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Anticandidal Agents

Anticandidal Agents Book
Author : Awanish Kumar
Publisher : Academic Press
Release : 2016-09-12
ISBN : 012811312X
Language : En, Es, Fr & De

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Book Description :

Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules. Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines. Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics. Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs Provides thorough information on candida drug resistance and its remedial implications Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics

Antifungal Agents

Antifungal Agents Book
Author : Ernst M. Jucker
Publisher : Birkhäuser
Release : 2012-12-06
ISBN : 3034879741
Language : En, Es, Fr & De

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Book Description :

This second volume of PDR SPECIAL TOPICS contains five review articles, covering nearly the entire field of fungal diseases in humans as well as therapeutic approaches. The main emphasis of the book lies in antifungal therapy: the most relevant information on the present state of the art of antifungal chemotherapy for dermatomycoses, subcutaneous and invasive mycoses is summarized, and open questions and unsolved problems are presented. The book is ideal for both the practitioner as well as advanced student.

Antifungal Agents

Antifungal Agents Book
Author : Ernst M. Jucker
Publisher : Birkhäuser
Release : 2003-02-24
ISBN : 9783764369262
Language : En, Es, Fr & De

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Book Description :

This second volume of PDR SPECIAL TOPICS contains five review articles, covering nearly the entire field of fungal diseases in humans as well as therapeutic approaches. The main emphasis of the book lies in antifungal therapy: the most relevant information on the present state of the art of antifungal chemotherapy for dermatomycoses, subcutaneous and invasive mycoses is summarized, and open questions and unsolved problems are presented. The book is ideal for both the practitioner as well as advanced student.

Hydroxy Pyridones as Antifungal Agents with Special Emphasis on Onychomycosis

Hydroxy Pyridones as Antifungal Agents with Special Emphasis on Onychomycosis Book
Author : Sam Shuster
Publisher : Springer Science & Business Media
Release : 2013-11-11
ISBN : 3642584012
Language : En, Es, Fr & De

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Book Description :

This book summarizes the results of two symposia held on hydroxy-pyridones as antifungal agents organized on the occasion of the International Summit on Cutaneous Antifungal Therapy 1996 in Vancouver and the 19th World Congress of Dermatology 1997 in Sydney. Some of the papers deal with the basic mechanisms of action and how these translate into product features, e.g. activity spectrum. Other papers describe the unique properties of hydroxy-pyridones, such as high penetration into and through keratinic tissues or their activity as dual inhibitor on 5-lipoxygenase and cyclooxygenase which leads to a remarkable antiinflammatory effect. Last but not least various accounts are given which show how this unique product profile aids the treatment of various fungal diseases, especially onychomycosis.

Antifungal Agents

Antifungal Agents Book
Author : Erika J. Ernst,P. David Rogers
Publisher : Springer Science & Business Media
Release : 2005
ISBN : 1592599435
Language : En, Es, Fr & De

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Book Description :

A collection of state-of-the-art molecular methods for studying antifungal resistance, for discovering and evaluating both new and existing antifungal drugs, and for understanding the host response and immunotherapy of such agents. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

Antifungal Agents

Antifungal Agents Book
Author : G. K. Dixon,Leonard G. Copping,Derek W. Hollomon
Publisher : Bios Scientific Pub Limited
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Explores how new molecular technologies are interfacing with chemistry and biology in the search for new fungicide targets.

Interactions of Yeasts Moulds and Antifungal Agents

Interactions of Yeasts  Moulds  and Antifungal Agents Book
Author : Gerri S. Hall
Publisher : Springer Science & Business Media
Release : 2011-12-02
ISBN : 9781597451345
Language : En, Es, Fr & De

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Book Description :

The incidence of fungal infections increases with the increase in antibiotic usage and increasing immunosuppressed populations. There is no longer only one antifungal agent and the response of fungi to various agents is not always predictable. The need for standardized antifungal susceptibility testing, and standardized interpretation of results in conjunction with studies that describe clinical outcomes based on those tools is ever important. Interactions of Yeasts, Moulds, and Antifungal Agents: How to Detect Resistance covers the available antifungal agents, how to perform in vitro testing and how those results should be interpreted for the most common fungal pathogens.

