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Alginates In Drug Delivery

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Alginates in Drug Delivery

Alginates in Drug Delivery Book
Author : Amit Kumar Nayak,MD Saquib Hasnain
Publisher : Academic Press
Release : 2020-02-15
ISBN : 9780128176405
Language : En, Es, Fr & De

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Book Description :

Alginates in Drug Delivery explores the vital precepts, basic and fundamental aspects of alginates in pharmaceutical sciences, biopharmacology, and the biotechnology industry in extensive detail to understand the field and develop high quality products. The use of natural polymers in healthcare applications over synthetic polymers is becoming more prevalent due to natural polymers' biocompatibility, biodegradability, economic extraction and ready availability. These natural materials are renewable if grown sustainably, and they can tender incessant supply of raw materials. Amongst these natural polymers, Alginates are considered excellent excipients because of their non-toxic, stable and biodegradable properties, and can be used in a variety of applications in pharmaceuticals, medical diagnostic aids and material science. Several innovations have been made on applications of alginate in drug delivery and biomedicines including in liquid gels, powders, beads, films, tablets, capsules, microspheres, microparticles, nanoparticles, nanosponges, nanofibrils and nanocomposites. To fully utilize and harness the potential of alginates, a thorough understanding of the synthesis, purification, and characterization of alginates and their derivatives needs to be is needed. This book collects in a single volume all relevant information on alginates in health care including recent advances in the field. Alginates in Drug Delivery is a highly useful resource for pharmaceutical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development of natural polymer containing drug delivery, as well as postgraduate students and postdoctoral research fellows in pharmaceutical sciences. Provides a single source examining the complete alginate chemistry, collection, chemical modifications, characterization and applications in healthcare fields Includes high quality illustrations along with practical examples and research case studies Contains contributions by global leaders and experts from academia, industry and regulatory agencies, who are pioneers in the application of natural polysaccharides in diverse pharmaceutical fields

Alginates

Alginates Book
Author : Md Saquib Hasnain,Amit Kumar Nayak
Publisher : CRC Press
Release : 2019-04-01
ISBN : 042965748X
Language : En, Es, Fr & De

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Book Description :

This new volume explores the latest research on the use of alginate as a biopolymer in various biomedical applications and therapeutics. The uses of alginates and modified alginates discussed in this book include tissue regeneration, encapsulation and delivery of drugs, nucleic acid materials, proteins and peptides, genes, herbal therapeutic agents, nutraceuticals, and more. This book also describes the synthesis and characterizations of various alginate and modified alginate systems, such as hydrogels, gels, composites, nanoparticles, scaffolds, etc., used for the biomedical applications and therapeutics. Alginate, a biopolymer of natural origin, is of immense interest for its variety of applications in pharmaceuticals (as medical diagnostic aids) and in materials science. It is the one of the most abundant natural biopolymers and is considered an excellent excipient because of its non-toxic, stable, and biodegradable properties. Several research innovations have been made on applications of alginate in drug delivery and biomedicines. There needs to be a thorough understanding of the synthesis, purification, and characterization of alginates and its derivatives for their utility in healthcare fields, and this volume offers an abundance of information toward that end.

Alginates in Drug Delivery

Alginates in Drug Delivery Book
Author : Amit Kumar Nayak,Md Saquib Hasnain
Publisher : Academic Press
Release : 2020-07-23
ISBN : 0128176415
Language : En, Es, Fr & De

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Book Description :

Alginates in Drug Delivery explores the vital precepts, basic and fundamental aspects of alginates in pharmaceutical sciences, biopharmacology, and in the biotechnology industry. The use of natural polymers in healthcare applications over synthetic polymers is becoming more prevalent due to natural polymers’ biocompatibility, biodegradability, economic extraction and ready availability. To fully utilize and harness the potential of alginates, this book presents a thorough understanding of the synthesis, purification, and characterization of alginates and their derivative. This book collects, in a single volume, all relevant information on alginates in health care, including recent advances in the field. This is a highly useful resource for pharmaceutical scientists, health care professionals and regulatory scientists actively involved in the pharmaceutical product and process development of natural polymer containing drug delivery, as well as postgraduate students and postdoctoral research fellows in pharmaceutical sciences. Provides a single source on the complete alginate chemistry, collection, chemical modifications, characterization and applications in healthcare fields Includes high quality illustrations, along with practical examples and research case studies Contains contributions by global leaders and experts from academia, industry and regulatory agencies who are pioneers in the application of natural polysaccharides in diverse pharmaceutical fields

Alginates

Alginates Book
Author : Shakeel Ahmed
Publisher : John Wiley & Sons
Release : 2019-02-13
ISBN : 1119487986
Language : En, Es, Fr & De

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Book Description :

Alginate is a hydrophilic, biocompatible, biodegradable, and relatively economical polymer generally found in marine brown algae. The modification in the alginate molecule after polymerization has shown strong potential in biomedical, pharmaceutical and biotechnology applications such as wound dressing, drug delivery, dental treatment, in cell culture and tissue engineering. Besides this, alginates have industrial applications too in the paper and food industries as plasticizers and additives. The few books that have been published on alginates focus more on their biology. This current book focuses on the exploration of alginates and their modification, characterization, derivatives, composites, hydrogels as well as the new and emerging applications.

