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Antifungal Compounds Discovery

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Antifungal Compounds Discovery

Antifungal Compounds Discovery Book
Author : Marina Sokovic,Konstantinos Liaras
Publisher : Elsevier
Release : 2020-09-18
ISBN : 0128158255
Language : En, Es, Fr & De

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Book Description :

Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compounds Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections. Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field. Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compounds Discovery is a comprehensive guide helping researchers understand the relationship between specific chemical structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds. Provides an overview of the most specific mycotic infections and fungal species as background for compound development Presents the chemical formulas of all natural and synthetic compounds reviewed Combines detailed information about origin, isolation and possible therapeutic uses of all indexed compounds, including biological activity, mechanism of action and SAR information

Antifungal Compounds Discovery development and uses

Antifungal Compounds  Discovery  development  and uses Book
Author : Malcolm R. Siegel,Hugh Delane Sisler
Publisher : Unknown
Release : 1977-01-01
ISBN : 9780824765576
Language : En, Es, Fr & De

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Book Description :

V. 1- Discovery, developments, and uses; v. 2 - Interactions in biological and ecological systems.

Anticandidal Agents

Anticandidal Agents Book
Author : Awanish Kumar
Publisher : Academic Press
Release : 2016-09-12
ISBN : 012811312X
Language : En, Es, Fr & De

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Book Description :

Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules. Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines. Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics. Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs Provides thorough information on candida drug resistance and its remedial implications Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics

Fungi

Fungi Book
Author : Sunil K. Deshmukh,J. K. Misra,Jalpa P. Tewari,Tamas Papp
Publisher : CRC Press
Release : 2018-12-20
ISBN : 1315360004
Language : En, Es, Fr & De

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Book Description :

The book deals with the application of fungi and the strategic management of some plant pathogens. It covers fungal bioactive metabolites, with emphasis on those secondary metabolites that are produced by various endophytes, their pharmaceutical and agricultural uses, regulation of the metabolites, mycotoxins, nutritional value of mushrooms, prospecting of thermophilic and wood-rotting fungi, and fungi as myconano factories. Strategies for the management of some plant pathogenic fungi of rice and soybean have also been dealt with. Updated information for all these aspects has been presented and discussed in different chapters.

Antifungal Drug Discovery New Theories and New Therapies

Antifungal Drug Discovery  New Theories and New Therapies Book
Author : Chaminda Jayampath Seneviratne,Edvaldo Antonio Ribeiro Rosa
Publisher : Frontiers Media SA
Release : 2016-09-13
ISBN : 2889199509
Language : En, Es, Fr & De

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Book Description :

Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

Combating Fungal Infections

Combating Fungal Infections Book
Author : Iqbal Ahmad,Mohammad Owais,Mohammed Shahid,Farrukh Aqil
Publisher : Springer Science & Business Media
Release : 2010-08-03
ISBN : 364212173X
Language : En, Es, Fr & De

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Book Description :

Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.

Antifungal Therapy

Antifungal Therapy Book
Author : Mahmoud A. Ghannoum, PhD, EMBA,Mahmoud A. Ghannoum,John R. Perfect,John R. Perfect, MD
Publisher : CRC Press
Release : 2016-04-19
ISBN : 0849387868
Language : En, Es, Fr & De

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Book Description :

A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a comprehensive, up-to-date overview of the pertinent issues pertaining to antifungal treatment. Divided into four interrelated sections for a cohesive discussion covers: history of antifungals from the discovery of the polyenes to the echinocandins antifungal susceptibility methods patient management animal models in drug development therapeutic strategies pharmacokinetic and pharmacogenomics trends in resistance

Worldwide Emergence of Drug Resistant Fungi from Basic to Clinic

Worldwide Emergence of Drug Resistant Fungi  from Basic to Clinic Book
Author : Weihua Pan,Keke Huo,Ying-Chun Xu,David S. Perlin,Macit Ilkit
Publisher : Frontiers Media SA
Release : 2021-11-08
ISBN : 2889716082
Language : En, Es, Fr & De

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Book Description :

Download Worldwide Emergence of Drug Resistant Fungi from Basic to Clinic book written by Weihua Pan,Keke Huo,Ying-Chun Xu,David S. Perlin,Macit Ilkit, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Antifungal Agents

Antifungal Agents Book
Author : G. K. Dixon,Leonard G. Copping,Derek W. Hollomon
Publisher : Bios Scientific Pub Limited
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Explores how new molecular technologies are interfacing with chemistry and biology in the search for new fungicide targets.

