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Advances In Molecular Toxicology

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Advances in Molecular Toxicology

Advances in Molecular Toxicology Book
Author : James C. Fishbein
Publisher : Elsevier
Release : 2012
ISBN : 0444593896
Language : En, Es, Fr & De

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Book Description :

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. Cutting-edge reviews by leading workers in the discipline In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Advances in Molecular Toxicology

Advances in Molecular Toxicology Book
Author : Anonim
Publisher : Elsevier Science
Release : 2006-12-23
ISBN : 9780444528421
Language : En, Es, Fr & De

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Book Description :

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. * Cutting edge reviews by leading workers in the discipline. * In depth dissection of molecular aspects of interest to a broad range of scientists, physisicans and any student in the allied disciplines. * Leading edge applications of technological innovations in the chemistry, biochemistry and molecular medicine.

Advances in Molecular Toxicology

Advances in Molecular Toxicology Book
Author : James C. Fishbein,Jacqueline M. Heilman
Publisher : Academic Press
Release : 2018-09-21
ISBN : 044464198X
Language : En, Es, Fr & De

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Book Description :

Advances in Molecular Toxicology, Volume Twelve, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The work not only documents these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field. Provides cutting-edge reviews by leading workers in the discipline Includes in-depth dissection of the molecular aspects that are of interest to a broad range of scientists, physicians and students in the allied disciplines Presents leading-edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Advances in Molecular Toxicology

Advances in Molecular Toxicology Book
Author : Anonim
Publisher : Academic Press
Release : 2017-09-15
ISBN : 0128125233
Language : En, Es, Fr & De

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Book Description :

Advances in Molecular Toxicology, Volume 11, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field. Provides cutting-edge reviews by leading workers in the discipline Includes in-depth dissection of the molecular aspects that are of interest to a broad range of scientists, physicians and any student in the allied disciplines Presents leading-edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Advances in Molecular Toxicology

Advances in Molecular Toxicology Book
Author : Claude Reiss,Simone Parvez,Gilles Labbe
Publisher : VSP
Release : 1998-02
ISBN : 9789067642781
Language : En, Es, Fr & De

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Book Description :

Molecular toxicology is on the way to setting a new standard in toxic risk assessment, with the powerful help of concepts and methods developed in the fields of molecular and cellular biology. The methods of molecular toxicology are endowed with qualities not always secured in more traditional approaches to toxicity assessment. These methods are easily standardized, reliable, reproducible and require only tiny amounts of the xenobiotic. They are much simpler, faster and less costly than current tests on animals and can be implemented with modest laboratory resources. This volume of Advances in Molecular Toxicology represents a collection of invited papers presented at the First European Workshop on Molecular Toxicology in Sophia Antipolis, France, The book covers 8 selected topics in molecular toxicology. The first two are devoted to ''physics'', dealing respectively with advanced instrumentation enabling location and quantification of xenobiotics in cells and organs with ultimate precision, and computer-assisted assessment of risk (QSAR). A comprehensive and up-to-date survey of molecular toxicology in the pharmaceutical industry is contributed by a pioneer in this field. The third section addresses the effect of xenobiotics on cell-cycle actors. Sections 4--6 deal with molecular toxicology in skin, kidney, nerve, liver and pancreatic cells. The last two sections describe methods to probe DNA damage and repair, and immunotoxicity.

Advances in Molecular Toxicology

Advances in Molecular Toxicology Book
Author : James C. Fishbein,Jacqueline M. Heilman
Publisher : Elsevier Science Serials
Release : 2013-08-07
ISBN : 9780444626455
Language : En, Es, Fr & De

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Book Description :

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed. Cutting-edge reviews by leading workers in the discipline In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Advances in Molecular Toxicology

Advances in Molecular Toxicology Book
Author : Sigeng Chen,John R. Cashman
Publisher : Elsevier Inc. Chapters
Release : 2013-08-12
ISBN : 0128084987
Language : En, Es, Fr & De

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Book Description :

Organophosphate (OP) exposure continues to be a threat to both civilian and military personnel. Sensitive and specific methods for the detection and remediation are needed not only for public health but also for farmers who are exposed to OPs frequently. Although detection approaches based on a mass spectrometry are sensitive and reliable, they require expensive equipment and expert operators. In addition, instrumentation such as mass spectrometer cannot be easily deployed in the field. Attempts to make point-of-care approaches have been the trend in both detecting and rescuing OP exposure in the current research of OP toxicity. This chapter will discuss some recent progress reported concerning the immunodetection of OP exposure and improved antidote therapy in the remediation of OP exposure.