Alginates

Alginates Book
Author : Taylor & Francis Group
Publisher : Apple Academic Press
Release : 2021-03-31
ISBN : 9781774634578
Language : En, Es, Fr & De

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Book Description :

This new volume explores the latest research on the use of alginate as a biopolymer in various biomedical applications and therapeutics. The uses of alginates and modified alginates discussed in this book include tissue regeneration, encapsulation and delivery of drugs, nucleic acid materials, proteins and peptides, genes, herbal therapeutic agents, nutraceuticals, and more. This book also describes the synthesis and characterizations of various alginate and modified alginate systems, such as hydrogels, gels, composites, nanoparticles, scaffolds, etc., used for the biomedical applications and therapeutics. Alginate, a biopolymer of natural origin, is of immense interest for its variety of applications in pharmaceuticals (as medical diagnostic aids) and in materials science. It is the one of the most abundant natural biopolymers and is considered an excellent excipient because of its non-toxic, stable, and biodegradable properties. Several research innovations have been made on applications of alginate in drug delivery and biomedicines. There needs to be a thorough understanding of the synthesis, purification, and characterization of alginates and its derivatives for their utility in healthcare fields, and this volume offers an abundance of information toward that end.

Alginates as Therapeutic and Drug Delivery Systems

Alginates as Therapeutic and Drug Delivery Systems Book
Author : K. G. Hutchinson,University of Aston
Publisher : Unknown
Release : 1982
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Alginates as Therapeutic and Drug Delivery Systems book written by K. G. Hutchinson,University of Aston, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Evaluation of Alginates of Soluble Drug Delivery System for Oral and Systematic Use

Evaluation of Alginates of Soluble Drug Delivery System for Oral and Systematic Use Book
Author : Aymen Al-Shamkhani
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Evaluation of Alginates of Soluble Drug Delivery System for Oral and Systematic Use book written by Aymen Al-Shamkhani, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Handbook of Alginate Based Nano Structure for Drug Delivery

Handbook of Alginate Based Nano Structure for Drug Delivery Book
Author : Tapan Kumar Giri,Ayan Giri
Publisher : Unknown
Release : 2015-05-02
ISBN : 9783659690471
Language : En, Es, Fr & De

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Book Description :

Download Handbook of Alginate Based Nano Structure for Drug Delivery book written by Tapan Kumar Giri,Ayan Giri, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Alginates

Alginates Book
Author : Anonim
Publisher : BoD – Books on Demand
Release : 2020-02-05
ISBN : 1789856418
Language : En, Es, Fr & De

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Book Description :

Alginates are polysaccharides found in both the intercellular matrix of brown algae and extracellularly covering some species of bacteria. Alginate varies in composition of the algae from 20% to 60% dry matter, but on average brown algae species has 40% alginate. Alginate from brown algae occurs as gels containing sodium, calcium, strontium, magnesium, and barium ions. They are widely used by the food industry, giving foods texture properties such as thickening, adhesion, emulsification, gelling, or fullness. This book covers the latest uses of this phycocolloid in the pharmaceutical, medical, and technological fields, namely bioink for 3D bioprinting in tissue engineering and regenerative medicine, and the application of artificial intelligence in modern healthcare systems.

Plant Polysaccharides Based Multiple Unit Systems for Oral Drug Delivery

Plant Polysaccharides Based Multiple Unit Systems for Oral Drug Delivery Book
Author : Amit Kumar Nayak,Md Saquib Hasnain
Publisher : Springer
Release : 2019-03-27
ISBN : 9811067848
Language : En, Es, Fr & De

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Book Description :

This book explores the use of various plant polysaccharides for pharmaceutical purposes, including drug delivery. It examines the exploitation of plant polysaccharides’ auxiliary functions to enhance drug release, stability, bioavailability and target specificity. Plant-derived materials are at the center of drug-delivery research thanks to their non-toxicity, biodegradability, ready availability, eco-friendliness and low extraction costs. These materials include polysaccharides, a class of naturally occurring polymers consisting of glucose monomers, which serve as storage carbohydrates in cereals, root vegetables, rhizomes, seeds, fruits, etc.

