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The Anticancer Drugs

The Anticancer Drugs Book
Author : William B. Pratt,William D. Ensminger,Raymond W. Ruddon
Publisher : Oxford University Press, USA
Release : 1994
ISBN : 9780195067392
Language : En, Es, Fr & De

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Book Description :

This is an up-to-date review of the pharmacology, mechanisms of action, development of resistance, and toxicity of cancer chemotherapeutic agents. A rationale for their clinical use, based on cancer cell biology, is given for each class of drugs.

Principles of Anticancer Drug Development

Principles of Anticancer Drug Development Book
Author : Elizabeth Garrett-Mayer
Publisher : Springer Science & Business Media
Release : 2010-12-29
ISBN : 9781441973580
Language : En, Es, Fr & De

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Book Description :

A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.

Principles of Cancer Treatment and Anticancer Drug Development

Principles of Cancer Treatment and Anticancer Drug Development Book
Author : Wolfgang Link
Publisher : Springer Nature
Release : 2019-09-10
ISBN : 3030187225
Language : En, Es, Fr & De

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Book Description :

This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.

Anticancer Agents from Natural Products

Anticancer Agents from Natural Products Book
Author : Gordon M. Cragg,David G. I. Kingston,David J. Newman
Publisher : CRC Press
Release : 2005-06-13
ISBN : 1420039652
Language : En, Es, Fr & De

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Book Description :

Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen

Anticancer

Anticancer Book
Author : David Servan-Schreiber
Publisher : Penguin UK
Release : 2011-01-06
ISBN : 0141970545
Language : En, Es, Fr & De

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Book Description :

An updated edition for 2011 including all the latest medical research and up-to-date studies. An approachable, empowering guide to staying healthy and fighting disease. Would it surprise you to hear that one in four people are affected by cancer? If you knew that simple lifestyle changes could significantly reduce your chances of developing the disease, would you take advantage of your natural defences? 'I had cancer. I was diagnosed for the first time 15 years ago. I received conventional treatment and the cancer went into remission, but I relapsed after that. Then I decided to learn everything I could to help my body defend itself against the illness. I've lived cancer free now for seven years. In this book, I'd like to tell you the stories - scientific and personal - behind what I learned.' Author David-Servan Schreiber is an academic physician with a wealth of experience in the field of integrative medicine. He will show you how, through simple alterations in diet, lifestyle and attitude, you can tackle cancer alongside conventional treatments, or even avoid it altogether. This is not a biology textbook, but a practical, insightful and individual guide that will allow you to make the best choices for your own health and well-being.

Anticancer Therapeutics

Anticancer Therapeutics Book
Author : Adam Todd,Paul W. Groundwater,Jason H. Gill
Publisher : John Wiley & Sons
Release : 2018-02-20
ISBN : 111862212X
Language : En, Es, Fr & De

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Book Description :

An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers. Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.

Cancer Pharmacology

Cancer Pharmacology Book
Author : Ashkan Emadi, MD, PhD,Judith E. Karp, MD
Publisher : Springer Publishing Company
Release : 2019-12-03
ISBN : 0826162045
Language : En, Es, Fr & De

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Book Description :

Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon malignancies. Beautifully illustrated throughout, each chapter contains visually engaging figures detailing the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic, and molecular properties of the various agents, and their mechanisms of action. As the first illustrated book of its kind, this highly visual text uses a uniform approach to each cancer drug class and agent presented in the book, and covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Flow diagrams, clinical tables, and bulleted text further explain important information pertaining to each cancer drug class including their indications, mechanisms of action, potential adverse reactions, dosing and dose adjustments, and safety monitoring. Organized in an easyto- digest format and replete with detailed images, clinical pearls, and end of chapter Q&As, this evidence-based reference presents all major classes, agents, targets, and approaches to cancer pharmacotherapy. Whether you are a trainee, a clinical scientist, or a clinician in practice, the book is an ideal reference. It presents challenging information in an instructional way, illustrates key concepts for ease of retention, and poses tough questions so readers can problem solve potential scenarios and test their pharmacologic acumen. Written by leading experts in oncopharmacology, this first-of-its kind manual is a “must have” for anyone involved in the basic, translational, or clinical aspects of oncology and hematology including clinicians, pharmacists, nurses, and trainees. KEY FEATURES: In Includes visual depictions of chemical structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents Describes how chemotherapy, targeted therapy, immunotherapy, and hormonal therapy work and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other modalities Over 100 highly stylized images and numerous comprehensive tables Covers challenges related to drug development, drug approval, and regulatory issues in relation to anticancer treatments All chapters conclude with clinical pearls and detailed clinical Q&As with descriptive rationales Purchase includes access to the ebook for use on most mobile devices or computers