Molecular Toxicology

Molecular Toxicology Book
Author : P. David Josephy,Bengt Mannervik
Publisher : Oxford University Press on Demand
Release : 2006
ISBN : 9780195176209
Language : En, Es, Fr & De

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Book Description :

The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things at the molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair, among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses, as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

British Toxicology Society Annual Congress Spring 2008

British Toxicology Society Annual Congress  Spring 2008 Book
Author : Matthew C. Wright,British Toxicology Society
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download British Toxicology Society Annual Congress Spring 2008 book written by Matthew C. Wright,British Toxicology Society, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Advances in Molecular Toxicology

Advances in Molecular Toxicology Book
Author : Umeo Takahama,Toshihiro Ansai,Sachiko Hirota
Publisher : Elsevier Inc. Chapters
Release : 2013-08-12
ISBN : 0128084960
Language : En, Es, Fr & De

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Book Description :

Salivary nitrate derived from foods is reduced to nitrite and nitric oxide (NO•) by oral bacteria. NO• is transformed into NO2•, N2O3, and ONOOH by chemical reactions, and nitrite is oxidized to NO2• by salivary peroxidase. The formation of reactive nitrogen oxides becomes faster with the decrease in pH of dental plaque from 7 to 5. Reactive nitrogen oxides formed in acidified plaque can activate leukocytes through oxidation, nitration, and nitrosation of free and bacterial proteins in plaque and the gingival crevice. O2•− and NO• produced by activated leukocytes can contribute to stresses to the gingival tissues. This chapter deals with mechanisms of production of reactive nitrogen oxides in the oral cavity, especially, acidified plaque. Since salivary nitrite is transported to the stomach, this chapter also deals with reactions of salivary nitrite in the stomach.

Advances in Molecular Toxicology

Advances in Molecular Toxicology Book
Author : Arno G. Siraki
Publisher : Elsevier Inc. Chapters
Release : 2013-08-12
ISBN : 0128084944
Language : En, Es, Fr & De

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Book Description :

Aromatic amines (also known as arylamines) form a very important class of xenobiotics. The arylamine substructure is found in pesticides, carcinogens, and drugs. It is therefore unsurprising that arylamine drugs possess varying degrees of toxicity which ultimately depend on dose, exposure, and the particular genetic makeup of the individual. Arylamines have been shown to undergo oxidation reactions to produce reactive metabolites. This chapter will focus on a subset of reactive metabolites which are the arylamine-free radical metabolites. A detailed discussion on how these free radical metabolites form is presented, and association between the latter and toxicity reactions are discussed. Particular emphasis is devoted to the subject of arylamine-induced blood dyscrasias and recent advances as well as future prospects in this area.

Advances in Molecular Toxicology

Advances in Molecular Toxicology Book
Author : Jason Matthews,Shaimaa Ahmed
Publisher : Elsevier Inc. Chapters
Release : 2013-08-12
ISBN : 0128084936
Language : En, Es, Fr & De

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Book Description :

The aryl hydrocarbon receptor (AHR) and estrogen receptors (ERs) are ligand-activated transcription factors and members of the basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) and nuclear receptor (NR) superfamilies, respectively. The bHLH-PAS and NRs regulate many vital physiological processes including metabolism, circadian rhythm, differentiation, development, and reproduction. However, both receptor families are also associated with numerous human diseases. Reciprocal crosstalk between AHR and ERs is proposed to both positively and negatively impact human health. ERs are the most important targets in the treatment of breast cancer. The AHR, which is activated by many environmental pollutants, natural/dietary compounds, and endogenous substances, is a negative regulator of ER function. The role of ERα in AHR signaling is less clear as it is known to exhibit cell-type and promoter-specific differences. In this chapter, we will highlight the current understanding of AHR and ER crosstalk and toxicity.

