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Advanced Mechanical Models Of Dna Elasticity

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Advanced Mechanical Models of DNA Elasticity

Advanced Mechanical Models of DNA Elasticity Book
Author : Yakov M. Tseytlin
Publisher : Academic Press
Release : 2016-04-01
ISBN : 9780128019993
Language : En, Es, Fr & De

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Book Description :

Advanced Mechanical Models of DNA Elasticity includes coverage on 17 different DNA models and the role of elasticity in biological functions with extensive references. The novel advanced helicoidal model described reflects the direct connection between the molecule helix structure and its specific properties, including nonlinear features and transitions. It provides an introduction to the state of the field of DNA mechanics, known and widely used models with their short analysis, as well as coverage on experimental methods and data, the influence of electrical, magnetic, ionic conditions on the persistence length, and dynamics with viscosity influence. It then addresses the need to understand the nature of the non-linear overstretching transition of DNA under force and why DNA has a negative twist-stretch coupling. Includes coverage of 17 contemporary models of DNA mechanics with analysis Provides comparison of DNA and RNA mechanical features Covers advances in experimental techniques including AFM, X-ray, and optical tweezers Contains extensive references for further reading

Advanced Mechanical Models of DNA Elasticity

Advanced Mechanical Models of DNA Elasticity Book
Author : Yakov M Tseytlin
Publisher : Academic Press
Release : 2016-07-29
ISBN : 0128020369
Language : En, Es, Fr & De

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Book Description :

Advanced Mechanical Models of DNA Elasticity includes coverage on 17 different DNA models and the role of elasticity in biological functions with extensive references. The novel advanced helicoidal model described reflects the direct connection between the molecule helix structure and its specific properties, including nonlinear features and transitions. It provides an introduction to the state of the field of DNA mechanics, known and widely used models with their short analysis, as well as coverage on experimental methods and data, the influence of electrical, magnetic, ionic conditions on the persistence length, and dynamics with viscosity influence. It then addresses the need to understand the nature of the non-linear overstretching transition of DNA under force and why DNA has a negative twist-stretch coupling. Includes coverage of 17 contemporary models of DNA mechanics with analysis Provides comparison of DNA and RNA mechanical features Covers advances in experimental techniques including AFM, X-ray, and optical tweezers Contains extensive references for further reading

Mechanics of Elastic Biomolecules

Mechanics of Elastic Biomolecules Book
Author : W.A. Linke,H.L. Granzier,M. Kellermayer
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401001472
Language : En, Es, Fr & De

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Book Description :

A representative cross-section of elastic biomolecules is covered in this volume, which combines seventeen contributions from leading research groups. State-of-the-art molecular mechanics experiments are described dealing with the elasticity of DNA and nucleoprotein complexes, titin and titin-like proteins in muscle, as well as proteins of the cytoskeleton and the extracellular matrix. The book speaks particularly to cell biologists, biophysicists, or bioengineers, and to senior researchers and graduate students alike, who are interested in recent advances in single-molecule technology (optical tweezers technique, atomic force microscopy), EM imaging, and computer simulation approaches to study nanobiomechanics. The findings discussed here have redefined our view of the role mechanical signals play in cellular functions and have greatly helped improve our understanding of biological elasticity in general.

Statistical Physics Of Dna An Introduction To Melting Unzipping And Flexibility Of The Double Helix

Statistical Physics Of Dna  An Introduction To Melting  Unzipping And Flexibility Of The Double Helix Book
Author : Theodorakopoulos Nikos
Publisher : World Scientific
Release : 2019-12-24
ISBN : 9811209553
Language : En, Es, Fr & De

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Book Description :

The stability of the DNA double helix is contingent on fine-tuning a number of physicochemical control parameters. Varying any one of them leads to separation of the two strands, in what constitutes a rare physical example of a thermodynamic phase transition in a one-dimensional system. The present book aims at providing a self-contained account of the statistical physics of cooperative processes in DNA, e.g. thermal and mechanical dissociation, force-induced melting, equilibria of hairpin-like secondary structures. In addition, the book presents some fundamental aspects of DNA elasticity, as observed in key experiments, old and new. The latter include some recently published scattering data on apparently soft, short DNA chains and their interpretation in terms of local structural defects (permanent bends, 'kinky DNA', after the original Crick-Klug hypothesis).The development of mathematical models used (Kratky-Porod polymer chain, Poland-Scheraga and Peyrard-Bishop-Dauxois models of DNA melting) emphasizes the use of realistic parameters and the relevance of practical numerical methods for comparing with experimental data. Accordingly, a large number of specially produced figures has been included.The presentation is at the level of an advanced undergraduate or introductory graduate course. An extra chapter provides the necessary mathematical background on elasticity of model polymer chains.