Metal based Anticancer Agents

Metal based Anticancer Agents Book
Author : Angela Casini,Anne Vessières,Samuel M Meier-Menches
Publisher : Royal Society of Chemistry
Release : 2019-04-23
ISBN : 1788014065
Language : En, Es, Fr & De

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Book Description :

Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology.

Anticancer Drugs

Anticancer Drugs Book
Author : Niamh M O’Boyle,Mary J Meegan
Publisher : MDPI
Release : 2019-10-11
ISBN : 3039215868
Language : En, Es, Fr & De

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Book Description :

The past decades have seen major developments in the understanding of the cellular and molecular biology of cancer. Significant progress has been achieved regarding long-term survival for the patients of many cancers with the use of tamoxifen for treatment of breast cancer, treatment of chronic myeloid leukaemia with imatinib, and the success of biological drugs. The transition from cytotoxic chemotherapy to targeted cancer drug discovery and development has resulted in an increasing selection of tools available to oncologists. In this Special Issue of Pharmaceuticals, we highlight the opportunities and challenges in the discovery and design of innovative cancer therapies, novel small-molecule cancer drugs and antibody–drug conjugates, with articles covering a variety of anticancer therapies and potential relevant disease states and applications. Significant efforts are being made to develop and improve cancer treatments and to translate basic research findings into clinical use, resulting in improvements in survival rates and quality of life for cancer patients. We demonstrate the possibilities and scope for future research in these areas and also highlight the challenges faced by scientists in the area of anticancer drug development leading to improved targeted treatments and better survival rates for cancer patients.

Anticancer Drug Development Guide

Anticancer Drug Development Guide Book
Author : Beverly A. Teicher,Paul A. Andrews
Publisher : Springer Science & Business Media
Release : 2004-02-01
ISBN : 1592597394
Language : En, Es, Fr & De

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Book Description :

This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response Book
Author : Federico Innocenti
Publisher : Springer Science & Business Media
Release : 2008-10-30
ISBN : 9781603270885
Language : En, Es, Fr & De

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Book Description :

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients. As a consequence of the intrinsic chromosomal and genetic instability of the tumor genome, it is generally believed that tailoring of chemotherapy in cancer - tients might be achieved by molecular analysis of patient tumor DNA. In addition, to reduce the toxicity risk of patients, the tumor DNA information should be in- grated with the available data on polymorphic drug-metabolizing enzyme and tra- porter genes mediating the exposure of patients to active drugs and/or their active metabolites. The chapters of this book clearly show how DNA information from both the host (germline) and the tumor should be taken into account for rational selection of drug therapies in cancer patients, an aspect that received little attention, despite its importance. The availability of new molecular approaches to the selection of drug therapy is an emerging need, because the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many treated patients do not experience signi?cant bene?ts from the treatment, while they often experience moderate to severe toxicities. In addition, the development and clinical use of novel molecularly targeted agents (alone or in combination with classical cytotoxic therapy) requires the und- standing of the molecular features of the tumors and the identi?cation of tumor markers of response.