Advances in Molecular Toxicology

Advances in Molecular Toxicology Book
Author : Anonim
Publisher : Elsevier
Release : 2008-03-10
ISBN : 9780080561011
Language : En, Es, Fr & De

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Book Description :

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed * Cutting edge reviews by leading workers in the discipline. * In depth dissection of molecular aspects of interest to a broad range of scientists, physisicans and any student in the allied disciplines. * Leading edge applications of technological innovations in the chemistry, biochemistry and molecular medicine.

Advances in Molecular Toxicology

Advances in Molecular Toxicology Book
Author : Oksana Lockridge
Publisher : Elsevier Inc. Chapters
Release : 2013-08-12
ISBN : 0128084979
Language : En, Es, Fr & De

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Book Description :

The acute toxicity of organophosphorus (OP) nerve agents and pesticides is due to inhibition of acetylcholinesterase (AChE) activity in cholinergic nerve synapses. Delayed neuropathy involves OP binding to neuropathy target esterase (NTE) in neurons. AChE and NTE are serine hydrolases. In vitro studies have demonstrated that OP toxicants bind not only to serine hydrolases but also to proteins that have no active site serine, for example, Tyr 411 of human albumin and Lys 296 of mouse transferrin. Mice treated with low doses of chlorpyrifos have OP-modified tubulin in brain. Mass spectrometry has identified OP-modified albumin in the blood of humans self-poisoned by chlorpyrifos and dichlorvos. Albumin is weakly reactive with OP, but the presence of OP-modified albumin in humans suggests the existence of additional noncholinesterase OP targets. In conclusion, long-term adverse effects from OP exposure may involve OP modification of proteins that have no active site serine.

Advances in Molecular Toxicology

Advances in Molecular Toxicology Book
Author : Sushmita Sen,Jeffrey M. Field
Publisher : Elsevier Inc. Chapters
Release : 2013-08-12
ISBN : 0128084952
Language : En, Es, Fr & De

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Book Description :

Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants, so widespread that it is impossible for anyone to avoid exposure to them. They are the products of partial combustion, and exposure comes from the fossil fuels that we use to drive our cars, cook our food, warm our home, and fuel our industry. Other exposure comes from tobacco smoke and oil spills. PAHs are responsible for more cancers, primarily lung cancers, than any other carcinogen. The most studied PAHs are unsubstituted multi-ring structures. These compounds are not DNA reactive, and must be modified to become carcinogenic. Metabolic pathways modify PAH during the detoxification process. Three pathways have been extensively documented: the diol-epoxide pathway, the radical cation pathway, and the o-quinone pathway. Some PAHs are generated during combustion in oxygenated forms, usually as quinones. Quinones also form as PAHs are exposed to sunlight, for example, in an oil spill. These metabolic products damage DNA through distinct mechanisms: diol epoxides form bulky adducts with DNA, radical cations form depurinating adducts and quinones undergo futile redox cycling to generate reactive oxygen. Here, we discuss the evidence for these pathways in PAH carcinogenesis.

Molecular Toxicology

Molecular Toxicology Book
Author : Nick Plant
Publisher : Garland Science
Release : 2003
ISBN : 9781859963456
Language : En, Es, Fr & De

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Book Description :

With the recent rapid developments in drug discovery, including advances in both drug design and combinatorial chemistry, toxicology is becoming an increasingly important proactive tool. In addition to new compound testing, toxicity studies can also shed light on normal bodily processes through the understanding of adverse ones. Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e. g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics.