IUTAM Symposium on Interaction between Dynamics and Control in Advanced Mechanical Systems

IUTAM Symposium on Interaction between Dynamics and Control in Advanced Mechanical Systems Book
Author : Dick H. van Campen
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401157782
Language : En, Es, Fr & De

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Book Description :

During the last decades, applications of dynamical analysis in advanced, often nonlinear, engineering systems have been evolved in a revolutionary way. In this context one can think of applications in aerospace engineering like satellites, in naval engineering like ship motion, in mechanical engineering like rotating machinery, vehicle systems, robots and biomechanics, and in civil engineering like earthquake dynamics and offshore technology. One could continue with this list for a long time. The application of advanced dynamics in the above fields has been possible due to the use of sophisticated computational techniques employing powerful concepts of nonlinear dynamics. These concepts have been and are being developed in mathematics, mechanics and physics. It should be remarked that careful experimental studies are vitally needed to establish the real existence and observability of the predicted dynamical phenomena. The interaction between nonlinear dynamics and nonlinear control in advanced engineering systems is becoming of increasing importance because of several reasons. Firstly, control strategies in nonlinear systems are used to obtain desired dynamic behaviour and improved reliability during operation, Applications include power plant rotating machinery, vehicle systems, robotics, etc. Terms like motion control, optimal control and adaptive control are used in this field of interest. Since mechanical and electronic components are often necessary to realize the desired action in practice, the engineers use the term mechatronics to indicate this field. If the desired dynamic behaviour is achieved by changing design variables (mostly called system parameters), one can think of fields like control of chaos.

Physical and Numerical Models in Knot Theory

Physical and Numerical Models in Knot Theory Book
Author : Jorge Alberto Calvo
Publisher : World Scientific
Release : 2005
ISBN : 9812703462
Language : En, Es, Fr & De

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Book Description :

The physical properties of knotted and linked configurations in space have long been of interest to mathematicians. More recently, these properties have become significant to biologists, physicists, and engineers among others. Their depth of importance and breadth of application are now widely appreciated and valuable progress continues to be made each year. This volume presents several contributions from researchers using computers to study problems that would otherwise be intractable. While computations have long been used to analyze problems, formulate conjectures, and search for special structures in knot theory, increased computational power has made them a staple in many facets of the field. The volume also includes contributions concentrating on models researchers use to understand knotting, linking, and entanglement in physical and biological systems. Topics include properties of knot invariants, knot tabulation, studies of hyperbolic structures, knot energies, the exploration of spaces of knots, knotted umbilical cords, studies of knots in DNA and proteins, and the structure of tight knots. Together, the chapters explore four major themes: physical knot theory, knot theory in the life sciences, computational knot theory, and geometric knot theory.

The Mathematics and Mechanics of Biological Growth

The Mathematics and Mechanics of Biological Growth Book
Author : Alain Goriely
Publisher : Springer
Release : 2017-05-29
ISBN : 038787710X
Language : En, Es, Fr & De

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Book Description :

This monograph presents a general mathematical theory for biological growth. It provides both a conceptual and a technical foundation for the understanding and analysis of problems arising in biology and physiology. The theory and methods are illustrated on a wide range of examples and applications. A process of extreme complexity, growth plays a fundamental role in many biological processes and is considered to be the hallmark of life itself. Its description has been one of the fundamental problems of life sciences, but until recently, it has not attracted much attention from mathematicians, physicists, and engineers. The author herein presents the first major technical monograph on the problem of growth since D’Arcy Wentworth Thompson’s 1917 book On Growth and Form. The emphasis of the book is on the proper mathematical formulation of growth kinematics and mechanics. Accordingly, the discussion proceeds in order of complexity and the book is divided into five parts. First, a general introduction on the problem of growth from a historical perspective is given. Then, basic concepts are introduced within the context of growth in filamentary structures. These ideas are then generalized to surfaces and membranes and eventually to the general case of volumetric growth. The book concludes with a discussion of open problems and outstanding challenges. Thoughtfully written and richly illustrated to be accessible to readers of varying interests and background, the text will appeal to life scientists, biophysicists, biomedical engineers, and applied mathematicians alike.

