermatological drugs likely to be prescribed, with a focus on safe and effective use throughout. Provides on-the-spot information regarding monitoring and informing patients about important adverse effects to report. Features multiple headings and subheadings and hundreds of easy-access tables for fast access to vital information. Lists costs for all major drugs, both trade and generic. Includes a highly detailed, disease-specific index, helping the reader evaluate drug options for each disease discussed. Contains Black Box monitoring guidelines that list the most important baseline and follow-up examinations and laboratory tests required for safe use of more than 25 common drugs.

Essentials of Medicinal Chemistry

Essentials of Medicinal Chemistry Book
Author : Andrejus Korolkovas
Publisher : Wiley-Interscience
Release : 1988-08-16
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This text/reference presents fundamental aspects of medicinal chemistry and contains comprehensive information on approximately 5,000 drugs currently in use, describing their therapeutic uses, their mechanisms of action, and their main side and harmful effects. Employs the latest World Health Organization (WHO) pharmacological classification and provides extensive information for drugs on WHO's latest list of basic or essential pharmaceuticals, including history: chemical, trade and generic names; chemical structure; obtention; physical and chemical properties; mechanisms of action; therapeutic uses; adverse reactions; biotransformation; chemical and pharmacological incompatibilities; bioavailability; dosage; storage; and assay.

HDBK OF CARDIOVASCULAR ANTI INFLAMMATORY AGENTS

HDBK OF CARDIOVASCULAR   ANTI INFLAMMATORY AGENTS Book
Author : Matthew Verderame
Publisher : CRC PressI Llc
Release : 1986-02
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download HDBK OF CARDIOVASCULAR ANTI INFLAMMATORY AGENTS book written by Matthew Verderame, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Malaria Reports

Malaria Reports Book
Author : United States. Board for Coordination of Malarial Studies
Publisher : Unknown
Release : 1946
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Malaria Reports book written by United States. Board for Coordination of Malarial Studies, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Virtual Activity Real Pharmacology

Virtual Activity  Real Pharmacology Book
Author : Anonim
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Virtual Activity Real Pharmacology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Use and Interpretation of Laboratory Tests in Gastroenterology

Use and Interpretation of Laboratory Tests in Gastroenterology Book
Author : James B. Peter
Publisher : Unknown
Release : 1998
ISBN : 9781889342122
Language : En, Es, Fr & De

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Book Description :

Download Use and Interpretation of Laboratory Tests in Gastroenterology book written by James B. Peter, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.