Biofunctionalization of Alginate Microcapsules

Biofunctionalization of Alginate Microcapsules Book
Author : Ane Garate Letona
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biofunctionalization of Alginate Microcapsules book written by Ane Garate Letona, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Alginates

Alginates Book
Author : Manuel E. Molina,Andres J. Quiroga
Publisher : Nova Science Pub Incorporated
Release : 2012
ISBN : 9781619425460
Language : En, Es, Fr & De

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Book Description :

Alginate is extracted from brown algae and some bacteria. It is an abundant natural polysaccharide and usually exists as sodium salt. In this book, the authors present topical research in the study of the production, types and applications of alginate. Topics discussed include the application of alginates in cell and enzyme immobilization; alginate based materials in environmental applications; cross-linked alginates for modified drug delivery applications; bacterial alginate production by fermentation and the preparation and functionalization of alginate-based hydrogels.

Analysis of Selected Physico chemical Properties of Pectin and Alginate Gels Intended for Drug Delivery

Analysis of Selected Physico chemical Properties of Pectin and Alginate Gels Intended for Drug Delivery Book
Author : Pornsak Sriamornsak
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Analysis of Selected Physico chemical Properties of Pectin and Alginate Gels Intended for Drug Delivery book written by Pornsak Sriamornsak, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Advanced Biopolymeric Systems for Drug Delivery

Advanced Biopolymeric Systems for Drug Delivery Book
Author : Amit Kumar Nayak,Md Saquib Hasnain
Publisher : Springer Nature
Release : 2020-07-11
ISBN : 3030469239
Language : En, Es, Fr & De

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Book Description :

This book discusses the recent innovations in the development of various advanced biopolymeric systems, including gels, in situ gels, hydrogels, interpenetrating polymer networks (IPNs), polyelectrolyte complexes (PECs), graft co-polymers, stimuli-responsive polymers, polymeric nanoparticles, nanocomposites, polymeric micelles, dendrimers, liposomes and scaffolds. It also examines their applications in drug delivery.

Alginate Chitosan Beads for Colonic Drug Delivery

Alginate Chitosan Beads for Colonic Drug Delivery Book
Author : Ryan Jeong-Yeon Kum,Brown University. Division of Engineering and Division of Biology and Medicine
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Alginate Chitosan Beads for Colonic Drug Delivery book written by Ryan Jeong-Yeon Kum,Brown University. Division of Engineering and Division of Biology and Medicine, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Polysaccharides in Advanced Drug Delivery

Polysaccharides in Advanced Drug Delivery Book
Author : Akhilesh Vikram Singh,Bang-Jing Li
Publisher : CRC Press
Release : 2020-03-24
ISBN : 1000050866
Language : En, Es, Fr & De

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Book Description :

This book contains selective chapters from eminent experts working in the interdisciplinary arena of material science and its use in drug delivery. From their recent research experience, the readers can achieve a wide vision on the new and ongoing potentialities of polysaccharides and its application in the field of advanced drug delivery. This book contains selective polymers that were recently explored in the field of drug delivery such as starch, konjac, chitosan, alginate and other natural polymers originated from sea. It also has one chapter exclusively on nanotechnology that explains multifaceted application of natural polymer in the field of advanced drug delivery. Note: T& F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.

Exploratory Studies on Calcium Alginate as a Vehicle for Sustained Drug Delivery

Exploratory Studies on Calcium Alginate as a Vehicle for Sustained Drug Delivery Book
Author : Elizabeth Anne Fisher
Publisher : Unknown
Release : 1980
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Exploratory Studies on Calcium Alginate as a Vehicle for Sustained Drug Delivery book written by Elizabeth Anne Fisher, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Preparation and Evaluation of Alginate pectin poly lysine Particulates for Drug Delivery and Evaluation of Melittin as a Novel Absorption Enhancer

Preparation and Evaluation of Alginate pectin poly   lysine Particulates for Drug Delivery and Evaluation of Melittin as a Novel Absorption Enhancer Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Preparation and Evaluation of Alginate pectin poly lysine Particulates for Drug Delivery and Evaluation of Melittin as a Novel Absorption Enhancer book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Use of Alginate montmorillonite Nanocomposites as Drug Delivery System for Curcumin