Nonlinear Deformable body Dynamics

Nonlinear Deformable body Dynamics Book
Author : Albert C. J. Luo
Publisher : Springer Science & Business Media
Release : 2011-06-08
ISBN : 9783642121364
Language : En, Es, Fr & De

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Book Description :

"Nonlinear Deformable-body Dynamics" mainly consists in a mathematical treatise of approximate theories for thin deformable bodies, including cables, beams, rods, webs, membranes, plates, and shells. The intent of the book is to stimulate more research in the area of nonlinear deformable-body dynamics not only because of the unsolved theoretical puzzles it presents but also because of its wide spectrum of applications. For instance, the theories for soft webs and rod-reinforced soft structures can be applied to biomechanics for DNA and living tissues, and the nonlinear theory of deformable bodies, based on the Kirchhoff assumptions, is a special case discussed. This book can serve as a reference work for researchers and a textbook for senior and postgraduate students in physics, mathematics, engineering and biophysics. Dr. Albert C.J. Luo is a Professor of Mechanical Engineering at Southern Illinois University, Edwardsville, IL, USA. Professor Luo is an internationally recognized scientist in the field of nonlinear dynamics in dynamical systems and deformable solids.

Multiple Aspects of DNA and RNA from Biophysics to Bioinformatics

Multiple Aspects of DNA and RNA  from Biophysics to Bioinformatics Book
Author : Thomas Anthony John Duke,Jean Dalibard
Publisher : Gulf Professional Publishing
Release : 2005
ISBN : 9780444520814
Language : En, Es, Fr & De

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Book Description :

Dedicated to the multiple aspects, that is, biological, physical and computational of DNA and RNA molecules, this book is divided into three main sections. It is intended to be a reference for advanced graduate students or young researchers to acquire an interdisciplinary understanding of the multiple aspects of DNA and RNA.

Applied Mechanics Reviews

Applied Mechanics Reviews Book
Author : Anonim
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Applied Mechanics Reviews book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mechanics and Model Based Control of Advanced Engineering Systems

Mechanics and Model Based Control of Advanced Engineering Systems Book
Author : Alexander K. Belyaev,Hans Irschik,Michael Krommer
Publisher : Springer Science & Business Media
Release : 2013-12-12
ISBN : 370911571X
Language : En, Es, Fr & De

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Book Description :

Mechanics and Model-Based Control of Advanced Engineering Systems collects 32 contributions presented at the International Workshop on Advanced Dynamics and Model Based Control of Structures and Machines, which took place in St. Petersburg, Russia in July 2012. The workshop continued a series of international workshops, which started with a Japan-Austria Joint Workshop on Mechanics and Model Based Control of Smart Materials and Structures and a Russia-Austria Joint Workshop on Advanced Dynamics and Model Based Control of Structures and Machines. In the present volume, 10 full-length papers based on presentations from Russia, 9 from Austria, 8 from Japan, 3 from Italy, one from Germany and one from Taiwan are included, which represent the state of the art in the field of mechanics and model based control, with particular emphasis on the application of advanced structures and machines.

Self Assembly Pattern Formation and Growth Phenomena in Nano Systems

Self Assembly  Pattern Formation and Growth Phenomena in Nano Systems Book
Author : Alexander A. Golovin,Alexander A. Nepomnyashchy
Publisher : Springer Science & Business Media
Release : 2006
ISBN : 9781402043543
Language : En, Es, Fr & De

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Book Description :

Nano-science and nano-technology are rapidly developing scientific and technological areas that deal with physical, chemical and biological processes that occur on nano-meter scale – one millionth of a millimeter. Self-organization and pattern formation play crucial role on nano-scales and promise new, effective routes to control various nano-scales processes. This book contains lecture notes written by the lecturers of the NATO Advanced Study Institute "Self-Assembly, Pattern Formation and Growth Phenomena in Nano-Systems" that took place in St Etienne de Tinee, France, in the fall 2004. They give examples of self-organization phenomena on micro- and nano-scale as well as examples of the interplay between phenomena on nano- and macro-scales leading to complex behavior in various physical, chemical and biological systems. They discuss such fascinating nano-scale self-organization phenomena as self-assembly of quantum dots in thin solid films, pattern formation in liquid crystals caused by light, self-organization of micro-tubules and molecular motors, as well as basic physical and chemical phenomena that lead to self-assembly of the most important molecule on the basis of which most of living organisms are built – DNA. A review of general features of all pattern forming systems is also given. The authors of these lecture notes are the leading experts in the field of self-organization, pattern formation and nonlinear dynamics in non-equilibrium, complex systems.