Recent Trends in Antifungal Agents and Antifungal Therapy

Recent Trends in Antifungal Agents and Antifungal Therapy Book
Author : Amit Basak,Ranadhir Chakraborty,Santi M. Mandal
Publisher : Springer
Release : 2016-09-21
ISBN : 8132227824
Language : En, Es, Fr & De

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Book Description :

Fungal infections have taken a new spectrum due to the increased incidence of multi-drug resistant fungal pathogens. Freedom of choice for drugs to treat fungal infections is also narrow because of lesser probability of discovering drugs that would bypass affecting human cells and target fungal cells producing fewer side effects in patients. An approach has gained prominence in research is to look for bioactive antifungal compounds from natural to synthetic sources. It is necessary to discover new classes of antifungals to control the recent emergence of multi-drug resistant fungal infections. This book proposed a details top to bottom outline of antifungal compounds derived naturally or synthetically. The details of their modifications or synthetic analogues have been described, helpful to understand the structure-activity relationship which leads to new compound development in antifungal chemotherapy. Each chapter begins with a comprehensive, top-bottom in-depth discussion of antifungal agents with updated bibliographic references. This compendium will serve as a companion not only for Scientists, Researchers, and Professors, Medical Practitioners but also a valuable reference text for the university students.

Recent Trends in the Discovery Development and Evaluation of Antifungal Agents

Recent Trends in the Discovery  Development and Evaluation of Antifungal Agents Book
Author : Robert A. Fromtling
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Recent Trends in the Discovery Development and Evaluation of Antifungal Agents book written by Robert A. Fromtling, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

In Vitro and in Vivo Evaluation of Antifungal Agents

In Vitro and in Vivo Evaluation of Antifungal Agents Book
Author : Kazuo Iwata,H. van den Bossche
Publisher : Elsevier Science & Technology
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download In Vitro and in Vivo Evaluation of Antifungal Agents book written by Kazuo Iwata,H. van den Bossche, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Antifungal Agents

Antifungal Agents Book
Author : Erika J. Ernst
Publisher : Humana Press
Release : 2005-05-16
ISBN : 9781588292773
Language : En, Es, Fr & De

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Book Description :

A collection of state-of-the-art molecular methods for studying antifungal resistance, for discovering and evaluating both new and existing antifungal drugs, and for understanding the host response and immunotherapy of such agents. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Antifungal Agents: Methods and Protocols offers clinician-scientists, microbiologists and molecular biologists the productive tools they need today to understand and successfully develop new therapeutic agents for yeast, mold, and fungal infections.

Antifungal Drug Discovery New Theories and New Therapies

Antifungal Drug Discovery  New Theories and New Therapies Book
Author : Chaminda Jayampath Seneviratne,Edvaldo Antonio Ribeiro Rosa
Publisher : Frontiers Media SA
Release : 2016-09-13
ISBN : 2889199509
Language : En, Es, Fr & De

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Book Description :

Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

Antifungal Therapy

Antifungal Therapy Book
Author : Mahmoud A. Ghannoum, PhD, EMBA,Mahmoud A. Ghannoum,John R. Perfect,John R. Perfect, MD
Publisher : CRC Press
Release : 2016-04-19
ISBN : 0849387868
Language : En, Es, Fr & De

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Book Description :

A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a comprehensive, up-to-date overview of the pertinent issues pertaining to antifungal treatment. Divided into four interrelated sections for a cohesive discussion covers: history of antifungals from the discovery of the polyenes to the echinocandins antifungal susceptibility methods patient management animal models in drug development therapeutic strategies pharmacokinetic and pharmacogenomics trends in resistance

Candida albicans Cellular and Molecular Biology

Candida albicans  Cellular and Molecular Biology Book
Author : Rajendra Prasad
Publisher : Springer
Release : 2017-01-31
ISBN : 3319504096
Language : En, Es, Fr & De