Use of Alginate montmorillonite Nanocomposites as Drug Delivery System for Curcumin Book
Author : Marwa Fathy Abdelfattah Ahmed
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract: Curcumin (Cur.) is a well known traditional medicine due to its anti-inflammatory and antioxidant properties. Its pharmacological mechanism of action and safety have been extensively studied to investigate its use in clinical and therapeutic applications. However, its low water solubility and rapid metabolism are main obstacles. Different techniques were used to overcome the drawbacks of curcumin, with recent attention focusing on approaches based on nanotechnology. Clay-polymer nanocomposites are getting to play a role in nanoformulations for drug delivery. This is due to their improved rheological and mechanical properties, and controlled drug release characteristics compared to their individual components, clays and polymers. Alginate/ montmorillonite (MMT) nanocomposites are used as drug delivery system for a wide variety of drugs due to numerous advantages of both components such as the high loading capacity of MMT and the ability of alginate release encapsulated drugs in a controlled manner. Accordingly, this study aimed at the preparation of curcumin loaded alginate/MMT nanocomposites and the investigation of their release properties. Exfoliated MMT clay was first prepared by stirring the clay in an aqueous suspension for 4 hours, followed by filtration and drying at 70 °C. Exfoliation was confirmed by X-ray diffraction (XRD) and Fourier Transform infrared (FTIR) spectroscopy. Curcumin loaded MMT was then prepared by dispersing the exfoliated clay into an ethanoic curcumin solution. Different parameters were tested, namely stirring time, curcumin solution concentration and ratio of MMT to curcumin, in order to find out the maximum loading conditions. Stirring exfoliated MMT into curcumin solution of 1 mg/ml for 1 hour and in 5% W/V ratio was found to be the best condition for maximum loading (6.56 mg/g, corresponding to entrapment efficiency of 25.62 %). The hybrid sample (curcumin loaded MMT) was thus prepared. Visible spectrophotometric measurements of the curcumin solution were used to determine the amount of curcumin loaded by measuring the absorbance of curcumin solution before and after the dispersion of the clay. The hybrid sample was then encapsulated into alginate beads with different hybrid to alginate ratios (W/W) using the ionotropic technique. XRD and FTIR analysis were used for the characterization of the prepared hybrid and nanocomposites. They revealed the increase in the degree of clay exfoliation upon drug loading and encapsulation into the alginate beads and the loss of the crystalline nature of curcumin upon v adsorption onto the clay surface without any chemical interaction between the clay and curcumin. The release of curcumin from different alginate/MMT nanocomposites was studied in different biorelevent media: fast gastric (FaSSGF), fast intestinal (FaSSIF) and fed intestinal media (FeSSIF). The curcumin release in gastric media was negligible and this was attributed to its low solubility in these media and to the shrinkage of alginate beads in the acidic pH environment. Curcumin release in intestinal media was significantly higher and was found to be affected by both the feeding state and the ratio of hybrid to alginate. Increasing the hybrid to alginate ratio decreased the percentage of curcumin release because of the decrease of the swelling ratio of alginate due to the crosslinking effect of the clay. Consequently, the 1:20 (W/W) hybrid to alginate ratio nanocomposite sample (NC 1) showed the highest release percentage in both fast and fed intestinal media (71% in the FaSSIF and 15.5 % in the FeSSIF). On the other hand, the 1:2 (W/W) hybrid to alginate ratio nanocomposite sample (NC 4) demonstrated the lowest release percentage in both media (17.4% in FaSSIF and 6.6 % in FeSSIF). The feeding state played additional role in the percentage of curcumin released as it was found to affect both the pH and the concentration of the natural solubilizing components such as phospholipids and bile salts of the intestine. Accordingly, the percentage of curcumin released was higher in the fasting state than in the fed state due to the higher pH of the former media (88.4% in the FaSSIF and 16.6% in the FeSSIF for NC 1. Curcumin release in both intestinal media demonstrated different behaviors: in FaSSIF sustained release behavior was found to occur for 24 hours, while curcumin release reached a plateau by 8 hours in the FeSSIF. This study reveals the promising use of alginate/MMT nanocomposites as sustained release drug delivery system for curcumin through surface adsorption of curcumin onto the surface of exfoliated clay and encapsulation of the loaded clay into alginate beads. The release of curcumin would be hindered into the gastric environment and start into the intestine. For maximum and sustained release behavior a fasting state is preferred.

Bioadhesives in Drug Delivery

Bioadhesives in Drug Delivery Book
Author : K. L. Mittal,Inderbir Singh Bakshi,Jasjit Kaur Narang
Publisher : John Wiley & Sons
Release : 2020-05-12
ISBN : 1119640253
Language : En, Es, Fr & De

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Book Description :

Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and efficient technique for targeting a drug to the desired location for a prolonged duration. This book addresses the various relevant aspects of bioadhesives in drug delivery in an easily accessible and unified manner. The book containing 12 chapters written by eminent researchers from many parts of the globe is divided into three parts: Part 1: Fundamental Aspects; Part 2: Bioadhesive Formulations; Part 3: Drug Delivery Applications. The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; and bioadhesive hydrogels and applications ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems ; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems.