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Antifungal Compounds Discovery

Antifungal Compounds Discovery Book
Author : Marina Sokovic,Konstantinos Liaras
Publisher : Elsevier
Release : 2020-09-15
ISBN : 9780128158241
Language : En, Es, Fr & De

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Book Description :

Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compound Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections. Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field. Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compound Discovery is a comprehensive guide helping researchers understand the relationship between specific chemicals structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds. Provides an overview of the most specific mycotic infections and fungal species as background for compound development Presents the chemical formulas of all natural and synthetic compounds reviewed Combines detailed information about origin, isolation and possible therapeutic uses of all indexed compounds, including biological activity, mechanism of action and SAR information

Antifungal Compounds Discovery development and uses

Antifungal Compounds  Discovery  development  and uses Book
Author : Malcolm R. Siegel,Hugh Delane Sisler
Publisher : Unknown
Release : 1977-01-01
ISBN : 9780824765576
Language : En, Es, Fr & De

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Book Description :

V. 1- Discovery, developments, and uses; v. 2 - Interactions in biological and ecological systems.

Antifungal Agents

Antifungal Agents Book
Author : G. K. Dixon,Leonard G. Copping,Derek W. Hollomon
Publisher : Bios Scientific Pub Limited
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Explores how new molecular technologies are interfacing with chemistry and biology in the search for new fungicide targets.

Antifungal Compounds Discovery

Antifungal Compounds Discovery Book
Author : Marina Sokovic,Konstantinos Liaras
Publisher : Elsevier
Release : 2020-09-30
ISBN : 0128158255
Language : En, Es, Fr & De

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Book Description :

Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compound Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections. Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field. Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compound Discovery is a comprehensive guide helping researchers understand the relationship between specific chemicals structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds. Provides an overview of the most specific mycotic infections and fungal species as background for compound development Presents the chemical formulas of all natural and synthetic compounds reviewed Combines detailed information about origin, isolation and possible therapeutic uses of all indexed compounds, including biological activity, mechanism of action and SAR information

Anti fungal Drug Discovery

Anti fungal Drug Discovery Book
Author : Bradley Mark Tebbets
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Anti fungal Drug Discovery book written by Bradley Mark Tebbets, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Antifungal Drug Discovery New Theories and New Therapies

Antifungal Drug Discovery  New Theories and New Therapies Book
Author : Chaminda Jayampath Seneviratne,Edvaldo Antonio Ribeiro Rosa
Publisher : Frontiers Media SA
Release : 2016-09-13
ISBN : 2889199509
Language : En, Es, Fr & De

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Book Description :

Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

New Antifungal Compounds from Marine Fungi

New Antifungal Compounds from Marine Fungi Book
Author : Akkharawit Kanjana-opas
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download New Antifungal Compounds from Marine Fungi book written by Akkharawit Kanjana-opas, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Antimicrobial Drug Discovery

Antimicrobial Drug Discovery Book
Author : George Tegos,Eleftherios Mylonakis
Publisher : CABI
Release : 2012
ISBN : 1845939433
Language : En, Es, Fr & De

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Book Description :

Resistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vertebrate model hosts and light and nano-based technologies. It is essential reading for researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.

Discovery Purification and Characterization of Antifungal Proteins and Other Defense related Compounds from Tropical Plants

Discovery  Purification and Characterization of Antifungal Proteins and Other Defense related Compounds from Tropical Plants Book
Author : Tahzeeba Hossain
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Discovery Purification and Characterization of Antifungal Proteins and Other Defense related Compounds from Tropical Plants book written by Tahzeeba Hossain, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Recent Trends in the Discovery Development and Evaluation of Antifungal Agents

Recent Trends in the Discovery  Development and Evaluation of Antifungal Agents Book
Author : Robert A. Fromtling
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Recent Trends in the Discovery Development and Evaluation of Antifungal Agents book written by Robert A. Fromtling, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Medicinal Chemistry and Drug Discovery Chemotherapeutic agents

Medicinal Chemistry and Drug Discovery  Chemotherapeutic agents Book
Author : Alfred Burger
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Medicinal Chemistry and Drug Discovery Chemotherapeutic agents book written by Alfred Burger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

7

7 Book
Author : J. Wuyts
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Impedance-based de-replication of antifungal drug classes High-throughput target-based drug screening of synthetic molecules so far has not resulted in new antifungal drug classes. One of the proposed reasons for this failure is the lack of penetration of synthetic molecules in the fungal cell, the high false-positive rates and the lack of selectivity. Three major classes of antifungal drugs are currently in use; the polyenes, the echinocandins and the azoles. Two of them, the polyenes and the echinocandins, are natural products or based on natural products produced by micro-organisms. Small molecules produced by micro-organisms have several desirable characteristics. First, they are highly specific due to their high degree of chirality. Second, they are intrinsically cell permeable and finally, they occupy a more diverse chemical space. However, natural product-based antifungal drug discovery is associated with a number of technical challenges. Fermentation extracts are composed of complex mixtures containing hundreds or thousands of unknown compounds and concomitantly natural product drug discovery is plagued by a high background of known and/or nuisance compounds. Recent efforts have revealed that the vast majority of micro-organisms are still unable to grow under laboratory conditions, indicating a huge unexplored source of new natural compounds. Mining this so-called u2018microbial dark matteru2019 has recently proven successful in the search for novel antibiotics, but has not been used in the search for novel antifungals. Even though previously uncultured micro-organisms can be a rich source of novel antimicrobials, they still produce known antimicrobials. Therefore, a high-throughput de-replication platform to filter out known or undesirable compounds would decrease costs and time consumption in antifungal drug discovery. We have developed a novel tool that can be used to de-replicate antifungal drug classes in a high-throughput and label-free fashion. This tool is based on multisine electrochemical impedance spectroscopy (EIS). Here, Candida albicans biofilms were grown on modified microtiter plates with gold electrodes coated at the bottom of the plates. Next, the cells were subjected to a small alternating potential inside the wells of the 96 well plates during biofilm development or destruction for 24h. The measurement of the resulting micro-current through the developing biofilm results in a signature profile based on multiple frequency components. When we challenged growing C. albicans biofilms with different antifungals we were able to obtain specific signatures for each class. By comparing the signature profile of unknown compounds with a library of signature profiles of known compounds we were able to identify the antifungal mode-of-action. Impedance based de-replication can become a valuable tool in the next-generation of natural product-based drug discovery platforms.