Macromolecular Anticancer Therapeutics

Macromolecular Anticancer Therapeutics Book
Author : L. Harivardhan Reddy,Patrick Couvreur
Publisher : Springer Science & Business Media
Release : 2010-03-20
ISBN : 9781441905079
Language : En, Es, Fr & De

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Book Description :

In spite of the development of various anticancer drugs, the therapy of cancer has remained challenging for decades. The current therapy of cancer is overwhelmed because of the inability to deliver therapeutics to all regions of a tumor in effective therapeutic concentrations, intrinsic or acquired resistance to the treatment with currently available agents via genetic and epigenetic mechanisms, and toxicity. As a result, cancer therapy using conventional therapeutics and different types of treatment regimens using this therapeutics has not led to a convincing survival benefit of the patients. In this context, Macromolecular therapeutics offer several advantages over conventional low molecular therapeutics by various ways such as, enable the use of larger doses of these agents by limiting the toxicity, by enhanced permeability and retention into tumors, by tumor targeting using tumor-specific antibodies, by specific inhibition of oncogenes using anticancer oligonucleotides etc. Cancer treatment using this macromolecular therapeutics has considerably improved the survival benefit for patients. As a result, various macromolecular therapeutics are already commercialized or are under clinical development. Although we are far from a real magic bullet today, looking at the pace of research and current success in this field of macromolecular therapeutics, it appears that we are approaching a magic bullet for the efficient treatment of cancer. Thus, we believe that the subject of this book is very timely, and that the book will fill an unmet need in the market. This book is unique and assembles various types and aspects of macromolecular anticancer therapeutics for cancer therapy in one shell and conveys the importance of this interdisciplinary field to the broad audience. Thus, in a nutshell, this book details the basics of cancer, and various therapeutic strategies such as those based on macromolecular therapeutics hence can become an important reference for practitioners, oncologists, medical pharmacologists, medicinal chemists, biomedical scientists, experimental pharmacologists, pharmaceutical technologists, and particularly it can essentially become a handbook of macromolecular therapeutics for cancer therapy for graduates, post-graduates and Ph.D. students in these fields.

Anticancer Botanicals

Anticancer Botanicals Book
Author : Sukanya Bhattacharya
Publisher : Daya Books
Release : 2006
ISBN : 9788170353836
Language : En, Es, Fr & De

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Book Description :