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Book Description :

This book on Candida albicans and similar pathogens provides a timely overview of the groundbreaking discoveries made in the areas of drug resistance, host–pathogen interactions, virulence, host immune system modulation, etc., in the last two decades. This comprehensive 2nd Edition includes chapters on fungal infections, hyphal morphogenesis, molecular mechanisms of antifungal resistance, antifungal agents, multidrug transporters, virulence mechanisms in Candida albicans, host–pathogen interactions, the cell wall, fungal biofilms, lipids and antifungal resistance, signaling mechanisms and last but not the least host-immune responses. As such, it offers an ideal reference guide for mycologists, researchers, pharmacists, clinicians, and undergraduate students engaged or interested in fungal research. It will also benefit clinicians, who are required to keep abreast of the current state of research on antifungal drug resistance and antifungal development.

The Effect of Antifungal Agents on Adherence of Candida Albicans to Buccal Epithelial Cells

The Effect of Antifungal Agents on Adherence of Candida Albicans to Buccal Epithelial Cells Book
Author : Suwanit Karnchanakom,Mahāwitthayālai Mahidon
Publisher : Unknown
Release : 1997
ISBN : 9789745892323
Language : En, Es, Fr & De

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Book Description :

Download The Effect of Antifungal Agents on Adherence of Candida Albicans to Buccal Epithelial Cells book written by Suwanit Karnchanakom,Mahāwitthayālai Mahidon, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Interactions of Yeasts Moulds and Antifungal Agents

Interactions of Yeasts  Moulds  and Antifungal Agents Book
Author : Gerri S. Hall
Publisher : Humana Press
Release : 2014-03-03
ISBN : 9781627039154
Language : En, Es, Fr & De

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Book Description :

The incidence of fungal infections increases with the increase in antibiotic usage and increasing immunosuppressed populations. There is no longer only one antifungal agent and the response of fungi to various agents is not always predictable. The need for standardized antifungal susceptibility testing, and standardized interpretation of results in conjunction with studies that describe clinical outcomes based on those tools is ever important. Interactions of Yeasts, Moulds, and Antifungal Agents: How to Detect Resistance covers the available antifungal agents, how to perform in vitro testing and how those results should be interpreted for the most common fungal pathogens.

Combating Fungal Infections

Combating Fungal Infections Book
Author : Iqbal Ahmad,Mohammad Owais,Mohammed Shahid,Farrukh Aqil
Publisher : Springer Science & Business Media
Release : 2010-08-03
ISBN : 9783642121739
Language : En, Es, Fr & De

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Book Description :

Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.

Peptide Transport in Candida Albicans and Synthetic Antifungal Agents

Peptide Transport in Candida Albicans and Synthetic Antifungal Agents Book
Author : D. A. Shallow,University of Durham
Publisher : Unknown
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Peptide Transport in Candida Albicans and Synthetic Antifungal Agents book written by D. A. Shallow,University of Durham, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fungal Biofilms and related infections

Fungal Biofilms and related infections Book
Author : Christine Imbert
Publisher : Springer
Release : 2016-08-09
ISBN : 3319423606
Language : En, Es, Fr & De

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Book Description :

This book covers the latest data available to understand the mechanisms causing the formation of single species fungal biofilms or polymicrobial biofilms involving fungal species; specific chapters present hot topics such as resistance mechanisms and composition and role of the matrix. Moreover, it reviews updated data on biofilms that contain yeasts or filamentous fungi and develop in the human body or in water and may cause infections. The latest available data for both diagnostic and treatment of infections associated to fungi growing in biofilms is also presented. The activity of antifungal and disinfectant agents against fungal biofilms is discussed in specific chapters and future treatments on natural sources are suggested. This book bridges the gap between basic and applied research. It is the result of many years of research work done by laboratories worldwide, all known for their expertise on fungal biofilms.

Office Dermatology

Office Dermatology Book
Author : Henry H. Roenigk
Publisher : Williams & Wilkins
Release : 1981
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Office Dermatology book written by Henry H. Roenigk, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.