Anti fungal Drug Discovery

Anti fungal Drug Discovery Book
Author : Bradley Mark Tebbets
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Anti fungal Drug Discovery book written by Bradley Mark Tebbets, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pathogenic Yeasts

Pathogenic Yeasts Book
Author : Ruth Ashbee,Elaine M. Bignell
Publisher : Springer Science & Business Media
Release : 2009-10-27
ISBN : 9783642031502
Language : En, Es, Fr & De

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Book Description :

Mycological studies of yeasts are entering a new phase, with the sequencing of multiple fungal genomes informing our understanding of their ability to cause disease and interact with the host. At the same time, the ongoing use of traditional methods in many clinical mycology laboratories continues to provide information for the diagnosis and treatment of patients. This volume reviews various aspects of pathogenic yeasts and what is known about their molecular and cellular biology and virulence, in addition to looking at clinical and laboratory findings. As each chapter is written by a leading expert in the field, this book summarizes in one volume much of the latest research on several pathogenic yeasts, including Candida, Cryptococcus, Malassezia and yeasts of emerging importance. The importance of laboratory diagnosis, antifungal susceptibility testing, antifungal resistance and yeast diseases in animals are reviewed.

Antimicrobial Drug Discovery

Antimicrobial Drug Discovery Book
Author : George Tegos,Eleftherios Mylonakis
Publisher : CABI
Release : 2012
ISBN : 1845939433
Language : En, Es, Fr & De

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Book Description :

Resistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vertebrate model hosts and light and nano-based technologies. It is essential reading for researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.

Biologically Active Natural Products

Biologically Active Natural Products Book
Author : Stephen J. Cutler,Horace G. Cutler
Publisher : CRC Press
Release : 1999-07-27
ISBN : 1420048651
Language : En, Es, Fr & De

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Book Description :

Biologically Active Natural Products: Pharmaceuticals demonstrates the connections between agrochemicals and pharmaceuticals and explores the use of plants and plant products in the formulation and development of pharmaceuticals. Experts from around the world examine a multitude of topics, including evaluation of extracts from tropical plants for p

The Fungal Cell Wall

The Fungal Cell Wall Book
Author : Jean-Paul Latgé
Publisher : Springer Nature
Release : 2020-08-12
ISBN : 3030499286
Language : En, Es, Fr & De

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Book Description :

This book illustrates, that the fungal cell wall is critical for the biology and ecology of all fungi and especially for human fungal pathogens. Readers will learn, that the composition of the fungal cell wall is a unique structure, which cannot be found in the human host. Consequently, the chapters outline, how the immune systems of both animals and humans have evolved to recognize conserved and unique elements of the fungal cell wall. As an application example, the authors also show, that the three-dimensional structures of the cell wall are excellent targets for the development of antifungal agents and chemotherapeutic strategies. With the combination of biological findings and medical outlooks, this volume is a fascinating read for scientists, clinicians and biomedical students.

Antibacterial and Antifungal Drug Discovery Benzimidazole Derivatives

Antibacterial and Antifungal Drug Discovery  Benzimidazole Derivatives Book
Author : Muhammad Imran,Muhammad Asim Farid,Muhammad Adnan Asghar
Publisher : LAP Lambert Academic Publishing
Release : 2015-06-29
ISBN : 9783659750588
Language : En, Es, Fr & De

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Book Description :

Drug discovery is a vast area of research due to increase in bacterial and fungal resistance against available drugs. This book will give the basic concepts of Schiff-Mannich Base derivatives of Benzimidazole, Metal complexes and their application in the field of drug discovery. It will also provide the basic mechanistic study as well as the knowledge about characterization techniques which will be helpful for young students and researchers to have a deep insight about Antibacterial and Antifungal agents.