The biological action of plant extracts has led epidemiologists to investigate a number of interesting observations in cases of lung, liver, breast and oral cancers. However, the literature pertaining to the role of Trianthema portulacastrum extracts in liver. Cancer is scanty or else in non-existent. The objective of the work incorporated in this book is an outcome of the lacunae in the existing scientific knowledge regarding the possible role of the various fractions of T portulacastrum in hepatocellular carcinogenesis. The chemopreventive efficacy of the plant was tested in a defined experimental carcinogenesis model. The book has been divided into six chapters. The first phase of experimentation was confined to morphometric evaluation of hepatic lesions. In the second phase of experimentation Antioxidant defence enzymes (GSH, GST) and drug metabolizing enzymes (Cyt-P-450 monoxygenase and UDPGT) were assayed in all experimental and control groups to assess the anti-carcinogenic potential of T portulacastrum. Lipid peroxidation cytosolic and microsomal were included in the study. The third phase of experimentation involved histopathological and histochemical evaluation of tissue samples. PAS and reticulin patterns were evaluated. The fourth phase of experimentation was confined to electron microscopic study (TEM) to gain ultrastructural insight into the changes brought about by carcinogen and the ability of the extract to restore the tissue to the normal state. In the fifth phase, genetic parameters such as chromosomal aberrations, G-banding patterns of rats were considered to understand the ability of the extract to combat the genotoxic effect of the carcinogen. The outcome of the incorporated in this book is that T portulacastrum could prevent neoplastic transformation in rat liver by reduction of nodule incidence, reduction of altered foci, alteration of patterns of antioxidant and drug metabolizing enzymes accompanied by diminished lipid peroxidation. Moreover at the histopathological and ultrastructural level the plant could maintain nearly normal tissue architecture. Further it could prevent the advent of neoplasia by limiting chromosomal aberrations without any toxic manifestation. Contents Chapter 1: Introduction; Anticancer plants, Chemo preventive efficacy of trianthema portulacastrum l as a promising anti-cancer agent, Cancer, Terminology, The cancerous state, Normal and abnormal growth control, Normal Growth control, Abnormal growth control, Carcinogenesis: From animal models to molecular models in one decade, Multistage carcinogenesis, Initiation, Promotion, Progression, Cell and molecular mechanisms in chemical carcinogenesis classification of chemical carcinogens, Experimental hepatocarcinogenesis: an overview, Hepatocarcinogens-classification, Initiation of liver carcinogenesis, Initiated cells-phenotypic characteristics, Assays for initiation, Promotion of initiated hepatocytes, Progression, Liver tumours- a pathological profile, Hepatocellur lesions, Altered foci, Neoplastic nodules, Hepato cellular carcinoma (HCC), The growing need studying liver tumours, Cancer chemo prevention, In vitro testing, In vivo testing, Cancer chemo prevention-objective-basic mechanism, Chemo prevention agents-classes, Objectives of the present study; Chapter 2: Anti-Carcingenic Potential of Different Fractions of Trianthema Porlacastrum L (A Morphometric Analysis in One-Stage and Two-Stage Rat Hepatocarcinogenesis); Introduction, Materials and methods, Plant material, Extraction of plant material, Animals and diet, Experimental regimen: One stage hepatocarcinogenesis, Morphology and Morphometry, Statistical analysis, Results, Food and water intakes, Body and liver weights of rats during the period of experiment, Hepatic neoplastic nodules, Altered hepatocyte foci, Histologic profile of rat liver in dena-induced hepto carcinogenesis, Discussion; Chapter 3: Anti-oxidant Defence and Heatic Bio-transformation Patterns in DENA-Induced Rat Hepatocarcinogenesis Following Supplementation with T Postulacastrum Extracts; Introduction, Antioxidant enzyme, Hepatic biotransformation enzymes, Mechanism of free radical-mediated injury, Lipid peroxidation, Glutathion, GSTs, Cytochrome P-450 monooxygenase, UDPGT, Materials and methods, plant material, Extraction of plant material, Experimental protocol-treatment schedule, Preparation of microsomal and cytosolic fractions, Biochemical assays, Results and discussion; Chapter 4: Influence of The Various Extracts of T Portulacastrum L on Hepatic Histology and Histochemistry Against Dena-Induced Rat Liver Carcinogensis; Introduction, Materials and methods, Extraction of the plant material, Experimental protocol, Histologic and histochemical evaluation, Routine haematoxylin and eosin staining procedure, Histochemical evaluation of tissue sample, Staining protocol: PAS reaction, Staining protocol for reticulin-silver impregnation, Result, Discussion; Chapter 5: Effect if The Chloroform Extract of Trianthema Portulacastrum L in Experimental Rat Hepatocarciogensis: An Ultrastructual Probe into The Changes; Introduction, Materials and methods, Plant material, Experimental protocol, Treatment of tissues for tem, Results, Discussion; Chapter 6: Suppression of Chromosomal Aberrations by The Chloroform Extract of Trianthema Portulacastrum L in Experimental Hepatic Tumorigenesis; Introduction, Materials and methods, Plant materials, Animal, analysis of chromosomes from peripheral blood, Experimental protocol for peripheral blood culture (Modification of that followed for humans), Preparation of chromosomes from peripheral blood, Giemsa or G-banding, Procedure for G-banding of chromosomes from fresh airdried preparations of leucocytes, Scoring of CA data, Results and discussion.

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics Book
Author : Michelle A. Rudek,Cindy H. Chau,William D. Figg,Howard L. McLeod
Publisher : Springer Science & Business Media
Release : 2014-01-10
ISBN : 1461491355
Language : En, Es, Fr & De

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Book Description :

There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development

Anticancer Drug Development

Anticancer Drug Development Book
Author : Bruce C. Baguley,David J. Kerr
Publisher : Elsevier
Release : 2001-11-17
ISBN : 9780080490441
Language : En, Es, Fr & De

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Book Description :

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs Book
Author : Carmen Avendano,J. Carlos Menendez
Publisher : Elsevier
Release : 2008-06-04
ISBN : 9780080559629
Language : En, Es, Fr & De

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Book Description :

Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of new active structures. * Explains the biological basis of cancer treatment and the role of chemists in improving anticancer drugs * Provides the historical background and serves as a comprehensive and practical guide on cancer research and anticancer drug development * Includes coverage of different approaches to treating cancer, drug resistance, and a chapter on cancer prevention