The Discovery of Natural Products with Therapeutic Potential

The Discovery of Natural Products with Therapeutic Potential Book
Author : Vincent Philip Gullo
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Although science has discovered effective drugs for many of the diseases that afflict mankind, many human health problems remain untreatable. The search for novel therapeutic agents is always ongoing. This book will describe some of the diverse sources of natural products, such as terrestrial and marine environments; and will review how research has increased knowledge of biological systems and human disease, leading to the design of targeted asssays, amenable to high volume screening.

Combating Fungal Infections

Combating Fungal Infections Book
Author : Iqbal Ahmad,Mohammad Owais,Mohammed Shahid,Farrukh Aqil
Publisher : Springer Science & Business Media
Release : 2010-08-03
ISBN : 9783642121739
Language : En, Es, Fr & De

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Book Description :

Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.

Antimicrobial Compounds

Antimicrobial Compounds Book
Author : Tomás G. Villa,Patricia Veiga-Crespo
Publisher : Springer Science & Business Media
Release : 2013-10-19
ISBN : 3642404448
Language : En, Es, Fr & De

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Book Description :

Since penicillin and salvarsan were discovered, a number of new drugs to combat infectious diseases have been developed, but at the same time, the number of multi-resistant microorganism strains is increasing. Thus, the design of new and effective antibacterial, antiviral and antifungal agents will be a major challenge in the next years. This book reviews the current state-of-the-art in antimicrobial research and discusses new strategies for the design and discovery of novel therapies. Topics covered include the use of genetic engineering, genome mining, manipulation of gene clusters, X-ray and neutron scattering as well as the antimicrobial effects of essential oils, antimicrobial agents of plant origin, beta-lactam antibiotics, antimicrobial peptides, and cell-wall-affecting antifungal antibiotics.

Insights in the Biosynthesis of Griseofulvin and Echinocandin B Two Antifungal Compounds from Ascomycetes

Insights in the Biosynthesis of Griseofulvin and Echinocandin B  Two Antifungal Compounds from Ascomycetes Book
Author : Ralph Adrian Cacho
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Natural products, since the discovery of the first antibiotic penicillin in 1928, have been the source of and inspiration for drugs. Due the emergence of drug-resistant pathogens and discovery of drug targets in cancer biology, the need for the discovery of new bioactive natural compounds and synthesis of analogs thereof remains present. Fortuitously, the development of next-generation sequencing and tools for the heterologous expression of the biosynthetic genes for natural products has accelerated the discovery of new natural products as well as the elucidation of the respective biosynthetic pathways. This dissertation describes the use of these two emerging technologies in revealing insights in the biosynthesis of two antifungal natural compounds synthesized by filamentous fungi: griseofulvin, an antifungal drug used in treatment against dermatophytes and is in the World Health Organization List of Essential Medicine and echinocandin B, the parent compound of the frontline anti-Candidiasis drug anidulafungin. This dissertation will first present the work in the investigation the biosynthesis of echinocandin B. Invasive candidiasis caused by opportunistic pathogenic strains of genus Candida, accounts for 17% of ICU-related infections and through understanding of the biosynthesis of echinocandin B will aid in the mutasynthesis of analogs with better efficacy than the parent compound. In this work, we characterized the key steps in the biosynthesis of the natural product. Deletion of the biosynthetic genes also allowed for the mutasynthesis of echinocandin B analogs with more potent antifungal activity and showed the potential for re-engineering of the pathway to produce "unnatural" natural compounds. Moreover, this work also describes the full elucidation and reconstitution of the enzymatic reactions leading to the biosynthesis of griseofulvin using a combination of gene knockout and biochemical characterization of the griseofulvin biosynthetic enzymes. Among the important biosynthetic enzymes characterized in this study is the non-reducing polyketide synthase GsfA which was implicated in the biosynthesis of norlichexanthone and the cytochrome P450 GsfF which catalyzes the formation of the spirobicyclic grisan ring in griseofulvin. The culmination of this study is the demonstration of the total in vitro biosynthesis of the compound using purified griseofulvin biosynthetic enzymes.

Antifungal Compounds

Antifungal Compounds Book
Author : Malcolm Richard Siegel,Hugh Delane Sisler
Publisher : Unknown
Release : 1977
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Antifungal Compounds book written by Malcolm Richard Siegel,Hugh Delane Sisler, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Antifungal Drugs

Antifungal Drugs Book
Author : New York Academy of Sciences
Publisher : Unknown
Release : 1988
ISBN : 9780897665100
Language : En, Es, Fr & De

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Book Description :

Download Antifungal Drugs book written by New York Academy of Sciences, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Current Topics in Marine Biotechnology

Current Topics in Marine Biotechnology Book
Author : Shigetō Miyaji,I. Karube,Y. Ishida
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Current Topics in Marine Biotechnology book written by Shigetō Miyaji,I. Karube,Y. Ishida, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.