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Analysis Of Complex Disease Association Studies

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Analysis of Complex Disease Association Studies

Analysis of Complex Disease Association Studies Book
Author : Eleftheria Zeggini,Andrew Morris
Publisher : Academic Press
Release : 2010-11-17
ISBN : 9780123751430
Language : En, Es, Fr & De

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Book Description :

According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease and patient care, and ultimately the realization of the promise of personalized medicine. In addition, rapid advances in understanding the patterns of human genetic variation and maturing high-throughput, cost-effective methods for genotyping are providing powerful research tools for identifying genetic variants that contribute to health and disease. This burgeoning science merges the principles of statistics and genetics studies to make sense of the vast amounts of information available with the mapping of genomes. In order to make the most of the information available, statistical tools must be tailored and translated for the analytical issues which are original to large-scale association studies. Analysis of Complex Disease Association Studies will provide researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. With the use of consistent examples throughout the work, chapters will provide readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests. Frequently used tests will be highlighted and a critical analysis of the advantages and disadvantage complimented by case studies for each will provide readers with the information they need to make the right choice for their research. Additional tools including links to analysis tools, tutorials, and references will be available electronically to ensure the latest information is available. Easy access to key information including advantages and disadvantage of tests for particular applications, identification of databases, languages and their capabilities, data management risks, frequently used tests Extensive list of references including links to tutorial websites Case studies and Tips and Tricks

Schizophrenia Bulletin

Schizophrenia Bulletin Book
Author : Anonim
Publisher : Unknown
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Schizophrenia Bulletin book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Schizophrenia Bulletin

Schizophrenia Bulletin Book
Author : Anonim
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Schizophrenia Bulletin book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Genetics of Complex Disease

Genetics of Complex Disease Book
Author : Peter Donaldson,Ann Daly,Luca Ermini,Debra Bevitt
Publisher : Garland Science
Release : 2015-08-25
ISBN : 1317334256
Language : En, Es, Fr & De

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Book Description :

Genetics of Complex Disease examines how the identification of genetic variations that increase or reduce the risk of common, genetically complex, diseases can be used to improve our understanding of the pathology of many common diseases; enable better patient management and care; and help with differential diagnosis. It starts with the quest

Genetic Analysis of Complex Disease

Genetic Analysis of Complex Disease Book
Author : Jonathan L. Haines,Margaret A. Pericak-Vance
Publisher : John Wiley & Sons
Release : 2006-05-05
ISBN : 0471781134
Language : En, Es, Fr & De

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Book Description :

Second Edition features the latest tools for uncovering thegenetic basis of human disease The Second Edition of this landmark publication bringstogether a team of leading experts in the field to thoroughlyupdate the publication. Readers will discover the tremendousadvances made in human genetics in the seven years that haveelapsed since the First Edition. Once again, the editorshave assembled a comprehensive introduction to the strategies,designs, and methods of analysis for the discovery of genes incommon and genetically complex traits. The growing social, legal,and ethical issues surrounding the field are thoroughly examined aswell. Rather than focusing on technical details or particularmethodologies, the editors take a broader approach that emphasizesconcepts and experimental design. Readers familiar with theFirst Edition will find new and cutting-edge materialincorporated into the text: Updated presentations of bioinformatics, multiple comparisons,sample size requirements, parametric linkage analysis, case-controland family-based approaches, and genomic screening New methods for analysis of gene-gene and gene-environmentinteractions A completely rewritten and updated chapter on determininggenetic components of disease New chapters covering molecular genomic approaches such asmicroarray and SAGE analyses using single nucleotide polymorphism(SNP) and cDNA expression data, as well as quantitative trait loci(QTL) mapping The editors, two of the world's leading genetic epidemiologists,have ensured that each chapter adheres to a consistent and highstandard. Each one includes all-new discussion questions andpractical examples. Chapter summaries highlight key points, and alist of references for each chapter opens the door to furtherinvestigation of specific topics. Molecular biologists, human geneticists, geneticepidemiologists, and clinical and pharmaceutical researchers willfind the Second Edition a helpful guide to understanding thegenetic basis of human disease, with its new tools for detectingrisk factors and discovering treatment strategies.

Linkage Disequilibrium and Association Mapping

Linkage Disequilibrium and Association Mapping Book
Author : Andrew Collins
Publisher : Springer Science & Business Media
Release : 2007
ISBN : 1597453897
Language : En, Es, Fr & De

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Book Description :

As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In "Linkage Disequilibrium and Association Mapping: Analysis and Applications," scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike. The volume comprises four general sections: the first presents an overview and historical basis of the subject. The second section considers the developing methodology and recent findings from studies which have characterized the genome-wide linkage disequilibrium structure in enormous detail. The following section examines all aspects of disease association mapping methodology, and the final two chapters review the early successes in mapping genes involved in two of the most important human diseases: asthma and type 2 diabetes.