Novel Anticancer Drug Protocols

Novel Anticancer Drug Protocols Book
Author : John K. Buolamwini,Alex A. Adjei
Publisher : Springer Science & Business Media
Release : 2003
ISBN : 1592593801
Language : En, Es, Fr & De

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Book Description :

This book not only surveys the whole arena of novel anticancer drug targets, but also presents a wide-ranging selection of cuttingedge techniques currently being applied throughout novel antitumor drug discovery and development. The methods are applied to experiments involving such topics as immunotherapy, angiogenesis, cancer metastasis, the cell cycle, signal transduction inhibitors, apoptosis, antibodies, antisense molecules, microarray gene expression, flow cytometry, and PET imaging for cancer target validation. There are also proven methods for the preclinical identification of drug targets. Validate new drug targets both preclinically and clinically Identify novel anticancer drug targets in preclinical stages Follow proven instructions to obtain successful results and avoid failure.

Anticancer Therapeutics

Anticancer Therapeutics Book
Author : Sotiris Missailidis
Publisher : John Wiley & Sons
Release : 2008-10-13
ISBN : 0470697032
Language : En, Es, Fr & De

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Book Description :

Written by the winner of the 2008 Mike Price Fellowship "This volume provides a comprehensive overview of the wealth of information now available in this important and fast-moving subject." Anticancer Research, November - December 2008 This book provides a clear introduction to the area, with an overview of the various drug design and development approaches for cancer therapeutics and their progress in today’s multidisciplinary approach to cancer treatment. Clearly structured throughout, the book not only provides information on currently used molecular treatment approaches, but also describes the various agents that are currently at various stages of development and clinical trials, thus making them the drugs of tomorrow. The book goes on to present current therapeutic regimes including their indications and side effects, as well as their position in the international market in terms of sales and development costs. Furthermore, coverage of our advancement in the understanding of cancer biology and how this has driven the drug discovery process is clearly discussed. Modern drug discovery aspects, through genomic, proteomic and metabolomic approaches are referred to as well as combinatorial chemistry techniques and discovery of chemotherapeutic agents from plant extracts, re-use of old drugs and drugs from other indications, or de novo rational drug design. Including contributions from leading experts in the field, this book provides the reader with a complete overview of the various types of therapeutic agents, current and emerging, as well as other aspects associated with anticancer therapy, drug design, resistance and clinical trials in oncology.

Anticancer

Anticancer Book
Author : David Servan-Schreiber, MD, PhD
Publisher : Penguin
Release : 2009-12-31
ISBN : 9781101163054
Language : En, Es, Fr & De

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Book Description :

The revolutionary, New York Times bestselling guide to the powerful lifestyle changes that fight and prevent cancer—an integrative approach based on the latest scientific research “A common-sense blueprint for healthy living.” —Chicago Tribune “Resonating with cancer support communities and recommended nationwide.” —Los Angeles Times “Life affirming . . . filled with practical advice.” —The Seattle Times David Servan-Schreiber was a rising neuroscientist with his own brain imaging laboratory when, in the middle of an equipment test, he discovered a tumor the size of a walnut in his own brain. Forced to confront what medicine knows about cancer, and all that we still do not know, Servan-Schreiber marshaled his will to live and set out to understand the complex inner workings of the body’s natural cancer-fighting capabilities. He soon found himself on a decades-long journey from disease and relapse into scientific exploration and, finally, a new view of health. Anticancer is at once the moving story of one doctor’s inner and outer search for wellness and a radical exposition of the roles that lifestyle, environment, and trauma play in our health. Drawing on the latest research in integrative medicine that blends conventional and alternative approaches, Servan-Schreiber concisely explains what makes cancer cells thrive, what inhibits them, and how we can empower ourselves to prevent their growth. His advice details how to develop a science-based anticancer diet (and the small changes that can make a big difference); how to reap the benefits of exercise, yoga, and meditation; which toxic, unsafe products to replace in your home; and how to stave off the effects of helplessness and unhealed wounds to regain balance. Anticancer’s synthesis of science and personal experience marks a transformation in the way we understand and confront cancer. A long-running bestseller that has changed the lives of millions around the world, Anticancer remains a pioneering and peerless resource, an inspirational and revolutionary guide to “a new way of life.”