Antimicrobial Compounds

Antimicrobial Compounds Book
Author : Tomás G. Villa,Patricia Veiga-Crespo
Publisher : Springer Science & Business Media
Release : 2013-10-19
ISBN : 3642404448
Language : En, Es, Fr & De

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Book Description :

Since penicillin and salvarsan were discovered, a number of new drugs to combat infectious diseases have been developed, but at the same time, the number of multi-resistant microorganism strains is increasing. Thus, the design of new and effective antibacterial, antiviral and antifungal agents will be a major challenge in the next years. This book reviews the current state-of-the-art in antimicrobial research and discusses new strategies for the design and discovery of novel therapies. Topics covered include the use of genetic engineering, genome mining, manipulation of gene clusters, X-ray and neutron scattering as well as the antimicrobial effects of essential oils, antimicrobial agents of plant origin, beta-lactam antibiotics, antimicrobial peptides, and cell-wall-affecting antifungal antibiotics.

Recent Trends in the Discovery Development and Evaluation of Antifungal Agents

Recent Trends in the Discovery  Development and Evaluation of Antifungal Agents Book
Author : Robert A. Fromtling
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Recent Trends in the Discovery Development and Evaluation of Antifungal Agents book written by Robert A. Fromtling, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fungal Siderophores

Fungal Siderophores Book
Author : Kalyani Dhusia,Kalpana Raja,Pramod Ramteke
Publisher : Springer Nature
Release : 2021-02-08
ISBN : 3030530779
Language : En, Es, Fr & De

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Book Description :

In the past few decades, it has been realized through research that fungal siderophores epitomize the uptake of iron as well as other essential elements like zinc, magnesium, copper, nickel and arsenic. Understanding the chemical structures of different fungal siderophores and the membrane receptors involved in uptake of mineral ions has opened new areas for research. In this edited volume, recent research is presented on fungal siderophores in one comprehensive volume to provide researchers a strong base for future research. Siderophores are the low molecular weight, high affinity iron-chelating compounds produced by bacteria and fungi. They are responsible for transporting iron across the cell membrane. Fungi produce a range of hydroxamate siderophores involved in the uptake of essential elements in almost all microorganisms and plants. In recent years, siderophores have been used in molecular imaging applications to visualize and understand cellular functions, which thus provide an opportunity to identify new drug targets. Therefore, knowledge of fungal siderophores has become vital in current research. Siderophores have received much attention in recent years because of their potential roles and applications in various research areas. Their significance in these applications is because siderophores have the ability to bind a variety of metals in addition to iron, and they have a wide range of chemical structures and specific properties. For instance, siderophores function as biocontrols, biosensors, and bioremediation and chelation agents, in addition to their important role in weathering soil minerals and enhancing plant growth. This book focuses on siderophores with the following significant points. It discusses leading, state-of-the-art research in all possible areas on fungal siderophores. The contributors are well-known and recognized authorities in the field of fungal siderophores. It discusses a projection of practical applications of fungal siderophores in various domains. This is the first book exclusively on fungal siderophores. In this comprehensive, edited volume, we show leading research on fungal siderophores and provide the most recent knowledge of researchers' work on siderophores. This book presents in-depth knowledge on siderophores to researchers working in areas of health sciences, microbiology, plant sciences, biotechnology, and bioinformatics.

New Approaches for Antifungal Drugs

New Approaches for Antifungal Drugs Book
Author : FERNANDES,PRABHAVATHI
Publisher : Birkhäuser
Release : 1992-08-01
ISBN : 9780817636029
Language : En, Es, Fr & De

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Book Description :

Reviews research on the chemotherapy of fungal diseases, which has progressed at a much slower rate than that against bacterial diseases. Emphasizes the search during the past decade for selective targets of therapeutic agents, selection being the main difficulty because of the eukaryotic nature of fungi. In addition to several novel drugs, considers structures, processes, and proteins as potential targets; and new approaches such as antifungal agents from plants, and genetic methods of drug discovery. Annotation copyrighted by Book News, Inc., Portland, OR