Computational studies of RNA and DNA

Computational studies of RNA and DNA Book
Author : Jirí Šponer,Filip Lankaš
Publisher : Springer Science & Business Media
Release : 2006-10-05
ISBN : 1402048513
Language : En, Es, Fr & De

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Book Description :

This book integrates modern computational studies of nucleic acids, ranging from advanced electronic structure quantum chemical calculations through explicit solvent molecular dynamics (MD) simulations up to mesoscopic modelling, with the main focus given to the MD field. It gives an equal emphasis to the leading methods and applications while successes as well as pitfalls of the computational techniques are discussed.

Design Modeling and Characterization of Bio Nanorobotic Systems

Design  Modeling and Characterization of Bio Nanorobotic Systems Book
Author : Mustapha Hamdi,Antoine Ferreira
Publisher : Springer Science & Business Media
Release : 2010-10-06
ISBN : 9789048131808
Language : En, Es, Fr & De

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Book Description :

Nanorobots represent a nanoscale device where proteins such as DNA, carbon nanotubes could act as motors, mechanical joints, transmission elements, or sensors. When these different components were assembled together they can form nanorobots with multi-degree-of-freedom, able to apply forces and manipulate objects in the nanoscale world. Design, Modeling and Characterization of Bio-Nanorobotic Systems investigates the design, assembly, simulation, and prototyping of biological and artificial molecular structures with the goal of implementing their internal nanoscale movements within nanorobotic systems in an optimized manner.

Advanced Structural Materials

Advanced Structural Materials Book
Author : Winston O. Soboyejo,T.S. Srivatsan
Publisher : CRC Press
Release : 2006-12-21
ISBN : 1420017462
Language : En, Es, Fr & De

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Book Description :

A snapshot of the central ideas used to control fracture properties of engineered structural metallic materials, Advanced Structural Materials: Properties, Design Optimization, and Applications illustrates the critical role that advanced structural metallic materials play in aerospace, biomedical, automotive, sporting goods, and other industries in the twenty-first century. The book presents an overview of the structure, properties, and applications of these materials, including the basic ideas behind their design. It contains examples and accessible language, elucidating the basic concepts that guide the development of new alloys and composite materials. With in-depth reviews from leading contributors, the text develops an understanding of the breadth and depth of advances in the field. It begins with a broad introduction to advanced structural materials, then examines materials at the frontiers of emerging applications such as biomaterials, MEMS, amorphous materials, and nanotechnology. The chapter authors are experts in their own right and they assume no prior knowledge of a given material system, delineating the fundamental concepts and applications of advanced structural materials. The rich array of carefully selected topics provides useful insights into the structure, properties, and applications of advanced structural materials.

Localization and Solitary Waves in Solid Mechanics

Localization and Solitary Waves in Solid Mechanics Book
Author : A R Champneys,G W Hunt,J M T Thompson
Publisher : World Scientific
Release : 1999-11-30
ISBN : 9814494623
Language : En, Es, Fr & De

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Book Description :

This book is a collection of recent reprints and new material on fundamentally nonlinear problems in structural systems which demonstrate localized responses to continuous inputs. It has two intended audiences. For mathematicians and physicists it should provide useful new insights into a classical yet rapidly developing area of application of the rich subject of dynamical systems theory. For workers in structural and solid mechanics it introduces a new methodology for dealing with structural localization and the related topic of the generation of solitary waves. Applications range from classical problems such as the buckling of cylindrical shells, twisted rods and pipelines, to the folding of geological strata, the failure of sandwich structures and the propagation of solitary waves in suspended beam systems. Contents:The Strut on an Elastic FoundationNumerics and DiscretizationTwisted RodsCylindrical ShellsOther Buckling ProblemsSolitary Waves Readership: Researchers in mathematics and engineering. Keywords:

Multiple Aspects of DNA and RNA from Biophysics to Bioinformatics

Multiple Aspects of DNA and RNA  from Biophysics to Bioinformatics Book
Author : Anonim
Publisher : Elsevier
Release : 2005-12-02
ISBN : 0080461549
Language : En, Es, Fr & De