PCR Protocols in Molecular Toxicology

PCR Protocols in Molecular Toxicology Book
Author : John P. Vanden Heuvel
Publisher : CRC Press
Release : 2019-05-07
ISBN : 1439805806
Language : En, Es, Fr & De

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Book Description :

Molecular toxicology is an emerging discipline that utilizes molecular and cell biology to understand how drugs and chemicals result in their unwanted effects. PCR Protocols in Molecular Toxicology is a practical guide to the use of polymerase chain reaction (PCR) to help examine, on a molecular and cellular level, how toxic responses are manifested. It offers a basic understanding of PCR and its optimization, as well as describing specific, high-impact areas of molecular toxicology and recent advances. The following techniques are described in detail: Quantitative reverse transcriptase PCR and methods to examine gene expression Differential display cloning Cloning and library screening by PCR Genotype and polymorphism analysis of drug and toxicant metabolizing enzymes Basic, non-PCR based molecular biology methods PCR Protocols in Molecular Toxicology will aid both novices and experienced PCR practitioners in using PCR to its fullest potential.

Cellular and Molecular Toxicology

Cellular and Molecular Toxicology Book
Author : J.P. Vanden Heuvel,W.F. Greenlee,G.H. Perdew,William B. Mattes
Publisher : Gulf Professional Publishing
Release : 2002-02-28
ISBN : 9780444508683
Language : En, Es, Fr & De

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Book Description :

Volume 14 in the series Comprehensive Toxicology extends and complements the previously published 13-volume set. This volume will be available separately. Toxicology is the study of the nature and actions of chemicals on biological systems. In more primitive times, it really was the study of poisons. However, in the early 1500s, it was apparent to Paracelsus that "the dose differentiates a poison and a remedy". Clearly, the two most important tenets of toxicology were established during that time. The level of exposure (dose) and the duration of exposure (time) will determine the degree and nature of a toxicological response. Since that time the discipline of toxicology has made major advances in identifying and characterizing toxicants. The growth of toxicology as a scientific discipline has been driven to a large extent by the use of extremely powerful molecular and cell biology techniques. The overall aim of this volume is to demonstrate how these advances are being used to elucidate causal pathways (or linkages) for potential adverse health consequences of human exposure to environmental chemicals or radiation. A unique feature of this volume is its illustration of how carefully-designed studies of the molecular mechanisms of chemical action provide not only understanding of the potential toxicity of the chemical under investigation, but also new insights into the functioning of the biological system used as an experimental model. Each chapter contains a listing of major peer-reviewed articles and reviews and useful web-sites. In addition, each chapter contains a broad introductory section that outlines the subsequent sections. These Introductory and Overview sections are designed to be stand alone chapters, and may be packaged as a textbook in graduate level courses.

Molecular and Biochemical Toxicology

Molecular and Biochemical Toxicology Book
Author : Robert C. Smart,Ernest Hodgson
Publisher : John Wiley & Sons
Release : 2018-01-04
ISBN : 1119042410
Language : En, Es, Fr & De

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Book Description :

Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. • Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies • Uses a didactic approach with basic biological or theoretical background for the methodology presented • Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology • Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts • “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition

Mechanistic Toxicology

Mechanistic Toxicology Book
Author : Urs A. Boelsterli
Publisher : CRC Press
Release : 2002-10-24
ISBN : 9780415284592
Language : En, Es, Fr & De

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Book Description :

Reductionism to cellular and molecular mechanisms is one of the cornerstones of modern toxicology, forming the basis for a better understanding of individual toxic effects, and providing an important tool for human risk assessment. Mechanistic Toxicology is a timely textbook that provides an introduction to this important, but often neglected, area within the toxicological sciences. This book gives new insights into the processes and mechanisms underlying the toxicity of chemicals and explains how foreign compounds (drugs, environmental pollutants, industrial chemicals) exert their potentially damaging effects on cells and tissues. Features include: *an extensive number of illustrations, tables and photographs *summaries of the main learning points *question and answer reviews at the end of each chapter Mechanistic Toxicology incorporates recent advances in molecular biology and develops concepts for the reader in a logical way. It also illustrates, using many examples and complementary background information, how a better understanding of these mechanistic pathways helps in estimating potential risk to human health. Ideal for use in undergraduate and graduate classes of pharma-toxicology and environmental toxicology, Mechanistic Toxicology is also a valuable reference for any other readers interested in this subject.