Skip to main content

Adme And Translational Pharmacokinetics Pharmacodynamics Of Therapeutic Proteins

In Order to Read Online or Download Adme And Translational Pharmacokinetics Pharmacodynamics Of Therapeutic Proteins Full eBooks in PDF, EPUB, Tuebl and Mobi you need to create a Free account. Get any books you like and read everywhere you want. Fast Download Speed ~ Commercial & Ad Free. We cannot guarantee that every book is in the library!

ADME and Translational Pharmacokinetics Pharmacodynamics of Therapeutic Proteins

ADME and Translational Pharmacokinetics   Pharmacodynamics of Therapeutic Proteins Book
Author : Honghui Zhou,Frank-Peter Theil
Publisher : John Wiley & Sons
Release : 2015-12-02
ISBN : 1118898648
Language : En, Es, Fr & De

GET BOOK

Book Description :

"This book focuses on the fundamental and practical aspects of ADME and translational PK/PD for therapeutic proteins -- cutting-edge research, lessons learned from small molecules, the utility of ADME and translational PK/PD to guide lead optimization, first-in-human study dose projection and design, and clinical development and registration"--Provided by publisher.

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune Mediated Inflammatory Diseases

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune Mediated Inflammatory Diseases Book
Author : Honghui Zhou,Diane R. Mould
Publisher : John Wiley & Sons
Release : 2019-02-14
ISBN : 111928922X
Language : En, Es, Fr & De

GET BOOK

Book Description :

Thorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen chapters from world-renowned experts and opinion leaders in pharmacology, translational medicine and immunology, editors Honghui Zhou and Diane Mould have curated a much-needed collection of research on the advanced applications of pharmacometrics and systems pharmacology to the development of biotherapeutics and individualized treatment strategies for the treatment of IMIDs. Authors discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: • Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins • Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) • Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus Zhou and Mould’s timely contribution to the critical study of biopharmaceuticals is a valuable resource for any academic and industry researcher working in pharmacokinetics, pharmacology, biochemistry, or biotechnology as well as the many clinicians seeking the safest and most effective treatments for patients dealing with chronic immune disorders.

Preclinical Drug Development

Preclinical Drug Development Book
Author : Mark Rogge,David R. Taft
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1420084739
Language : En, Es, Fr & De

GET BOOK

Book Description :

Preclinical Drug Development, Second Edition discusses the broad and complicated realm of preclinical drug development. Topics range from assessment of pharmacology and toxicology to industry trends and regulatory expectations to requirements that support clinical trials. Highlights of the Second Edition include: PharmacokineticsModeling and simula

Translational ADMET Drug for Therapy

Translational ADMET Drug for Therapy Book
Author : Souzan B. Yanni
Publisher : John Wiley & Sons
Release : 2015-10-19
ISBN : 1118838270
Language : En, Es, Fr & De

GET BOOK

Book Description :

Serving as a practical handbook about ADMET for drug therapy, this book presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and computational tools for drug discovery and development, with new translational approaches to clinical drug investigations in various human populations. Illustrates ADME properties, from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations Provides examples that demonstrate the integration of in vitro, in vivo, and in silico data to address human PKPD and TKTD and help determine the proper therapeutic dosage Presents successful tools for evaluating drugs and covers current translational ADMET with regulatory guidelines Offers a hands-on manual for researchers and scientists to design and execute in vitro, in silico, preclinical, and clinical studies Includes discussion of IND / NDA filing and drug labeling to support drug registration and approval

New Scientist

New Scientist Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download New Scientist book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cancer Research

Cancer Research Book
Author : Anonim
Publisher : Unknown
Release : 2000-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Cancer Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Goodman and Gilman Manual of Pharmacology and Therapeutics Second Edition

Goodman and Gilman Manual of Pharmacology and Therapeutics  Second Edition Book
Author : Randa Hilal-Dandan,Laurence Brunton,Louis Sanford Goodman
Publisher : McGraw Hill Professional
Release : 2013-12-30
ISBN : 007176917X
Language : En, Es, Fr & De

GET BOOK

Book Description :

Goodman & Gilman Manual of Pharmacology and Therapeutics, 2e delivers the renowned content of Goodman & Gilman's Pharmacological Basis of Therapeutics, 12e condensed into an ultra-handy, streamlined reference

Biosimilars

Biosimilars Book
Author : Hiten J. Gutka,Harry Yang,Shefali Kakar
Publisher : Springer
Release : 2018-12-13
ISBN : 3319996800
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book provides a comprehensive overview of the biosimilar regulatory framework, the development process and clinical aspects for development of biosimilars. The development path of a biosimilar is just as unique as a development path of a new drug, tailored by the mechanism of action, the quality of the molecule, published information on the reference product, the current competitive environment, the target market and regulatory guidance, and most importantly, the emerging totality of evidence for the proposed biosimilar during development. For the ease of readers, the book comprises of six sections as follows: Section I: Business, Health Economics and Intellectual Property Landscape for Biosimilars Section II: Regulatory Aspects of Development and Approval for Biosimilars Section III: Biopharmaceutical Development and Manufacturing of Biosimilars Section IV: Analytical Similarity Considerations for Biosimilars Section V: Clinical aspects of Biosimilar Development Section VI: Biosimilars- Global Development and Clinical Experience Chapters have been written by one or more experts from academia, industry or regulatory agencies who have been involved with one or more aspects of biosimilar product development. The authors and editors have an expertise in commercialization and pricing of biosimilars, intellectual property considerations for biosimilars, chemistry manufacturing controls (CMC) and analytical development for biosimilars, regulatory and clinical aspects of biosimilar development. Besides the industry practitioners, the book includes several contributions from regulators across the globe.