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Book Description :

This book is dedicated to the multiple aspects, that is, biological, physical and computational of DNA and RNA molecules. These molecules, central to vital processes, have been experimentally studied by molecular biologists for five decades since the discovery of the structure of DNA by Watson and Crick in 1953. Recent progresses (e.g. use of DNA chips, manipulations at the single molecule level, availability of huge genomic databases...) have revealed an imperious need for theoretical modelling. Further progresses will clearly not be possible without an integrated understanding of all DNA and RNA aspects and studies. The book is intended to be a desktop reference for advanced graduate students or young researchers willing to acquire a broad interdisciplinary understanding of the multiple aspects of DNA and RNA. It is divided in three main sections: The first section comprises an introduction to biochemistry and biology of nucleic acids. The structure and function of DNA are reviewed in R. Lavery's chapter. The next contribution, by V. Fritsch and E. Westhof, concentrates on the folding properties of RNA molecules. The cellular processes involving these molecules are reviewed by J. Kadonaga, with special emphasis on the regulation of transcription. These chapters does not require any preliminary knowledge in the field (except that of elementary biology and chemistry). The second section covers the biophysics of DNA and RNA, starting with basics in polymer physics in the contribution by R. Khokhlov. A large space is then devoted to the presentation of recent experimental and theoretical progresses in the field of single molecule studies. T. Strick's contribution presents a detailed description of the various micro-manipulation techniques, and reviews recent experiments on the interactions between DNA and proteins (helicases, topoisomerases, ...). The theoretical modeling of single molecules is presented by J. Marko, with a special attention paid to the elastic and topological properties of DNA. Finally, advances in the understanding of electrophoresis, a technique of crucial importance in everyday molecular biology, are exposed in T. Duke's contribution. The third section presents provides an overview of the main computational approaches to integrate, analyse and simulate molecular and genetic networks. First, J. van Helden introduces a series of statistical and computational methods allowing the identification of short nucleic fragments putatively involved in the regulation of gene expression from sets of promoter sequences controlling co-expressed genes. Next, the chapter by Samsonova et al. connects this issue of transcriptional regulation with that of the control of cell differentiation and pattern formation during embryonic development. Finally, H. de Jong and D. Thieffry review a series of mathematical approaches to model the dynamical behaviour of complex genetic regulatory networks. This contribution includes brief descriptions and references to successful applications of these approaches, including the work of B. Novak, on the dynamical modelling of cell cycle in different model organisms, from yeast to mammals. . Provides a comprehensive overview of the structure and function of DNA and RNA at the interface between physics, biology and information science.

Scanning Probe Microscopies Beyond Imaging

Scanning Probe Microscopies Beyond Imaging Book
Author : Paolo Samorì
Publisher : John Wiley & Sons
Release : 2006-08-21
ISBN : 3527608567
Language : En, Es, Fr & De

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Book Description :

This first book to focus on the use of SPMs to actively manipulate molecules and nanostructures on surfaces goes way beyond conventional treatments of scanning microscopy merely for imaging purposes. It reviews recent progress in the use of SPMs on such soft materials as polymers, with a particular emphasis on chemical discrimination, mechanical properties, tip-induced reactions and manipulations, as well as their nanoscale electrical properties. Detailing the practical application potential of this hot topic, this book is of great interest to specialists of wide-ranging disciplines, including physicists, chemists, materials scientists, spectroscopy experts, surface scientists, and engineers.

Scientific and Technical Aerospace Reports

Scientific and Technical Aerospace Reports Book
Author : Anonim
Publisher : Unknown
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Scientific and Technical Aerospace Reports book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Mechanics of Ribbons and M bius Bands

The Mechanics of Ribbons and M  bius Bands Book
Author : Roger Fosdick,Eliot Fried
Publisher : Springer
Release : 2015-08-14
ISBN : 9401773009
Language : En, Es, Fr & De

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Book Description :

Recent developments in biology and nanotechnology have stimulated a rapidly growing interest in the mechanics of thin, flexible ribbons and Mobius bands. This edited volume contains English translations of four seminal papers on this topic, all originally written in German; of these, Michael A. Sadowsky published the first in 1929, followed by two others in 1930, and Walter Wunderlich published the last in 1962. The volume also contains invited, peer-reviewed, original research articles on related topics. Previously published in the Journal of Elasticity, Volume 119, Issue 1-2, 2015.