Journal of the National Cancer Institute

Journal of the National Cancer Institute Book
Author : Anonim
Publisher : Unknown
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of the National Cancer Institute book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Rheumatoid Arthritis

Rheumatoid Arthritis Book
Author : Gary S. Firestein,Gabriel Stavros Panayi,Frank A. Wollheim
Publisher : Oxford University Press, USA
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book presents the cutting edge of developments in etiology, mechanisms of inflammation, disease manifestations and management of this common, crippling disease. Here is a new major volume on the subject of great importance in rheumatology - the first in-depth, multiauthor textbook on RAfor 15 years. Therapy for RA has traditionally been with non-steroid anti-inflammatory drugs, progressing to second-line drugs, but this has not been effective in preventing erosion of bone and symptoms. Rapid recent advances in knowledge have led to new concepts in the mechanisms of the disease andexciting new possibilities for treatment. This book deals with the scientific basis of the pathogenesis of rheumatoid arthritis which then goes on to form the basis of scientific discussion and the rationale for the treatment, both drug and non-drug, of the disease. The book describes the latestadvances in our understanding of this common, crippling disease and relates this knowledge to the application of a more rational therapeutic approach to its management The book covers all areas of importance to disease management including social and psychological aspects, genetic susceptibility,biological/immunological research, classic and other treatments (eg. physiotherapy, occupational therapy, complementary therapy, diet and patient education), management of pain, health economics and disease management strategies. This book is a 'must' for all rheumatologists and anyone working inthe field.

Multivariate survival analysis methods for mapping genes for complex diseases

Multivariate survival analysis methods for mapping genes for complex diseases Book
Author : Xiaoyun Zhong
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Multivariate survival analysis methods for mapping genes for complex diseases book written by Xiaoyun Zhong, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

abstracts in anthropology

abstracts in anthropology Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download abstracts in anthropology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biostatistical Genetics and Genetic Epidemiology

Biostatistical Genetics and Genetic Epidemiology Book
Author : Robert C. Elston,Jane M. Olson,Lyle Palmer
Publisher : John Wiley & Sons
Release : 2002-04-22
ISBN : 0471486310
Language : En, Es, Fr & De

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Book Description :

Human Genetics concerns the study of genetic forces in man. By studying our genetic make-up we are able to understand more about our heritage and evolution. Some of the original, and most significant research in genetics centred around the study of the genetics of complex diseases - genetic epidemiology. This is the third in a highly successful series of books based on articles from the Encyclopedia of Biostatistics. This volume will be a timely and comprehensive reference, for a subject that has seen a recent explosion of interest following the completion of the first draft of the Human Genome Mapping Project. The editors have updated the articles from the Human Genetics section of the EoB, have adpated other articles to give them a genetic feel, and have included a number of newly commissioned articles to ensure the work is comprehensive and provides a self-contained reference.

Current Topics in Human Genetics

Current Topics in Human Genetics Book
Author : Hong-wen Deng,Hui Shen
Publisher : World Scientific
Release : 2007
ISBN : 9812704728
Language : En, Es, Fr & De

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Book Description :

The sequencing of the human genome has brought human genetics into a new era of study resulting in the generation of an explosive amount of information. Application of genomic, proteomic, and bioinformatics technologies to the study of human genetics has made it possible for human genetic diseases to be studied on an unprecedented scale, both in silico and in the wet lab. This volume provides up-to-date coverage of the broad range of research topics in this fascinating area. In the first part of the book, a whole spectrum of approaches to human genetics research is reviewed for both background and the latest progress. In the second, important topics related to genetic research of various complex human diseases are discussed. The robust content and diverse array of subjects allow the book to serve as both a concise ?encyclopedia? that introduces basic and essential concepts of human genetics and an in-depth review of the current understanding of genetic research in human diseases.

Genetic Dissection of Complex Traits

Genetic Dissection of Complex Traits Book
Author : D. C. Rao,Michael Arthur Province
Publisher : Academic Press
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Genetic Dissection of Complex Traits will present the full range of methodologies that are essential for understanding the basis of human genetic disorders, the origin of such diseases, and theories on how to determine one's genetic predisposition to certain genetic diseases.

Encyclopedia of Genetics Genomics Proteomics and Bioinformatics Genetics

Encyclopedia of Genetics  Genomics  Proteomics  and Bioinformatics  Genetics Book
Author : Lynn B. Jorde
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Encyclopedia of Genetics Genomics Proteomics and Bioinformatics Genetics book written by Lynn B. Jorde, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Best Practice Research

Best Practice   Research Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Best Practice Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Genome Research

Genome Research Book
Author : Anonim
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Genome Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular Genetic Analysis of Two Complex Human Diseases

Molecular Genetic Analysis of Two Complex Human Diseases Book
Author : Elizabeth Ann Ostermeyer
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Molecular Genetic Analysis of Two Complex Human Diseases book written by Elizabeth Ann Ostermeyer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Dissection of Complex Disease

The Dissection of Complex Disease Book
Author : Sudheer Doss
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Dissection of Complex Disease book written by Sudheer Doss, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Aneurysms

Aneurysms Book
Author : Alain Laurent,Ethan Morel
Publisher : Nova Biomedical
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

An aneurysm is a localised dilation of the wall of a blood vessel, usually caused by atherosclerosis and hypertension, or less frequently, by trauma, infection or a congenital weakness in the vessel wall. Aneurysms most commonly occur in arteries at the base of the brain and in the aorta. As the size of the aneurysm increases, there is an increased risk of rupture, which can result in severe haemorrhage and other complications including sudden death. This book describes different types of aneurysms, their causes, diagnosis and how they can be treated.